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Biochemical Journal, ISSN 0264-6021, 06/2009, Volume 420, Issue 3, pp. 391 - 402
L1-CAM (L1 cell-adhesion molecule), or more simply L1, plays an important role ill the progression of human carcinoma. Overexpression promotes tumour-cell... 
Presenilin (PS)/γ-secretase activity | Raft | Nuclear translocation | Signalling | L1 cell-adhesion molecule (L1-CAM) | A disintegrin and metalloprotease 10 (ADAM10) | MIGRATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | raft | AMYLOID PRECURSOR PROTEIN | CLEAVAGE | presenilin (PS)/gamma-secretase activity | nuclear translocation | a disintegrin and metalloprotease 10 (ADAM10) | COLORECTAL-CANCER | LIPID RAFTS | GENE-EXPRESSION | L1 ADHESION MOLECULE | GAMMA-SECRETASE | BINDING | signalling | INTRACELLULAR DOMAIN | Amyloid Precursor Protein Secretases - genetics | RNA, Small Interfering - genetics | Cricetulus | Membrane Microdomains - metabolism | Humans | Neural Cell Adhesion Molecule L1 - genetics | Ovarian Neoplasms - pathology | Receptors, Retinoic Acid - genetics | Ovarian Neoplasms - genetics | Cell Nucleus - metabolism | Flow Cytometry | Transfection | Presenilins - metabolism | Presenilins - genetics | Female | Transcription, Genetic | Membrane Proteins - metabolism | Ovarian Neoplasms - metabolism | Active Transport, Cell Nucleus | Neural Cell Adhesion Molecule L1 - metabolism | CHO Cells | Cell Line | Cricetinae | Lysosome-Associated Membrane Glycoproteins - metabolism | Signal Transduction | Membrane Proteins - genetics | ADAM10 Protein | Binding Sites - genetics | Reverse Transcriptase Polymerase Chain Reaction | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Cell Line, Tumor | ADAM Proteins - genetics | Microscopy, Fluorescence | Index Medicus | mAb, monoclonal antibody | CRABPII, cellular retinoic acid-binding protein II | LAMP-1, lysosomal-associated membrane protein 1 | pAb, polyclonal antibody | MT1-MMP, membrane type-1 matrix metalloproteinase | hL1, human L1 | TAPI-0, N-(R)-[2-(hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine amide | DRM, detergent-resistant membrane | ECL®, enhanced chemiluminescence | ERK, extracellular-signal-regulated kinase | HRP, horseradish peroxidase | L1cyt, the cytoplasmic part of L1 | L1, L1 cell-adhesion molecule | qRT-PCR, quantitative real-time PCR | FNIII, fibronectin III | MDK, midkine or neurite growth-promoting factor 2 | ADAM, a disintegrin and metalloprotease | TACE, tumour-necrosis factor-α converting enzyme | FCS, fetal-calf serum | DAPT, N-[N-(3,5-difluorophenacetyl)-L-alanyl]-(S)-phenylglycine t-butyl ester (also known as presenilin inhibitor IX) | presenilin (PS) | ICD, intracellular domain | γ-secretase activity | siRNA, small interfering RNA | CTF, C-terminal fragment | CHO, Chinese-hamster ovary | HEK-293, human embryonic kidney-293 | PS, presenilin(-1) | APP, amyloid precursor protein | RIP, regulated intramembrane proteolysis
Journal Article
Journal Article
PLOS ONE, ISSN 1932-6203, 10/2018, Volume 13, Issue 10, p. e0206155
Alzheimer’s disease is the most common form of age-related dementia. At least 15 mutations in the human gene PRESENILIN 2 (PSEN2) have been found to cause... 
Larvae | Brain | Laboratories | Genes | Genomics | Retina | Genomes | Retinal pigment epithelium | Proteins | Signal transduction | Coding | Aging | Dementia disorders | Genetics | Skin diseases | Localization | Age | CRISPR | Zebrafish | Mammals | Gene expression | Epithelium | Pigmentation | Flavin-adenine dinucleotide | Homozygotes | Presenilin 2 | Hypoxia | Adults | Mutation | Codons | Secretase | Dementia
Journal Article
Clinical Interventions in Aging, ISSN 1176-9092, 05/2016, Volume 11, pp. 665 - 681
Journal Article
Genetics, ISSN 0016-6731, 02/2018, Volume 208, Issue 2, pp. 745 - 762
Journal Article
BioFactors, ISSN 0951-6433, 05/2011, Volume 37, Issue 3, pp. 189 - 196
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 2019
Presenilin 1 (PSEN1) is a γ-secretase component, which is in charge of the amyloid precursor protein (APP) cleavage. APP is believed to play a central role in... 
Presenilin | Genetics | Mutation | PSEN1 | Alzheimer's disease
Journal Article
The Journal of neuroscience : the official journal of the Society for Neuroscience, ISSN 0270-6474, 03/2019, Volume 39, Issue 12, pp. 2195 - 2207
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2019, Volume 116, Issue 1, pp. 141 - 147
Journal Article
Journal Article
by Hanson, P and Li, C and Jang, E and Rai, H and Chang, A and Mo, A and McManus, B and Seidman, M
Canadian Journal of Cardiology, ISSN 0828-282X, 10/2017, Volume 33, Issue 10, pp. S204 - S205
Journal Article
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 12/2018, Volume 66, Issue 4, pp. 1323 - 1339
PRESENILIN 1 (PSEN1) and PRESENILIN 2 (PSEN2) genes are loci for mutations causing familial Alzheimer’s disease (fAD). However, the function of these genes and... 
Pathogenesis | Genes | Innate immunity | Immunity | Autophagy | Loci | Proteins | Mitochondria | Presenilin 2 | Presenilin 1 | Physiology | Mutation | Alzheimer's disease | Secretase | Phagocytosis
Journal Article