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Toxicology and Applied Pharmacology, ISSN 0041-008X, 09/2014, Volume 279, Issue 3, pp. 266 - 274
Acetaminophen (APAP) overdose is the most prevalent cause of drug-induced liver injury in western countries. Numerous studies have been conducted to... 
Oncotic necrosis | Drug-induced liver injury | Mitochondrial dysfunction | c-Jun-N-terminal kinase | Acetaminophen protein adducts | C-Jun-N-terminal kinase | OXIDANT STRESS | HEPATIC-NECROSIS | N-ACETYLCYSTEINE | INDUCED LIVER-INJURY | TERMINAL KINASE | CULTURED MOUSE HEPATOCYTES | PHARMACOLOGY & PHARMACY | MICE | TOXICOLOGY | INDUCED HEPATOTOXICITY | PROTEIN ADDUCTS | Glutathione - metabolism | Humans | Middle Aged | Mitochondrial Diseases - metabolism | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Necrosis - pathology | Young Adult | Analgesics, Non-Narcotic - toxicity | Mitochondrial Diseases - chemically induced | Adult | Female | Cell Death - drug effects | Hepatocytes - drug effects | Antidotes - pharmacology | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Subcellular Fractions - drug effects | Acetaminophen - toxicity | Acetaminophen - antagonists & inhibitors | Enzyme Activation - drug effects | Subcellular Fractions - metabolism | Mitochondria, Liver - drug effects | Proteins - metabolism | Acetylcysteine - pharmacology | Aged | Primary Cell Culture | Subcellular Fractions - enzymology | Hepatocytes - enzymology | HUMAN POPULATIONS | APOPTOSIS | INJURIES | NECROSIS | GLUTATHIONE | LIVER | MITOCHONDRIA | LIVER CELLS | ADDUCTS | TIME DEPENDENCE | 60 APPLIED LIFE SCIENCES | acetaminophen protein adducts | mitochondrial dysfunction | oncotic necrosis
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 03/2015, Volume 283, Issue 3, pp. 168 - 177
Accumulation of bile acids is a major mediator of cholestatic liver injury. Recent studies indicate bile acid composition between humans and rodents is... 
Biomarkers | Inflammation | Bile acids | HMGB1 | Primary human hepatocytes | Obstructive cholestasis | RAT HEPATOCYTES | ACETAMINOPHEN HEPATOTOXICITY | INDUCED LIVER-INJURY | CELL-DEATH | DUCT-LIGATED MICE | RECEPTOR TGR5 | URSODEOXYCHOLIC ACID | ONCOTIC NECROSIS | PRIMARY BILIARY-CIRRHOSIS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PRIMARY SCLEROSING CHOLANGITIS | Bile Acids and Salts - blood | Species Specificity | Bile Acids and Salts - toxicity | Humans | Mice, Inbred C57BL | Cells, Cultured | Hepatocytes - pathology | Biomarkers - blood | Hepatocytes - metabolism | Jaundice, Obstructive - pathology | Necrosis | Dose-Response Relationship, Drug | Animals | Cholestasis, Extrahepatic - blood | Jaundice, Obstructive - blood | Glycochenodeoxycholic Acid - toxicity | Acetylation | Primary Cell Culture | Keratin-18 - blood | Cholestasis, Extrahepatic - pathology | HMGB1 Protein - blood | Hepatocytes - drug effects | Keratin | Care and treatment | Jaundice, Obstructive | Analysis | Cholestasis | Deoxycholic acid | Index Medicus | HUMAN POPULATIONS | APOPTOSIS | GLYCINE | PATIENTS | INJURIES | RODENTS | BILIARY TRACT | TOXICITY | LEVELS | 60 APPLIED LIFE SCIENCES | CONCENTRATION RATIO | POLYPEPTIDES | NECROSIS | CHOLIC ACID | INFLAMMATION | LIVER | LIVER CELLS | AMINOTRANSFERASES | BILE | bile acids | primary human hepatocytes | inflammation | biomarkers | obstructive cholestasis | apoptosis
Journal Article
Journal Article
EXPERIMENTAL BIOLOGY AND MEDICINE, ISSN 1535-3702, 05/2015, Volume 240, Issue 5, pp. 645 - 656
Primary human hepatocytes (PHH) are considered to be the gold standard for in vitro testing of xenobiotic metabolism and hepatotoxicity. However, PHH... 
RAT-LIVER | MEDICINE, RESEARCH & EXPERIMENTAL | primary cell isolation | COLLAGEN | primary human hepatocytes | Liver | liver tissue engineering | CULTURE | LIPOCYTES | IN-VITRO | HEPATIC STELLATE CELLS | non-parenchymal liver cells | SINUSOIDAL ENDOTHELIAL-CELLS | DISEASE | KUPFFER CELLS | liver in vitro model | INDUCED HEPATOTOXICITY
Journal Article
Toxicological Sciences, ISSN 1096-6080, 06/2015, Volume 145, Issue 2, pp. 307 - 320
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 08/2017, Volume 61, Issue 8
Hepatitis B virus (HBV) capsid assembly is a critical step in the propagation of the virus and is mediated by the core protein. Due to its multiple functions... 
CccDNA | Hepatitis | Capsid assembly modulator | Hepatitis B virus | Capsid | Primary human hepatocytes | Core | cccDNA | RNA | NUCLEOCAPSIDS | primary human hepatocytes | hepatitis B virus | PERSISTENCE | capsid | MICROBIOLOGY | hepatitis | CELL-CULTURES | core | INHIBITION | HBV REPLICATION | VIRAL-DNA | CCC-DNA | PHARMACOLOGY & PHARMACY | capsid assembly modulator | MINICHROMOSOME | DERIVATIVES
Journal Article
Experimental Cell Research, ISSN 0014-4827, 11/2019, Volume 384, Issue 2, p. 111643
Human hepatocarcinogenesis is a complex process with many unresolved issues, including the cell of origin (differentiated and/or progenitor/stem cells) and the... 
Hepatocellular carcinoma | Transformation | Primary human hepatocytes | Immature phenotype
Journal Article
EXPERIMENTAL CELL RESEARCH, ISSN 0014-4827, 11/2019, Volume 384, Issue 2
Human hepatocarcinogenesis is a complex process with many unresolved issues, including the cell of origin (differentiated and/or progenitor/stem cells) and the... 
Transformation | VIRUS | CONVERSION | Hepatocellular carcinoma | STEMNESS | Immature phenotype | CELL BIOLOGY | LIVER-CANCER | PATHOGENESIS | INHIBITION | ONCOLOGY | PATHWAY | HA-RAS | Primary human hepatocytes | CELL | TUMORIGENESIS
Journal Article
Experimental Biology and Medicine, ISSN 1535-3702, 5/2015, Volume 240, Issue 5, pp. 645 - 656
Primary human hepatocytes (PHH) are considered to be the gold standard for in vitro testing of xenobiotic metabolism and hepatotoxicity. However, PHH... 
liver in vitro model | primary cell isolation | primary human hepatocytes | Liver | liver tissue engineering | non-parenchymal liver cells | Hepatocytes - cytology | Microscopy, Electron, Scanning | Humans | Cells, Cultured | Liver - cytology | Cell Adhesion | Phagocytosis | Original Research
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 01/2020, Volume 499, p. 110604
Until three decades, ago 3,5-diiodothyronine (3,5-T ) and 3,3′-diiodothyronine (3,3′-T ) were considered products of thyroid hormone catabolism without... 
Diiodothyronines | Metabolic homeostasis | Human primary hepatocytes | mTORC2 | mTORC1 | Lipid and glucose metabolism
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2006, Volume 46, Issue 3, pp. 411 - 419
Background/Aims The direct implication of low-density lipoprotein receptor (LDLR) in hepatitis C virus (HCV) infection of human hepatocyte has not been... 
Gastroenterology and Hepatology | Virus receptor | Genome replication | Virus entry | LDL RECEPTOR | CULTURED HUMAN HEPATOCYTES | IN-VITRO INFECTION | virus receptor | genome replication | CANDIDATE RECEPTOR | SCAVENGER RECEPTOR | HUMAN HEPATOMA-CELLS | STRUCTURAL PROTEINS | virus entry | TERM PRIMARY CULTURES | BINDING-SITE | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | CD18 Antigens - physiology | Humans | Middle Aged | Hepacivirus - genetics | Lipoproteins, LDL - physiology | Hepacivirus - pathogenicity | Hepatocytes - pathology | Male | Antibodies - physiology | Scavenger Receptors, Class B - physiology | Viral Load | RNA, Viral - genetics | Virion | Adult | Female | Hepacivirus - physiology | RNA, Viral - metabolism | Receptors, LDL - genetics | Tricarboxylic Acids - pharmacology | Cells, Cultured | Receptors, LDL - immunology | Hydroxycholesterols - pharmacology | Lipoproteins, HDL - physiology | Gene Expression Regulation - drug effects | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Adolescent | Hepatocytes - virology | Hepatitis C - physiopathology | Aged | Hepatitis C - pathology | Receptors, LDL - physiology | Anticholesteremic Agents - pharmacology | Hepatitis C | Health aspects | Scavenger Receptors, Class B | Receptors, LDL | Antibodies | Bicyclo Compounds, Heterocyclic | Life Sciences | Tricarboxylic Acids | Anticholesteremic Agents | Hépatology and Gastroenterology | Gene Expression Regulation | Human health and pathology | Hepatocytes | Hydroxycholesterols | RNA, Viral | Antigens, CD18 | Lipoproteins, HDL | Hepacivirus | Lipoproteins, LDL
Journal Article