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1. Prodrug design to improve pharmacokinetic and drug delivery properties: Challenges to the discovery scientists
by Jana, S and Mandlekar, S and Marathe, P
Current medicinal chemistry, ISSN 0929-8673, 11/2010, Volume 17, Issue 32, pp. 3874 - 3908
Carrier-mediated transport | Absorption | Solubility | Drug targeting | Bioavailability | Permeability | Prodrug | Transporter | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Prodrugs - administration & dosage | Prodrugs - pharmacokinetics | Drug Design | Biological Availability | Membrane Transport Proteins - metabolism | Clinical Trials as Topic | Prodrugs - chemistry | Drug Carriers - chemistry | Reviews | Drug delivery | Drug discovery | Drug development | Pharmacokinetics | prodrugs | Pharmaceuticals
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2. Full Text Is prodrug design an approach to increase water solubility?
by Sanches, Bruna M.A and Ferreira, Elizabeth I
International journal of pharmaceutics, ISSN 0378-5173, 09/2019, Volume 568, pp. 118498 - 118498
Prodrug design | Ester prodrugs | Drug solubility | Phosphate prodrugs | Amide prodrugs | N-Mannich base prodrugs | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Prodrugs - administration & dosage | Animals | Humans | Drug Design | Solubility | Water - chemistry | Water - administration & dosage | Prodrugs - chemistry | Index Medicus
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3. Full Text The prodrug approach: A successful tool for improving drug solubility
by Jornada, Daniela Hartmann and Dos Santos Fernandes, Guilherme Felipe and Chiba, Diego Eidy and De Melo, Thais Regina Ferreira and Dos Santos, Jean Leandro and Chung, Man Chin
Molecules (Basel, Switzerland), ISSN 1420-3049, 01/2016, Volume 21, Issue 1, pp. 42 - 42
Solubility of prodrugs | Prodrug | Water-soluble prodrugs | Molecular modification | Solubility | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Drug Design | Prodrugs - chemical synthesis | Biological Availability | Prodrugs - chemistry | Prodrugs - pharmacology | Drug Delivery Systems | Index Medicus | prodrug | solubility | solubility of prodrugs | water-soluble prodrugs | molecular modification
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4. Full Text Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
by Warren, Travis K and Jordan, Robert and Lo, Michael K and Ray, Adrian S and Mackman, Richard L and Soloveva, Veronica and Siegel, Dustin and Perron, Michel and Bannister, Roy and Hui, Hon C and Larson, Nate and Strickley, Robert and Wells, Jay and Stuthman, Kelly S and Van Tongeren, Sean A and Garza, Nicole L and Donnelly, Ginger and Shurtleff, Amy C and Retterer, Cary J and Gharaibeh, Dima and Zamani, Rouzbeh and Kenny, Tara and Eaton, Brett P and Grimes, Elizabeth and Welch, Lisa S and Gomba, Laura and Wilhelmsen, Catherine L and Nichols, Donald K and Nuss, Jonathan E and Nagle, Elyse R and Kugelman, Jeffrey R and Palacios, Gustavo and Doerffler, Edward and Neville, Sean and Carra, Ernest and Clarke, Michael O and Zhang, Lijun and Lew, Willard and Ross, Bruce and Wang, Queenie and Chun, Kwon and Wolfe, Lydia and Babusis, Darius and Park, Yeojin and Stray, Kirsten M and Trancheva, Iva and Feng, Joy Y and Barauskas, Ona and Xu, Yili and Wong, Pamela and Braun, Molly R and Flint, Mike and McMullan, Laura K and Chen, Shan-Shan and Fearns, Rachel and Swaminathan, Swami and Mayers, Douglas L and Spiropoulou, Christina F and Lee, William A and Nichol, Stuart T and Cihlar, Tomas and Bavari, Sina
Nature (London), ISSN 0028-0836, 03/2016, Volume 531, Issue 7594, pp. 381 - 385
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Alanine - therapeutic use | Antiviral Agents - pharmacokinetics | Hemorrhagic Fever, Ebola - prevention & control | Humans | Molecular Sequence Data | Male | Ribonucleotides - pharmacokinetics | Ebolavirus - drug effects | Ribonucleotides - pharmacology | Alanine - analogs & derivatives | Macaca mulatta - virology | Female | Hemorrhagic Fever, Ebola - drug therapy | Alanine - pharmacology | Amino Acid Sequence | Antiviral Agents - pharmacology | Alanine - pharmacokinetics | Antiviral Agents - therapeutic use | Organ Specificity | Ribonucleotides - therapeutic use | Animals | Prodrugs - pharmacokinetics | Cell Line, Tumor | Prodrugs - therapeutic use | HeLa Cells | Prodrugs - pharmacology | Ebola virus | Rhesus monkey | Treatment outcome | Control | Analysis | Drug therapy | Testing | Prodrugs | Research | Health aspects | Pathogens | RNA polymerase | Monkeys & apes | Index Medicus
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5. Full Text Disulfide Bond-Driven Oxidation- and Reduction-Responsive Prodrug Nanoassemblies for Cancer Therapy
by Sun, Bingjun and Luo, Cong and Yu, Han and Zhang, Xuanbo and Chen, Qin and Yang, Wenqian and Wang, Menglin and Kan, Qiming and Zhang, Haotian and Wang, Yongjun and He, Zhonggui and Sun, Jin
Nano letters, ISSN 1530-6984, 06/2018, Volume 18, Issue 6, pp. 3643 - 3650
cancer therapy | paclitaxel | Disulfide bond | prodrug nanoassemblies | redox dual responsive | Materials Science | Materials Science, Multidisciplinary | Physics, Condensed Matter | Science & Technology - Other Topics | Chemistry, Physical | Physics | Science & Technology | Physics, Applied | Physical Sciences | Chemistry | Nanoscience & Nanotechnology | Technology | Chemistry, Multidisciplinary | Prodrugs - administration & dosage | Nanoparticles - chemistry | Oxidation-Reduction | Humans | Antineoplastic Agents, Phytogenic - chemistry | Delayed-Action Preparations - chemistry | Paclitaxel - pharmacokinetics | Prodrugs - chemistry | Paclitaxel - therapeutic use | Neoplasms - drug therapy | Paclitaxel - chemistry | Antineoplastic Agents, Phytogenic - administration & dosage | Animals | Prodrugs - pharmacokinetics | Disulfides - chemistry | Mice, Nude | Drug Liberation | Prodrugs - therapeutic use | Antineoplastic Agents, Phytogenic - therapeutic use | Paclitaxel - administration & dosage | Antineoplastic Agents, Phytogenic - pharmacokinetics | Index Medicus
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6. Full Text New generation nanomedicines constructed from self-assembling small-molecule prodrugs alleviate cancer drug toxicity
by Wang, Hangxiang and Lu, Zhongjie and Wang, Lijiang and Guo, Tingting and Wu, Jiaping and Wan, Jianqin and Zhou, Liqian and Li, Hui and Li, Zhen and Jiang, Donghai and Song, Penghong and Xie, Haiyang and Zhou, Lin and Xu, Xiao and Zheng, Shusen
Cancer research (Chicago, Ill.), ISSN 0008-5472, 2017, Volume 77, Issue 24, pp. 6963 - 6974
Life Sciences & Biomedicine | Oncology | Science & Technology | Neoplasms - metabolism | Drug-Related Side Effects and Adverse Reactions - prevention & control | Humans | Prodrugs - chemistry | Antineoplastic Agents - administration & dosage | Nanomedicine - trends | Antineoplastic Agents - adverse effects | Antineoplastic Agents - pharmacokinetics | Taxoids - adverse effects | Polymers - chemical synthesis | Polymerization | Rats | Materials Testing | Rats, Sprague-Dawley | Mice, Inbred ICR | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Taxoids - administration & dosage | Animals | Prodrugs - pharmacokinetics | Mice, Nude | Nanomedicine - methods | Polymers - pharmacokinetics | Cell Line, Tumor | Prodrugs - chemical synthesis | Polymers - chemistry | Mice | Mice, Inbred BALB C | Prodrugs - therapeutic use | Drug Delivery Systems - methods | Drugs | Self assembly | Drug delivery systems | Prodrugs | Effectiveness | Toxicity | Polyunsaturated fatty acids | Cytotoxicity | Pharmacology | Hydrophobicity | Docosahexaenoic acid | Chemical compounds | Fatty acids | Self-assembly | Assembling | Xenografts | Combinatorial analysis | Cancer | Index Medicus
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7. Full Text Theranostic Liposomes with Hypoxia-Activated Prodrug to Effectively Destruct Hypoxic Tumors Post-Photodynamic Therapy
by Feng, Liangzhu and Cheng, Liang and Dong, Ziliang and Tao, Danlei and Barnhart, Todd E and Cai, Weibo and Chen, Meiwan and Liu, Zhuang
ACS nano, ISSN 1936-0851, 01/2017, Volume 11, Issue 1, pp. 927 - 937
tumor hypoxia | hypoxia-activated therapy | liposomes | multimodal imaging | photodynamic therapy | Amines - chemistry | Photosensitizing Agents - chemistry | Theranostic Nanomedicine | Hydrocarbons - chemical synthesis | Antineoplastic Agents - chemical synthesis | Positron-Emission Tomography | Prodrugs - chemistry | Structure-Activity Relationship | Photochemotherapy | Prodrugs - metabolism | Breast Neoplasms - metabolism | Hypoxia - metabolism | Dose-Response Relationship, Drug | Photosensitizing Agents - pharmacology | Hydrocarbons - chemistry | Female | Antineoplastic Agents - pharmacology | Hydrocarbons - pharmacology | Photosensitizing Agents - chemical synthesis | Amines - chemical synthesis | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Animals | Breast Neoplasms - pathology | Cell Line, Tumor | Prodrugs - chemical synthesis | Cell Proliferation - drug effects | Mice | Liposomes | Amines - pharmacology | Prodrugs - pharmacology | Index Medicus
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8. Full Text Prodrugs-from serendipity to rational design
by Huttunen, Kristiina M and Raunio, Hannu and Rautio, Jarkko
Pharmacological reviews, ISSN 0031-6997, 09/2011, Volume 63, Issue 3, pp. 750 - 771
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Technology, Pharmaceutical - trends | Prodrugs - adverse effects | Animals | Drug-Related Side Effects and Adverse Reactions - prevention & control | Prodrugs - pharmacokinetics | Biotransformation | Humans | Drug Design | Prodrugs - therapeutic use | Drug Discovery | Prodrugs - pharmacology | Index Medicus
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9. Full Text Prodrug approach: An overview of recent cases
by Abet, Valentina and Filace, Fabiana and Recio, Javier and Alvarez-Builla, Julio and Burgos, Carolina
European journal of medicinal chemistry, ISSN 0223-5234, 02/2017, Volume 127, pp. 810 - 827
Bioprecursors | Carrier-linked prodrug | Prodrug | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Prodrugs - adverse effects | Animals | Humans | Solubility | Water - chemistry | Cell Membrane Permeability | Drug Discovery - methods | Prodrugs - chemistry | Absorption, Physicochemical | Prodrugs - metabolism | Index Medicus
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