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Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2005, Volume 387, Issue 3, pp. 711 - 717
Journal Article
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2007, Volume 401, Issue 1, pp. 227 - 234
The activity and levels of the metazoan HIT (hypoxia-inducible factor) are regulated by its hydroxylation, catalysed by 2015 (2-oxoglutarate)- and... 
Oxygen consumption assay | Dioxygenase | Hypoxia-inducible factor (HIF) | Hydroxylase | 2-oxoglutarate (2OG) | Glucose oxidase (GOX) | oxygen consumption assay | PROTEIN | HIF HYDROXYLASES | GLUCOSE-OXIDASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | dioxygenase | ALPHA | PHYTANOYL-COA 2-HYDROXYLASE | hydroxylase | FAMILY | hypoxia-inducible factor (HIF) | STRUCTURAL BASIS | PROLYL 4-HYDROXYLASES | glucose oxidase (GOX) | DEPENDENT DEGRADATION | Recombinant Proteins - metabolism | Glucose Oxidase - metabolism | Peptide Fragments - metabolism | Oxygen Consumption | Repressor Proteins - genetics | Substrate Specificity | Hypoxia-Inducible Factor-Proline Dioxygenases | Transcription Factors - genetics | Procollagen-Proline Dioxygenase - metabolism | Mixed Function Oxygenases | Transcription Factors - metabolism | Peptide Fragments - chemistry | Procollagen-Proline Dioxygenase - genetics | Cloning, Molecular | Protein Binding | Kinetics | Repressor Proteins - metabolism | CAD, C-terminal transcriptional activation domain | 2OG, 2-oxoglutarate | TauD, taurine dioxygenase | FIH, factor inhibiting HIF | mPAHX, mature PAHX | ESI-MS, electrospray ionization MS | GOX, glucose oxidase | HIF, hypoxia-inducible factor | NODD, N-terminal oxygen-dependent degradation domain | PHD, prolyl hydroxylase domain-containing protein | CODD, C-terminal oxygen-dependent degradation domain | o, observed | c, calculated | PAHX, phytanoyl-CoA hydroxylase | SPR, surface plasmon resonance
Journal Article
Clinical Science, ISSN 0143-5221, 05/2014, Volume 126, Issue 9, pp. 671 - 678
In the present study we sought to determine the effect of CoCl2, an inhibitor of PHD (prolyl hydroxylase domain protein), on the development of MA (abdominal... 
Matrix metalloproteinase (MMP) | Cobalt chloride (CoCl | Prolyl hydroxylase domain protein (PHD) | Abdominal aortic aneurysm | Cytokine | cytokine | MEDICINE, RESEARCH & EXPERIMENTAL | COBALT CHLORIDE | ACTIVATION | cobalt chloride (CoCl2) | matrix metalloproteinase (MMP) | NITRIC-OXIDE | INJURY | abdominal aortic aneurysm | prolyl hydroxylase domain protein (PHD) | PATHOPHYSIOLOGY | Aortic Aneurysm, Abdominal - chemically induced | Aortitis - immunology | Phosphorylation | Aortic Aneurysm, Abdominal - prevention & control | Aortic Aneurysm, Abdominal - immunology | Extracellular Matrix - metabolism | Aortitis - enzymology | Aortitis - chemically induced | Hypoxia-Inducible Factor-Proline Dioxygenases - antagonists & inhibitors | Aortitis - prevention & control | Aorta, Abdominal - drug effects | Matrix Metalloproteinase 9 - metabolism | Cobalt - pharmacology | Time Factors | Inflammation Mediators - metabolism | Aorta, Abdominal - pathology | Aortitis - pathology | Aortic Aneurysm, Abdominal - pathology | Macrophages - immunology | Superoxide Dismutase - metabolism | Disease Models, Animal | Calcium Chloride | Cytokines - metabolism | Matrix Metalloproteinase 2 - metabolism | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Aorta, Abdominal - enzymology | Aorta, Abdominal - immunology | Catalase - metabolism | Animals | Aortic Aneurysm, Abdominal - enzymology | Transcription Factor RelA - metabolism | Hypoxia-Inducible Factor-Proline Dioxygenases - metabolism | Macrophages - drug effects | Mice | Superoxide Dismutase-1 | Index Medicus
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2018, Volume 28, Issue 10, pp. 1725 - 1730
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 2, pp. 231 - 240
HIFs [hypoxia-inducible (transcription) factors] are essential for the induction of an adaptive gene expression programme under low oxygen partial pressure.... 
Hypoxia | Von Hippel-Lindau protein (VHL protein) | Proline hydroxylase domain (PHD) | EGL nine homologue (EGLN) | Hypoxia-inducible factor (HIF) | Oxygen-degradation domain (ODD) | hypoxia | CELLS | ACTIVATION | MODIFY | BIOCHEMISTRY & MOLECULAR BIOLOGY | von Hippel-Lindau protein (VHL protein) | proline hydroxylase domain (PHD) | FAMILY | HIGH-EFFICIENCY TRANSFORMATION | DESTRUCTION | hypoxia-inducible factor (HIF) | HYDROXYLASES PHD1 | INHIBITION | FACTOR-1-ALPHA | oxygen-degradation domain (ODD) | HIF-ALPHA | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Humans | Substrate Specificity - physiology | Oxygen - metabolism | Procollagen-Proline Dioxygenase - metabolism | Sequence Homology, Amino Acid | Procollagen-Proline Dioxygenase - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - chemistry | HeLa Cells | Procollagen-Proline Dioxygenase - chemistry | Protein Binding - physiology | Protein Structure, Tertiary - physiology | NODD, N-terminal ODD (oxygen-dependent degradation domain) | VHL, von Hippel–Lindau | HRE, hypoxia-response element | AD, Gal4 activation domain | HIF, hypoxia-inducible factor | SD, synthetic defined | DBD, Gal4 DNA-binding domain | CODD, C-terminal ODD | MYND, myeloid, Nervy, and DEAF-1 | EGLN, EGL nine homologue | von Hippel–Lindau protein (VHL protein)
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2004, Volume 381, Issue 3, pp. 761 - 767
An important regulator involved in oxygen-dependent gene expression is the transcription factor HIF (hypoxia-inducible factor), which is composed of an... 
Post-translational modification | Hypoxia-inducible factor | Protein degradation | Oxygen sensing | Prolyl hydroxylation | Von-Hippel-Lindau protein | TRANSCRIPTIONAL ACTIVITY | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA | hypoxia-inducible factor | oxygen sensing | post-translational modification | von-Hippel-Lindau protein | FAMILY | OXYGEN | FACTOR-1-ALPHA | GENE-EXPRESSION | HIF-1-ALPHA | VHL | protein degradation | prolyl hydroxylation | Humans | Half-Life | Kidney Neoplasms - metabolism | Ubiquitin-Protein Ligases - physiology | Bone Neoplasms - pathology | Hypoxia-Inducible Factor 1, alpha Subunit | RNA, Messenger - biosynthesis | Liver Neoplasms - pathology | Liver Neoplasms - enzymology | Kidney Tubules, Proximal - cytology | DNA-Binding Proteins - physiology | Hypoxia - enzymology | Hydroxylation | Hypoxia-Inducible Factor 1 | Immediate-Early Proteins - biosynthesis | Carcinoma, Hepatocellular - enzymology | Tumor Suppressor Proteins - physiology | Epithelial Cells - enzymology | Liver Neoplasms - metabolism | Cell Line, Tumor | Von Hippel-Lindau Tumor Suppressor Protein | Enzyme Induction - physiology | Osteosarcoma - pathology | Carcinoma, Hepatocellular - metabolism | Epithelial Cells - metabolism | Gene Expression Regulation, Enzymologic - physiology | Oxygen - metabolism | Procollagen-Proline Dioxygenase - biosynthesis | Bone Neoplasms - metabolism | Procollagen-Proline Dioxygenase - metabolism | DNA-Binding Proteins - metabolism | Kidney Tubules, Proximal - enzymology | Gene Expression Regulation, Neoplastic - physiology | Osteosarcoma - metabolism | Cell Line | Transcription Factors - physiology | Bone Neoplasms - enzymology | Osteosarcoma - enzymology | Adenocarcinoma, Clear Cell - metabolism | Nuclear Proteins - metabolism | Hypoxia-Inducible Factor-Proline Dioxygenases | Dioxygenases | Transcription Factors - metabolism | Kidney Neoplasms - enzymology | Carcinoma, Hepatocellular - pathology | Kidney Tubules, Proximal - metabolism | Kidney Neoplasms - pathology | Adenocarcinoma, Clear Cell - pathology | Nuclear Proteins - physiology | Adenocarcinoma, Clear Cell - enzymology | DNA-Binding Proteins - biosynthesis | ODD, oxygen-dependent degradation domain | aRP, acidic ribosomal protein | RNAi, RNA interference | pVHL, von-Hippel-Lindau protein | EGLN, egg-laying deficient nine-like protein | HIF, hypoxia-inducible factor | siRNA, small interfering RNA | IVTT, in vitro transcription | PHD, prolyl hydroxylase domain containing protein | translation | RT, reverse transcriptase | RPTEC, human renal proximal tubular epithelial cells
Journal Article