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Journal of the American Heart Association, ISSN 2047-9980, 10/2017, Volume 6, Issue 10, p. n/a
Background Intermittent hypoxia (IH) induced by obstructive sleep apnea is the key factor involved in cardiovascular fibrosis. Under persistent hypoxia... 
obstructive sleep apnea | endothelial‐to‐mesenchymal transition | cardiac perivascular fibrosis | intermittent hypoxia | prolyl 4‐hydroxylase domain protein 3 | Intermittent hypoxia | Endothelial-to-mesenchymal transition | Cardiac perivascular fibrosis | Obstructive sleep apnea | Prolyl 4-hydroxylase domain protein 3 | HYPOXIA-INDUCIBLE FACTOR | CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | MECHANISMS | NEUTROPHIL APOPTOSIS | endothelial-to-mesenchymal transition | HEART | DISEASE | CONSEQUENCES | prolyl 4-hydroxylase domain protein 3 | EXTRACELLULAR-MATRIX | obstructive slee apnea | SNAIL | Ventricular Function, Left | Humans | Sleep Apnea, Obstructive - enzymology | Cardiomyopathies - prevention & control | Male | Sleep Apnea, Obstructive - complications | Smad3 Protein - metabolism | Cardiomyopathies - enzymology | Procollagen-Proline Dioxygenase - biosynthesis | Cardiomyopathies - genetics | Ventricular Remodeling | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Cell Shape | Epithelial-Mesenchymal Transition | Disease Models, Animal | Signal Transduction | Mice, Inbred C57BL | Sleep Apnea, Obstructive - genetics | Cells, Cultured | Hypoxia-Inducible Factor-Proline Dioxygenases - genetics | Smad2 Protein - metabolism | Enzyme Induction | Cardiomyopathies - pathology | Myocardium - pathology | Collagen - metabolism | Myocardium - enzymology | Animals | Human Umbilical Vein Endothelial Cells - enzymology | Procollagen-Proline Dioxygenase - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases - metabolism | Fibrosis | Human Umbilical Vein Endothelial Cells - pathology | Endothelial Cells - pathology | Endothelial Cells - enzymology | Cell Movement
Journal Article
The Journal of Pathology, ISSN 0022-3417, 07/2017, Volume 242, Issue 3, pp. 322 - 333
Osteogenic–angiogenic coupling is promoted by the hypoxia‐inducible factor 1‐alpha (HIF‐1α) transcription factor, provoking interest in HIF activation as a... 
hypoxia‐inducible factor (HIF) | differentiation | PHD2 | osteoclast | bone resorption | hypoxia-inducible factor (HIF) | RHEUMATOID-ARTHRITIS | ACTIVATION | PROLYL HYDROXYLATION | TUMOR | PATHOLOGY | IN-VITRO | ONCOLOGY | H+-ATPASE | NF-KAPPA-B | SKELETAL DEVELOPMENT | Bone Resorption - physiopathology | Osteogenesis - physiology | Humans | RNA, Messenger - metabolism | Hypoxia-Inducible Factor-Proline Dioxygenases - deficiency | Leukocytes, Mononuclear - pathology | Animals | Cell Adhesion - physiology | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Female | Mice | Hypoxia-Inducible Factor 1, alpha Subunit - physiology | Osteoclasts - physiology | Cell Differentiation - physiology | Cancellous Bone - physiology | Prolyl Hydroxylases - physiology | Bone resorption | Bones | Hydroxylases | RNA | Density | Analysis | Osteoprogenitor cells | Hypoxia-inducible factor 1 | Activation | Bone (trabecular) | CD14 antigen | Osteolysis | Osteoblasts | Angiogenesis | Biomedical materials | Hypoxia-inducible factor 1a | Mineralization | Bone marrow | Biocompatibility | Inhibition | Coupling | Hypoxia-inducible factors | Enzymes | Hydroxylase | Gene expression | Diseases | Osteoclastogenesis | Pathology | Monocytes | Bone mass | Glycolysis | Hypoxia | Osteoclasts | Differentiation | Original Papers | Original Paper
Journal Article
ISSN 0085-2538, 2017
Complement C1q is part of the C1 macromolecular complex that mediates the classical complement activation pathway: a major arm of innate immune defense. C1q is... 
complement C1q | hypoxia-inducible factor | prolyl hydroxylase inhibitors
Journal Article
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 09/2014, Volume 96, Issue 3, pp. 365 - 375
Journal Article
Journal Article
The Korean Journal of Physiology & Pharmacology, ISSN 1226-4512, 04/2013, Volume 17, Issue 2, pp. 111 - 120
Prolyl 4 hydroxylases (P4H) are iron-and 2-oxoglutamate-dependent dioxygenase enzymes and hypoxia-inducible transcription factor (HIF)-P4Hs play a critical... 
Hypoxia inducible factor | inflammation | prolyl hydroxylase | ischemia | Inflammation | Prolyl hydroxylase | Ischemia | HYPOXIA-INDUCIBLE FACTOR | PHYSIOLOGY | HEART-FAILURE | ALPHA-SUBUNIT ISOFORM | FACTOR-I | SYNCATALYTIC INACTIVATION | PHARMACOLOGY & PHARMACY | HEME OXYGENASE-1 | HIF PROLYL | UP-REGULATION | ENZYME TETRAMER | ENDOTHELIAL GROWTH-FACTOR | Review
Journal Article
Muscle & Nerve, ISSN 0148-639X, 08/2010, Volume 42, Issue 2, pp. 218 - 229
In muscular dystrophies (MD) the loss of muscle and its ability to function are associated with fibrosis. We evaluated the efficacy of halofuginone in reducing... 
collagen | Smad3 | fibrosis | prolyl 4 hydroxylase | halofuginone | Halofuginone | Collagen | Prolyl 4 hydroxylase | Fibrosis
Journal Article
Journal Article