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Annals of Internal Medicine, ISSN 0003-4819, 07/2015, Volume 163, Issue 1, pp. 40 - 51
Journal Article
Circulation, ISSN 0009-7322, 11/2012, Volume 126, Issue 20, pp. 2408 - 2417
Journal Article
Circulation, ISSN 0009-7322, 10/2015, Volume 132, Issue 17, pp. 1648 - 1666
Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in the regulation of cholesterol homeostasis. By binding to hepatic low-density... 
Antibodies, monoclonal | Clinical trial | PCSK9 protein, human | Proprotein Convertases - antagonists & inhibitors | Cardiovascular Diseases - prevention & control | Humans | Serine Endopeptidases - physiology | Antibodies, Monoclonal - therapeutic use | Intestines - metabolism | Structure-Activity Relationship | Cardiovascular Diseases - enzymology | Molecular Targeted Therapy | Cardiovascular Diseases - genetics | Proprotein Convertases - genetics | Incidence | Brain - metabolism | RNA Interference | Oligonucleotides, Antisense - therapeutic use | Serine Endopeptidases - genetics | Cardiovascular Diseases - epidemiology | Protein Structure, Tertiary | Genetic Predisposition to Disease | Antibodies, Monoclonal, Humanized - therapeutic use | Serine Endopeptidases - deficiency | Liver - metabolism | Receptors, LDL - metabolism | Serine Endopeptidases - chemistry | Clinical Trials as Topic | Proprotein Convertases - chemistry | Proprotein Convertases - deficiency | Proprotein Convertases - physiology | Animals | RNA, Small Interfering - therapeutic use | Adipocytes - metabolism | Cholesterol, LDL - metabolism | Hyperlipoproteinemias - genetics | Mice | Peptide Fragments - therapeutic use | Mutation | Proprotein Convertase 9 | antibodies, monoclonal | clinical trial | CARDIAC & CARDIOVASCULAR SYSTEMS | LOWERING THERAPY | MONOCLONAL-ANTIBODY | DENSITY-LIPOPROTEIN-CHOLESTEROL | HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA | DOUBLE-BLIND | PERIPHERAL VASCULAR DISEASE | STATIN-INTOLERANT PATIENTS | HEALTHY-VOLUNTEERS | CORONARY-HEART-DISEASE | PLASMA LDL CHOLESTEROL | PCSK9 GENE | Monoclonal antibodies | Clinical trials | Usage | Care and treatment | Dosage and administration | Cardiovascular diseases
Journal Article
Circulation, ISSN 0009-7322, 08/2013, Volume 128, Issue 9, pp. 962 - 969
Journal Article
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2013, Volume 62, Issue 16, pp. 1401 - 1408
Hypercholesterolemia is a major risk factor for cardiovascular diseases, increasing the incidence of myocardial infarction and death. Statin-induced lowering... 
Cardiovascular | Internal Medicine | atherosclerosis | proprotein convertase subtilisin/kexin type 9 | PCSK9 | LDL cholesterol | LDL receptor | atherosclerosis LDL cholesterol LDL receptor PCSK9 proprotein convertase subtilisin/kexin type 9 | NONHUMAN-PRIMATES | LDL-CHOLESTEROL | CARDIAC & CARDIOVASCULAR SYSTEMS | RANDOMIZED-TRIAL | MONOCLONAL-ANTIBODY | DENSITY-LIPOPROTEIN-CHOLESTEROL | SECRETED PCSK9 | RECEPTOR-MEDIATED ENDOCYTOSIS | STATIN THERAPY | HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA | SERINE-PROTEASE | Proprotein Convertases - antagonists & inhibitors | Dyslipidemias - complications | Humans | Lipoproteins, LDL - genetics | Proprotein Convertases - genetics | Molecular Targeted Therapy - trends | Serine Endopeptidases - genetics | Lipid Metabolism - genetics | Lipoproteins, LDL - metabolism | Molecular Targeted Therapy - methods | Receptors, LDL - genetics | Dyslipidemias - drug therapy | Atherosclerosis - drug therapy | Proprotein Convertases - metabolism | Risk Factors | Receptors, LDL - metabolism | Atherosclerosis - complications | Hypolipidemic Agents - pharmacology | Forecasting | Atherosclerosis - metabolism | Lipid Metabolism - drug effects | Dyslipidemias - metabolism | Serine Endopeptidases - metabolism | Mutation | Proprotein Convertase 9 | Hypertension | Hypercholesterolemia | Low density lipoproteins | Mortality | Atherosclerosis | Drug therapy | Statins | Cholesterol | Protein binding | Studies | Rodents
Journal Article
Journal Article
Journal Article
Journal Article
Lancet, The, ISSN 0140-6736, 2014, Volume 383, Issue 9911, pp. 60 - 68
Summary Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to LDL receptors, leading to their degradation. Genetics studies have shown that... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | DENSITY-LIPOPROTEIN CHOLESTEROL | DOUBLE-STRANDED-RNA | PLASMA-CHOLESTEROL | METAANALYSIS | CARDIOVASCULAR-DISEASE | MONOCLONAL-ANTIBODY | HYPERCHOLESTEROLEMIA | STATINS | AMG 145 | ATORVASTATIN | Single-Blind Method | Serine Endopeptidases - biosynthesis | Humans | Middle Aged | RNA, Small Interfering - pharmacology | RNA, Small Interfering - adverse effects | Cholesterol, LDL - drug effects | Male | Healthy Volunteers | Proprotein Convertases - genetics | Dose-Response Relationship, Drug | Proprotein Convertases - biosynthesis | RNA Interference | Serine Endopeptidases - blood | Serine Endopeptidases - genetics | Adult | Cholesterol, LDL - blood | Female | Proprotein Convertases - blood | RNA, Small Interfering - administration & dosage | Genetic Therapy - adverse effects | Genetic Therapy - methods | Proprotein Convertase 9 | Enzymes | Research | Gene mutations | Properties | Gene expression | Identification and classification | Medical research | RNA | Low density lipoproteins | Anticholesteremic agents | Clinical trials | Aluminum compounds | Coronary heart disease | Cholesterol | Hypercholesterolemia | Analysis | Medicine, Experimental | Product development | Trans fatty acids | Blood proteins | Studies | Heart | Nanoparticles | Plasma | Nutrition research | Cardiovascular disease | Lipids | Mutation | Drug dosages | Statins
Journal Article
Journal Article
Lancet, The, ISSN 0140-6736, 2012, Volume 380, Issue 9858, pp. 2007 - 2017
Journal Article