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protecting groups (93) 93
chemistry, organic (85) 85
chemistry, multidisciplinary (45) 45
index medicus (39) 39
solid-phase synthesis (32) 32
protecting group (31) 31
biochemistry & molecular biology (26) 26
chemistry (26) 26
derivatives (23) 23
peptides (23) 23
organic chemistry (21) 21
esters (18) 18
orthogonality (18) 18
strategy (18) 18
photochemistry (17) 17
alcohols (15) 15
deprotection (15) 15
amines (14) 14
cleavage (14) 14
molecular structure (14) 14
amino acids (13) 13
glycosylation (13) 13
light (13) 13
synthesis (13) 13
carbohydrates (12) 12
chemical synthesis (11) 11
cysteine (11) 11
oxidation (11) 11
peptides - chemical synthesis (11) 11
photolysis (11) 11
acids (10) 10
oligosaccharides (10) 10
solid‐phase synthesis (10) 10
amino-acids (9) 9
biochemistry, general (9) 9
life sciences (9) 9
native chemical ligation (9) 9
organic-synthesis (9) 9
protective-groups (9) 9
proteins (9) 9
schutzgruppe (9) 9
thiols (9) 9
amino-protecting group (8) 8
chromatic orthogonality (8) 8
humans (8) 8
carboxylic-acids (7) 7
chemical-synthesis (7) 7
cystine (7) 7
design (7) 7
oligonucleotides (7) 7
oligosaccharide synthesis (7) 7
peptide synthesis (7) 7
peptide-synthesis (7) 7
peptides - chemistry (7) 7
photochemie (7) 7
photoremovable protecting groups (7) 7
polymerization (7) 7
rechtwinkligkeit (7) 7
removal (7) 7
activation (6) 6
amides (6) 6
analogs (6) 6
analysis (6) 6
article (6) 6
biophysics (6) 6
carboxylic acids (6) 6
catalysis (6) 6
chemical reactions (6) 6
chemistry, applied (6) 6
cyclic-peptides (6) 6
efficient (6) 6
ethers (6) 6
mass spectrometry (6) 6
methods (6) 6
orthogonal photolysis (6) 6
photolabile protecting groups (6) 6
polymers (6) 6
wavelengths (6) 6
acid (5) 5
aldehydes (5) 5
amino acids - chemistry (5) 5
animal anatomy / morphology / histology (5) 5
animals (5) 5
binding (5) 5
carbamate (5) 5
carbamates (5) 5
chemical sciences (5) 5
chemistry, analytical (5) 5
combinatorial chemistry (5) 5
crystal-structure (5) 5
cystein (5) 5
disulfides (5) 5
dna (5) 5
enzymes (5) 5
glycopeptides (5) 5
glycosides (5) 5
hydrolysis (5) 5
metathesis (5) 5
mild (5) 5
molecular sequence data (5) 5
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1. Full Text A new method testing the orthogonality of different protecting groups
by Ágoston, Ágnes and Ágoston, Károly and Dorgan, Colin R and Fügedi, Péter
Carbohydrate Research, ISSN 0008-6215, 12/2015, Volume 418, pp. 98 - 103
A new test was elaborated to identify a new set of orthogonal protecting groups. With the developed method eight different protecting groups were tested under... 
Method development | Orthogonal protection | Protecting groups | PROPARGYL ETHERS | OLIGOSACCHARIDES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | DEPROTECTION | CHEMISTRY, APPLIED | CLEAVAGE | DERIVATIVES | Glucosides - chemistry | Biological Products - chemical synthesis | Biological Products - chemistry | Glucosides - chemical synthesis | Chromatography, High Pressure Liquid - methods | Molecular Conformation | Chemotherapy | Methods | Cancer | Analysis | Business parks | High performance liquid chromatography
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2. Full Text Handles for Fmoc Solid-Phase Synthesis of Protected Peptides
by Góngora-Benítez, Miriam and Tulla-Puche, Judit and Albericio, Fernando
ACS Combinatorial Science, ISSN 2156-8952, 05/2013, Volume 15, Issue 5, pp. 217 - 228
Protected peptide fragments are valuable building blocks for the assembly of large peptide sequences through fragment condensation approaches, whereas... 
handles | protecting group orthogonality | solid-phase peptide synthesis | Fmoc/ t Bu strategy | protected peptides | fragment condensation approach | CHEMISTRY, MEDICINAL | 2-CHLOROTRITYL CHLORIDE RESIN | BUILDING-BLOCKS | Fmoc/tBu strategy | EFFICIENT SYNTHESIS | ACYL ISOPEPTIDE METHOD | LABILE ANCHOR GROUP | CHEMISTRY, MULTIDISCIPLINARY | SAFETY-CATCH LINKER | COMBINATORIAL CHEMISTRY | SEQUENCE-CONTAINING PEPTIDES | DIFFICULT SEQUENCE | CHEMISTRY, APPLIED | BACKBONE AMIDE LINKER | Solid-Phase Synthesis Techniques | Amino Acids - chemistry | Fluorenes - chemistry | Peptides - chemical synthesis | Synthesis | Peptides | Methodology | Fragments | Condensing | Handles | Attachment | Combinatorial analysis | Assembly
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3. Full Text Unusual Orthogonality in the Cleavage Process of Closely Related Chelating Protecting Groups for Carboxylic Acids by Using Different Metal Ions
by Mundinger, Stephan and Jakob, Uwe and Bannwarth, Willi
Chemistry – A European Journal, ISSN 0947-6539, 01/2014, Volume 20, Issue 5, pp. 1258 - 1262
Three structurally related relay protecting groups for carboxylic acids that are based on chelating amines have been developed. These protecting groups can... 
amides | protecting groups | orthogonality | chelators | carboxylic acids | Chelators | Amides | Carboxylic acids | Orthogonality | Protecting groups | CHEMISTRY, MULTIDISCIPLINARY | Organic acids | Fluorides | Acids
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4. Full Text Orthogonality and compatibility between Tsc and Fmoc amino-protecting groups
by Seok Choi, Jin and Kang, Hunhui and Jeong, Nakcheol and Han, Hogyu
Tetrahedron, ISSN 0040-4020, 2005, Volume 61, Issue 9, pp. 2493 - 2503
New deprotection conditions that provide a complete orthogonality between Tsc and Fmoc amino-protecting groups are described. The potential of these orthogonal... 
Orthogonal deprotection | Branched peptide | Fmoc | Tsc | Amino-protecting group | METHYLATION | ACID | SOLID-PHASE SYNTHESIS | ANALOGS | CHEMISTRY, ORGANIC | orthogonal deprotection | THIOESTERS | amino-protecting group | AQUEOUS-SOLUTION | REMOVAL | PEPTIDE-SYNTHESIS | branched peptide | POLYAMIDES | CYCLIZATION | Peptides
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5. Full Text Temporary Carbohydrate Diol Protection with Ester Groups – Orthogonality under Solid‐Phase Oligosaccharide Synthesis Conditions
by Markad, Shankar D and Schmidt, Richard R
10/2009, Volume 2009, Issue 29, 10
For regioselective deprotection studies under SPOS conditions the glucosamine derivatives 4ab/4ba, 4ac/4ca and 4ad/4da – with Fmoc/PA, Fmoc/Lev or Fmoc/Alloc,... 
Carbohydrates | Glucosamine | Diols, vicinal | Oligosaccharides | Solid‐phase synthesis | Protecting groups | Solid-phase synthesis | COMPLEX | STRATEGY | CHEMISTRY, ORGANIC | HEXASACCHARIDE | LIBRARIES | SUPPORT | GLYCOSIDE-BOND FORMATION
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6. Full Text A new set of orthogonal protecting groups on a monosaccharide scaffold
by Ágoston, Károly and Watt, Gregory M and Fügedi, Péter
Tetrahedron Letters, ISSN 0040-4039, 08/2015, Volume 56, Issue 35, pp. 5010 - 5012
A monosaccharide unit was synthesized bearing four different temporary protecting groups. The protecting groups used (Fmoc carbonate, NAP ether, levulinoyl and... 
Monosaccharide Scaffold | Orthogonal protection | Protecting groups | Full orthogonality | LIBRARIES | DESIGN | BIOLOGICAL EVALUATION | CHEMISTRY, ORGANIC | OLIGOSACCHARIDE | Fructose
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7. Full Text Regioselective Chromatic Orthogonality with Light‐Activated Metathesis Catalysts
by Levin, Efrat and Mavila, Sudheendran and Eivgi, Or and Tzur, Eyal and Lemcoff, N. Gabriel
Angewandte Chemie International Edition, ISSN 1433-7851, 10/2015, Volume 54, Issue 42, pp. 12384 - 12388
The ability to selectively guide consecutive chemical processes towards a preferred pathway by using light of different frequencies is an appealing concept.... 
olefin metathesis | chromatic orthogonality | heterocycles | photochemistry | cyclization | GENERATOR | N-HETEROCYCLIC CARBENE | ISOMERIZATION | CHEMISTRY, MULTIDISCIPLINARY | ETHERS | CHEMISTRY | CYCLOISOMERIZATION | PHOTOLABILE PROTECTING GROUPS | PHOTOCHEMICAL-REACTIONS | RUTHENIUM-CARBENE CATALYST | Alkenes - chemistry | Cycloparaffins - chemistry | Stereoisomerism | Light | Cycloparaffins - chemical synthesis | Molecular Structure | Catalysis | Photochemical Processes | Sulfur compounds | Synthesis | Wavelengths | Pathways | Catalysts | Decomposition reactions | Metathesis | Activation | Orthogonality
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8. Regioselection and orthogonality of the 1-phenyl-3-butenyl (PBU) protecting group in glucopyranosides
by Peri, F and Cipolla, L and Nicotra, F
Carbohydrate letters, ISSN 1073-5070, 2000, Volume 4, Issue 1, pp. 21 - 27
The 1-phenyl-3-butenyl (PBU) protecting group was alternatively introduced in position 4 or 6 by regioselective opening of methyl... 
Carbohydrates | Regioselection | Protecting groups
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9. Full Text Orthogonality in organic, polymer, and supramolecular chemistry: from Merrifield to click chemistry
by Wong, Chun-Ho and Zimmerman, Steven C
Chemical Communications, ISSN 1359-7345, 1/2013, Volume 49, Issue 17, pp. 1679 - 1695
The concept of orthogonality has been applied to many areas of chemistry, ranging from wave functions to chromatography. But it was Barany and Merrifield's... 
TERPYRIDINE METAL-COMPLEXES | 1,3-DIPOLAR CYCLOADDITIONS | HYDROGEN-BONDED COMPLEXES | FREE TRIAZOLE FORMATION | ONE-POT SYNTHESIS | IN-VIVO | PROTECTING GROUPS | RAPID SYNTHESIS | CHEMISTRY, MULTIDISCIPLINARY | DYNAMIC COMBINATORIAL LIBRARIES | THIOL-ENE CLICK | Binding | Self assembly | Peptides | Nanomaterials | Strategy | Activation | Nanostructure | Orthogonality
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10. Full Text On the Orthogonality of Two Thiol‐Based Modular Ligations
by Turgut, Hatice and Delaittre, Guillaume
Chemistry – A European Journal, ISSN 0947-6539, 01/2016, Volume 22, Issue 4, pp. 1511 - 1521
The chemoselectivity of two thiol‐based modular ligations operating under mild conditions is assessed. For this purpose, a macromolecular scaffold possessing... 
block copolymer | pentafluorostyrene | chemoselectivity | para-fluoro thiol | thiol–ene | thiol-ene | BLOCK-COPOLYMERS | CLICK CHEMISTRY | PORPHYRINS | CROSS-LINKING | NETWORKS | CHEMISTRY, MULTIDISCIPLINARY | SUBSTITUTION REACTION | SEQUENTIAL MICHAEL ADDITION | para-fluorothiol | POLYMER | EFFICIENT | ENE | Nuclear magnetic resonance spectroscopy | Thiols | Magnetic resonance spectroscopy | Size exclusion chromatography | Chemistry | Purification | Light irradiation | Macromolecules | Irradiation | NMR spectroscopy | Orthogonality | Light effects | Chromatography | Transformations | Modular | Scaffolds
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11. Preparation of acetals from aldehydes and alcohols under basic conditions
by Jakub Grabowski and Jarosław M Granda and Janusz Jurczak
Organic & Biomolecular Chemistry, ISSN 1477-0520, 01/2018, Volume 16, Issue 17, pp. 3114 - 3120
A new, simple protocol for the synthesis of acetals under basic conditions from non-enolizable aldehydes and alcohols has been reported. Such reactivity is... 
Synthesis | Sodium | Protecting groups | Alcohol | Aldehydes | Orthogonality | Acetals | Functional groups | Alcohols
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12. Full Text Isotope Effects in Photochemistry:  Application to Chromatic Orthogonality
by Blanc, Aurélien and Bochet, Christian G
Organic Letters, ISSN 1523-7060, 07/2007, Volume 9, Issue 14, pp. 2649 - 2651
The main challenge in developing new wavelength-specific photolabile protecting groups is the rigorous control of the photolysis rate. This rate is controlled... 
ORGANIC-SYNTHESIS | ETHERS | 2-NITROBENZYL COMPOUNDS | CHEMISTRY, ORGANIC | REACTION-MECHANISMS | ALDEHYDES | RELEASE | PHOTOREMOVABLE PROTECTING GROUPS | CLEAVAGE | DERIVATIVES
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13. Full Text MgI2‐Mediated Chemoselective Cleavage of Protecting Groups: An Alternative to Conventional Deprotection Methodologies
by Berthet, Mathéo and Davanier, Florian and Dujardin, Gilles and Martinez, Jean and Parrot, Isabelle
Chemistry – A European Journal, ISSN 0947-6539, 07/2015, Volume 21, Issue 31, pp. 11014 - 11016
The scope of MgI2 as a valuable tool for quantitative and mild chemoselective cleavage of protecting groups is described here. This novel synthetic approach... 
protecting groups | carbamates | esters | solid‐phase synthesis | cleavage reactions | solid-phase synthesis | ALPHA-AMINO | DETRITYLATION | HYDROLYSIS | DIPEPTIDE METHYL-ESTERS | CHEMISTRY, MULTIDISCIPLINARY | MILD | ALUMINUM TRICHLORIDE | AMINO ACID | TERT-BUTYL ESTERS | BENZYLIC ESTERS | EFFICIENT | Green Chemistry Technology | Solvents | Magnesium Compounds - chemical synthesis | Esters - chemistry | Magnesium Compounds - chemistry | Amino Acids - chemistry | Iodides - chemistry | Amino Acids - chemical synthesis | Iodides - chemical synthesis | Solid-Phase Synthesis Techniques - methods | Esterification | Carbamates | Esters | Methods
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14. Full Text Desyl and Phenacyl as Versatile, Photocatalytically Cleavable Protecting Groups: A Classic Approach in a Different (Visible) Light
by Speckmeier, Elisabeth and Zeitler, Kirsten
ACS Catalysis, ISSN 2155-5435, 10/2017, Volume 7, Issue 10, pp. 6821 - 6826
A highly efficient, catalytic strategy for the deprotection of classical phenacyl (Pac) as well as desyl (Dsy) protection groups has been developed using... 
Photoredox catalysis | Peptide synthesis | Acids | Orthogonality | Photocleavable linker | Protecting groups | ORGANIC-SYNTHESIS | P-HYDROXYPHENACYL | CHEMISTRY, PHYSICAL | RELEASE | orthogonality | protecting groups | acids | ROBUSTNESS SCREEN | ESTERS | SYNTHETIC APPLICATIONS | RAPID ASSESSMENT | photocleavable linker | photoredox catalysis | peptide synthesis | ECONOMY | CARBOXYLIC-ACIDS
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15. Full Text Chromatic Orthogonality in Organic Synthesis
by Bochet, Christian G
Synlett, ISSN 0936-5214, 11/2004, Volume 2004, Issue 13, pp. 2268 - 2274
ABSTRACT A major challenge in organic synthesis is the selective reaction of a functional group in the presence of others. This can be achieved by using an... 
account | Cleavage | Chromophores | Protecting groups | Photochemistry | chromophores | protecting groups | cleavage | photochemistry | SOLID-PHASE SYNTHESIS | CHEMISTRY, ORGANIC | PHOTOLYSIS | LINKER | AMIDES
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16. Full Text Photochemical of various functional groups
by Bochet, Christian G
Pure and Applied Chemistry, ISSN 0033-4545, 02/2006, Volume 78, Issue 2, pp. 241 - 247
Chromatic orthogonality | Protecting groups | Photochemistry
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17. Full Text Factors affecting orthogonality in the deprotection of 2,4-di-protected aromatic ethers employing solid-supported acids
by Tangdenpaisal, Kassrin and Sualek, Supannee and Ruchirawat, Somsak and Ploypradith, Poonsakdi
Tetrahedron, ISSN 0040-4020, 2009, Volume 65, Issue 22, pp. 4316 - 4325
Selective deprotection of aromatic ethers bearing two protecting groups on the same aromatic ring by solid-supported acids (Amberlyst-15 and PTS-Si) was... 
ALCOHOLS | MILD | SELECTIVE DEPROTECTION | ALLYL ETHERS | HYDROGENOLYSIS | CHEMISTRY, ORGANIC | PROTECTING GROUPS | NEUTRAL CONDITIONS | CATALYST | EFFICIENT | BENZYL ETHERS
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18. Full Text Synthesis of highly functional carbamates through ring-opening of cyclic carbonates with unprotected α-amino acids in water
by Olsén, Peter and Oschmann, Michael and Johnston, Eric V and Åkermark, Björn
Green Chemistry, ISSN 1463-9262, 2018, Volume 20, Issue 2, pp. 469 - 475
The present work shows that it is possible to ring-open cyclic carbonates with unprotected amino acids in water. Fine tuning of the reaction parameters made it... 
GLYCINE | GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | AQUEOUS-SOLUTIONS | NON-ISOCYANATE POLYURETHANE | GLYCEROL | ASYMMETRIC ALLYLIC ALKYLATION | NMR CHEMICAL-SHIFTS | KINETICS | 2-ALLYLOXYMETHYL-2-ETHYLTRIMETHYLENE CARBONATE | POLYMERIZATION | PROTECTING GROUPS | CHEMISTRY, MULTIDISCIPLINARY | Transformation | Thiols | Purification | Alkenes | Serine | Macromolecules | Amino acids | Carboxylic acids | Glycine | Orthogonality | Alcohols | Carbamates (tradename) | Synthesis | Carbonates | Functional groups
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19. Full Text Synthesis of highly functional carbamates through ring-opening of cyclic carbonates with unprotected α-amino acids in water
by Olsén, Peter and Oschmann, Michael and Johnston, Eric V and Åkermark, Björn and Stockholms universitet and Naturvetenskapliga fakulteten and Institutionen för organisk kemi
Green Chemistry, ISSN 1463-9262, 2018, Volume 20, Issue 2, pp. 469 - 475
The present work shows that it is possible to ring-open cyclic carbonates with unprotected amino acids in water. Fine tuning of the reaction parameters made it... 
Naturvetenskap | Natural Sciences | Organisk kemi | Kemi | Chemical Sciences | Organic Chemistry
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20. Full Text Photochemical release of various functional groups
by Bochet, Christian G
Pure and Applied Chemistry, ISSN 0033-4545, 01/2006, Volume 78, Issue 2, pp. 241 - 247
The photochemical liberation of functional groups is an attractive alternative to the traditional chemical approach. Several photolabile protecting groups have... 
photochemistry | protecting groups | chromatic orthogonality | ORGANIC-SYNTHESIS | ORTHOGONAL PHOTOLYSIS | ALDEHYDES | CHEMISTRY, MULTIDISCIPLINARY
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