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Journal of the American Chemical Society, ISSN 0002-7863, 05/2007, Volume 129, Issue 18, pp. 5843 - 5845
Journal Article
Nature structural & molecular biology, ISSN 1545-9985, 2019, Volume 26, Issue 7, pp. 628 - 636
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2011, Volume 121, Issue 2, pp. 628 - 639
RHO family proteins are important for the function of inflammatory cells. They are modified with a 20-carbon geranylgeranyl lipid in a process catalyzed by protein geranylgeranyltransferase type I (GGTase... 
INDUCED LUNG-CANCER | RHEUMATOID-ARTHRITIS | PROTEIN PRENYLTRANSFERASES | SIGNAL-TRANSDUCTION | MEDICINE, RESEARCH & EXPERIMENTAL | CELL-DIVISION | K-RAS | DISSOCIATION INHIBITORS | INTERLEUKIN-1-BETA SECRETION | RHO-GTPASES | T-CELLS | Macrophages - physiology | rap1 GTP-Binding Proteins - metabolism | Arthritis - pathology | Mice, Inbred C57BL | cdc42 GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - metabolism | Macrophages - cytology | rhoA GTP-Binding Protein - genetics | Macrophages - enzymology | Mice, Knockout | Animals | Alkyl and Aryl Transferases - genetics | cdc42 GTP-Binding Protein - genetics | Arthritis - immunology | Mice | rap1 GTP-Binding Proteins - genetics | Alkyl and Aryl Transferases - deficiency | Macrophages - immunology | rac1 GTP-Binding Protein - metabolism | Cytokines - immunology | rac1 GTP-Binding Protein - genetics | Physiological aspects | Rheumatoid factor | Macrophages | Rheumatoid arthritis | Transferases | Risk factors | cytology | pathology | Cytokines | Cell and Molecular Biology | physiology | rhoA GTP-Binding Protein | Arthritis | enzymology | Inbred C57BL | Knockout | genetics | deficiency | rap1 GTP-Binding Proteins | Alkyl and Aryl Transferases | cdc42 GTP-Binding Protein | metabolism | rac1 GTP-Binding Protein | Cell- och molekylärbiologi | immunology
Journal Article
Journal Article
Journal Article
Journal Article
Current Cancer Drug Targets, ISSN 1568-0096, 09/2016, Volume 16, Issue 7, pp. 563 - 571
...) isoprenoid lipds to conserved cysteine residues in the carboxyl-terminus of proteins. Protein geranylgeranyltransferase I (GGTase... 
Prenylation | CaaX protein | GGTI | FTI | Farnesyl | Isoprenoid | Geranylgeranyl | Isoprenylation | CELLS | farnesyl | GGTASE-I | geranylgeranyl | I INHIBITOR | METAL REQUIREMENTS | ANGSTROM RESOLUTION | ONCOLOGY | VIRUS-RNA REPLICATION | GERANYLGERANYLATION | KINETIC MECHANISM | RHO GTPASES | isoprenylation | FARNESYLTRANSFERASE | isoprenoid
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, p. e0137595
Small molecule inhibitors against protein geranylgeranyltransferase-I such as P61A6 have been shown to inhibit proliferation of a variety of human cancer cells and exhibit antitumor activity in mouse models... 
PROTEIN TRANSFERASE | LUNG-CANCER | H-RAS | K-RAS | DRUG-DELIVERY | N-RAS | MULTIDISCIPLINARY SCIENCES | MESOPOROUS SILICA NANOPARTICLES | POLYMERIC MICELLES | FARNESYLTRANSFERASE INHIBITORS | TRANSFERASE INHIBITORS | Protein Prenylation - drug effects | Liposomes - therapeutic use | Phenylalanine - analogs & derivatives | Liposomes - administration & dosage | Humans | Alkyl and Aryl Transferases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Drug Delivery Systems | Neoplasms - drug therapy | Enzyme Inhibitors - administration & dosage | Sulfonamides - therapeutic use | Cell Cycle Checkpoints - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Phenylalanine - therapeutic use | Phenylalanine - administration & dosage | Sulfonamides - administration & dosage | Antimitotic agents | Complications and side effects | Care and treatment | Dosage and administration | Genetic aspects | Research | Antineoplastic agents | Methods | Cancer | Encapsulation | Cell proliferation | Drugs | Therapy | Animal models | Drug delivery systems | Laboratories | Lung cancer | Lipids | Biochemistry | Phospholipids | Kinases | pH effects | Cancer therapies | K-Ras protein | Anticancer properties | Nanoparticles | Proteins | Immunology | Hydrogen ions | Geranylgeranyltransferase | Rodents | Farnesyltransferase | Cell cycle | pH | Inhibition | Controlled release | Enzymes | Breast cancer | Tumor cell lines | Signaling | Cyclin-dependent kinase inhibitor p21 | Inhibitors | Pancreatic cancer | Antitumor activity | Liposomes | Synergistic effect
Journal Article