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Journal Article
The Journal of Physiology, ISSN 0022-3751, 11/2007, Volume 585, Issue 1, pp. 203 - 215
Oxidative stress promotes controlled mechanical ventilation (MV)-induced diaphragmatic atrophy. Nonetheless, the signalling pathways responsible for oxidative... 
CHAIN MESSENGER-RNA | DISUSE ATROPHY | SKELETAL-MUSCLE | OXIDATIVE STRESS | VITAMIN-E | IN-VITRO | PHYSIOLOGY | SOLEUS MUSCLE | FOXO TRANSCRIPTION FACTORS | UBIQUITIN LIGASES | EXPRESSION | NEUROSCIENCES | Diaphragm - drug effects | Insulin - physiology | SKP Cullin F-Box Protein Ligases - genetics | Oxidative Stress - physiology | Insulin-Like Growth Factor I - genetics | Proto-Oncogene Proteins c-akt - genetics | Tripartite Motif Proteins | Chromans - pharmacology | Respiration, Artificial - adverse effects | Forkhead Transcription Factors - metabolism | Muscle Proteins - metabolism | Female | Muscular Atrophy - prevention & control | Diaphragm - metabolism | Muscular Atrophy - etiology | Diaphragm - physiopathology | Ubiquitin-Protein Ligases - metabolism | Rats | Proto-Oncogene Proteins c-akt - physiology | SKP Cullin F-Box Protein Ligases - metabolism | Antioxidants - pharmacology | Forkhead Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Rats, Sprague-Dawley | Muscle Proteins - genetics | Nerve Tissue Proteins - metabolism | Phosphatidylinositol 3-Kinases - genetics | Antioxidants - therapeutic use | Animals | Chromans - therapeutic use | Insulin-Like Growth Factor I - physiology | Phosphatidylinositol 3-Kinases - physiology | Signal Transduction - physiology | Oxidative Stress - drug effects | Forkhead Box Protein O3 | Ubiquitin-Protein Ligases - genetics | Antioxidants | Physiological aspects | Protein kinases | Index Medicus | Respiratory
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2005, Volume 280, Issue 23, pp. 22297 - 22307
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2011, Volume 286, Issue 22, pp. 19439 - 19445
cAMP is an important second messenger that executes diverse physiological function in living cells. In this study, we investigated the effect of cAMP on... 
GLOMERULOSCLEROSIS | TRANSLOCATION | GLOMERULAR MESANGIAL CELLS | CALCIUM-ENTRY | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTHELIAL-CELLS | DOWN-REGULATION | HIGH GLUCOSE | OSCILLATIONS | EXPRESSION | MAP Kinase Signaling System - physiology | Calcium - metabolism | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Male | Phosphatidylinositol 3-Kinases - metabolism | Mutation, Missense | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - genetics | Cyclic AMP - analogs & derivatives | Mitogen-Activated Protein Kinase 1 - genetics | HEK293 Cells | Cyclic AMP - genetics | MAP Kinase Kinase Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - metabolism | TRPC Cation Channels - genetics | Cyclic AMP - metabolism | TRPC6 Cation Channel | Mitogen-Activated Protein Kinase 3 - genetics | MAP Kinase Kinase Kinases - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | Mesangial Cells - cytology | MAP Kinase Kinase Kinases - metabolism | Mesangial Cells - metabolism | Glucagon - pharmacology | Rats, Sprague-Dawley | Protein Transport | Phosphatidylinositol 3-Kinases - genetics | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | TRPC Cation Channels - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Amino Acid Substitution | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus | Calcium Imaging | Glomerular Mesangial Cells | ERK1 | Calcium Channels | Ion Channels | Glucagon | TRP Channels | Membrane Biology | Cyclic AMP (cAMP)
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2011, Volume 286, Issue 25, pp. 22017 - 22027
Pkh1, -2, and -3 are the yeast orthologs of mammalian 3-phosphoinositide- dependent protein kinase-1 (PDK1). Although essential for viability, their... 
AGC KINASES | CATALYTIC SUBUNIT | PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | BINDING POCKET | SACCHAROMYCES-CEREVISIAE | ADENYLATE-CYCLASE | RAS PROTEINS | DOCKING SITE | Protein-Serine-Threonine Kinases - deficiency | Sequence Deletion | Phosphorylation | Cyclic AMP-Dependent Protein Kinases - chemistry | Saccharomyces cerevisiae - drug effects | Saccharomyces cerevisiae Proteins - biosynthesis | Saccharomyces cerevisiae - metabolism | Nitrogen - pharmacology | 3-Phosphoinositide-Dependent Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Catalytic Domain | Proto-Oncogene Proteins c-akt - chemistry | Protein-Serine-Threonine Kinases - genetics | Cell Size | Saccharomyces cerevisiae Proteins - genetics | Protein-Serine-Threonine Kinases - biosynthesis | Saccharomyces cerevisiae - cytology | Sequence Homology, Amino Acid | Animals | Mutagenesis | Saccharomyces cerevisiae Proteins - metabolism | Hydrophobic and Hydrophilic Interactions | Protein Binding | Saccharomyces cerevisiae - enzymology | Protein-Serine-Threonine Kinases - chemistry | Saccharomyces cerevisiae Proteins - chemistry | Index Medicus | Site-directed Mutagenesis | Protein Kinase A (PKA) | Yeast | Signal Transduction | Protein Kinases | PKB | Sch9 | Protein Phosphorylation | Saccharomyces cerevisiae | PDK1 | Pkh1–3
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 05/2012, Volume 141, Issue 1, pp. 517 - 525
The leaves of Mill. (Lauraceae) have been popularly used in the treatment of diabetes in countries in Latin America and Africa. To investigate the... 
Persea americana Mill | Protein kinase B (PKB/Akt) | Diabetes | Lauraceae | AQUEOUS EXTRACT | CHEMISTRY, MEDICINAL | LEAVES | MUSCLE | FLAVONOIDS | MASS-SPECTROMETRY | PLANT SCIENCES | INHIBITION | INTEGRATIVE & COMPLEMENTARY MEDICINE | GLUCOSE | PLANTS | PHARMACOLOGY & PHARMACY | COMPLICATIONS | Enzyme Activators - pharmacology | Diabetes Mellitus, Experimental - drug therapy | Phosphorylation | Liver - enzymology | Rats, Wistar | Diabetes Mellitus, Experimental - enzymology | Plant Extracts - pharmacology | Solvents - chemistry | Plant Leaves | Male | Insulin - blood | Diabetes Mellitus, Experimental - blood | Plant Extracts - administration & dosage | Hypoglycemic Agents - administration & dosage | Liver - drug effects | Time Factors | Enzyme Activators - administration & dosage | Muscle, Skeletal - drug effects | Weight Gain - drug effects | Phytotherapy | Proto-Oncogene Proteins c-akt - metabolism | Glucose Tolerance Test | Muscle, Skeletal - enzymology | Persea - chemistry | Administration, Oral | Enzyme Activators - isolation & purification | Rats | Plant Extracts - isolation & purification | Hypoglycemic Agents - pharmacology | Blood Glucose - drug effects | Eating - drug effects | Hypoglycemic Agents - isolation & purification | Animals | Signal Transduction - drug effects | Ethanol - chemistry | Drinking - drug effects | Enzyme Activation | Energy Metabolism - drug effects | Plants, Medicinal | Medicine, Herbal | Toiletries industry | Protein kinases | Medicine, Botanic | Index Medicus
Journal Article
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