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Biochemical journal, ISSN 1470-8728, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | drug discovery | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | inhibitor specificity | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | anti-cancer drugs | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | protein kinase | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | kinase profiling | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biochemical journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
... (protein kinase A/protein kinase G/protein kinase Q family kinases such as Akt (protein kinase 13), S6K (p70 ribosomal S6 kinase... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | Index Medicus | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | kinase inhibitor | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | cancer | serum and glucocorticoid protein kinase (SGK) | MAPK, mitogen-activated protein kinase
Journal Article
FEBS letters, ISSN 0014-5793, 2001, Volume 496, Issue 1, pp. 44 - 48
The specificity of 4,5,6,7-tetrabromo-2-azabenzimidazole (TBB), an ATP/GTP competitive inhibitor of protein kinase casein kinase-2 (CK2... 
Casein kinase | Inhibitor | Casein kinase-2 | Protein phosphorylation | Protein kinase | nCK, native casein kinase | OA, okadaic acid | PRAK, p38-regulated/activated kinase | CSK, C-terminal Src kinase | AMPK, AMP-activated protein kinase | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | MAPKAP, MAPK-activated protein kinase | p70S6K, p70 ribosomal protein S6 kinase | CK, casein kinase | SAPK, stress-activated protein kinase | PDK, 3-phosphoinositide-dependent kinase | ROCK, Rho-dependent protein kinase | CDK, cyclin-dependent kinase | G-CK, Golgi casein kinase | PKC, protein kinase C | MKK, MAPK kinase (also called MEK) | PKA, cAMP-dependent protein kinase | DRB, 1-(β-D-ribofuranosyl)-5,6-dichlorobenzimidazole | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | rCK, recombinant casein kinase | ERK, extracellular signal-regulated kinase | HS1, hematopoietic lineage cell-specific protein 1 | MSK, mitogen- and stress-activated protein kinase | TBB, 4,5,6,7-tetrabromo-2-azabenzimidazole or 4,5,6,7-tetrabromobenzotriazole | MAPK, mitogen-activated protein kinase | SGK, serum- and glucocorticoid-induced kinase | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Kinases - metabolism | Jurkat Cells - cytology | Protein Kinases - drug effects | Casein Kinase II | Emodin - pharmacology | Jurkat Cells - metabolism | Humans | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Substrate Specificity | Adenosine Triphosphate | Binding Sites - genetics | Binding, Competitive - drug effects | Triazoles - pharmacology | Triazoles - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Binding Sites - drug effects | Protein-Serine-Threonine Kinases - metabolism | Staurosporine - pharmacology | Amino Acid Substitution | Jurkat Cells - drug effects | Index Medicus
Journal Article
Biochemical journal, ISSN 1470-8728, 01/2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B (also known as Akt), PKC, S6K p70 (ribosomal S6 kinase), RSK... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | Index Medicus | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | phosphorylation | protein kinase C | kinase-specific inhibitor | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | mitogen-activated protein kinase (MAPK) | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical journal, ISSN 0264-6021, 03/2005, Volume 386, Issue 2, pp. 201 - 214
.... Kinases form an important class of Rho effector, and part of the biological complexity brought about by switching on a single GTPase results from downstream phosphorylation cascades... 
Rho | ROK (rho-kinase) | Rac | MLK (mixed-lineage kinase) | PAK (p21-activated kinase) | Cdc42 | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | p21-Activated Kinases | Amino Acid Sequence | Animals | Humans | rho-Associated Kinases | Intracellular Signaling Peptides and Proteins | Molecular Sequence Data | Genetic Variation - physiology | Protein-Serine-Threonine Kinases - metabolism | Index Medicus | PBD, p21-binding domain | ROK, Rho-kinase | PDK1, 3-phosphoinositide-dependent kinase 1 | Review | ACC, anti-parallel coiled-coil | MEKK, MAPK | SH3, Src homology 3 | JNK, c-Jun N-terminal kinase | CRIB, Cdc42 and Rac interactive binding | KIM, KI motif | MRCK, myotonin-related Cdc42-binding kinase | MLK, mixed-lineage kinase | PKN, protein kinase novel | PKC, protein kinase C | PAK, p21-activated kinase | Crmp, collapsin response mediator protein | CRIK, citron kinase | R-MLC, regulatory myosin light chain | KI, kinase inhibitory | MKK, MAPK kinase | ERK (extracellular-signal-regulated kinase) kinase kinase | PH, pleckstrin homology | GEF, guanine nucleotide exchange factor | MBS, myosin-binding subunit | PP1, protein phosphatase type 1 | DMPK, myotonic dystrophy kinase | GIT1, G-protein-coupled receptor kinase-interacting target 1 | PIX, PAK-interacting exchange factor | ROK (Rho-kinase) | Hsp90, heat shock protein 90 | MAPK, mitogen-activated protein kinase | LIMK, LIM domain kinase
Journal Article