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蛋白质与细胞:英文版, ISSN 1674-800X, 2017, Volume 8, Issue 8, pp. 601 - 611
.... Base editors convert C in the deamination window to thymidine (T) efficiently, however, it remains unclear whether targeted base editing in mouse embryos is feasible... 
编辑系统 | 临床应用 | 编辑器 | 受精卵 | 高保真 | 小鼠胚胎 | 定点突变 | 基因突变 | Life Sciences | Biochemistry, general | Protein Science | Stem Cells | Human Genetics | mouse embryos | base editor | high-fidelity | proximal-site deamination | whole-genome sequencing | Developmental Biology | Cell Biology | CRISPR | MUTAGENESIS | RNA | HUMAN-CELLS | GUIDE | GENOME | NUCLEASES | CELL BIOLOGY | DNA | GENERATION | CAS9 | Endonucleases - genetics | RNA, Guide - genetics | Embryo, Mammalian | RNA, Guide - metabolism | Humans | Zygote - metabolism | APOBEC-1 Deaminase - genetics | Endonucleases - metabolism | Zygote - transplantation | Base Sequence | HEK293 Cells | Cytidine - genetics | Zygote - growth & development | Thymidine - metabolism | Thymidine - genetics | Microinjections | Mice, Inbred C57BL | Bacterial Proteins - genetics | APOBEC-1 Deaminase - metabolism | Plasmids - metabolism | Point Mutation | Animals | Embryo Transfer | CRISPR-Cas Systems | Plasmids - chemistry | Bacterial Proteins - metabolism | Cytidine - metabolism | Gene Editing - methods | High-Throughput Nucleotide Sequencing | Mice | Gene mutations | Biological control | Genomics | Genetically modified organisms | Genetic research | Genetic engineering | Pests | Cells | Fidelity | Homologous recombination | Thymidine | Embryos | gRNA | Plant cells | Zygotes | Mutagenesis | Deamination | Editors | Mosaicism | Mutation
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