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pyrophosphorolysis (64) 64
biochemistry & molecular biology (34) 34
index medicus (33) 33
humans (21) 21
mutation (16) 16
mechanism (15) 15
kinetics (14) 14
fidelity (13) 13
base sequence (12) 12
dna (12) 12
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polymerization (12) 12
hiv (11) 11
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cell biology (9) 9
dna polymerase (9) 9
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hiv reverse transcriptase - metabolism (9) 9
multidisciplinary sciences (8) 8
phosphates (8) 8
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crystallography, x-ray (7) 7
dna sequencing (7) 7
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enzymes (7) 7
molecular biology (7) 7
mutation detection (7) 7
polymerase (7) 7
polymerase chain reaction (7) 7
pyrophosphorolysis-activated polymerization (7) 7
replication (7) 7
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dna-directed dna polymerase (6) 6
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nucleotides (6) 6
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reverse transcriptase inhibitors - pharmacology (6) 6
science (6) 6
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anti-hiv agents - pharmacology (5) 5
biochemistry (5) 5
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deoxyribonucleic acid (5) 5
dna polymerases (5) 5
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3'-azido-3'-deoxythymidine azt (4) 4
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reverse-transcriptase (4) 4
sensitivity (4) 4
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zidovudine - pharmacology (4) 4
3'-azido-3'-deoxythymidine (3) 3
allele-specific amplification (3) 3
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Nucleic Acids Research, ISSN 0305-1048, 01/2002, Volume 30, Issue 2, pp. 598 - 604
Pyrophosphorolysis-activated polymerization (PAP) was initially developed to enhance the specificity of allele-specific PCR for detection of known mutations in... 
pyrophosphorolysis
Journal Article
ISSN 1355-8382, 12/2018, Volume 24, Issue 12, p. 1878
Amino acids are attached to the tRNA 3′-end as a prerequisite for entering the ribosome for protein synthesis. Amino acid attachment also gives tRNA access to... 
Enzymes | tRNA | Pyrophosphorolysis | Ribose | Amino acids | Protein biosynthesis
Journal Article
Nucleosides, Nucleotides and Nucleic Acids, ISSN 1525-7770, 08/2012, Volume 31, Issue 8, pp. 608 - 615
The incorporation of deoxynucleoside triphosphates (dNTPs) catalyzed by polymerases is conventionally examined using gel electrophoresis autoradiography. Here,... 
Pyrosequencing | pyrophosphorolysis | unnatural nucleotides
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 07/2018, Volume 46, Issue 12, pp. 5875 - 5885
Abstract DNA synthesis by DNA polymerases (dPols) is central to duplication and maintenance of the genome in all living organisms. dPols catalyze the formation... 
REPLICATION | MOTION | FIDELITY | PYROPHOSPHOROLYSIS | MECHANISM | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESIDUE | 2-DEOXYNUCLEOSIDE 5-TRIPHOSPHATES | POLYMERASE IV | METAL-IONS | NAR Breakthrough
Journal Article
EMBO Reports, ISSN 1469-221X, 01/2012, Volume 13, Issue 1, pp. 68 - 74
Journal Article
PROTEIN SCIENCE, ISSN 0961-8368, 02/2019, Volume 28, Issue 2, pp. 439 - 447
Extensive evidence exists that DNA polymerases use two metal ions to catalyze the phosphoryl transfer reaction. Recently, competing evidence emerged,... 
polymerization | MECHANISM | polymerases | BIOCHEMISTRY & MOLECULAR BIOLOGY | TERNARY COMPLEXES | three-metal-ion catalysis | TRANSITION-STATE | ALPHA-S | DNA-POLYMERASE-BETA | OCCUPANCY | MAGNESIUM | two-metal-ion catalysis | saveED | pyrophosphorolysis | PHOTOSYSTEM-II | spherically averaged electron density function | METAL-IONS | INSIGHTS
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 10/2017, Volume 13, Issue 10, p. 1074
DNA polymerases catalyze efficient and high-fidelity DNA synthesis. While this reaction favors nucleotide incorporation, polymerases also catalyze a reverse... 
Phosphates | Fidelity | Sensitivity analysis | DNA polymerase | Chemical reactions | Crystallography | Equilibrium | DNA biosynthesis | Polymerase | Bridging | Pyrophosphorolysis | Chemical synthesis | Deoxyribonucleic acid--DNA | DNA-directed DNA polymerase
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 10/2017, Volume 13, Issue 10, pp. 1074 - 1080
DNA polymerases catalyze efficient and high-fidelity DNA synthesis. While this reaction favors nucleotide incorporation, polymerases also catalyze a reverse... 
CATALYSIS | BISPHOSPHONATES | NUCLEOTIDE INCORPORATION | MECHANISM | PYROPHOSPHOROLYSIS | FIDELITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTASE | TRANSITION-STATE | METAL-IONS | STATE KINETIC-ANALYSIS | Thermodynamics | Phosphates - metabolism | DNA Polymerase beta - metabolism | Humans | DNA Polymerase beta - chemistry | Phosphates - chemistry
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, p. e84051
Journal Article
Protein Science, ISSN 0961-8368, 02/2019, Volume 28, Issue 2, pp. 439 - 447
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 6674 - 10
Journal Article