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Journal Article
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 11/2010, Volume 6, Issue 11, pp. 829 - 836
Journal Article
Anti-Cancer Drugs, ISSN 1473-5741, 08/2019, Volume 30, Issue 7, pp. e0747 - e0747
Pyrvinium tosylate (PT) is an anthelminthic drug that has recently been shown to suppress various human cancers. However, whether PT is effective in... 
CELLS | APOPTOSIS | nasopharyngeal carcinoma | PYRVINIUM PAMOATE | BETA-CATENIN | SUPPRESSION | CANCER | CHEMOTHERAPY | casine kinase 1 alpha | tosylate | pyrvinium | ONCOLOGY | Wnt/beta-catenin | PHARMACOLOGY & PHARMACY | RADIOTHERAPY
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 32, pp. 33769 - 33780
The use of BCR-ABL1 tyrosine kinase inhibitors (TKI) has led to excellent clinical responses in patients with chronic phase chronic myeloid leukemia (CML).... 
Mitochondrial respiration | Pyrvinium | Chronic myeloid leukemia | PAMOATE | TRANSFORMATION | OXIDATIVE-PHOSPHORYLATION | STEM-CELLS | ACTIVATION | ANTITUMOR-ACTIVITY | TRANSLATION | COMBINATION | mitochondrial respiration | CELL BIOLOGY | pyrvinium | ANIMAL-MODELS | chronic myeloid leukemia | CRISIS | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2012, Volume 7, Issue 12, pp. e51449 - e51449
Activation of Wnt signalling due to inability to degrade beta-catenin is found in >85% of colorectal cancers. Approximately half of colon cancers express a... 
COLON-CANCER | CARCINOMA-CELLS | IN-VITRO | K-RAS | THYROID CARCINOMAS | MULTIDISCIPLINARY SCIENCES | PYRVINIUM PAMOATE | PANCREATIC TUMOR-GROWTH | BETA-CATENIN | FARNESYLTHIOSALICYLIC ACID | PROMOTES APOPTOSIS | Proto-Oncogene Proteins p21(ras) | Colorectal Neoplasms - genetics | Farnesol - pharmacology | Humans | ras Proteins - metabolism | Wnt Proteins - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Salicylates - chemistry | Salicylates - pharmacology | Colorectal Neoplasms - drug therapy | Gene Expression Regulation, Neoplastic - drug effects | Colorectal Neoplasms - metabolism | Farnesol - chemistry | Perylene - analogs & derivatives | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Perylene - chemistry | Pyrvinium Compounds - chemistry | ras Proteins - antagonists & inhibitors | Perylene - pharmacology | Drug Synergism | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Cell Line, Tumor | Farnesol - analogs & derivatives | Mice | Wnt Proteins - antagonists & inhibitors | Pyrvinium Compounds - pharmacology | Prevention | Gene mutations | Cell death | Analysis | Genes | Cancer cells | Colorectal cancer | Health aspects | Cancer | Health sciences | Biotechnology | Wnt protein | Transcription | Gene regulation | Colorectal carcinoma | Genomes | Myc protein | Kinases | Cancer therapies | Synergism | K-Ras protein | Proteins | Synergistic effects | β-catenin | Cell growth | Colon cancer | CD44 antigen | Colon | Inhibition | RNA-mediated interference | Abnormalities | Cyclin-dependent kinases | Survivin | Gene expression | Signaling | Inhibitors | Mutation | Apoptosis | Index Medicus
Journal Article
Frontiers in cellular and infection microbiology, ISSN 2235-2988, 2019, Volume 9, p. 181
The incidence of fungal diseases is on the rise and the number of fatalities is still unacceptably high. While advances into antifungal drug development have... 
Homeostasis | Mycoses | Pyrvinium | Antifungal agents | artemisinin | zinc homeostasis | antifungals | iron homeostasis | Candida | high throughput drug screening
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2014, Volume 57, Issue 15, pp. 6458 - 6467
The human androgen receptor (AR) is considered as a master regulator in the development and progression of prostate cancer (PCa). As resistance to clinically... 
IN-VITRO | CHEMISTRY, MEDICINAL | ANTIANDROGEN | STRUCTURAL BASIS | 3 BF3 SITE | INCREASED SURVIVAL | RESISTANT PROSTATE-CANCER | CASTRATION-RESISTANT | ANTAGONISTS | SPLICE VARIANTS | ENZALUTAMIDE | Antineoplastic Agents - chemical synthesis | Humans | Molecular Conformation | Receptors, Androgen - metabolism | Imidazoles - chemistry | Drug Resistance, Neoplasm | Male | Structure-Activity Relationship | Androgen Receptor Antagonists - pharmacology | Androgen Receptor Antagonists - chemistry | Computer Simulation | Transcription, Genetic | Antineoplastic Agents - pharmacology | Imidazoles - chemical synthesis | Binding Sites | Prostatic Neoplasms - drug therapy | Morpholines - chemical synthesis | Phenylthiohydantoin - pharmacology | Cell Survival - drug effects | Pyrvinium Compounds - chemistry | Prostate-Specific Antigen - secretion | Morpholines - pharmacology | Rats | Thiophenes - pharmacology | Imidazoles - pharmacology | DNA - metabolism | Antineoplastic Agents - chemistry | Morpholines - chemistry | Phenylthiohydantoin - analogs & derivatives | Thiophenes - chemical synthesis | Animals | Receptors, Androgen - genetics | Thiazoles - chemical synthesis | Databases, Chemical | Androgen Receptor Antagonists - chemical synthesis | Cell Line, Tumor | Thiazoles - chemistry | Molecular Docking Simulation | Thiazoles - pharmacology | Mutation | Thiophenes - chemistry | Pyrvinium Compounds - pharmacology | Index Medicus
Journal Article