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Journal Article
by Wang, ZG and Dai, Z and Luo, ZC and Zuo, CQ
MOLECULES, ISSN 1420-3049, 07/2019, Volume 24, Issue 13, p. 2391
Obesity is a serious health problem, while the current anti-obesity drugs are not very effective. The Connectivity Map (C-Map), an in-silico drug screening... 
microarray | ACTIVATION | pyrvinium | INHIBITION | adipogenic differentiation | BIOCHEMISTRY & MOLECULAR BIOLOGY | PPAR-GAMMA | connectivity map | DIFFERENTIATION | PREADIPOCYTES | CELL | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2011, Volume 108, Issue 38, pp. 15858 - 15863
Journal Article
Journal Article
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 07/2019, Volume 294, Issue 29, pp. 11259 - 11275
Journal Article
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 2, pp. 220 - 228
Previously, we developed a method to evaluate states of cells treated with anticancer drugs via the comprehensive analysis of amino acids, termed amino acid... 
pancreatic cancer cell | amino acid metabolomics | glucose depletion | biomarker candidate | TOLERANCE | PYRVINIUM PAMOATE | MASS-SPECTROMETRY | NUTRIENT DEPRIVATION | MITOCHONDRIAL ENERGY-METABOLISM | DISEASE | RESISTANCE | TUMOR MICROENVIRONMENTS | PHARMACOLOGY & PHARMACY | STARVATION | FUMARATE REDUCTASE SYSTEM | Pancreatic Neoplasms - metabolism | Humans | Amino Acids - chemistry | Deoxycytidine - pharmacology | Chromatography, High Pressure Liquid | Pancreatic Neoplasms - drug therapy | Amino Acids - metabolism | Tandem Mass Spectrometry | Biomarkers, Tumor - metabolism | Antimetabolites, Antineoplastic - pharmacology | Hypoglycemia - blood | Principal Component Analysis | Intracellular Fluid - metabolism | Cell Survival - drug effects | Pancreatic Neoplasms - blood | Reproducibility of Results | Blood Glucose - analysis | Hypoglycemia - metabolism | Metabolomics - methods | Discriminant Analysis | Biomarkers, Tumor - blood | Extracellular Fluid - metabolism | Cell Line, Tumor | Glucose - metabolism | Hydrophobic and Hydrophilic Interactions | Hypoglycemia - complications | Least-Squares Analysis | Pancreatic Neoplasms - complications | Deoxycytidine - analogs & derivatives | Pyrvinium Compounds - pharmacology | Pancreatic cancer cell | Amino acid metabolomics | Biomarker candidate | Glucose depletion | Drugs | Metabolomics | Discriminant analysis | Starvation | Gemcitabine | Amino acids | Mass spectroscopy | Glucose | Drug resistance | Anticancer properties | Antitumor agents | Pancreatic cancer | Pretreatment | Intracellular | Mass spectrometry
Journal Article
Drug Design, Development and Therapy, ISSN 1177-8881, 03/2015, Volume 9, pp. 2399 - 2407
Journal Article
The American Journal of the Medical Sciences, ISSN 0002-9629, 03/2018, Volume 355, Issue 3, pp. 274 - 280
Aberrant Wnt/β-catenin activation has been shown to play essential roles in cancer, including renal cell carcinoma (RCC). In this work, we demonstrate that... 
Drug repurposing | Pyrvinium | Renal cell carcinoma | Wnt/β-catenin | CK1α | CK1 alpha | PAMOATE | MEDICINE, GENERAL & INTERNAL | PATHWAY | Wnt/beta-catenin | EXPRESSION
Journal Article
International Journal of Oncology, ISSN 1019-6439, 3/2016, Volume 48, Issue 3, pp. 1175 - 1186
Acquisition of chemoresistance and metastatic phenotype are the major causes of breast cancer treatment failure and cancer-related mortality. Recently, a... 
WNT pathway | breast cancer stem cells | mammosphere | pyrvinium pamoate | heterogeneity | Heterogeneity | Pyrvinium pamoate | Mammosphere | Breast cancer stem cells | PROLIFERATION | HEDGEHOG | MARKERS CD44 | COLON-CANCER | THERAPY | ONCOLOGY | WNT/BETA-CATENIN | ALDH1 | CROSSTALK | CD24 | Stem cell research | Care and treatment | Breast cancer | Genetic aspects | Metastasis |