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chemistry, organic (177) 177
quinolinone (142) 142
derivatives (122) 122
quinolinones (121) 121
chemistry, multidisciplinary (87) 87
humans (60) 60
chemistry (57) 57
chemistry, medicinal (56) 56
index medicus (55) 55
inhibitors (49) 49
animals (46) 46
quinolones - pharmacology (41) 41
pharmacology & pharmacy (37) 37
biochemistry & molecular biology (36) 36
quinolones - chemistry (36) 36
cyclization (30) 30
alkaloids (29) 29
analysis (29) 29
agents (27) 27
design (27) 27
male (27) 27
quinolones - chemical synthesis (27) 27
structure-activity relationship (27) 27
quinoline (25) 25
synthesis (24) 24
organic chemistry (22) 22
rats (22) 22
heterocycles (20) 20
molecular structure (20) 20
quinolines - pharmacology (20) 20
2-quinolinones (19) 19
3,4-dihydro-6-<4--1-piperazinyl>-2 (19) 19
quinolones (18) 18
2-quinolinone (17) 17
acid (17) 17
antineoplastic agents - pharmacology (17) 17
vesnarinone (16) 16
catalysis (15) 15
chemistry, physical (15) 15
dose-response relationship, drug (15) 15
female (15) 15
pharmacology (15) 15
drug therapy (14) 14
quinolinone derivatives (14) 14
activation (13) 13
aldehydes (13) 13
alkylation (13) 13
antagonists (13) 13
apoptosis (13) 13
letter (13) 13
mice (13) 13
palladium (13) 13
quinolines - chemistry (13) 13
aripiprazole (12) 12
cell line, tumor (12) 12
chemistry, applied (12) 12
in-vitro (12) 12
inorganic chemistry (12) 12
potent (12) 12
rearrangement (12) 12
spectroscopy (12) 12
acids (11) 11
biological evaluation (11) 11
biological-activity (11) 11
cancer (11) 11
coumarin (11) 11
coumarins (11) 11
efficient synthesis (11) 11
magnetic resonance spectroscopy (11) 11
physical chemistry (11) 11
quinolone antibacterial agents (11) 11
resveratrol (11) 11
2-quinolinone derivatives (10) 10
antibacterial activity (10) 10
baylis-hillman adducts (10) 10
biological-activities (10) 10
chemistry, inorganic & nuclear (10) 10
congestive heart failure (10) 10
construction (10) 10
facile synthesis (10) 10
identification (10) 10
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organic-synthesis (10) 10
quinolines - chemical synthesis (10) 10
quinolinone alkaloids (10) 10
substituted quinolinones (10) 10
tetrahedrons (10) 10
4-quinolinone (9) 9
amidation (9) 9
analogs (9) 9
anti-infective agents (9) 9
antibacterial agents (9) 9
antineoplastic agents - chemistry (9) 9
cardiotonic agents - pharmacology (9) 9
chemistry/food science, general (9) 9
copper (9) 9
fluorescence (9) 9
ligands (9) 9
mechanism (9) 9
nmr (9) 9
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1. Full Text Direct exchange of a ketone methyl or aryl group to another aryl group through ciC bond activation assisted by rhodium chelation
by Wang, Jingjing and Chen, Weiqiang and Zuo, Sujing and Liu, Lu and Zhang, Xinrui and Wang, Jianhui
Angewandte Chemie - International Edition, ISSN 1433-7851, 12/2012, Volume 51, Issue 49, pp. 12334 - 12338
CiC activation | quinolinones | chelation | cross-coupling | rhodium
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2. Full Text Transition-metal-free direct cross-dehydrogenative coupling reactions of quinolinones with ethers
by Wang, Gang and Wang, Jun-Tao and Zhao, Bing and Chen, Huan and Zhang, Pan-Ke and Han, Shu-Lei
Tetrahedron Letters, ISSN 0040-4039, 11/2019, p. 151426
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3. Full Text Studies on the chemical behavior of 3-(nitroacetyl)-1-ethyl-4- hydroxyquinolin-2(1h)-one towards some electrophilic and nucleophilic reagents
by Ibrahim, Magdy A and Hassanin, Hany M and Gabr, Yassin A and Alnamer, Youssef A
Journal of the Brazilian Chemical Society, ISSN 0103-5053, 2012, Volume 23, Issue 5, pp. 905 - 912
A variety of heterocyclic systems linked to 1-ethylquinolin-2(1H)-one was prepared from reaction of 3-(nitroacetyl)-1-ethyl-4-hydroxyquinolin-2(1H)-one with... 
ß-ketoacid | Pyrazolo[4,3-c]quinolinones | Cyclocondensation | 3-nitroacetylquinolinone | Pyrimido[5,4-c]quinolinones | beta-ketoacid | pyrazolo[4,3-c]quinolinones | RECEPTOR | pyrimido[5,4-c] quinolinones | SUBSTITUTED QUINOLINONES | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | cyclocondensation
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4. Full Text Lewis base catalyzed ring-expansion of isatin with 2,2,2-trifluorodiazoethane (CF3CHN2): An efficient route to 3-hydroxy-4-(trifluoromethyl)quinolinones
by Lv, Shuipeng and Sun, Yunfang and Xu, Yue and Yang, Shihai and Wang, Lei
Chinese Chemical Letters, ISSN 1001-8417, 11/2019
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5. Full Text Lewis base catalyzed ring-expansion of isatin with 2,2,2-trifluorodiazoethane (CF3CHN2): An efficient route to 3-hydroxy-4-(trifluoromethyl)quinolinones
by Lv, Shuipeng and Sun, Yunfang and Xu, Yue and Yang, Shihai and Wang, Lei
Chinese Chemical Letters, ISSN 1001-8417, 11/2019
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6. Full Text Palladium/copper-catalyzed cross-coupling reactions for the synthesis of 4-heteroaryl quinolinone
by Guo, Tao
Tetrahedron Letters, ISSN 0040-4039, 12/2016, Volume 57, Issue 51, pp. 5837 - 5840
A convenient and efficient approach for the synthesis of 4-heteroaryl quinolinones was developed via palladium/copper-catalyzed coupling reactions between... 
4-Benzothiazolyl quinolinones | 4-Benzoxazolyl quinolinones | Antiproliferative activity | Coupling reaction | DRUG | DIRECT ARYLATION | CHEMISTRY, ORGANIC | BIOLOGICAL-ACTIVITIES | GLYCINE SITE | POTENT | DISEASE | INHIBITORS | ANTAGONISTS | DERIVATIVES
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7. Full Text Asymmetric Synthesis of 3,4-Dihydroquinolin-2-ones via a Stereoselective Palladium-Catalyzed Decarboxylative [4 + 2]- Cycloaddition
by Jin, Jing-Hai and Wang, Hao and Yang, Zhong-Tao and Yang, Wu-Lin and Tang, Wenjun and Deng, Wei-Ping
Organic Letters, ISSN 1523-7060, 01/2018, Volume 20, Issue 1, pp. 104 - 107
An efficient, palladium-catalyzed, decarboxylative [4 + 2]-cycloaddition of 4-vinyl benzoxazinanones with carboxylic acids has been developed with the... 
QUINOLINONES | ACTIVATION | HETEROCYCLES | CONSTRUCTION | CHEMISTRY, ORGANIC | 4+2 CYCLOADDITIONS | GENERATION | DERIVATIVES | EFFICIENT | ACCESS | CASCADE REACTION
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8. Synthesis of Quinoline-2, 4-diones from Cyanoacetanilide Derivatives
by Zhong, Shuaishuai and Huang, Peng and Wang, Xingyue and Lin, Mi and Ge, Chunhua
Chinese Journal of Organic Chemistry, ISSN 0253-2786, 05/2018, Volume 38, Issue 5, pp. 1199 - 1206
Quinolinone | Nitrile | Cyclization | Methylation
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9. Full Text Copper‐Catalyzed Regioselective Cross‐Dehydrogenative Coupling of Coumarins with Benzylic Csp3–H Bonds
by Zhou, Shi‐Liu and Guo, Li‐Na and Duan, Xin‐Hua
European Journal of Organic Chemistry, ISSN 1434-193X, 12/2014, Volume 2014, Issue 36, pp. 8094 - 8100
A new copper‐catalyzed regioselective cross‐dehydrogenative coupling of coumarins with benzylic Csp3–H bonds has been developed. This reaction provides direct... 
C–C coupling | Coumarins | Benzylation | Radical reactions | Copper | Quinolinones | C-C coupling
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10. Concise Synthesis of Quinolinone Derivatives
by Chen, Xuebing and Bai, Hairui and Huang, Chao
Chinese Journal of Organic Chemistry, ISSN 0253-2786, 04/2017, Volume 37, Issue 4, pp. 881 - 888
Intramolecular cyclization | Regionselectivity acylation | β-enaminones | Quinolinones
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11. Full Text Oxidative ring opening of 3-hydroxyquinoline-2,4(1H,3H)-diones into N-(α-ketoacyl)anthranilic acids Dedicated to Professor Slovenko Polanc on his 65th birthday
by Kafka, Stanislav and Proisl, Karel and Kašpárková, Věra and Urankar, Damijana and Kimmel, Roman and Košmrlj, Janez
Tetrahedron, ISSN 0040-4020, 12/2013, Volume 69, Issue 51, pp. 10826 - 10835
N-(α-Ketoacyl)anthranilic acids were prepared by oxidative ring opening of 3-hydroxyquinoline-2,4(1H,3H)-diones by using paraperiodic acid (H IO ) or sodium... 
Periodate | Quinolinediones | N-(α-Ketoacyl)anthranilic acid | Paraperiodic acid | Quinolinones
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12. The quinolones
by Andriole, Vincent T
1998, 2nd ed., ISBN 0120595141, xx, 441
Quinolinones | Quinolone antibacterial agents
Book
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13. Full Text Synthesis of 2-alkenyl-3-hydroxyquinolin-4(1H)-ones as promising antimicrobial and fluorescent agents
by Horák, Radim and Kvapil, Lubomír and Motyka, Kamil and Slaninová, Ludmila and Grepl, Martin and Kořistek, Kamil and Urbášek, Miroslav and Hradil, Pavel and Soural, Miroslav
Tetrahedron, ISSN 0040-4020, 01/2018, Volume 74, Issue 2, pp. 366 - 374
2-Alkenyl-3-hydroxyquinolin-4(1 )-ones were prepared by the rearrangement of anthranilic acid esters synthesized by two alternative methods. The prepared... 
Fluorescence | Antibacterial | Anthranilates | Quinolinones | Rearrangement | DYES | PQSR | MOLECULE | CHEMISTRY, ORGANIC | SOLVENT | 2-ARYL-3-HYDROXYQUINOLONES | PSEUDOMONAS-AERUGINOSA | ANTAGONISTS
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14. Friedel-Crafts chemistry. Part 50. Convergent and diversity-oriented constructions of polycyclic quinolines via Friedel-Crafts and Beckmann ring enlargement approaches
by Abd El-Aal, Hassan A.K
Arkivoc, ISSN 1551-7004, 12/2017, Volume 2018, Issue 3, pp. 45 - 61
Condensed heterocyclic systems containing N- & S-medium-sized rings, in particular, thiazepine, thiazocine, and thiazonine systems are important substructures... 
1,4-thiazonino[3,2-h]quinolinones | Heterocyclic acids | 1,4-thiazocino[3,2-h]quinolinones | Heteropolycycles | heterocyclic acids | CHEMISTRY, ORGANIC | CLOSING METATHESIS | REARRANGEMENT | HETEROCYCLES | EXPEDIENT | N,S-HETEROCYCLES | 2-AMINOTHIOPHENOL | CHALCONE | DERIVATIVES | 1,5-BENZOTHIAZEPINES | EXCHANGER
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15. Full Text A General Synthesis of 7-Phenyl-7,13-dihydro-8H-benzo[6,7]azepino[3,2-c]quinolin-8-ones
by Dobrowolski, Jeremy C and Nguyen, Duyen H.T and Fraser, Benjamin H and Bhadbhade, Mohan and Black, David StC and Kumar, Naresh
Synlett, ISSN 0936-5214, 03/2019, Volume 30, Issue 5, pp. 567 - 572
Abstract Complex benzazepinoquinolone scaffolds can be accessed from the reaction of 2-aminoacetophenones and oxindole derivatives and feature the... 
letter | 7]azepino | fused-ring systems | ANION | heterocycles | umpolung | condensation | CHEMISTRY, ORGANIC | quinolones | 2-c]quinolinones | dihydrobenzo
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16. Full Text Prenylated quinolinone alkaloids and prenylated isoindolinone alkaloids from the fungus Aspergillus nidulans
by Li, Qin and Chen, Chunmei and He, Yan and Wei, Mengsha and Cheng, Li and Kang, Xin and Wang, Jianping and Hao, Xincai and Zhu, Hucheng and Zhang, Yonghui
Phytochemistry, ISSN 0031-9422, 01/2020, Volume 169, p. 112177
Two undescribed prenylated quinolinone alkaloids, aspoquinolones E and F, and three undescribed prenylated isoindolinone alkaloids aspernidines F–H, were... 
Isoindolinone | Quinolinone | Aspergillus nidulans (Trichocomaceae) | Cytotoxic activities
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17. Full Text Synthesis of 10-aryl-7,9-dihydro-3H-furo[3,4-b]pyrazolo[4,3-f]quinolin-9-one using supported ionic liquid
by Sandaroos, Reza and Sandaroos, Reza and Damavandi, Saman and Damavandi, Saman and Molaei, Hamid Reza and Molaei, Hamid Reza
Research on Chemical Intermediates, ISSN 0922-6168, 3/2015, Volume 41, Issue 3, pp. 1517 - 1524
A series of 3H-furo[3,4-b]pyrazolo[4,3-f]quinolinone derivatives has been synthesized through three-component reaction of tetronic acid, 5-aminoindazole and... 
Chemistry | Physical Chemistry | One-pot | Catalysis | Inorganic Chemistry | Pyrazolo[4,3- f ]quinolinones | Ionic liquid | Pyrazolo[4 3-f]quinolinones | LIBRARIES | SOLVENT-FREE CONDITIONS | Pyrazolo[4,3-f]quinolinones | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | Sulfates | Aldehydes | Hydrogen | Resveratrol | Sulfuric acid
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18. Full Text Novel Tacrine‐Based Pyrano[3’,4’:5,6]pyrano[2,3‐b]quinolinones: Synthesis and Cholinesterase Inhibitory Activity
by Hariri, Roshanak and Afshar, Zahra and Mahdavi, Mohammad and Safavi, Maliheh and Saeedi, Mina and Najafi, Zahra and Sabourian, Reyhaneh and Karimpour‐Razkenari, Elahe and Edraki, Najmeh and Moghadam, Farshad Homayouni and Shafiee, Abbas and Khanavi, Mahnaz and Akbarzadeh, Tahmineh
Archiv der Pharmazie, ISSN 0365-6233, 12/2016, Volume 349, Issue 12, pp. 915 - 924
In order to develop effective anti‐cholinesterase compounds, a novel series of pyrano[3’,4’:5,6]pyrano[2,3‐b]quinolinones were designed, synthesized, and... 
Fused heterocycles | Pyrano[3’,4’:5,6]pyrano[2,3‐b]quinolinones | Acetylcholinesterase | Butyrylcholinesterase | Alzheimer's disease | Pyrano[3’,4’:5,6]pyrano[2,3-b]quinolinones | DESIGN | CHEMISTRY, MEDICINAL | DOCKING | CHEMISTRY, MULTIDISCIPLINARY | Pyrano[3 ',4 ':5,6]pyrano[2,3-b]quinolinones | DISEASE | DRUGS | BIOLOGICAL EVALUATION | PHARMACOLOGY & PHARMACY | ACETYLCHOLINESTERASE INHIBITORS | ALZHEIMERS | BRAIN | HYBRIDS | Neuroprotective Agents | Hydrogen Peroxide | Cholinesterase Inhibitors - chemistry | Models, Molecular | Cholinesterase Inhibitors - chemical synthesis | Quinolones - pharmacology | Structure-Activity Relationship | Animals | Quinolones - chemistry | Rivastigmine - pharmacology | Cholinesterase Inhibitors - pharmacology | Quinolones - chemical synthesis | Butyrylcholinesterase - drug effects | Acetylcholinesterase - drug effects | Molecular Docking Simulation | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Cell Death - drug effects | Tacrine - analogs & derivatives | Binding Sites - drug effects | Surface active agents | Cell death
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19. Full Text A visible-light-irradiated electron donor-acceptor complex-promoted radical reaction system for the CH perfluoroalkylation of quinolin-4-ols
by Li, Yunze and Rao, Min and Fan, Zhenwei and Nian, Baoyi and Yuan, Yaofeng and Cheng, Jiajia
Tetrahedron Letters, ISSN 0040-4039, 09/2019, Volume 60, Issue 38
An efficient method for visible-light-induced perfluoroalkylaion of quinolin-4-ol has been reported. In the presence of -BuONa and perfluoroalkyl iodide,... 
EDA complex | Quinolinone | C[sbnd]H perfluoroalkylation | Visible-light irradiation
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20. Full Text The quinolones
by Andriole, Vincent T
2000, 3rd ed., ISBN 9780120595174, 539
Quinolones constitute a large class of synthetic antimicrobial agents that are highly effective in the treatment of many types of infectious diseases,... 
Quinolone antibacterial agents | Other branches of medicine | Pharmaceutical chemistry
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