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American Journal of Physiology: Cell Physiology, ISSN 0363-6143, 06/2016, Volume 310, Issue 11, pp. C942 - C954
Rab | Lacrimal gland | Exocytosis | Lysosomal protease | Sjögren’s Syndrome | Tears | Physiology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Male | rab GTP-Binding Proteins - genetics | Transfection | rab3 GTP-Binding Proteins - metabolism | Lacrimal Apparatus - secretion | rab3 GTP-Binding Proteins - deficiency | Secretory Vesicles - enzymology | Sjogren's Syndrome - genetics | rab GTP-Binding Proteins - deficiency | Disease Models, Animal | Sjogren's Syndrome - enzymology | Tears - drug effects | Tears - enzymology | rab GTP-Binding Proteins - metabolism | Rabbits | Lacrimal Apparatus - drug effects | Membrane Microdomains - enzymology | Mice, Inbred C57BL | Cells, Cultured | Genotype | Cathepsins - secretion | rab3 GTP-Binding Proteins - genetics | Carbachol - pharmacology | Phenotype | Animals | Cathepsins - genetics | Cathepsins - metabolism | Lacrimal Apparatus - enzymology | Tears - secretion | rab27 GTP-Binding Proteins | Mice, Inbred NOD | Mice, Inbred BALB C | Exocrine glands | Protein expression | Autoimmune diseases | Rodents | Index Medicus | lysosomal protease | lacrimal gland | exocytosis | Sjögren's Syndrome | tears
Journal Article
Open biology, ISSN 2046-2441, 06/2015, Volume 5, Issue 6, pp. 150047 - 150047
RAB18 | GEF | RAB | Ras | GAP | Rab | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Abnormalities, Multiple - metabolism | Abnormalities, Multiple - pathology | Abnormalities, Multiple - etiology | Humans | Cataract - pathology | Endoplasmic Reticulum - metabolism | rab GTP-Binding Proteins - genetics | Guanosine Triphosphate - metabolism | Case-Control Studies | Intellectual Disability - metabolism | Optic Atrophy - pathology | Flow Cytometry | Optic Atrophy - etiology | rab3 GTP-Binding Proteins - metabolism | Hypogonadism - metabolism | Optic Atrophy - metabolism | Microcephaly - pathology | Cornea - pathology | Real-Time Polymerase Chain Reaction | Fibroblasts - metabolism | Hypogonadism - pathology | rab GTP-Binding Proteins - metabolism | rab1 GTP-Binding Proteins - metabolism | Cataract - etiology | RNA, Messenger - genetics | Cells, Cultured | Gene Expression Regulation | Intellectual Disability - pathology | Microcephaly - metabolism | Cataract - metabolism | Fibroblasts - pathology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | rab1 GTP-Binding Proteins - genetics | Hydrolysis | rab3 GTP-Binding Proteins - genetics | Cornea - metabolism | Animals | Cataract - congenital | Fluorescent Antibody Technique | Microcephaly - etiology | Cytosol - metabolism | Mice | Cornea - abnormalities | HeLa Cells | Intellectual Disability - etiology | Hypogonadism - etiology | Index Medicus | gef | rab | ras | rab18 | gap
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 114, Issue 19, pp. 4117 - 4127
Life Sciences & Biomedicine | Hematology | Science & Technology | Hematologic and hematopoietic diseases | Biological and medical sciences | Medical sciences | Tetradecanoylphorbol Acetate - pharmacology | Humans | Lymphohistiocytosis, Hemophagocytic - physiopathology | GPI-Linked Proteins | Lymphocyte Function-Associated Antigen-1 - metabolism | rab GTP-Binding Proteins - genetics | Case-Control Studies | Receptors, IgG - metabolism | Membrane Proteins - deficiency | Cytoplasmic Granules - metabolism | Killer Cells, Natural - immunology | Membrane Proteins - metabolism | Lymphohistiocytosis, Hemophagocytic - genetics | Child | Lymphohistiocytosis, Hemophagocytic - immunology | rab GTP-Binding Proteins - deficiency | rab GTP-Binding Proteins - metabolism | Cell Degranulation | Signal Transduction | Lymphocyte Activation | Membrane Proteins - genetics | Killer Cells, Natural - physiology | Ionomycin - pharmacology | rab27 GTP-Binding Proteins | Killer Cells, Natural - drug effects | Perforin - metabolism | Mutation | In Vitro Techniques | Cytoplasmic Granules - immunology | Receptors, Immunologic - metabolism | Cytotoxicity, Immunologic | Index Medicus | Abridged Index Medicus | Medicin och hälsovetenskap
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 02/2013, Volume 77, Issue 3, pp. 425 - 439
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | rab5 GTP-Binding Proteins - genetics | Immunoprecipitation | Humans | Middle Aged | Cerebral Cortex - pathology | Male | Tubulin - genetics | rab GTP-Binding Proteins - genetics | Green Fluorescent Proteins - genetics | Statistics as Topic | Vesicle-Associated Membrane Protein 2 - genetics | Cerebral Cortex - cytology | Tyrosine 3-Monooxygenase | rab5 GTP-Binding Proteins - metabolism | Tubulin - metabolism | Transfection | Aged, 80 and over | Female | Neurons - metabolism | Parkinson Disease - metabolism | Protein-Serine-Threonine Kinases - metabolism | Animals, Newborn | Synaptosomal-Associated Protein 25 - genetics | rab GTP-Binding Proteins - metabolism | Genetic Predisposition to Disease | Genome-Wide Association Study | Parkinson Disease - pathology | Animals, Genetically Modified | Drosophila | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Rats | Parkinson Disease - genetics | Mutation - genetics | Rats, Sprague-Dawley | Protein Transport - genetics | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Animals | Polymorphism, Single Nucleotide - genetics | Aged | Mice | Synaptosomal-Associated Protein 25 - metabolism | Vesicle-Associated Membrane Protein 2 - metabolism | Parkinson's disease | Neurons | Genomics | Risk factors | Brain | Laboratories | Parkinsons disease | Kinases | Gene expression | Experiments | Defects | Proteins | Pathology | Insects | Neurodegeneration | Gene loci | Mutation | Index Medicus
Journal Article
The Journal of neuroscience, ISSN 0270-6474, 02/2012, Volume 32, Issue 8, pp. 2628 - 2636
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Protein Binding - genetics | Immunoprecipitation | Humans | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | rab GTP-Binding Proteins - genetics | Axons - physiology | Synapses - genetics | Amino Acid Sequence - genetics | Guanine Nucleotide Exchange Factors - metabolism | Mass Spectrometry | Mechanoreceptors - cytology | rab GTP-Binding Proteins - metabolism | Guanine Nucleotide Exchange Factors - genetics | Animals, Genetically Modified | F-Box Proteins - metabolism | Gene Expression Regulation - genetics | Synapses - physiology | Ubiquitin-Protein Ligases - metabolism | Nuclear Matrix-Associated Proteins - metabolism | Signal Transduction - genetics | Mutation - genetics | Nucleocytoplasmic Transport Proteins - genetics | Caenorhabditis elegans | Microscopy, Confocal | Nuclear Matrix-Associated Proteins - deficiency | Animals | Nucleocytoplasmic Transport Proteins - metabolism | Nuclear Matrix-Associated Proteins - genetics | Adaptor Proteins, Signal Transducing - genetics | Luminescent Proteins - genetics | Nucleocytoplasmic Transport Proteins - deficiency | Adaptor Proteins, Signal Transducing - metabolism | Amino Acid Motifs - genetics | Ubiquitin-Protein Ligases - genetics | Caenorhabditis elegans Proteins - genetics | F-Box Proteins - genetics | Index Medicus
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2014, Volume 135, Issue 5, pp. 1310 - 1318.e1
Allergy and Immunology | Griscelli syndrome type 2 | melanophilin | Hemophagocytic lymphohistiocytosis | familial hemophagocytic lymphohistiocytosis | natural killer cells | cytotoxic T lymphocyte | Allergy | Immunology | Life Sciences & Biomedicine | Science & Technology | Perforin - genetics | Humans | Child, Preschool | Infant | Male | rab GTP-Binding Proteins - genetics | Case-Control Studies | Skin Pigmentation - genetics | DNA Mutational Analysis | Female | Membrane Proteins - metabolism | Lymphohistiocytosis, Hemophagocytic - genetics | Child | rab GTP-Binding Proteins - metabolism | Cell Line | Gene Expression | Cell Degranulation | Lymphohistiocytosis, Hemophagocytic - diagnosis | Models, Molecular | Genetic Markers | Phenotype | Membrane Proteins - chemistry | Lymphohistiocytosis, Hemophagocytic - metabolism | Adolescent | Albinism - genetics | Protein Binding | rab27 GTP-Binding Proteins | Protein Conformation | rab GTP-Binding Proteins - chemistry | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Cohort Studies | Cytotoxicity, Immunologic | Transplantation | Hematopoietic stem cells | Proteins | Stem cells | Amino acids | Cytotoxicity | Patients | Immune system | Index Medicus | Abridged Index Medicus | Immune Deficiencies, Infection, and Systemic Immune Disorders | Slp2a, Synaptotagmin-like protein 2a | GRA, Granule release assay | GFP, Green fluorescent protein | GTP, Guanosine triphosphate | GS2, Griscelli syndrome type 2 | FHL, Familial Hemophagocytic lymphohistiocytosis | OMIM, Online Mendelian Inheritance in Man | HLH, Hemophagocytic lymphohistiocytosis | CTL, Cytotoxic T lymphocyte | Mlph, melanophilin | NK, Natural killer
Journal Article
Blood, ISSN 0006-4971, 04/2013, Volume 121, Issue 15, pp. 2943 - 2951
Life Sciences & Biomedicine | Hematology | Science & Technology | Lymphohistiocytosis, Hemophagocytic - etiology | Adaptor Protein Complex beta Subunits - deficiency | Humans | Child, Preschool | rab GTP-Binding Proteins - genetics | Young Adult | Flow Cytometry | Adaptor Protein Complex 3 - deficiency | Adult | Adaptor Protein Complex beta Subunits - immunology | Adaptor Protein Complex beta Subunits - genetics | Lymphohistiocytosis, Hemophagocytic - genetics | Child | Lymphohistiocytosis, Hemophagocytic - immunology | rab GTP-Binding Proteins - deficiency | T-Lymphocytes, Cytotoxic - immunology | Adaptor Protein Complex 3 - immunology | Cytotoxicity, Immunologic - genetics | Mice, Inbred C57BL | Risk Factors | Mice, Knockout | Hermanski-Pudlak Syndrome - immunology | Hermanski-Pudlak Syndrome - genetics | Animals | T-Lymphocytes, Cytotoxic - metabolism | rab GTP-Binding Proteins - immunology | Hermanski-Pudlak Syndrome - complications | Adolescent | Adaptor Protein Complex 3 - genetics | rab27 GTP-Binding Proteins | Mice | Mutation | Cytotoxicity, Immunologic - immunology | Index Medicus | Abridged Index Medicus | Immunobiology
Journal Article
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Full Text
Kinetics of Rab27a‐dependent actions on vesicle docking and priming in pancreatic β‐cells
The Journal of physiology, ISSN 0022-3751, 11/2008, Volume 586, Issue 22, pp. 5367 - 5381
Neurosciences | Physiology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Male | rab GTP-Binding Proteins - genetics | Exocytosis - physiology | Exocytosis - drug effects | rab3A GTP-Binding Protein - genetics | Insulin-Secreting Cells - metabolism | Guanine Nucleotide Exchange Factors - metabolism | rab3A GTP-Binding Protein - deficiency | Female | Cyclic AMP - metabolism | Insulin Secretion | rab GTP-Binding Proteins - deficiency | rab GTP-Binding Proteins - metabolism | Signal Transduction | rab3A GTP-Binding Protein - metabolism | Glucose - pharmacology | Mice, Inbred C3H | Mice, Knockout | Insulin - metabolism | Animals | Carrier Proteins - metabolism | Insulin-Secreting Cells - drug effects | rab27 GTP-Binding Proteins | Mice | Kinetics | In Vitro Techniques | Index Medicus | Cellular
Journal Article
The Journal of cell biology, ISSN 0021-9525, 09/2009, Volume 186, Issue 6, pp. 881 - 895
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Synaptic Vesicles - metabolism | Phosphatidylinositol Phosphates - metabolism | Evoked Potentials | rab GTP-Binding Proteins - genetics | rab2 GTP-Binding Protein - deficiency | Neurons - ultrastructure | Excitatory Postsynaptic Potentials | Secretory Vesicles - enzymology | rab GTP-Binding Proteins - deficiency | GTP-Binding Protein alpha Subunits - metabolism | Caenorhabditis elegans - genetics | Secretory Vesicles - ultrastructure | Axons - metabolism | Synapses - enzymology | Genotype | Neuropeptides - metabolism | Protein Transport | Caenorhabditis elegans - ultrastructure | Locomotion | Phenotype | Animals | Miniature Postsynaptic Potentials | Neurons - enzymology | rab2 GTP-Binding Protein - genetics | Muscles - innervation | Endosomes - enzymology | Mutation | Caenorhabditis elegans Proteins - genetics | Caenorhabditis elegans - enzymology | Physiological aspects | Caenorhabditis elegans | Genetic aspects | Cell organelles | Research | Gene mutations | Proteins | Bacteria | Genetics | Peptides | Index Medicus | s
Journal Article
Journal of cell science, ISSN 0021-9533, 2017, Volume 130, Issue 21, pp. 3698 - 3712