X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
rac1 gtp-binding protein - metabolism (3509) 3509
animals (3280) 3280
humans (2966) 2966
mice (1827) 1827
cell biology (1597) 1597
signal transduction (1350) 1350
rac1 (1241) 1241
biochemistry & molecular biology (1189) 1189
rac1 gtp-binding protein - genetics (1184) 1184
activation (1089) 1089
cells, cultured (938) 938
phosphorylation (862) 862
cdc42 gtp-binding protein - metabolism (763) 763
cell line (748) 748
cell line, tumor (743) 743
rats (724) 724
proteins (716) 716
male (698) 698
expression (665) 665
actins - metabolism (634) 634
rhoa gtp-binding protein - metabolism (631) 631
female (587) 587
rho-gtpases (553) 553
neuropeptides - metabolism (541) 541
rac1 protein (516) 516
cell movement (515) 515
enzyme activation (515) 515
rac gtp-binding proteins - metabolism (512) 512
oncology (503) 503
transfection (500) 500
actin (499) 499
protein binding (489) 489
migration (481) 481
cytoskeleton (478) 478
rho gtp-binding proteins - metabolism (466) 466
cdc42 (444) 444
protein (437) 437
guanine nucleotide exchange factors - metabolism (417) 417
research (417) 417
signal transduction - drug effects (403) 403
signal transduction - physiology (398) 398
cells (397) 397
rho gtpases (395) 395
cancer (389) 389
mice, inbred c57bl (388) 388
rac (388) 388
mice, knockout (387) 387
apoptosis (376) 376
rac1 gtp-binding protein (363) 363
research article (355) 355
cell migration (354) 354
cell movement - physiology (354) 354
gene expression (350) 350
multidisciplinary sciences (350) 350
cell movement - drug effects (339) 339
kinases (338) 338
mutation (332) 332
rac1 gtp-binding protein - antagonists & inhibitors (331) 331
reactive oxygen species - metabolism (319) 319
rac1 gtp-binding protein - physiology (316) 316
rho (312) 312
physiological aspects (310) 310
phosphatidylinositol 3-kinases - metabolism (309) 309
cell adhesion (307) 307
cell proliferation (307) 307
g proteins (303) 303
cell adhesion & migration (302) 302
actin cytoskeleton (300) 300
adhesion (300) 300
blotting, western (293) 293
biology (291) 291
models, biological (291) 291
cell membrane - metabolism (290) 290
neurosciences (288) 288
cytoskeleton - metabolism (285) 285
kinase (280) 280
metastasis (269) 269
nadph oxidases - metabolism (269) 269
neuropeptides - genetics (265) 265
growth (263) 263
rna interference (262) 262
binding (261) 261
analysis (259) 259
gtpases (258) 258
inhibition (258) 258
time factors (258) 258
medicine (256) 256
protein structure, tertiary (256) 256
cdc42 gtp-binding protein - genetics (253) 253
oxidative stress (250) 250
in-vivo (249) 249
rac gtp-binding proteins - genetics (247) 247
protein-serine-threonine kinases - metabolism (245) 245
hela cells (244) 244
nadph oxidase (241) 241
amino acid sequence (235) 235
enzyme inhibitors - pharmacology (231) 231
molecular sequence data (230) 230
motility (229) 229
immunology (227) 227
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


The Journal of biological chemistry, ISSN 1083-351X, 2016, Volume 291, Issue 9, pp. 4323 - 4333
...) undergo rapid remodeling into dynamic extracellular matrix-degrading rosettes by distinct G protein-coupled receptor agonists, notably lysophosphatidic acid (LPA... 
Receptors, Lysophosphatidic Acid - metabolism | Lysophospholipids - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Extracellular Matrix - metabolism | Melanoma - enzymology | Podosomes - enzymology | Neoplasm Proteins - antagonists & inhibitors | Receptors, Lysophosphatidic Acid - agonists | Receptors, Lysophosphatidic Acid - genetics | cdc42 GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - genetics | Endothelins - metabolism | Neoplasm Proteins - metabolism | Time-Lapse Imaging | Podosomes - metabolism | RNA Interference | cdc42 GTP-Binding Protein - antagonists & inhibitors | Fluorescence Resonance Energy Transfer | Receptors, Lysophosphatidic Acid - antagonists & inhibitors | Neoplasm Proteins - genetics | Biomarkers - metabolism | Melanoma - metabolism | Recombinant Proteins - metabolism | rac1 GTP-Binding Protein - agonists | rhoA GTP-Binding Protein - antagonists & inhibitors | Recombinant Proteins - genetics | Melanoma - pathology | cdc42 GTP-Binding Protein - agonists | Hydrolysis | Podosomes - pathology | Microscopy, Confocal | Neoplasm Proteins - agonists | cdc42 GTP-Binding Protein - genetics | Receptors, G-Protein-Coupled - antagonists & inhibitors | rac1 GTP-Binding Protein - antagonists & inhibitors | Cell Line, Tumor | Luminescent Proteins - genetics | Receptors, G-Protein-Coupled - genetics | Extracellular Matrix - pathology | Microscopy, Fluorescence | rac1 GTP-Binding Protein - metabolism | Luminescent Proteins - metabolism | rac1 GTP-Binding Protein - genetics | CDC42 | invadopodia | biosensor | fluorescence resonance energy transfer (FRET) | calcium intracellular release | G protein-coupled receptor (GPCR) | Rho (Rho GTPase) | phosphatidylinositide 3-kinase (PI 3-kinase) | imaging | Rac (Rac GTPase) | Cell Biology
Journal Article
Oncogene, ISSN 0950-9232, 04/2009, Volume 28, Issue 13, pp. 1570 - 1583
The motility of cancer cells in 3D matrices is of two types: mesenchymal motility, in which the cells are elongated and amoeboid motility, in which the cells... 
Amoeboid | Rac | Migration | Invasion | Cancer | Mesenchymal | PERICELLULAR PROTEOLYSIS | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | amoeboid | MECHANISMS | CELL BIOLOGY | ACTIN-RELATED PROTEIN-2 | WAVE2 | MODES | invasion | GTPASES | ONCOLOGY | mesenchymal | GENETICS & HEREDITY | migration | cancer | PLASTICITY | Neoplasms - metabolism | Humans | rac GTP-Binding Proteins - metabolism | rhoA GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - physiology | Cell Shape - genetics | rhoA GTP-Binding Protein - genetics | Cell Culture Techniques - methods | Cell Movement - genetics | Cell Movement - physiology | Neoplasms - genetics | rac GTP-Binding Proteins - genetics | Collagen - pharmacology | Tumor Cells, Cultured | rac GTP-Binding Proteins - physiology | Cell Adhesion - genetics | Neoplasm Invasiveness | rho GTP-Binding Proteins - genetics | Mutant Proteins - metabolism | Signal Transduction - genetics | Mutant Proteins - physiology | rho GTP-Binding Proteins - physiology | rac1 GTP-Binding Protein - physiology | Cell Adhesion - physiology | rho GTP-Binding Proteins - metabolism | Signal Transduction - physiology | Cell Shape - physiology | Neoplasms - pathology | rac1 GTP-Binding Protein - metabolism | Gels - pharmacology | rac1 GTP-Binding Protein - genetics | Physiological aspects | Cellular signal transduction | Motility | Research | Cells | Cancer cells | Signal transduction | Oncology | Genetics | Substrates | Cell adhesion & migration
Journal Article
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2014, Volume 289, Issue 22, pp. 15244 - 15258
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2011, Volume 121, Issue 2, pp. 628 - 639
RHO family proteins are important for the function of inflammatory cells. They are modified with a 20-carbon geranylgeranyl lipid in a process catalyzed by protein geranylgeranyltransferase type I (GGTase... 
INDUCED LUNG-CANCER | RHEUMATOID-ARTHRITIS | PROTEIN PRENYLTRANSFERASES | SIGNAL-TRANSDUCTION | MEDICINE, RESEARCH & EXPERIMENTAL | CELL-DIVISION | K-RAS | DISSOCIATION INHIBITORS | INTERLEUKIN-1-BETA SECRETION | RHO-GTPASES | T-CELLS | Macrophages - physiology | rap1 GTP-Binding Proteins - metabolism | Arthritis - pathology | Mice, Inbred C57BL | cdc42 GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - metabolism | Macrophages - cytology | rhoA GTP-Binding Protein - genetics | Macrophages - enzymology | Mice, Knockout | Animals | Alkyl and Aryl Transferases - genetics | cdc42 GTP-Binding Protein - genetics | Arthritis - immunology | Mice | rap1 GTP-Binding Proteins - genetics | Alkyl and Aryl Transferases - deficiency | Macrophages - immunology | rac1 GTP-Binding Protein - metabolism | Cytokines - immunology | rac1 GTP-Binding Protein - genetics | Physiological aspects | Rheumatoid factor | Macrophages | Rheumatoid arthritis | Transferases | Risk factors | cytology | pathology | Cytokines | Cell and Molecular Biology | physiology | rhoA GTP-Binding Protein | Arthritis | enzymology | Inbred C57BL | Knockout | genetics | deficiency | rap1 GTP-Binding Proteins | Alkyl and Aryl Transferases | cdc42 GTP-Binding Protein | metabolism | rac1 GTP-Binding Protein | Cell- och molekylärbiologi | immunology
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 06/2006, Volume 11, Issue 6, pp. 557 - 566
...) as critical regulators of spine structure. In addition, Duo and drebrin are spine-specific proteins that are critical for spine maintenance and spine formation, respectively... 
Dendritic spine | Schizophrenia | Drebrin | Pyramidal neuron | RhoGTPase | Duo | EXCHANGE FACTOR | CORTICAL PYRAMIDAL NEURONS | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | dendritic spine | schizophrenia | NEUROSCIENCES | MEDIODORSAL THALAMIC NUCLEUS | SOMAL SIZE | MESSENGER-RNA | AXON TERMINALS | pyramidal neuron | GENE-EXPRESSION | drebrin | ACTIN CYTOSKELETON | RHO-GTPASES | POSTSYNAPTIC DENSITY | duo | Schizophrenia - metabolism | Humans | Middle Aged | RNA, Messenger - analysis | Male | cdc42 GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - metabolism | Dendritic Spines - metabolism | Gene Expression Profiling | rhoA GTP-Binding Protein - genetics | Guanine Nucleotide Exchange Factors - drug effects | Prefrontal Cortex - drug effects | Dendritic Spines - drug effects | Guanine Nucleotide Exchange Factors - metabolism | Matched-Pair Analysis | Adult | Female | Neuropeptides - genetics | Neuropeptides - drug effects | Protein-Serine-Threonine Kinases - metabolism | Guanine Nucleotide Exchange Factors - genetics | rho GTP-Binding Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Neuropeptides - metabolism | Prefrontal Cortex - cytology | Haplorhini | rho GTP-Binding Proteins - drug effects | Animals | rac1 GTP-Binding Protein - drug effects | cdc42 GTP-Binding Protein - genetics | rho GTP-Binding Proteins - metabolism | Prefrontal Cortex - metabolism | Protein-Serine-Threonine Kinases - drug effects | Antipsychotic Agents - pharmacology | Schizophrenia - drug therapy | cdc42 GTP-Binding Protein - drug effects | rac1 GTP-Binding Protein - metabolism | rac1 GTP-Binding Protein - genetics
Journal Article
The Journal of cell biology, ISSN 1540-8140, 2003, Volume 162, Issue 2, pp. 223 - 232
Journal Article
PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 1, p. e0147758
A critical and understudied property of endothelial cells is their ability to form lumens and tube networks. Although considerable information has been... 
COLLAGEN MATRIX | 3-DIMENSIONAL EXTRACELLULAR MATRICES | VASCULAR LUMEN FORMATION | IN-VITRO | CELL MORPHOGENESIS | ANGIOGENESIS | ACTIVATING PROTEIN | MULTIDISCIPLINARY SCIENCES | CAPILLARY LUMEN | BLOOD-VESSEL FORMATION | MOLECULAR-MECHANISMS | rap GTP-Binding Proteins - antagonists & inhibitors | ras Proteins - genetics | p120 GTPase Activating Protein - metabolism | Humans | rac GTP-Binding Proteins - metabolism | ras Proteins - metabolism | Male | cdc42 GTP-Binding Protein - metabolism | Phosphoproteins - antagonists & inhibitors | GTPase-Activating Proteins - metabolism | p120 GTPase Activating Protein - genetics | Phosphoproteins - metabolism | rac GTP-Binding Proteins - antagonists & inhibitors | Tubulin - metabolism | RNA Interference | rac GTP-Binding Proteins - genetics | cdc42 GTP-Binding Protein - antagonists & inhibitors | rap GTP-Binding Proteins - genetics | Phorbol Esters - pharmacology | Female | Cell Line | Endothelial Cells - metabolism | GTPase-Activating Proteins - antagonists & inhibitors | ras Proteins - antagonists & inhibitors | Phosphoproteins - genetics | p120 GTPase Activating Protein - antagonists & inhibitors | Animals | Signal Transduction - drug effects | Endothelial Cells - cytology | cdc42 GTP-Binding Protein - genetics | Cytoskeleton - metabolism | Vacuoles - metabolism | Mice | GTPase-Activating Proteins - genetics | rap GTP-Binding Proteins - metabolism | Microscopy, Fluorescence | Endothelial Cells - drug effects | Physiological aspects | Genetic aspects | Cellular signal transduction | Research | Guanosine triphosphatase | Endothelium | Cdc42 protein | Polarization | Membranes | Raf protein | K-Ras protein | Morphogenesis | Proteins | Lumens | Tubulin | Actin | IQGAP1 protein | Tubes | Physiology | Growth factors | Skewed distributions | RhoA protein | Rac1 protein | Pharmacology | siRNA | Rac2 protein | Endothelial cells | Effectors | Cytoskeleton | Membrane trafficking | Regulation | Molecular biology | Vacuoles | Guanosinetriphosphatase | Integrins
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2013, Volume 288, Issue 32, pp. 23543 - 23553
Journal Article
Cell Death and Disease, ISSN 2041-4889, 01/2014, Volume 5, Issue 11, pp. e1517 - e1517
... pyrophosphates which were substrates for prenylation processes of small guanine-nucleotide-binding regulatory proteins (small G proteins... 
TRANSLOCASE | CONTAINING BISPHOSPHONATES INHIBIT | ISOPENTENYL PYROPHOSPHATE | GTPASES | PRENYLATION | CLODRONATE | ATP ANALOG | MEVALONATE PATHWAY | CANCER | CELL BIOLOGY | RNA, Small Interfering - genetics | Leucine - pharmacology | Mesothelioma - pathology | Apoptosis - drug effects | Farnesol - pharmacology | Humans | Gene Expression Regulation, Neoplastic | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | cdc42 GTP-Binding Protein - metabolism | rab GTP-Binding Proteins - genetics | rhoA GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - genetics | Protein Prenylation | Transferases - genetics | cdc42 GTP-Binding Protein - antagonists & inhibitors | Transferases - metabolism | Leucine - analogs & derivatives | Diterpenes - pharmacology | rab GTP-Binding Proteins - metabolism | DNA Topoisomerases, Type II - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Signal Transduction | rhoA GTP-Binding Protein - antagonists & inhibitors | Imidazoles - pharmacology | Mesothelioma - genetics | S Phase - genetics | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Diphosphonates - antagonists & inhibitors | Mesothelioma - metabolism | cdc42 GTP-Binding Protein - genetics | rac1 GTP-Binding Protein - antagonists & inhibitors | Cell Line, Tumor | DNA Topoisomerases, Type II - genetics | rab GTP-Binding Proteins - antagonists & inhibitors | Imidazoles - antagonists & inhibitors | S Phase - drug effects | Diphosphonates - pharmacology | rac1 GTP-Binding Protein - metabolism | RNA, Small Interfering - metabolism | rac1 GTP-Binding Protein - genetics | Original
Journal Article
British Journal of Cancer, ISSN 0007-0920, 09/2002, Volume 87, Issue 6, pp. 635 - 644
Journal Article