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1. Full Text Visible‐Light‐Driven, Copper‐Catalyzed Decarboxylative C(sp3)−H Alkylation of Glycine and Peptides
by Wang, Chao and Guo, Mengzhun and Qi, Rupeng and Shang, Qinyu and Liu, Qiang and Wang, Shan and Zhao, Long and Wang, Rui and Xu, Zhaoqing
Angewandte Chemie International Edition, ISSN 1433-7851, 11/2018, Volume 57, Issue 48, pp. 15841 - 15846
Despite a well‐developed and growing body of work in Cu catalysis, the potential of Cu to serve as a photocatalyst remains underexplored. Reported herein is... 
cross-coupling | copper | peptides | radicals | photochemistry | ENDOMORPHIN-1 ANALOGS | N-HYDROXYPHTHALIMIDE ESTERS | CROSS-COUPLING REACTION | PHOTOREDOX | ALPHA | CHEMISTRY, MULTIDISCIPLINARY | AMINO-ACIDS | ALKYLMAGNESIUM HALIDES | REDOX-ACTIVE ESTERS | GRIGNARD-REAGENTS | N-(ACYLOXY)PHTHALIMIDES | Peptides | Glycine | Copper | Amino acids | Catalysis | Alkylation
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2. Full Text Metal‐Free Direct Alkylation of Ketene Dithioacetals by Oxidative C(sp2)−H/C(sp3)−H Cross‐Coupling
by Wen, Jiangwei and Zhang, Fan and Shi, Wenyan and Lei, Aiwen
Chemistry – A European Journal, ISSN 0947-6539, 07/2017, Volume 23, Issue 37, pp. 8814 - 8817
The functionalization of internal olefins has been a challenging task in organic synthesis. This protocol provides an efficient and transition‐metal‐free... 
cross-coupling | alkylation | C−H activation | metal-free | internal olefins | DIRECT ALKENYLATION | ACTIVATION | EFFICIENT SYNTHESIS | TERMINAL ALKYNES | RADICAL CYCLIZATION CONDITIONS | CHEMISTRY, MULTIDISCIPLINARY | C-H BONDS | FUNCTIONALIZATION | C-H activation | 6-MEMBERED HETEROCYCLIC RINGS | HECK REACTION | ALKANES | Cross coupling | Alkenes | Hydrogen bonds | Metals | Scaling up | Chemical bonds | Alkanes | Cleavage | Substrates | Alkylation
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3. Full Text Photoredox-Catalyzed Site-Selective alpha-C(sp(3))-H Alkylation of Primary Amine Derivatives
by Ashley, MA and Yamauchi, C and Chu, JCK and Otsuka, S and Yorimitsu, H and Rovis, T
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, ISSN 1433-7851, 03/2019, Volume 58, Issue 12, pp. 4002 - 4006
The synthetic utility of tertiary amines to oxidatively generate a-amino radicals is well established, however, primary amines remain challenging because of... 
radicals | ACIDS | amines | reaction mechanisms | ALPHA-AMINOALKYL RADICALS | CHEMISTRY, MULTIDISCIPLINARY | C-H BONDS | ATOM | FUNCTIONALIZATION | ABSTRACTION | photochemistry | ADDITION-REACTIONS | ARENECARBONITRILES | ALIPHATIC-AMINES | PHOTOCHEMICAL-REACTIONS | synthetic methods | Side reactions | Divergence | Amines | Alkenes | Sulfonamides | Selectivity | Catalysis | Derivatives | Amino radical | Alkylation | Intermediates
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4. Full Text Directed γ‑C(sp3)–H Alkylation of Carboxylic Acid Derivatives through Visible Light Photoredox Catalysis
by Chen, Dian-Feng and Chu, John C. K and Rovis, Tomislav
Journal of the American Chemical Society, ISSN 0002-7863, 10/2017, Volume 139, Issue 42, pp. 14897 - 14900
Visible light photoredox catalysis enables direct γ- C­(sp3)–H alkylation of saturated aliphatic carbonyl compounds. Electron-deficient alkenes are used as the... 
FUNCTIONALIZATION | C(SP)-H BONDS | ACTIVATION | AMINATION | OLEFINATION | NITROGEN-CENTERED RADICALS | ARYLATION | CHEMISTRY, MULTIDISCIPLINARY | C-H BONDS
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5. Full Text Direct β‑Alkylation of Aldehydes via Photoredox Organocatalysis
by Terrett, Jack A and Clift, Michael D and MacMillan, David W. C
Journal of the American Chemical Society, ISSN 0002-7863, 05/2014, Volume 136, Issue 19, pp. 6858 - 6861
Direct β-alkylation of saturated aldehydes has been accomplished by synergistically combining photo­redox catalysis and organo­catalysis. Photon-induced... 
OXIDATION | ORGANIC-SYNTHESIS | CATALYSIS | ACTIVATION | ASYMMETRIC CONJUGATE ADDITION | VISIBLE-LIGHT PHOTOCATALYSIS | ARYLATION | CARBOXYLIC ESTERS | RADICALS | MICHAEL ACCEPTORS | CHEMISTRY, MULTIDISCIPLINARY | Activated | Spectroscopy | Pathways | Spectroscopic analysis | Catalysis | Aldehydes | Radicals | Quenching | Communication
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6. Full Text Mechanism of the Stereoselective α‑Alkylation of Aldehydes Driven by the Photochemical Activity of Enamines
by Bahamonde, Ana and Melchiorre, Paolo
Journal of the American Chemical Society, ISSN 0002-7863, 06/2016, Volume 138, Issue 25, pp. 8019 - 8030
Herein we describe our efforts to elucidate the key mechanistic aspects of the previously reported enantioselective photochemical α-alkylation of aldehydes... 
VISIBLE-LIGHT | SOMO ACTIVATION | COMPLEX | ELECTRON-TRANSFER | ORGANOCATALYSIS | CHEMISTRY | RADICALS | SUBSTITUTION-REACTIONS | CHEMISTRY, MULTIDISCIPLINARY | 2+2 PHOTOCYCLOADDITION REACTIONS | PHOTOREDOX CATALYSIS | Chemical properties | Aldehydes | Analysis | Alkylation | Photochemistry | Trapping | Catalysts | Reaction kinetics | Chain reactions | Chains | Assessments | Radicals
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7. Full Text Dioxygen‐Mediated Decarbonylative CH Alkylation of Heteroaromatic Bases with Aldehydes
by Paul, Subhasis and Guin, Joyram
Chemistry – A European Journal, ISSN 0947-6539, 12/2015, Volume 21, Issue 49, pp. 17618 - 17622
An operationally simple and economical method for the direct alkylation of heteroaromatic bases employing readily available aldehydes as alkyl radical... 
auto‐oxidation | radical reactions | CH functionalization | heterocycles | oxygen | C-H functionalization | auto-oxidation | SUBSTITUTION | SECONDARY | BOND FORMATION | CHEMISTRY, MULTIDISCIPLINARY | FUNCTIONALIZATION | FREE-RADICAL REACTIONS | PHOTOCHEMICAL-REACTIONS | HOMOLYTIC ALKYLATION | DERIVATIVES | METAL-FREE | MOLECULAR-OXYGEN | Economics | Transformations | Aldehydes | Precursors | Radicals | Alkylation
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8. Full Text Pd-Catalyzed Alkylation of (Iso)quinolines and Arenes: 2‑Acylpyridine Compounds as Alkylation Reagents
by Wu, Qingsong and Han, Shuaijun and Ren, Xiaoxiao and Lu, Hongtao and Li, Jingya and Zou, Dapeng and Wu, Yangjie and Wu, Yusheng
Organic Letters, ISSN 1523-7060, 10/2018, Volume 20, Issue 20, pp. 6345 - 6348
The first Pd-catalyzed alkylation of (iso)­quinolines and arenes is reported. The readily available and bench-stable 2-acylpyridine compounds were used as an... 
ARYL BROMIDES | DIARYLMETHANES | FREE REGIOSELECTIVE ALKYLATION | PALLADIUM | CROSS-COUPLING REACTIONS | HETEROARENES | ALPHA-ARYLATION | CHEMISTRY, ORGANIC | PYRIDINE N-OXIDES | RADICAL ALKYLATION | ALKYLZINC HALIDES
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9. Full Text Asymmetric alkylation of remote C(sp3)-H bonds by combining proton-coupled electron transfer with chiral Lewis acid catalysis
by Yuan, Wei and Zhou, Zijun and Gong, Lei and Meggers, Eric
Chemical Communications, ISSN 1359-7345, 2017, Volume 53, Issue 64, pp. 8964 - 8967
The catalytic asymmetric alkylation of the remote, unactivated delta-position of N-alkyl amides was enabled by the combination of visible-light-induced... 
FUNCTIONALIZATION | ACTIVATION | AMINATION | COMPLEX | STRATEGY | IODINE | RADICALS | CHEMISTRY, MULTIDISCIPLINARY | C-H BONDS | PHOTOREDOX CATALYSIS
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10. Full Text Catalytic alkylation of remote C-H bonds enabled by proton-coupled electron transfer
by Choi, Gilbert J and Choi, Gilbert J and Zhu, Qilei and Zhu, Qilei and Miller, David C and Miller, David C and Gu, Carol J and Gu, Carol J and Knowles, Robert R and Knowles, Robert R
Nature, ISSN 0028-0836, 11/2016, Volume 539, Issue 7628, pp. 268 - 271
Despite advances in hydrogen atom transfer (HAT) catalysis(1-5), there are currently no molecular HAT catalysts that are capable of homolysing the strong... 
CENTERED RADICALS | FUNCTIONALIZATION | OXIDATION | ABSTRACTION | MULTIDISCIPLINARY SCIENCES | ATOM-TRANSFER | CARBOXAMIDES | GENERATION | HYDROAMINATION | ENERGIES | CYCLIZATION | Alkylation - radiation effects | Protons | Alkenes - chemistry | Electron Transport | Amination | Nitrogen - chemistry | Oxidation-Reduction | Amides - chemistry | Catalysis - radiation effects | Hydrogen - chemistry | Iridium - chemistry | Carbon - chemistry | Chemical bonds | Catalysis | Nitrogen | Hydrogen | Carbon | Luminescence quenching
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11. Full Text Palladium‐Catalyzed Direct CH Alkylation of Electron‐Deficient Pyrrole Derivatives
by Jiao, Lei and Bach, Thorsten
Angewandte Chemie International Edition, ISSN 1433-7851, 06/2013, Volume 52, Issue 23, pp. 6080 - 6083
The apparent and the real: What looks like a Friedel–Crafts alkylation reaction of electron‐deficient pyrroles is actually a PdII‐catalyzed,... 
alkylation | CH activation | palladium | homogeneous catalysis | heterocycles | C-H activation | 1,3-DICARBONYL COMPOUNDS | ALPHA,BETA-UNSATURATED ALDEHYDES | BOND FUNCTIONALIZATION | PYRRYLMAGNESIUM BROMIDE | ALKENE-PHOSPHINE LIGANDS | AROMATIC-SUBSTITUTION | CHEMISTRY, MULTIDISCIPLINARY | CH activation | ASYMMETRIC ALLYLIC ALKYLATION | FRIEDEL-CRAFTS ALKYLATION | RADICAL ALKYLATION | FUNCTIONALIZED PYRROLES | Activation | Derivatives | Alkylation | Pyrroles
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12. Full Text Synthesis and Evaluation of 1,2,8,8a-Tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one, the Parent Alkylation Subunit of CC-1065 and the Duocarmycins:  Impact of the Alkylation Subunit Substituents and Its Implications for DNA Alkylation Catalysis
by Boger, Dale L and Santillán, Alejandro and Searcey, Mark and Brunette, Steven R and Wolkenberg, Scott E and Hedrick, Michael P and Jin, Qing
The Journal of Organic Chemistry, ISSN 0022-3263, 06/2000, Volume 65, Issue 13, pp. 4101 - 4111
The synthesis of 1,2,8,8a-tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one (CPI), the parent CC-1065 and duocarmycin SA alkylation subunit, is detailed.... 
ARYL RADICAL CYCLIZATION | ANTITUMOR ANTIBIOTICS | STREPTOMYCES SP | SITE MODELS | PYRINDAMYCIN-A | ANALOGS | ENT-(-)-DUOCARMYCIN SA | BINDING SUBUNIT | CHEMISTRY, ORGANIC | VINYL-CHLORIDE | LINKING AMIDE | Molecular Conformation | Oligodeoxyribonucleotides - chemistry | Models, Molecular | Crystallography, X-Ray | Alkylation | Alkylating Agents - chemistry | DNA, Viral - chemistry | DNA - chemistry | Quinolones - chemistry | Antibiotics, Antineoplastic - chemistry | Quinolones - chemical synthesis | Base Sequence | Pyrroles - chemistry | Indicators and Reagents | Molecular Structure | Indoles | Leucomycins - chemistry | Indolequinones | Research | Catalysis | Alkylating agents | Analysis | Structure-activity relationships (Biochemistry)
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13. Full Text Photoredox-mediated Minisci C-H alkylation of N -heteroarenes using boronic acids and hypervalent iodine
by Li, Guo-Xing and Morales-Rivera, Christian A and Wang, Yaxin and Gao, Fang and He, Gang and Liu, Peng and Chen, Gong
Chemical science, ISSN 2041-6520, 10/2016, Volume 7, Issue 10, pp. 6407 - 6412
A photoredox-mediated Minisci C-H alkylation reaction of -heteroarenes with alkyl boronic acids is reported. A broad range of primary and secondary alkyl... 
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14. Full Text Sunlight photocatalyzed regioselective β-alkylation and acylation of cyclopentanones
by Okada, Megumi and Fukuyama, Takahide and Yamada, Keiichi and Ryu, Ilhyong and Ravelli, Davide and Fagnoni, Maurizio
Chemical Science, ISSN 2041-6520, 2014, Volume 5, Issue 7, pp. 2893 - 2898
Sunlight-induced direct regioselective beta-alkylation of cyclopentanones with electron-deficient alkenes was accomplished by using tetrabutylammonium... 
FUNCTIONALIZATION | CYCLIC-KETONES | CATALYSIS | ALKENES | PHOTOREDOX | ARYLATION | PEROXYCARBONATE | ARYL KETONES | CHEMISTRY, MULTIDISCIPLINARY | C-H BONDS | RADICAL REACTIONS | Sunlight | Alkenes | Catalysts | Acylation
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