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Angewandte Chemie International Edition, ISSN 1433-7851, 06/2018, Volume 57, Issue 26, pp. 7536 - 7536
RNA modification research is like natural product chemistry on a biopolymer scaffold. A thorough search, based on liquid chromatography mass spectrometry,... 
isotope labelling | thioacetals | LC-MS | radical-SAM enzymes | RNA modifications
Journal Article
Angewandte Chemie (International ed. in English), ISSN 1433-7851, 1/2015, Volume 54, Issue 3, pp. 860 - 863
DesII is a radical SAM enzyme that catalyzes the C4-deamination of TDP-4-amino-4,6-dideoxyglucose via a C3 radical intermediate. However, if the C4 amino group... 
Biosynthesis | Enzyme catalysis | Radical SAM | Alcohols
Journal Article
Angewandte Chemie (International ed. in English), ISSN 1433-7851, 3/2016, Volume 55, Issue 11, pp. 3724 - 3728
C3′-deoxygenation of aminoglycosides results in their decreased susceptibility to phosphorylation thereby increasing their efficacy as antibiotics. However,... 
radical SAM enzymes | enzyme catalysis | radical mechanism | aminoglycosides | biosynthesis
Journal Article
Biochemistry, ISSN 0006-2960, 7/2013, Volume 52, Issue 27
The radical S -adenosylmethionine (SAM) enzyme MqnC catalyzes conversion of dehypoxanthine futalosine (DHFL) to the unique spiro-compound cyclic DHFL in the... 
futalosine | radical SAM enzyme | Menaquinone
Journal Article
Chemical Reviews, ISSN 0009-2665, 01/2018, Volume 118, Issue 1, pp. 73 - 118
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 03/2017, Volume 56, Issue 14, pp. 3726 - 3726
A powerful methylating agent:In contrast to all other known S‐adenosylmethionine (SAM) dependent methyltransferases, the enzyme NosN does not produce... 
radical SAM enzymes | methyltransferases | natural products | thiopeptides | biosynthesis | Adenosylmethionine | Catalysis | Methylation | Workers | S-Adenosylmethionine | Methyltransferase
Journal Article
BIOCHEMISTRY, ISSN 0006-2960, 07/2018, Volume 57, Issue 30, pp. 4431 - 4439
Cfr is a radical S-adenosylmethionine (RS) methylase that appends methyl groups to C8 and C2 of adenosine 2503 in 23S rRNA. Methylation of C8 confers... 
ENZYME | METHYLTRANSFERASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | METHYL TRANSFER | RADICAL SAM | RIBOSOMAL-RNA | RLMN | CONFERS RESISTANCE | RIMN
Journal Article
Methods in Enzymology, ISSN 0076-6879, 2017, Volume 596, pp. 459 - 499
Steady-state kinetic isotope effects on enzyme-catalyzed reactions are often interpreted in terms of the microscopic rate constants associated with the... 
Catalysis | Enzyme | Radical SAM | EPR | DesII | Rate-limiting step | enzyme | catalysis | radical SAM | rate limiting step
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 07/2019, Volume 294, Issue 40, pp. 14512 - 14525
The human microbiota plays a central role in human physiology. This complex ecosystem is a promising, but untapped source of bioactive compounds and... 
enzyme | peptide biosynthesis | radical | radical AdoMet enzyme | microbiome | natural product biosynthesis | RiPP | radical SAM enzyme | ruminococcin | ruminococcin C | Enzymology | antibiotics | antimicrobial peptide (AMP)
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2019, Volume 294, Issue 31, pp. 11726 - 11727
Radical S -adenosylmethionine (SAM) (RS) methylases perform methylation reactions at unactivated carbon and phosphorus atoms. RS enzymes typically abstract a... 
iron–sulfur protein | S-adenosylmethionine (SAM) | cobalamin | radical | protein methylation | vitamin B12 | post-translational modification | radical SAM | Editors' Picks Highlights
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2016, Volume 113, Issue 43, pp. 12138 - 12143
Journal Article
ACS MEDICINAL CHEMISTRY LETTERS, ISSN 1948-5875, 03/2019, Volume 10, Issue 3, pp. 363 - 366
Aminofutalosine synthase (MqnE) catalyzes an important rearrangement reaction in menaquinone biosynthesis by the futalosine pathway. In this Letter, we report... 
antibiotic | Radical SAM enzyme | CHEMISTRY, MEDICINAL | Helicobacter pylori | PATHWAY | VITAMIN-K | HELICOBACTER | bisubstrate inhibitor | MqnE
Journal Article
CURRENT OPINION IN CHEMICAL BIOLOGY, ISSN 1367-5931, 04/2017, Volume 37, pp. 63 - 70
Journal Article
Current Opinion in Chemical Biology, ISSN 1367-5931, 04/2019, Volume 49, pp. 25 - 32
Direct functionalization of C–H bond is rapidly becoming an indispensible tool in chemical synthesis. However, due to the ubiquity of C–H bonds, achieving... 
ANTIBIOTICS | VANCOMYCIN AGLYCON | BIOPHYSICS | CHEMOENZYMATIC TOTAL-SYNTHESIS | RADICAL SAM ENZYMES | ACIDS | STAGE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CONSTRUCTION | HYDROXYLATION | MANZACIDIN C | ALKALOIDS | Enzymes | Usage | Biological products | Synthesis | Organic compounds
Journal Article
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