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1. Full Text The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells
by Hoang, Van T and Nyswaner, Katherine and Torres-Ayuso, Pedro and Brognard, John
The Journal of biological chemistry, ISSN 0021-9258, 06/2020, Volume 295, Issue 25, pp. 8470 - 8479
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Survival - drug effects | MAP Kinase Kinase Kinases - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Lung Neoplasms - metabolism | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Drug Resistance, Neoplasm | JNK Mitogen-Activated Protein Kinases - metabolism | Lung Neoplasms - pathology | MAP Kinase Kinase Kinases - metabolism | Proto-Oncogene Proteins c-raf - metabolism | MAP Kinase Signaling System | Mitogen-Activated Protein Kinase Kinases - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | RNA Interference | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins c-raf - antagonists & inhibitors | Phosphorylation - drug effects | MAP Kinase Kinase Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | RNA, Small Interfering - metabolism | Index Medicus | Editors' Picks | extracellular-signal-regulated kinase (ERK) | lung cancer | GTPase Kras (KRAS) | cell proliferation | kinase signaling | kinome | mitogen-activated protein kinase kinase kinase 19 (MAP3K19) | c-Jun N-terminal kinase (JNK) | YSK4 | oncogene | protein kinase
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2. Full Text RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
by Hatzivassiliou, Georgia and Song, Kyung and Yen, Ivana and Brandhuber, Barbara J and Anderson, Daniel J and Alvarado, Ryan and Ludlam, Mary J. C and Stokoe, David and Gloor, Susan L and Vigers, Guy and Morales, Tony and Aliagas, Ignacio and Liu, Bonnie and Sideris, Steve and Hoeflich, Klaus P and Jaiswal, Bijay S and Seshagiri, Somasekar and Koeppen, Hartmut and Belvin, Marcia and Friedman, Lori S and Malek, Shiva
Nature (London), ISSN 0028-0836, 03/2010, Volume 464, Issue 7287, pp. 431 - 435
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | General aspects | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Animal tumors. Experimental tumors | Experimental tumors, general aspects | Antineoplastic agents | Tumors | Neoplasms - metabolism | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Diphenylamine - pharmacology | raf Kinases - antagonists & inhibitors | Humans | Protein Multimerization | ras Proteins - metabolism | Protein Transport - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | Diphenylamine - analogs & derivatives | Mitogen-Activated Protein Kinase Kinases - metabolism | Adenosine Triphosphate - metabolism | Indoles - pharmacology | Benzamides - pharmacology | Cell Membrane - metabolism | raf Kinases - genetics | Cell Membrane - drug effects | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Pyrazoles - pharmacology | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | Indenes - pharmacology | raf Kinases - chemistry | Proto-Oncogene Proteins c-raf - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Neoplasms - enzymology | Proto-Oncogene Proteins - genetics | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | Neoplasms - drug therapy | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Proto-Oncogene Proteins c-raf - deficiency | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Ras genes | Growth | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Mitogen-activated protein kinases | Competition | Clinical trials | Enzymes | Kinases | Index Medicus | Proteins | Cellular | Inhibitors | Pathways | Tumours | Signalling | Dimerization
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3. Full Text Smyd3 links lysine methylation of map3k2 to ras-driven cancer
by Mazur, P.K and Reynoird, N and Khatri, P and Jansen, P. W and Wilkinson, A.W and Liu, S and Barbash, O and Aller, G.S. Van and Huddleston, M and Dhanak, D and Tummino, P.J and Kruger, R.G and Garcia, B.A and Butte, A.J and Vermeulen, M and Sage, J and Gozani, O
Nature (London), ISSN 0028-0836, 2014, Volume 510, Issue 7504, pp. 283 - 287
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Adenocarcinoma - pathology | Pancreatic Neoplasms - metabolism | Adenocarcinoma of Lung | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Oncogene Protein p21(ras) - metabolism | MAP Kinase Kinase Kinases - chemistry | Adenocarcinoma - metabolism | Cell Transformation, Neoplastic - genetics | MAP Kinase Kinase Kinase 2 - chemistry | Adenocarcinoma - genetics | Lysine - metabolism | Disease Models, Animal | Lung Neoplasms - genetics | MAP Kinase Kinase Kinase 2 - metabolism | Lung Neoplasms - enzymology | Protein Phosphatase 2 - antagonists & inhibitors | Signal Transduction | Pancreatic Neoplasms - pathology | Adenocarcinoma - enzymology | Pancreatic Neoplasms - enzymology | Pancreatic Neoplasms - genetics | MAP Kinase Kinase Kinases - metabolism | Cell Transformation, Neoplastic - metabolism | Proto-Oncogene Proteins A-raf - metabolism | Animals | Histone-Lysine N-Methyltransferase - metabolism | Protein Phosphatase 2 - metabolism | Cell Line, Tumor | Mice | Cell Transformation, Neoplastic - pathology | Methylation | Mitogen-Activated Protein Kinases - metabolism | Oncogene Protein p21(ras) - genetics | Physiological aspects | Research | Lysine | Oncology, Experimental | Cancer | DNA methylation | Peptides | Kinases | Rodents | Tumors | Index Medicus | Life Sciences
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4. Full Text COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
by Emery, Caroline M and Hieronymus, Haley and Zhao, Jean J and Boehm, Jesse S and Golub, Todd and Yang, Xiaoping and Root, David E and Roberts, Thomas M and Hahn, William C and Hill, David E and Wilson, Christopher J and Weber, Barbara L and Garraway, Levi A and Johnson, Laura A and Kim, Sungjoon and Harris, Jennifer L and Kim, So Young and Vidal, Marc and Finan, Peter M and Myer, Vic E and Sellers, William R and Barretina, Jordi and Alkan, Ozan and Thomas, Sapana R and Wardwell, Leslie and Cogdill, Alexandria P and Dummer, Reinhard and Schlegel, Robert and Stransky, Nicolas and Flaherty, Keith T and Wargo, Jennifer A and Murray, Ryan R and Johannessen, Cory M and Salehi-Ashtiani, Kourosh and Caponigro, Giordano
Nature (London), ISSN 0028-0836, 12/2010, Volume 468, Issue 7326, pp. 968 - 972
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Allosteric Regulation | Humans | Gene Expression Regulation, Neoplastic | Melanoma - enzymology | Gene Expression Profiling | MAP Kinase Signaling System | Mitogen-Activated Protein Kinase Kinases - metabolism | Melanoma - genetics | Indoles - pharmacology | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Gene Library | Proto-Oncogene Proteins c-raf - genetics | MAP Kinase Kinase Kinases - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Proto-Oncogene Proteins - genetics | Clinical Trials as Topic | MAP Kinase Kinase Kinases - metabolism | Enzyme Activation - drug effects | Open Reading Frames - genetics | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Drug Resistance, Neoplasm - genetics | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Indoles - therapeutic use | Protein Kinase Inhibitors - pharmacology | Drug Resistance, Neoplasm - drug effects | Mitogen-Activated Protein Kinases - metabolism | Protein research | Research | Properties | Protein kinases | Cancer cells | Cell lines | Biochemistry | Mutation | Kinases | Genes | Cancer | Index Medicus
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5. Full Text Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mtor cascades which alter therapy response
by McCubrey, James A and Steelman, Linda S and Chappell, William H and Abrams, Stephen L and Montalto, Giuseppe and Cervello, Melchiorre and Nicoletti, Ferdinando and Fagone, Paolo and Malaponte, Grazia and Mazzarino, Maria C and Candido, Saverio and Libra, Massimo and Bäsecke, Jörg and Mijatovic, Sanja and Milella, Danijela Maksimovic-Ivanic and Tafuri, Agostino and Cocco, Lucio and Evangelisti, Camilla and Chiarini, Francesca and Martelli, Alberto M
Oncotarget, ISSN 1949-2553, 2012, Volume 3, Issue 9, pp. 954 - 987
Mutations | Therapy resistance | Pi3k | Targeted therapy | Raf | Akt | Mtor | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | PTEN Phosphohydrolase - genetics | ras Proteins - genetics | Signal Transduction | TOR Serine-Threonine Kinases - metabolism | MAP Kinase Kinase Kinases - genetics | Humans | PTEN Phosphohydrolase - metabolism | ras Proteins - metabolism | MAP Kinase Kinase Kinases - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | MAP Kinase Signaling System | Phosphatidylinositol 3-Kinases - genetics | Animals | TOR Serine-Threonine Kinases - genetics | Mitogen-Activated Protein Kinases - genetics | Mutation | Proto-Oncogene Proteins c-akt - metabolism | raf Kinases - genetics | Mitogen-Activated Protein Kinases - metabolism | Index Medicus
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