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Proceedings of the National Academy of Sciences, ISSN 0027-8424, 12/2013, Volume 110, Issue 51, pp. E4968 - E4977
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2012, Volume 14, Issue 3, pp. 311 - 317
Mitotic spindle positioning by cortical pulling forces(1) defines the cell division axis and location(2), which is critical for proper cell division and... 
ACTIVATION | PROTEIN | MECHANISM | KINETOCHORE | IMPORTIN-BETA | MITOTIC SPINDLE | SEGREGATION | ASYMMETRIC CELL-DIVISION | GRADIENT | RAN | CELL BIOLOGY | NIH 3T3 Cells | ran GTP-Binding Protein - genetics | Microtubule-Associated Proteins - genetics | Antigens, Nuclear - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Molecular Sequence Data | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Centrioles - physiology | Spindle Apparatus - metabolism | RNA Interference | Cell Cycle Proteins - genetics | Chromosome Segregation - physiology | Spindle Apparatus - physiology | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Cytoplasmic Dyneins - metabolism | Dyneins - metabolism | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Green Fluorescent Proteins - metabolism | Cell Cycle Proteins - metabolism | Cytoplasmic Dyneins - genetics | Protein-Serine-Threonine Kinases - genetics | Dynactin Complex | Nuclear Matrix-Associated Proteins - metabolism | Proto-Oncogene Proteins - genetics | ran GTP-Binding Protein - metabolism | Blotting, Western | Animals | Antigens, Nuclear - genetics | Mitosis - physiology | Nuclear Matrix-Associated Proteins - genetics | Models, Biological | Protein Binding | Signal Transduction - physiology | Mice | Centrioles - metabolism | Dyneins - genetics | HeLa Cells | Microscopy, Fluorescence | Spindle (Cell division) | Physiological aspects | Cell division | Research | Chromosomes | Dynein
Journal Article
Gastroenterology, ISSN 0016-5085, 2013, Volume 145, Issue 1, pp. 176 - 187
Journal Article
Cell, ISSN 0092-8674, 05/2018, Volume 173, Issue 4, pp. 958 - 971.e17
Defects in nucleocytoplasmic transport have been identified as a key pathogenic event in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)... 
ALS | nucleocytoplasmic transport | C9ORF72 | stress granule | NUCLEAR IMPORT | PHASE-SEPARATION | RNA | DIPEPTIDE-REPEAT PROTEINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | AMYOTROPHIC-LATERAL-SCLEROSIS | FRONTOTEMPORAL LOBAR DEGENERATION | HEXANUCLEOTIDE REPEAT | GGGGCC REPEAT | CELL BIOLOGY | C9orf72 Protein - genetics | alpha Karyopherins - metabolism | beta Karyopherins - genetics | alpha Karyopherins - antagonists & inhibitors | ran GTP-Binding Protein - genetics | Membrane Glycoproteins - metabolism | Active Transport, Cell Nucleus - physiology | DNA Repeat Expansion - genetics | Humans | Middle Aged | Male | beta Karyopherins - antagonists & inhibitors | Ataxin-2 - genetics | Frontotemporal Dementia - metabolism | RNA Interference | Arsenites - toxicity | Ataxin-2 - metabolism | HEK293 Cells | Female | C9orf72 Protein - metabolism | Frontotemporal Dementia - pathology | Nuclear Pore Complex Proteins - metabolism | ran GTP-Binding Protein - metabolism | Amyotrophic Lateral Sclerosis - pathology | ran GTP-Binding Protein - antagonists & inhibitors | Sodium Compounds - toxicity | Active Transport, Cell Nucleus - drug effects | Amyotrophic Lateral Sclerosis - metabolism | alpha Karyopherins - genetics | Aged | Oxidative Stress - drug effects | beta Karyopherins - metabolism | Ataxin-2 - antagonists & inhibitors | RNA, Small Interfering - metabolism | Proteins | Medical colleges | Nervous system diseases | Neurosciences | Research institutes | Molecular biology | Dementia
Journal Article
Cancer Cell, ISSN 1535-6108, 11/2015, Volume 28, Issue 5, pp. 599 - 609
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2017, Volume 68, Issue 3, pp. 479 - 490.e5
Transcription of expanded microsatellite repeats is associated with multiple human diseases, including myotonic dystrophy, Fuchs endothelial corneal dystrophy,... 
myotonic dystrophy | CRISPR | RNA toxicity | transcription | microsatellite repeat disease | Cas9 | amyotrophic lateral sclerosis | RNA polymerase II | C9ORF72/ALS/FTD | STAPHYLOCOCCUS-AUREUS CAS9 | STEM-CELLS | MUSCLEBLIND PROTEINS | SMALL-MOLECULE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE MODEL | MUSCULAR-DYSTROPHY | GENE-EXPRESSION | MYOTONIC-DYSTROPHY | RNA FOCI | HUNTINGTON-DISEASE | CELL BIOLOGY | C9orf72 Protein - genetics | Dependovirus - genetics | Myotonic Dystrophy - metabolism | ran GTP-Binding Protein - genetics | Alternative Splicing | RNA, Guide - genetics | CD24 Antigen - metabolism | Humans | Male | Chloride Channels - genetics | Endonucleases - metabolism | Myoblasts - metabolism | Myotonic Dystrophy - pathology | RNA, Guide - biosynthesis | HEK293 Cells | CD24 Antigen - genetics | Myotonic Dystrophy - genetics | Female | Transcription, Genetic | C9orf72 Protein - metabolism | Microsatellite Repeats | Disease Models, Animal | Transduction, Genetic | Down-Regulation | Mice, Transgenic | ran GTP-Binding Protein - metabolism | Myotonic Dystrophy - therapy | Myoblasts - pathology | Chloride Channels - metabolism | Animals | CRISPR-Associated Proteins - metabolism | CRISPR-Cas Systems | Enzyme Activation | HeLa Cells | Genetic Vectors | Genetic Therapy - methods | Enzymes | Genetic transcription | RNA | Health aspects | Analysis | Microbiology
Journal Article