X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (21036) 21036
Publication (3184) 3184
Book Review (2480) 2480
Newsletter (2040) 2040
Book Chapter (252) 252
Conference Proceeding (166) 166
Newspaper Article (109) 109
Dissertation (82) 82
Magazine Article (24) 24
Book / eBook (11) 11
Government Document (10) 10
Trade Publication Article (8) 8
Reference (7) 7
Data Set (4) 4
Web Resource (4) 4
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
rapamycin (17074) 17074
index medicus (15363) 15363
humans (9552) 9552
animals (8154) 8154
mice (4507) 4507
mammalian target (4309) 4309
mtor (4143) 4143
male (4101) 4101
tor serine-threonine kinases - metabolism (4038) 4038
signal transduction (3863) 3863
phosphorylation (3752) 3752
cell biology (3607) 3607
female (3502) 3502
research (3470) 3470
proteins (3455) 3455
cancer (3308) 3308
sirolimus - pharmacology (3147) 3147
biochemistry & molecular biology (3010) 3010
oncology (2969) 2969
tor protein (2880) 2880
autophagy (2810) 2810
apoptosis (2660) 2660
activation (2594) 2594
kinases (2573) 2573
mechanistic target of rapamycin complex 1 (2570) 2570
analysis (2165) 2165
article (1998) 1998
cell line, tumor (1974) 1974
signal transduction - drug effects (1970) 1970
expression (1947) 1947
sirolimus (1909) 1909
growth (1894) 1894
transplantation (1893) 1893
mammalian target of rapamycin (1823) 1823
tor serine-threonine kinases (1806) 1806
inhibition (1791) 1791
multiprotein complexes - metabolism (1732) 1732
rats (1699) 1699
pathway (1691) 1691
tor serine-threonine kinases - antagonists & inhibitors (1677) 1677
physiological aspects (1626) 1626
gene expression (1623) 1623
health aspects (1606) 1606
immunology (1587) 1587
middle aged (1511) 1511
sirolimus - therapeutic use (1494) 1494
metabolism (1475) 1475
proto-oncogene proteins c-akt - metabolism (1465) 1465
multidisciplinary sciences (1409) 1409
cells (1384) 1384
care and treatment (1375) 1375
surgery (1364) 1364
adult (1321) 1321
pharmacology & pharmacy (1320) 1320
cell proliferation (1279) 1279
cells, cultured (1267) 1267
everolimus (1267) 1267
akt (1230) 1230
cell proliferation - drug effects (1215) 1215
research article (1214) 1214
rodents (1213) 1213
tor serine-threonine kinases - genetics (1134) 1134
tumors (1087) 1087
genetic aspects (1085) 1085
biology (1078) 1078
mice, inbred c57bl (1072) 1072
medicine (1067) 1067
sirolimus - administration & dosage (1050) 1050
cell growth (1049) 1049
neurosciences (1033) 1033
immunosuppressive agents - therapeutic use (1028) 1028
medicine, research & experimental (1027) 1027
akt protein (1016) 1016
aged (1007) 1007
mutation (1007) 1007
signaling (980) 980
phagocytosis (979) 979
cell line (968) 968
insulin (954) 954
phosphatidylinositol 3-kinases - metabolism (950) 950
immunosuppressive agents - pharmacology (941) 941
sirolimus - analogs & derivatives (933) 933
apoptosis - drug effects (925) 925
cell cycle (922) 922
physiology (921) 921
therapy (917) 917
medical research (912) 912
disease models, animal (902) 902
signal transduction - physiology (881) 881
in-vivo (865) 865
proliferation (859) 859
inflammation (837) 837
in-vitro (835) 835
protein biosynthesis (835) 835
science (832) 832
survival (827) 827
treatment outcome (808) 808
tuberous sclerosis (804) 804
kinase (802) 802
abridged index medicus (799) 799
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (23203) 23203
Chinese (73) 73
French (64) 64
German (52) 52
Spanish (42) 42
Korean (41) 41
Japanese (31) 31
Polish (16) 16
Russian (15) 15
Hungarian (5) 5
Turkish (3) 3
Czech (2) 2
Dutch (2) 2
Portuguese (2) 2
Croatian (1) 1
Italian (1) 1
Persian (1) 1
Slovak (1) 1
Swedish (1) 1
Ukrainian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


2012, Methods in molecular biology, ISBN 1617794309, Volume 821
Web Resource
Frontiers in Immunology, ISSN 1664-3224, 06/2019
Journal Article
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 06/2007, Volume 42, Issue 6, p. S231
Journal Article
Nature, ISSN 0028-0836, 12/2017, Volume 552, Issue 7685, pp. 368 - 373
Journal Article
Angiogenesis, ISSN 0969-6970, 7/2016, Volume 19, Issue 3, pp. 359 - 371
Journal Article
International Journal of Molecular Medicine, ISSN 1107-3756, 04/2018, Volume 41, Issue 4, pp. 2099 - 2107
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 44, pp. 18052 - 18061
The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of protein synthesis and potential target for modifying cellular metabolism in... 
autophagy | mechanistic target of rapamycin (mTOR) | RAG GTPASES | amino acid | BIOCHEMISTRY & MOLECULAR BIOLOGY | mammalian target of rapamycin (mTOR) | RAGULATOR | CANCER | dynamin | GROWTH | DYNASORE | endocytosis | REQUIRES | PROTEINS | INHIBITOR | mTORC1 | SUFFICIENCY | Humans | Cytoplasm - metabolism | Ras Homolog Enriched in Brain Protein - genetics | Protein Transport - drug effects | Ras Homolog Enriched in Brain Protein - metabolism | Recombinant Fusion Proteins - metabolism | Autophagy - drug effects | Amino Acids - metabolism | Mechanistic Target of Rapamycin Complex 1 - genetics | Lysosomes - metabolism | Membrane Transport Modulators - pharmacology | HEK293 Cells | Dynamin II - metabolism | Biomarkers - metabolism | Lysosomes - drug effects | Endocytosis - drug effects | Enzyme Inhibitors - pharmacology | Dynamin II - genetics | Mechanistic Target of Rapamycin Complex 1 - antagonists & inhibitors | Monomeric GTP-Binding Proteins - genetics | Enzyme Activation - drug effects | Clathrin - metabolism | Mechanistic Target of Rapamycin Complex 1 - metabolism | Dynamin II - antagonists & inhibitors | Clathrin - antagonists & inhibitors | Mechanistic Target of Rapamycin Complex 1 - agonists | Monomeric GTP-Binding Proteins - metabolism | Mutation | Cytoplasm - drug effects | Microscopy, Fluorescence | Amino Acid Substitution | Index Medicus | Cell Biology
Journal Article
Oncogene, ISSN 0950-9232, 05/2013, Volume 32, Issue 20, pp. 2521 - 2526
Rictor and its binding partner Sin1 are indispensable components of mTORC2 (mammalian target of rapamycin complex 2). The mTORC2 signaling complex functions as... 
Rictor (rapamycin-insensitive companion of mTOR) | RhoGDI2 | Rho proteins | Cell migration | SITE | ACTIVATION | METASTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | rictor (rapamycin-insensitive companion of mTOR) | CELL BIOLOGY | DICTYOSTELIUM | GDP-DISSOCIATION INHIBITOR | AKT PHOSPHORYLATION | ONCOLOGY | GROWTH | GENETICS & HEREDITY | cell migration | ENDOPLASMIC-RETICULUM | MTOR COMPLEX | Up-Regulation | TOR Serine-Threonine Kinases - metabolism | Minor Histocompatibility Antigens | Humans | rac GTP-Binding Proteins - metabolism | Multiprotein Complexes - genetics | cdc42 GTP-Binding Protein - metabolism | Mechanistic Target of Rapamycin Complex 2 | Cell Movement - physiology | Gene Knockdown Techniques | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | TOR Serine-Threonine Kinases - genetics | rho Guanine Nucleotide Dissociation Inhibitor beta - genetics | rac GTP-Binding Proteins - genetics | Neuropeptides - genetics | Proteomics - methods | rho Guanine Nucleotide Dissociation Inhibitor beta - metabolism | Fibroblasts - metabolism | Rapamycin-Insensitive Companion of mTOR Protein | Cells, Cultured | Neuropeptides - metabolism | Proteins - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Proteins - metabolism | cdc42 GTP-Binding Protein - genetics | Fibroblasts - cytology | Mice | rac1 GTP-Binding Protein | Proteins | Usage | Physiological aspects | Cellular signal transduction | Rapamycin | Research | Health aspects | Signal transduction | Oncology | Kinases | Cell adhesion & migration | Index Medicus | rictor (rapamycin-insensitive companion of mTOR | RhoGDI2 (Rho-GDP dissociation inhibitor 2)
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2007, Volume 405, Issue 3, pp. 513 - 522
The mTOR (mammalian target of rapamycin) protein kinase is an important regulator of cell growth. Two complexes of mTOR have been identified: complex 1,... 
Mammalian target of rapamycin (mTOR) | Protein kinase | Protein observed with Rictor-1 (Protor) | mTOR complex-2 (mTORC2) | Proline-rich repeat protein-5 (PRR-5) | Rapamycin-insensitive companion of mTOR (Rictor) | Cancer | proline-rich repeat protein-5 (PRR-5) | protein observed with Rictor-1 (Protor) | ACTIVATION | AKT/PKB | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | mammalian target of rapamycin (mTOR) | rapamycin-insensitive companion of mTOR (Rictor) | protein kinase | RAPTOR | REGULATOR | PATHWAY | TOR | GROWTH | cancer | PDK1 | Protein Kinases - metabolism | Cell Line | Carrier Proteins - metabolism | Humans | Protein Isoforms | Gene Silencing | Protein Binding | TOR Serine-Threonine Kinases | Rapamycin-Insensitive Companion of mTOR Protein | Index Medicus | HEK-293 cells, human embryonic kidney cells | SPAK, Ste20 | PI3K, phosphoinositide 3-kinase | mTORC, mTOR complex | EST, expressed sequence tag | Protor, protein observed with Rictor | DTT, dithiothreitol | HRP, horseradish peroxidase | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | NCBI, National Center for Biotechnology Information | IGF-1, insulin-like growth factor-1 | S6K, S6 kinase | mTOR, mammalian target of rapamycin | TAP, tandem affinity purification | Rictor, rapamycin-insensitive companion of mTOR | Raptor, regulatory associated protein of mTOR | siRNA, small interfering RNA | I.M.A.G.E., Integrated Molecular Analysis of Genomes and their Expression | SPS1-related proline | alanine-rich kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2011, Volume 438, Issue 1, pp. 53 - 62
Genetic alterations in PI3K (phosphoinositide 3-kinase) signalling are common in cancer and include deletions in PTEN (phosphatase and tensin homologue deleted... 
Phosphoinositide 4-kinase (PI4K) | Pan-phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235; phosphoinositide 3-kinase α (PI3Kα) | PIK3CA | p110α E545k mutation | PIK3CA H1047R mutation | 3T3-L1 ADIPOCYTES | CATALYTIC SUBUNIT | BIOCHEMISTRY & MOLECULAR BIOLOGY | p110 alpha E545K mutation | phosphoinositide 4-kinase (PI4K) | pan-phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235 | BREAST-CANCER | INSULIN | P110-BETA | phosphoinositide 3-kinase alpha (PI3K alpha) | PIK3CA GENE | IN-VIVO | MUTATIONS | INHIBITORS | IA PI3K ISOFORMS | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Humans | Neoplasms, Experimental - prevention & control | Enzyme Inhibitors - therapeutic use | Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Mice, Knockout | Neoplasms, Experimental - pathology | Tissue Distribution | Animals | Enzyme Inhibitors - pharmacokinetics | Signal Transduction - drug effects | Protein Isoforms | Mice | Neoplasms, Experimental - metabolism | Tumor Cells, Cultured | Homeodomain Proteins - physiology | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus | PI3K, phosphoinositide 3-kinase | BID, twice daily dosing | p110α E545K mutation | mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235; phosphoinositide 3-kinase α (PI3Kα) | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | PKB, protein kinase B | pan-phosphoinositide 3kinase (PI3K) | PI4K, phosphoinositide 4-kinase | QD, once daily dosing | mTOR, mammalian target of rapamycin | TGI, tumour growth inhibition
Journal Article
PloS one, ISSN 1932-6203, 2019, Volume 14, Issue 3, pp. e0213489 - e0213489
[This corrects the article DOI: 10.1371/journal.pone.0099719.]. 
Glaucoma | Hypertension | Neuroprotection | Rapamycin
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2017, Volume 114, Issue 12, pp. 3186 - 3191
Journal Article
Nature Communications, ISSN 2041-1723, 11/2016, Volume 7, Issue 1, pp. 1 - 19
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2017, Volume 12, Issue 11, pp. e0188417 - e0188417
Myelin abnormalities are increasingly being recognized as an important component of a number of neurologic developmental disorders. The integration of many... 
MAMMALIAN TARGET | RAPAMYCIN | TUBEROUS SCLEROSIS COMPLEX | WHITE-MATTER | INTEGRITY | MULTIDISCIPLINARY SCIENCES | REMYELINATION | AKT | RICTOR | DIFFERENTIATION | CNS MYELINATION | Cell Proliferation - genetics | Central Nervous System - metabolism | Signal Transduction | White Matter - metabolism | White Matter - growth & development | Mechanistic Target of Rapamycin Complex 1 - metabolism | Mice, Knockout | Myelin Sheath - metabolism | Central Nervous System - growth & development | Cell Differentiation - genetics | Mechanistic Target of Rapamycin Complex 2 - metabolism | Mechanistic Target of Rapamycin Complex 1 - genetics | Animals | Rapamycin-Insensitive Companion of mTOR Protein - genetics | Gene Expression Regulation, Developmental | Myelin Sheath - genetics | Mice | Mechanistic Target of Rapamycin Complex 2 - genetics | Oligodendrocyte Precursor Cells - metabolism | Myelination | Demyelinating diseases | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Risk factors | TOR protein | Brain | Conduction | Pediatrics | Neurosciences | Phosphorylation | Spinal cord | Nuclear magnetic resonance--NMR | Laboratories | Change detection | Nervous system | Gene deletion | Kinases | Glial stem cells | Proteins | Nerve conduction | Signal transduction | Pathways | Clonal deletion | Precursors | Rodents | Oligodendrocytes | Deletion | Biomedical engineering | Myelin | Abnormalities | Rapamycin | Substantia alba | 1-Phosphatidylinositol 3-kinase | Neurology | Signaling | Cell number | Index Medicus | Nuclear magnetic resonance | NMR
Journal Article