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Nature, ISSN 0028-0836, 06/2009, Volume 459, Issue 7248, pp. 852 - 856
Journal Article
Cancer cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 547 - 559
In mice, Lkb1 deletion and activation of Kras G12D results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these... 
CELLCYCLE | SIGNALING | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Lung Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - deficiency | Protein-Tyrosine Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Genomics | Humans | Lung Neoplasms - metabolism | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Cell Movement - genetics | Phosphorylation - genetics | RNA Interference | Gene Expression Regulation, Neoplastic - genetics | MAP Kinase Kinase 1 - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - metabolism | Signal Transduction - genetics | Enzyme Inhibitors - therapeutic use | Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors | Focal Adhesion Protein-Tyrosine Kinases - genetics | Focal Adhesions - genetics | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Mice | TOR Serine-Threonine Kinases | src-Family Kinases - genetics | Protein-Tyrosine Kinases - antagonists & inhibitors | ras Proteins - genetics | Lung Neoplasms - pathology | Cell Transdifferentiation - genetics | Protein-Tyrosine Kinases - genetics | Neoplasm Metastasis - drug therapy | Mice, Mutant Strains | Protein-Serine-Threonine Kinases - antagonists & inhibitors | src-Family Kinases - metabolism | Female | Drug Therapy, Combination | Lung Neoplasms - genetics | Cell Adhesion - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Up-Regulation - genetics | Xenograft Model Antitumor Assays | Neoplasm Metastasis - genetics | Animals | MAP Kinase Kinase 2 - antagonists & inhibitors | Protein Kinase Inhibitors - therapeutic use | Focal Adhesions - metabolism | Proteomics | Protein Kinase Inhibitors - pharmacology | Oncology, Experimental | Analysis | Lung cancer | Development and progression | Metastasis | Research | Cancer | Index Medicus
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 04/2012, Volume 142, Issue 4, pp. 1021 - 1031.e15
Background & Aims Cholangiocarcinoma is a heterogeneous disease with a poor outcome that accounts for 5%−10% of primary liver cancers. We characterized its... 
Gastroenterology and Hepatology | CCA | Gene Expression | Hepatic | Genetic Analysis | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Immunohistochemistry | Receptor, Epidermal Growth Factor - genetics | Proto-Oncogene Proteins p21(ras) | Oligonucleotide Array Sequence Analysis | Humans | Middle Aged | Tumor Microenvironment | Male | Bile Duct Neoplasms - enzymology | Time Factors | Bile Duct Neoplasms - genetics | Cholangiocarcinoma - enzymology | Precision Medicine | Genetic Predisposition to Disease | Risk Assessment | Risk Factors | ras Proteins - antagonists & inhibitors | Survival Rate | Blotting, Western | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Phenotype | Belgium | Cell Line, Tumor | Cholangiocarcinoma - genetics | Mutation | Quinazolines - pharmacology | Trastuzumab | Cluster Analysis | Protein-Tyrosine Kinases - antagonists & inhibitors | ras Proteins - genetics | Prognosis | United States | Laser Capture Microdissection | Molecular Targeted Therapy | Patient Selection | Protein-Tyrosine Kinases - genetics | Antibodies, Monoclonal, Humanized - pharmacology | Female | Antineoplastic Agents - pharmacology | Bile Duct Neoplasms - drug therapy | Proto-Oncogene Proteins - antagonists & inhibitors | Bile Ducts, Intrahepatic - pathology | Cholangiocarcinoma - mortality | Kaplan-Meier Estimate | Proportional Hazards Models | Gene Expression Profiling - methods | Proto-Oncogene Proteins - genetics | Chi-Square Distribution | Bile Ducts, Intrahepatic - enzymology | Cholangiocarcinoma - pathology | Cholangiocarcinoma - drug therapy | Proto-Oncogene Proteins B-raf - genetics | Bile Duct Neoplasms - mortality | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Aged | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Bile Duct Neoplasms - pathology | Protein-Tyrosine Kinases - analysis | Queensland | Tyrosine | Genes | Amino acids | Transforming growth factors | Gene expression | Liver cancer | Epidermal growth factor | Analysis | Phenols | Genetic research | Genetic aspects | Health aspects | Cancer | Index Medicus | Abridged Index Medicus
Journal Article
Cancer Letters, ISSN 0304-3835, 2017, Volume 392, pp. 71 - 82
.... AJUBA protein expression was undetectable in most AJUBA -mutant HNSCC cell lines, and total PLK1 and Bora protein... 
Hematology, Oncology and Palliative Medicine | WEE1 | Head neck squamous cell carcinoma | Polo-like kinase 1 | CHK1 | AJUBA | Life Sciences & Biomedicine | Oncology | Science & Technology | Apoptosis - drug effects | Protein-Tyrosine Kinases - metabolism | Carcinoma, Squamous Cell - pathology | Humans | G2 Phase Cell Cycle Checkpoints - drug effects | RNA Interference | Smad4 Protein - genetics | Time Factors | Protein-Serine-Threonine Kinases - metabolism | Cell Cycle Proteins - metabolism | Head and Neck Neoplasms - drug therapy | Thiophenes - pharmacology | Genotype | Pyrimidines - pharmacology | Head and Neck Neoplasms - pathology | Checkpoint Kinase 1 - metabolism | Phenotype | Carcinoma, Squamous Cell - drug therapy | Signal Transduction - drug effects | Mice, Nude | Checkpoint Kinase 2 - antagonists & inhibitors | Cell Line, Tumor | Head and Neck Neoplasms - genetics | Mutation | Urea - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors | ras Proteins - genetics | Carcinoma, Squamous Cell - genetics | Molecular Targeted Therapy | Cell Cycle Proteins - antagonists & inhibitors | Checkpoint Kinase 2 - metabolism | Dose-Response Relationship, Drug | Squamous Cell Carcinoma of Head and Neck | Transfection | Urea - analogs & derivatives | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Antineoplastic Agents - pharmacology | Head and Neck Neoplasms - enzymology | Pyrazoles - pharmacology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Carcinoma, Squamous Cell - enzymology | Pteridines - pharmacology | Checkpoint Kinase 1 - antagonists & inhibitors | Nuclear Proteins - metabolism | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Nuclear Proteins - antagonists & inhibitors | LIM Domain Proteins - genetics | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Squamous cell carcinoma | Care and treatment | Genetic aspects | Drug therapy | Analysis | Cancer | Index Medicus
Journal Article
Oncotarget, ISSN 1949-2553, 03/2011, Volume 2, Issue 3, pp. 135 - 164
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 01/2016, Volume 291, Issue 3, pp. 1014 - 1027
The majority of biosynthetic secretory proteins initiate their journey through the endomembrane system from specific sub-domains of the endoplasmic reticulum... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Vesicular Transport Proteins - metabolism | Caenorhabditis elegans Proteins - chemistry | Humans | Membrane Microdomains - ultrastructure | Endoplasmic Reticulum - ultrastructure | GTP Phosphohydrolases - chemistry | Caenorhabditis elegans - physiology | ras GTPase-Activating Proteins - genetics | Vesicular Transport Proteins - antagonists & inhibitors | RNA Interference | ras GTPase-Activating Proteins - metabolism | Enzyme Inhibitors - pharmacology | COP-Coated Vesicles - metabolism | Recombinant Proteins - chemistry | Guanylyl Imidodiphosphate - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Monomeric GTP-Binding Proteins - antagonists & inhibitors | Caenorhabditis elegans - ultrastructure | GTP Phosphohydrolases - metabolism | GTP Phosphohydrolases - genetics | Models, Biological | Monomeric GTP-Binding Proteins - chemistry | GTPase-Activating Proteins - genetics | Mutation | Caenorhabditis elegans Proteins - genetics | Caenorhabditis elegans - enzymology | Membrane Microdomains - metabolism | Caenorhabditis elegans Proteins - metabolism | Endoplasmic Reticulum - metabolism | Guanosine Triphosphate - metabolism | GTP Phosphohydrolases - antagonists & inhibitors | GTPase-Activating Proteins - metabolism | Microscopy, Atomic Force | Organelle Shape - drug effects | Recombinant Proteins - metabolism | COP-Coated Vesicles - ultrastructure | GTPase-Activating Proteins - antagonists & inhibitors | Vesicular Transport Proteins - genetics | COP-Coated Vesicles - drug effects | Monomeric GTP-Binding Proteins - genetics | Animals | Caenorhabditis elegans - drug effects | Caenorhabditis elegans Proteins - antagonists & inhibitors | Monomeric GTP-Binding Proteins - metabolism | Receptor Protein-Tyrosine Kinases - genetics | Membrane Microdomains - drug effects | Lipid Bilayers - chemistry | Lipid Bilayers - metabolism | Amino Acid Substitution | Index Medicus | COPII | membrane transport | endoplasmic reticulum (ER) | GTPase | membrane bilayer | Cell Biology
Journal Article