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Cell (Cambridge), ISSN 0092-8674, 04/2016, Volume 165, Issue 3, pp. 643 - 655
Oncogenic activation of RAS genes via point mutations occurs in 20%–30% of human cancers. The development of effective RAS inhibitors has been challenging, necessitating new approaches to inhibit this oncogenic protein... 
rigosertib | RAS-binding domain | PI3K | MAPK | RAS | RAF | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Glycine - analogs & derivatives | Phosphorylation | Humans | Molecular Sequence Data | ras Proteins - metabolism | Crystallography, X-Ray | Proto-Oncogene Proteins - chemistry | Sulfones - pharmacology | MAP Kinase Signaling System | Cell Cycle Proteins - chemistry | Pancreatic Neoplasms - drug therapy | Glycine - chemistry | Sulfones - chemistry | Nuclear Magnetic Resonance, Biomolecular | Dimerization | Glycine - administration & dosage | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | RNA-Binding Proteins - chemistry | Cell Cycle Proteins - metabolism | Models, Molecular | Sequence Alignment | Animals | Glycine - pharmacology | Signal Transduction - drug effects | Mice, Nude | Mice | Protein-Serine-Threonine Kinases - chemistry | Cell Transformation, Neoplastic - drug effects | RNA-Binding Proteins - metabolism | Sulfones - administration & dosage | Proteins | Medical colleges | Gene mutations | Protein binding | Jewish schools | Phosphotransferases | Index Medicus
Journal Article
2004, Molecular biology intelligence unit, ISBN 9780306479922, 235
Book
Journal of Biological Chemistry, ISSN 0021-9258, 05/2005, Volume 280, Issue 19, pp. 18717 - 18727
...). Recent work demonstrated the importance of the tuberous sclerosis protein TSC2 for regulation of mTOR by insulin... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Humans | Multienzyme Complexes - metabolism | Immunoblotting | Ras Homolog Enriched in Brain Protein | Elongation Factor 2 Kinase | AMP-Activated Protein Kinases | Phosphoproteins - chemistry | Time Factors | Guanosine Triphosphate - chemistry | Guanosine Diphosphate - chemistry | Protein Synthesis Inhibitors - pharmacology | Transgenes | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Fibroblasts - metabolism | Tumor Suppressor Proteins - metabolism | Signal Transduction | Neuropeptides - metabolism | Tumor Suppressor Proteins - physiology | Adaptor Proteins, Signal Transducing | Models, Biological | Monomeric GTP-Binding Proteins - chemistry | Glucose - chemistry | Mice | TOR Serine-Threonine Kinases | Mutation | Neuropeptides - chemistry | Protein Kinases - metabolism | Monomeric GTP-Binding Proteins - physiology | Phosphorylation | Immunoprecipitation | Amino Acids - chemistry | Neuropeptides - physiology | Dose-Response Relationship, Drug | Repressor Proteins - physiology | Amino Acids - metabolism | Carrier Proteins - chemistry | Guanine - chemistry | Protein Structure, Tertiary | Cell Line | Cells, Cultured | Gene Expression Regulation | Hydrogen Peroxide - pharmacology | Cycloheximide - pharmacology | Hydrolysis | Animals | Monomeric GTP-Binding Proteins - metabolism | Ribosomal Protein S6 - metabolism | Adenosine Triphosphate - chemistry | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Sorbitol - pharmacology | Index Medicus
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 08/2005, Volume 25, Issue 16, pp. 6964 - 6979
Journal Article
Nature (London), ISSN 1476-4687, 04/2014, Volume 508, Issue 7495, pp. 222 - 227
... with RAS posttranslational modifications to prevent maturation and translocation of the active protein to the plasma membrane (4-6). In addition, phenotypic screens... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | ras Proteins - genetics | Colonic Neoplasms - genetics | Proto-Oncogene Proteins p21(ras) | Pyridines - chemistry | Colonic Neoplasms - drug therapy | Humans | Substrate Specificity | DNA Breaks, Single-Stranded - drug effects | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Phosphoric Monoester Hydrolases - biosynthesis | DNA Repair Enzymes - metabolism | Female | Antineoplastic Agents - pharmacology | DNA Repair Enzymes - antagonists & inhibitors | Homeostasis - drug effects | Aminoquinolines - pharmacology | DNA Repair Enzymes - chemistry | Disease Models, Animal | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Pyrazoles - pharmacology | Crystallization | Models, Molecular | Proto-Oncogene Proteins - genetics | Antineoplastic Agents - chemistry | Mice, SCID | Nucleotides - metabolism | Xenograft Model Antitumor Assays | Animals | Colonic Neoplasms - pathology | DNA Repair | DNA Repair Enzymes - biosynthesis | Proteomics | Protein Conformation | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Crizotinib | Enzymes | Colon cancer | Physiological aspects | Genetic aspects | Research | Nucleotides | Studies | Oxidative stress | Inhibitor drugs | Medical prognosis | Homeostasis | Mutation | Kinases | Experiments | Cancer | Index Medicus | Life Sciences | crizotinib | cancer | stereoselectivity | MTH1 | DNA repair | drug
Journal Article
Scientific reports, ISSN 2045-2322, 10/2015, Volume 5, Issue 1, pp. 15334 - 15334
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 02/2016, Volume 291, Issue 9, pp. 4589 - 4602
.... In response to netrin-1 stimulation, DCC becomes a signaling platform to recruit proteins that promote axon outgrowth and guidance... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Humans | Nerve Growth Factors - metabolism | p120 GTPase Activating Protein - chemistry | RNA Interference | Tumor Suppressor Proteins - chemistry | Neurons - metabolism | Peptide Fragments - genetics | DCC Receptor | Tumor Suppressor Proteins - metabolism | Signal Transduction | Rats | Recombinant Proteins - chemistry | Recombinant Fusion Proteins - chemistry | p120 GTPase Activating Protein - antagonists & inhibitors | Peptide Fragments - chemistry | Embryo, Mammalian - cytology | Nerve Growth Factors - genetics | Peptide Fragments - antagonists & inhibitors | Chickens | Mutant Proteins - agonists | Tumor Suppressor Proteins - antagonists & inhibitors | p120 GTPase Activating Protein - metabolism | Netrin-1 | Neurons - cytology | p120 GTPase Activating Protein - genetics | Cerebral Cortex - cytology | Recombinant Fusion Proteins - metabolism | Cerebral Cortex - metabolism | Nerve Tissue Proteins - chemistry | Glutathione Transferase - genetics | Tumor Suppressor Proteins - genetics | HEK293 Cells | Receptors, Cell Surface - chemistry | Protein Interaction Domains and Motifs | Recombinant Proteins - metabolism | Nerve Tissue Proteins - antagonists & inhibitors | Peptide Fragments - metabolism | Cells, Cultured | Mutant Proteins - genetics | Receptors, Cell Surface - agonists | Axons - metabolism | Glutathione Transferase - metabolism | Receptors, Cell Surface - metabolism | Mutant Proteins - metabolism | Nerve Growth Factors - chemistry | Nerve Tissue Proteins - genetics | Protein Transport | Nerve Tissue Proteins - metabolism | Animals | Nerve Growth Factors - antagonists & inhibitors | Tumor Suppressor Proteins - agonists | Amino Acid Substitution | Index Medicus | neurodevelopment | signal transduction | DCC | Neurobiology | Ras protein | neurite outgrowth | netrin-1
Journal Article
Nature (London), ISSN 1476-4687, 12/2013, Volume 504, Issue 7479, pp. 301 - 305
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 01/2016, Volume 291, Issue 3, pp. 1014 - 1027
The majority of biosynthetic secretory proteins initiate their journey through the endomembrane system from specific sub-domains of the endoplasmic reticulum... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Vesicular Transport Proteins - metabolism | Caenorhabditis elegans Proteins - chemistry | Humans | Membrane Microdomains - ultrastructure | Endoplasmic Reticulum - ultrastructure | GTP Phosphohydrolases - chemistry | Caenorhabditis elegans - physiology | ras GTPase-Activating Proteins - genetics | Vesicular Transport Proteins - antagonists & inhibitors | RNA Interference | ras GTPase-Activating Proteins - metabolism | Enzyme Inhibitors - pharmacology | COP-Coated Vesicles - metabolism | Recombinant Proteins - chemistry | Guanylyl Imidodiphosphate - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Monomeric GTP-Binding Proteins - antagonists & inhibitors | Caenorhabditis elegans - ultrastructure | GTP Phosphohydrolases - metabolism | GTP Phosphohydrolases - genetics | Models, Biological | Monomeric GTP-Binding Proteins - chemistry | GTPase-Activating Proteins - genetics | Mutation | Caenorhabditis elegans Proteins - genetics | Caenorhabditis elegans - enzymology | Membrane Microdomains - metabolism | Caenorhabditis elegans Proteins - metabolism | Endoplasmic Reticulum - metabolism | Guanosine Triphosphate - metabolism | GTP Phosphohydrolases - antagonists & inhibitors | GTPase-Activating Proteins - metabolism | Microscopy, Atomic Force | Organelle Shape - drug effects | Recombinant Proteins - metabolism | COP-Coated Vesicles - ultrastructure | GTPase-Activating Proteins - antagonists & inhibitors | Vesicular Transport Proteins - genetics | COP-Coated Vesicles - drug effects | Monomeric GTP-Binding Proteins - genetics | Animals | Caenorhabditis elegans - drug effects | Caenorhabditis elegans Proteins - antagonists & inhibitors | Monomeric GTP-Binding Proteins - metabolism | Receptor Protein-Tyrosine Kinases - genetics | Membrane Microdomains - drug effects | Lipid Bilayers - chemistry | Lipid Bilayers - metabolism | Amino Acid Substitution | Index Medicus | COPII | membrane transport | endoplasmic reticulum (ER) | GTPase | membrane bilayer | Cell Biology
Journal Article