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Cell, ISSN 0092-8674, 04/2016, Volume 165, Issue 3, pp. 643 - 655
Oncogenic activation of genes via point mutations occurs in 20%–30% of human cancers. The development of effective RAS inhibitors has been challenging,... 
rigosertib | RAS-binding domain | PI3K | MAPK | RAS | RAF | POINT MUTATIONS | BLADDER-CARCINOMA ONCOGENE | MUTANT | SELECTIVE INHIBITOR | ACTIVATION | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | KINASE | BINDING | TRANSFORMING PROPERTIES | CELL BIOLOGY | Glycine - analogs & derivatives | Phosphorylation | Humans | Molecular Sequence Data | ras Proteins - metabolism | Crystallography, X-Ray | Proto-Oncogene Proteins - chemistry | Sulfones - pharmacology | MAP Kinase Signaling System | Cell Cycle Proteins - chemistry | Pancreatic Neoplasms - drug therapy | Glycine - chemistry | Sulfones - chemistry | Nuclear Magnetic Resonance, Biomolecular | Dimerization | Glycine - administration & dosage | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | RNA-Binding Proteins - chemistry | Cell Cycle Proteins - metabolism | Models, Molecular | Sequence Alignment | Animals | Glycine - pharmacology | Signal Transduction - drug effects | Mice, Nude | Mice | Protein-Serine-Threonine Kinases - chemistry | Cell Transformation, Neoplastic - drug effects | RNA-Binding Proteins - metabolism | Sulfones - administration & dosage | Proteins | Medical colleges | Gene mutations | Protein binding | Jewish schools | Phosphotransferases | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2015, Volume 290, Issue 8, pp. 4908 - 4927
synGAP is a neuron-specific Ras and Rap GTPase-activating protein (GAP) found in high concentrations in the postsynaptic density (PSD) fraction from the... 
NMDA RECEPTOR | DOMAIN | STIMULATION | INHIBITION | CALPAIN | CLONING | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTATIONS | HIPPOCAMPAL-NEURONS | PLASTICITY | Oncogene Proteins - genetics | ras Proteins - genetics | Phosphorylation | ras GTPase-Activating Proteins - chemistry | rap1 GTP-Binding Proteins - chemistry | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Receptors, N-Methyl-D-Aspartate - metabolism | ras Proteins - metabolism | Neurons - cytology | GTPase-Activating Proteins - metabolism | Receptors, N-Methyl-D-Aspartate - genetics | Cyclin-Dependent Kinase 5 - chemistry | Cyclin-Dependent Kinase 5 - genetics | ras GTPase-Activating Proteins - genetics | Receptors, N-Methyl-D-Aspartate - chemistry | ras Proteins - chemistry | Proto-Oncogene Proteins p21(ras) - chemistry | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | rap1 GTP-Binding Proteins - metabolism | ras GTPase-Activating Proteins - metabolism | Oncogene Proteins - chemistry | Cells, Cultured | Oncogene Proteins - metabolism | Rats | Synapses - enzymology | GTPase-Activating Proteins - chemistry | Cyclin-Dependent Kinase 5 - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | Animals | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - chemistry | Neurons - enzymology | GTPase-Activating Proteins - genetics | rap1 GTP-Binding Proteins - genetics | rap GTP-Binding Proteins | Index Medicus | Ras Protein | Ras-related Protein 1 (Rap1) | Postsynaptic Density | Ca2 | Synaptic Plasticity | Small GTPase | Neurobiology | Mass Spectrometry (MS) | Cyclin-dependent Kinase 5 (CDK5) | Protein Kinase | Calmodulin-dependent Protein Kinase II (CaMKII) | Synaptic GTPase-activating Protein (synGAP)
Journal Article
Nature, ISSN 0028-0836, 08/2009, Volume 460, Issue 7257, pp. 904 - 908
Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to loss of heterozygosity. aUPD is associated not only with loss-of-function... 
TRANSFORMATION | PROTEIN | RETROVIRAL VECTOR GCDNSAP | NEGATIVE REGULATION | MULTIDISCIPLINARY SCIENCES | HEMATOPOIETIC STEM-CELLS | V-CBL | MUTATIONS | UBIQUITIN LIGASES | MYELODYSPLASTIC SYNDROMES | P53 | NIH 3T3 Cells | Neoplasm Transplantation | ras Proteins - genetics | Phosphorylation | Proto-Oncogene Proteins c-cbl - metabolism | Humans | Leukemia, Myeloid - genetics | Molecular Sequence Data | ras Proteins - metabolism | Male | Leukemia, Myeloid - pathology | Allelic Imbalance | Ubiquitination | Base Sequence | Female | Proto-Oncogene Proteins c-cbl - deficiency | Genes, Tumor Suppressor | Proto-Oncogene Proteins c-cbl - genetics | Amino Acid Sequence | Oncogenes - genetics | Mutant Proteins - genetics | Models, Molecular | Mutant Proteins - metabolism | Chromosomes, Human, Pair 11 - genetics | Proto-Oncogene Proteins c-cbl - chemistry | Mice, Knockout | Animals | Uniparental Disomy - genetics | Leukemia, Myeloid - metabolism | Mice, Nude | Mutant Proteins - chemistry | Proto-Oncogene Proteins c-cbl - antagonists & inhibitors | Protein Conformation | Mice | Mutation | Gene mutations | Myelocytic leukemia | Physiological aspects | Tumor suppressor genes | Development and progression | Genetic aspects | Nonlymphoid leukemia | Research | Protein kinases | Proteins | Genes | Amino acids | Kinases | Cells | Clinical outcomes | Crystal structure | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 31, pp. 12981 - 12993
H-Ras, K-Ras, and N-Ras are small GTPases that are important in the control of cell proliferation, differentiation, and survival, and their mutants occur... 
EVOLUTIONARY TREE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | enzyme catalysis | Ras protein | allosteric regulation | conformational change | oncogene | enzyme structure | P21 | PHOSPHATE | STRUCTURAL BASIS | NUCLEOTIDE-FREE | ACTIVATING PROTEINS | EXPRESSION | GTP HYDROLYSIS | CONFORMATIONAL STATES | Proto-Oncogene Proteins p21(ras) - genetics | Allosteric Regulation | Humans | Crystallography, X-Ray | Guanosine Triphosphate - metabolism | Isoenzymes - chemistry | Dinucleoside Phosphates - chemistry | GTP Phosphohydrolases - chemistry | Isoenzymes - metabolism | Proto-Oncogene Proteins c-raf - chemistry | Proto-Oncogene Proteins p21(ras) - chemistry | Guanosine Triphosphate - chemistry | Membrane Proteins - metabolism | Protein Interaction Domains and Motifs | Peptide Fragments - genetics | Proto-Oncogene Proteins p21(ras) - metabolism | Recombinant Proteins - metabolism | Catalytic Domain | Peptide Fragments - metabolism | Biocatalysis | Proto-Oncogene Proteins c-raf - genetics | Isoenzymes - genetics | Membrane Proteins - genetics | Enzyme Stability | Guanosine Triphosphate - analogs & derivatives | Models, Molecular | Recombinant Proteins - chemistry | Dinucleoside Phosphates - metabolism | Proto-Oncogene Proteins c-raf - metabolism | Point Mutation | Peptide Fragments - chemistry | GTP Phosphohydrolases - metabolism | Membrane Proteins - chemistry | GTP Phosphohydrolases - genetics | Allosteric Site | Ligands | Protein Conformation | Amino Acid Substitution | Index Medicus | Enzymology
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 504, Issue 7479, pp. 301 - 305
CAAX proteins have essential roles in multiple signalling pathways, controlling processes such as proliferation, differentiation and carcinogenesis(1). The... 
A-FACTOR | ENDOPROTEOLYSIS | RAS-DERIVED PEPTIDES | LOCALIZATION | SPECIFICITY | STRUCTURAL BASIS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | SECONDARY STRUCTURE | PROTEOLYSIS | CIRCULAR-DICHROISM SPECTROSCOPY | Prenylation | Humans | Archaeal Proteins - chemistry | Molecular Sequence Data | Substrate Specificity | Crystallography, X-Ray | Metalloendopeptidases - metabolism | DNA-Binding Proteins - metabolism | Methanococcus - enzymology | Endopeptidases - chemistry | Proto-Oncogene Proteins p21(ras) - chemistry | Conserved Sequence | Cysteine - metabolism | Membrane Proteins - metabolism | Peptide Hydrolases - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Archaeal Proteins - metabolism | Endoplasmic Reticulum - enzymology | Protein Structure, Tertiary | Amino Acid Sequence | Endopeptidases - metabolism | Biocatalysis | Signal Transduction | Models, Molecular | Escherichia coli Proteins - metabolism | DNA-Binding Proteins - chemistry | Peptide Hydrolases - chemistry | Amino Acid Motifs | Animals | Membrane Proteins - chemistry | Peptide Hydrolases - classification | Metalloendopeptidases - chemistry | Glutamic Acid - metabolism | Mice | Escherichia coli Proteins - chemistry | Proteins | Cysteine | Proteases | Physiological aspects | Amino acids | Cell membranes | Research | Molecular biology | Health aspects | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2005, Volume 280, Issue 19, pp. 18717 - 18727
Amino acids positively regulate signaling through the mammalian target of rapamycin (mTOR). Recent work demonstrated the importance of the tuberous sclerosis... 
ELONGATION-FACTOR-2 KINASE | TRANSLATION FACTORS | RHEB | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-PRODUCTS | FACTOR 4E-BINDING PROTEIN-1 | INITIATION-FACTOR 4E | ISOLATED RAT HEPATOCYTES | BINDING | PHOSPHORYLATION SITE | MTOR | Humans | Multienzyme Complexes - metabolism | Immunoblotting | Ras Homolog Enriched in Brain Protein | Elongation Factor 2 Kinase | AMP-Activated Protein Kinases | Phosphoproteins - chemistry | Time Factors | Guanosine Triphosphate - chemistry | Guanosine Diphosphate - chemistry | Protein Synthesis Inhibitors - pharmacology | Transgenes | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Fibroblasts - metabolism | Tumor Suppressor Proteins - metabolism | Signal Transduction | Neuropeptides - metabolism | Tumor Suppressor Proteins - physiology | Adaptor Proteins, Signal Transducing | Models, Biological | Monomeric GTP-Binding Proteins - chemistry | Glucose - chemistry | Mice | TOR Serine-Threonine Kinases | Mutation | Neuropeptides - chemistry | Protein Kinases - metabolism | Monomeric GTP-Binding Proteins - physiology | Phosphorylation | Immunoprecipitation | Amino Acids - chemistry | Neuropeptides - physiology | Dose-Response Relationship, Drug | Repressor Proteins - physiology | Amino Acids - metabolism | Carrier Proteins - chemistry | Guanine - chemistry | Protein Structure, Tertiary | Cell Line | Cells, Cultured | Gene Expression Regulation | Hydrogen Peroxide - pharmacology | Cycloheximide - pharmacology | Hydrolysis | Animals | Monomeric GTP-Binding Proteins - metabolism | Ribosomal Protein S6 - metabolism | Adenosine Triphosphate - chemistry | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Sorbitol - pharmacology | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 04/2016, Volume 7, Issue 1, pp. 11360 - 11360
The prenyl-binding protein PDEδ is crucial for the plasma membrane localization of prenylated Ras. Recently, we have reported that the small-molecule... 
Small Molecule Libraries - pharmacology | Epithelial Cells - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Pyrazoles - chemical synthesis | Antineoplastic Agents - chemical synthesis | Epithelial Cells - drug effects | Humans | Pancreatic Ducts - drug effects | Gene Expression Regulation, Neoplastic | Cyclic Nucleotide Phosphodiesterases, Type 6 - antagonists & inhibitors | Crystallography, X-Ray | Cyclic Nucleotide Phosphodiesterases, Type 6 - chemistry | Cyclic Nucleotide Phosphodiesterases, Type 6 - genetics | Pancreatic Ducts - pathology | Benzimidazoles - chemistry | Pancreatic Ducts - metabolism | Pyrazoles - chemistry | Proto-Oncogene Proteins p21(ras) - chemistry | Phosphodiesterase Inhibitors - chemical synthesis | Antineoplastic Agents - pharmacology | Protein Interaction Domains and Motifs | Phosphodiesterase Inhibitors - chemistry | Binding Sites | Proto-Oncogene Proteins p21(ras) - metabolism | Pyrazoles - pharmacology | Recombinant Proteins - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 6 - metabolism | Gene Expression | Protein Structure, Secondary | Signal Transduction | Phosphodiesterase Inhibitors - pharmacology | Recombinant Proteins - chemistry | Small Molecule Libraries - chemical synthesis | Epithelial Cells - pathology | Recombinant Proteins - genetics | Antineoplastic Agents - chemistry | Pyrazines - chemical synthesis | Pyrazines - chemistry | Small Molecule Libraries - chemistry | Proto-Oncogene Proteins p21(ras) - antagonists & inhibitors | Cell Line, Tumor | Protein Binding | Benzimidazoles - pharmacology | Molecular Docking Simulation | Pyrazines - pharmacology | Index Medicus
Journal Article
Journal Article