X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (35449) 35449
Book Review (4761) 4761
Publication (4638) 4638
Book Chapter (353) 353
Conference Proceeding (79) 79
Dissertation (39) 39
Book / eBook (23) 23
Government Document (22) 22
Newsletter (21) 21
Newspaper Article (12) 12
Magazine Article (10) 10
Reference (8) 8
Web Resource (8) 8
Data Set (4) 4
Trade Publication Article (2) 2
Paper (1) 1
Presentation (1) 1
Streaming Video (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (32384) 32384
humans (23423) 23423
animals (16173) 16173
oncology (10647) 10647
mutation (9943) 9943
mice (9397) 9397
female (8966) 8966
biochemistry & molecular biology (7918) 7918
male (7609) 7609
cell biology (7372) 7372
cancer (7256) 7256
ras (6679) 6679
signal transduction (6078) 6078
ras proteins - genetics (5745) 5745
ras proteins - metabolism (4970) 4970
middle aged (4920) 4920
genes, ras (4891) 4891
expression (4853) 4853
aged (4312) 4312
proteins (4296) 4296
research (4169) 4169
genetic aspects (4032) 4032
tumors (3931) 3931
proto-oncogene proteins - genetics (3842) 3842
adult (3740) 3740
molecular sequence data (3710) 3710
cell line, tumor (3597) 3597
proto-oncogene proteins p21 - genetics (3580) 3580
phosphorylation (3498) 3498
activation (3473) 3473
gene expression (3276) 3276
genetics & heredity (3212) 3212
proto-oncogene proteins p21 (3190) 3190
cell line (2958) 2958
apoptosis (2945) 2945
base sequence (2886) 2886
rats (2848) 2848
article (2834) 2834
k-ras (2812) 2812
transfection (2654) 2654
amino acid sequence (2626) 2626
analysis (2623) 2623
cells (2609) 2609
colorectal neoplasms - genetics (2606) 2606
gene expression regulation, neoplastic (2589) 2589
gene (2463) 2463
colorectal cancer (2439) 2439
multidisciplinary sciences (2394) 2394
prognosis (2385) 2385
genes (2300) 2300
mutations (2226) 2226
genes, ras - genetics (2164) 2164
lung neoplasms - genetics (2156) 2156
aged, 80 and over (2154) 2154
cells, cultured (2143) 2143
protein (2133) 2133
pathology (2086) 2086
immunohistochemistry (2042) 2042
proto-oncogene proteins b-raf - genetics (2039) 2039
growth (1993) 1993
cell proliferation (1984) 1984
kras (1980) 1980
polymerase chain reaction (1976) 1976
physiological aspects (1960) 1960
oncogenes (1935) 1935
kinases (1931) 1931
carcinoma (1892) 1892
metastasis (1855) 1855
proto-oncogene proteins p21 - metabolism (1832) 1832
tumor cells, cultured (1829) 1829
colorectal neoplasms - pathology (1766) 1766
phenotype (1758) 1758
abridged index medicus (1747) 1747
adenocarcinoma - genetics (1718) 1718
protein binding (1680) 1680
p53 (1668) 1668
health aspects (1666) 1666
dna mutational analysis (1633) 1633
research article (1623) 1623
cell transformation, neoplastic - genetics (1582) 1582
pathway (1581) 1581
mutation - genetics (1570) 1570
adenocarcinoma (1549) 1549
chemotherapy (1517) 1517
transformation (1492) 1492
gene mutations (1488) 1488
lung neoplasms - pathology (1477) 1477
gene-expression (1453) 1453
care and treatment (1448) 1448
enzyme activation (1437) 1437
dna (1435) 1435
signal transduction - physiology (1433) 1433
lung cancer (1403) 1403
identification (1386) 1386
tumor suppressor protein p53 - genetics (1386) 1386
biology (1369) 1369
blotting, western (1357) 1357
cell transformation, neoplastic (1349) 1349
proto-oncogene proteins - metabolism (1335) 1335
cell cycle (1333) 1333
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (34932) 34932
Japanese (221) 221
Chinese (201) 201
French (111) 111
Russian (74) 74
German (62) 62
Spanish (26) 26
Hungarian (15) 15
Polish (13) 13
Korean (11) 11
Czech (8) 8
Italian (7) 7
Hebrew (5) 5
Portuguese (4) 4
Danish (2) 2
Dutch (2) 2
Finnish (2) 2
Lithuanian (2) 2
Norwegian (2) 2
Romanian (2) 2
Swedish (2) 2
Arabic (1) 1
Croatian (1) 1
Serbian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


by McRae, Jeremy F and Clayton, Stephen and Fitzgerald, Tomas W and Kaplanis, Joanna and Prigmore, Elena and Rajan, Diana and Sifrim, Alejandro and Aitken, Stuart and Akawi, Nadia and Alvi, Mohsan and Ambridge, Kirsty and Barrett, Daniel M and Bayzetinova, Tanya and Jones, Philip and Jones, Wendy D and King, Daniel and Krishnappa, Netravathi and Mason, Laura E and Singh, Tarjinder and Tivey, Adrian R and Ahmed, Munaza and Anjum, Uruj and Archer, Hayley and Armstrong, Ruth and Awada, Jana and Balasubramanian, Meena and Banka, Siddharth and Baralle, Diana and Barnicoat, Angela and Batstone, Paul and Baty, David and Bennett, Chris and Berg, Jonathan and Bernhard, Birgitta and Bevan, A. Paul and Bitner-Glindzicz, Maria and Blair, Edward and Blyth, Moira and Bohanna, David and Bourdon, Louise and Bourn, David and Bradley, Lisa and Brady, Angela and Brent, Simon and Brewer, Carole and Brunstrom, Kate and Bunyan, David J and Burn, John and Canham, Natalie and Castle, Bruce and Chandler, Kate and Chatzimichali, Elena and Cilliers, Deirdre and Clarke, Angus and Clasper, Susan and Clayton-Smith, Jill and Clowes, Virginia and Coates, Andrea and Cole, Trevor and Colgiu, Irina and Collins, Amanda and Collinson, Morag N and Connell, Fiona and Cooper, Nicola and Cox, Helen and Cresswell, Lara and Cross, Gareth and Crow, Yanick and D'Alessandro, Mariella and Dabir, Tabib and Davidson, Rosemarie and Davies, Sally and De Vries, Dylan and Dean, John and Deshpande, Charu and Devlin, Gemma and Dixit, Abhijit and Dobbie, Angus and Donaldson, Alan and Donnai, Dian and Donnelly, Deirdre and Donnelly, Carina and Douglas, Angela and Douzgou, Sofia and Duncan, Alexis and Eason, Jacqueline and Ellard, Sian and Ellis, Ian and Elmslie, Frances and Evans, Karenza and Everest, Sarah and Fendick, Tina and Fisher, Richard and Flinter, Frances and Foulds, Nicola and Fry, Andrew and Fryer, Alan and Gardiner, Carol and Gaunt, Lorraine and Ghali, Neeti and ... and Deciphering Developmental Disorders Study
Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7642, pp. 433 - 438
The genomes of individuals with severe, undiagnosed developmental disorders are enriched in damaging de novo mutations (DNMs) in developmentally important... 
INTELLECTUAL DISABILITY | METAANALYSIS | VARIANTS | GENETICS | HEART-DEFECTS | MULTIDISCIPLINARY SCIENCES | GENES | SEQUENCE | FRAMEWORK | DISCOVERY | GENOME | Prevalence | Humans | Middle Aged | Parents | Male | Mi-2 Nucleosome Remodeling and Deacetylase Complex - genetics | Developmental Disabilities - genetics | Casein Kinase II - genetics | Autoantigens - genetics | Young Adult | ras GTPase-Activating Proteins - genetics | Adult | Female | Child | CDC2 Protein Kinase - genetics | Histone-Lysine N-Methyltransferase - genetics | Repressor Proteins - genetics | Sex Characteristics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Nerve Tissue Proteins - genetics | Sequence Analysis, DNA | Homeodomain Proteins - genetics | DEAD-box RNA Helicases - genetics | Exome - genetics | Phenotype | Myeloid-Lymphoid Leukemia Protein - genetics | Adolescent | Heredity - genetics | Protein Phosphatase 2C - genetics | Cohort Studies | Child development deviations | Genetic aspects | Genetic disorders | Developmental disabilities | Distribution | Genes | Families & family life | Births | Genomes | Mutation | Causality | Estimates | Age | Index Medicus | TRIO | MYT1L | EHMT1 | HNRNPU | SUV420H1 | COL4A3BP | SYNGAP1 | PPP2R1A | POGZ | EP300 | KCNH1 | SCN1A | MEF2C | CDKL5 | CSNK2A1 | DYRK1A | CASK | ALG13 | FOXP1 | KAT6B | TBL1XR1 | KAT6A | SCN8A | KCNQ2 | EEF1A2 | KCNQ3 | ADNP | PhenIcons | SET | KMT2A | ANKRD11 | STXBP1 | FOXG1 | ZC4H2 | ITPR1 | De novo mutation | Seizures | ZBTB18 | CREBBP | SMAD4 | PDHA1 | IQSEC2 | AUTS2 | BCL11A | BRAF | SMARCA2 | GRIN2B | MED13L | GNAO1 | CNOT3 | TCF4 | SCN2A | CDK13 | GABRB3 | SETD5 | KDM5B | Developmental Disease | DDX3X | CHD8 | PTEN | CHD4 | TCF20 | CTCF | CHD2 | WDR45 | SLC6A1 | MECP2 | CHAMP1 | KIF1A | Average Faces | MSL3 | PPP2R5D | SMC1A | ARID1B | DNM1 | CNKSR2 | PACS1 | WAC | ZMYND11 | AHDC1 | NFIX | SATB2 | HDAC8 | PPM1D | GNAI1 | PURA | PUF60 | NSD1 | Intellectual Disability | SLC35A2 | DYNC1H1 | NAA10 | USP9X | PTPN11 | GATAD2B | ASXL1 | KANSL1 | ASXL3 | CTNNB1 | QRICH1
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 12/2013, Volume 31, Issue 34, pp. 4333 - 4342
Purpose The Group for Research in Adult Acute Lymphoblastic Leukemia (GRAALL) recently reported a significantly better outcome in T-cell acute lymphoblastic... 
REGRESSION | ACTIVATION | THERAPY | NOTCH1 | PRETHYMIC PHENOTYPE | ONCOLOGY | PATHWAY | GENES | PTEN | MUTATIONS | EXPRESSION | F-Box-WD Repeat-Containing Protein 7 | Multivariate Analysis | Predictive Value of Tests | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Humans | Male | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - mortality | Young Adult | Time Factors | DNA Mutational Analysis | Gene Deletion | Cell Cycle Proteins - genetics | Adult | Female | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - therapy | PTEN Phosphohydrolase - genetics | Genetic Predisposition to Disease | Membrane Proteins - genetics | Risk Factors | Kaplan-Meier Estimate | Proportional Hazards Models | Proto-Oncogene Proteins - genetics | Disease-Free Survival | Phenotype | GTP Phosphohydrolases - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - classification | Mutation | Receptor, Notch1 - genetics | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Index Medicus | GTP Phosphohydrolases | ras Proteins | Innate immunity | Life Sciences | F-Box Proteins | Immunology | PTEN Phosphohydrolase | Proto-Oncogene Proteins | Membrane Proteins | Ubiquitin-Protein Ligases | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Receptor, Notch1 | Cell Cycle Proteins
Journal Article
Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, pp. 6744 - 6744
Pancreatic ductal adenocarcinoma (PDA) has a dismal prognosis and insights into both disease etiology and targeted intervention are needed. A total of 109... 
SIGNATURES | MODELS | DUCTAL ADENOCARCINOMA | MULTIDISCIPLINARY SCIENCES | TUMOR | SOMATIC MUTATION | COPY-NUMBER ALTERATION | GENOMIC CHARACTERIZATION | CARCINOMA | PROGRESSION | DISCOVERY | Cell Cycle - genetics | RNA-Binding Proteins - genetics | Prognosis | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Middle Aged | Carcinoma, Adenosquamous - drug therapy | Male | Antineoplastic Agents - therapeutic use | DNA Repair - genetics | Molecular Targeted Therapy | Tumor Suppressor Protein p53 - genetics | Carcinoma, Pancreatic Ductal - genetics | DNA Copy Number Variations | Genetic Variation | Pancreatic Neoplasms - drug therapy | Aged, 80 and over | Adult | Female | Nuclear Proteins - genetics | Carcinoma, Adenosquamous - pathology | Pancreatic Neoplasms - pathology | Kaplan-Meier Estimate | Pancreatic Neoplasms - genetics | Carcinoma, Adenosquamous - genetics | Transcription Factors - genetics | Carcinoma, Pancreatic Ductal - pathology | Sequence Analysis, DNA | Carcinoma, Pancreatic Ductal - drug therapy | Drug Resistance, Neoplasm - genetics | Exome - genetics | Gene Amplification | Sulfonamides - therapeutic use | Wnt Signaling Pathway - genetics | Proto-Oncogene Proteins B-raf - genetics | Retinoblastoma Protein - genetics | Genes, myc - genetics | Indoles - therapeutic use | Aged | BRCA2 Protein - genetics | Index Medicus
Journal Article
by Burk, Robert D and Chen, Zigui and Saller, Charles and Tarvin, Katherine and Carvalho, Andre L and Scapulatempo-Neto, Cristovam and Silveira, Henrique C and Fregnani, José H and Creighton, Chad J and Anderson, Matthew L and Castro, Patricia and Wang, Sophia S and Yau, Christina and Benz, Christopher and Gordon Robertson, A and Mungall, Karen and Lim, Lynette and Bowlby, Reanne and Sadeghi, Sara and Brooks, Denise and Sipahimalani, Payal and Mar, Richard and Ally, Adrian and Clarke, Amanda and Mungall, Andrew J and Tam, Angela and Lee, Darlene and Chuah, Eric and Schein, Jacqueline E and Tse, Kane and Kasaian, Katayoon and Ma, Yussanne and Marra, Marco A and Mayo, Michael and Balasundaram, Miruna and Thiessen, Nina and Dhalla, Noreen and Carlsen, Rebecca and Moore, Richard A and Holt, Robert A and Jones, Steven J. M and Wong, Tina and Pantazi, Angeliki and Parfenov, Michael and Kucherlapati, Raju and Hadjipanayis, Angela and Seidman, Jonathan and Kucherlapati, Melanie and Ren, Xiaojia and Xu, Andrew W and Yang, Lixing and Park, Peter J and Lee, Semin and Rabeno, Brenda and Huelsenbeck-Dill, Lori and Borowsky, Mark and Cadungog, Mark and Iacocca, Mary and Petrelli, Nicholas and Swanson, Patricia and Ojesina, Akinyemi I and Ojesina, Akinyemi I and Ojesina, Akinyemi I and Le, Xuan and Sandusky, George and Adebamowo, Sally N and Akeredolu, Teniola and Adebamowo, Clement and Reynolds, Sheila M and Shmulevich, Ilya and Shelton, Candace and Crain, Daniel and Mallery, David and Curley, Erin and Gardner, Johanna and Penny, Robert and Morris, Scott and Shelton, Troy and Liu, Jia and Lolla, Laxmi and Chudamani, Sudha and Wu, Ye and Birrer, Michael and McLellan, Michael D and Bailey, Matthew H and Miller, Christopher A and Wyczalkowski, Matthew A and Fulton, Robert S and Fronick, Catrina C and Lu, Charles and Mardis, Elaine R and Appelbaum, Elizabeth L and Schmidt, Heather K and Fulton, Lucinda A and Cordes, Matthew G and Li, Tiandao and Ding, Li and Wilson, Richard K and Rader, Janet S and Behmaram, Behnaz and ... and Canc Genome Atlas Res Network and Eli &Edythe L. Broad Institute of Massachusetts Institute of Technology &Harvard University and Research Institute at Nationwide Children's Hospital and University of Alabama at Birmingham and McDonnell Genome Institute at Washington University and Washington University in St Louis and University of Wisconsin School of Medicine &Public Health and National Hospital, Abuja, Nigeria and Baylor College of Medicine and Barretos Cancer Hospital and Indiana University School of Medicine and Ontario Tumour Bank, The Ottawa Hospital and Massachusetts General Hospital and University of New Mexico Health Sciences Center and National Institute on Deafness &Other Communication Disorders and University of North Carolina at Chapel Hill and Buck Institute for Research on Aging and Cancer Genome Atlas Research Network and Medical College of Wisconsin and University of Abuja Teaching Hospital and University of Oklahoma Health Sciences Center and Institute of Human Virology and St Joseph's Candler Health System and University of Pittsburgh and University of Texas MD Anderson Cancer Center and National Cancer Institute and Montefiore Medical Center and University of Southern California and Institute for Systems Biology and University of Washington and Analytical Biological Services and Harvard Medical School and National Human Genome Research Institute and Memorial Sloan Kettering Cancer Center and Medical University of South Carolina and Ontario Tumour Bank, London Health Sciences Centre and SRA International and University of Kansas Medical Center and University of Lausanne and ILSbio, LLC and University of Bergen and University of California, Irvine and Canada's Michael Smith Genome Sciences Centre and International Genomics Consortium and Oregon Health &Science University and NantOmics and Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University and University of São Paulo, Ribeir ão Preto Medical School and HudsonAlpha Institute for Biotechnology and Albert Einstein College of Medicine and Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center and National Institute of Environmental Health Sciences and Van Andel Research Institute and Ontario Tumour Bank, Ontario Institute for Cancer Research and University of California Santa Cruz and Beckman Research Institute of City of Hope and Leidos Biomedical and Helen F. Graham Cancer Center &Research Institute at Christiana Care Health Services and The Cancer Genome Atlas Research Network
Nature, ISSN 0028-0836, 03/2017, Volume 543, Issue 7645, pp. 378 - 384
Cervical cancer remains one of the leading causes of cancer-related deaths worldwide. Here we report the extensive molecular characterization of 228 primary... 
TRANSCRIPTION FACTORS | BREAST-CANCER | TO-MESENCHYMAL TRANSITION | ACCURATE | DNA METHYLATION | RNA-SEQ | MULTIDISCIPLINARY SCIENCES | 14-3-3-SIGMA | RESISTANCE | EXPRESSION | SIGNATURE | Receptors, Transforming Growth Factor beta - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Carcinoma, Squamous Cell - genetics | Genomics | Humans | APOBEC-1 Deaminase - genetics | Phosphatidylinositol 3-Kinases - metabolism | Molecular Targeted Therapy | Caspase 8 - genetics | Mitogen-Activated Protein Kinase Kinases - metabolism | Human papillomavirus 16 - isolation & purification | Female | Adenocarcinoma - genetics | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | PTEN Phosphohydrolase - genetics | Signal Transduction | Programmed Cell Death 1 Ligand 2 Protein - genetics | Protein-Serine-Threonine Kinases - genetics | Uterine Cervical Neoplasms - drug therapy | RNA, Long Noncoding - genetics | Receptor, ErbB-3 - genetics | Transcription Factors - genetics | Uterine Cervical Neoplasms - genetics | Virus Integration | B7-H1 Antigen - genetics | Receptors, Transforming Growth Factor beta - metabolism | HLA-A Antigens - genetics | Proteomics | Mutation | Keratins - genetics | Human papillomavirus 16 - genetics | Uterine Cervical Neoplasms - classification | Causes of | Care and treatment | Genetic aspects | Gene mutations | Health aspects | Cervical cancer | Human papillomavirus | Gynecology | Molecular biology | Cancer therapies | Tumors | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 07/2011, Volume 475, Issue 7354, pp. 106 - 110
Reactive oxygen species (ROS) are mutagenic and may thereby promote cancer(1). Normally, ROS levels are tightly controlled by an inducible antioxidant program... 
TRANSFORMATION | OXIDATIVE STRESS | ACTIVATION | INHIBITION | K-RAS | PATHWAY | MULTIDISCIPLINARY SCIENCES | PANCREATIC-CANCER | HEME OXYGENASE-1 | MUTATIONS | EXPRESSION | NIH 3T3 Cells | Cell Proliferation | Pancreatic Neoplasms - metabolism | Reactive Oxygen Species - metabolism | Cytoskeletal Proteins - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Antioxidants - metabolism | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | MAP Kinase Signaling System | Mitogen-Activated Protein Kinase Kinases - metabolism | Cell Transformation, Neoplastic - genetics | Cytoskeletal Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Intracellular Signaling Peptides and Proteins - genetics | Kelch-Like ECH-Associated Protein 1 | Proto-Oncogene Proteins B-raf - metabolism | Fibroblasts - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Oncogenes - genetics | Oxidation-Reduction | Pancreatic Neoplasms - pathology | Cells, Cultured | Pancreatic Neoplasms - genetics | NF-E2-Related Factor 2 - deficiency | Cell Transformation, Neoplastic - metabolism | Animals | Proto-Oncogene Proteins B-raf - genetics | Genes, myc - genetics | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Alleles | Cell Line, Tumor | Mice | Adaptor Proteins, Signal Transducing - metabolism | Cell Transformation, Neoplastic - pathology | Polymerase chain reaction | Usage | Reactive oxygen species | Physiological aspects | Research | Gene expression | Oncogenes | Studies | Mass spectrometry | Rodents | Evacuations & rescues | Cancer | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 08/2009, Volume 460, Issue 7257, pp. 904 - 908
Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to loss of heterozygosity. aUPD is associated not only with loss-of-function... 
TRANSFORMATION | PROTEIN | RETROVIRAL VECTOR GCDNSAP | NEGATIVE REGULATION | MULTIDISCIPLINARY SCIENCES | HEMATOPOIETIC STEM-CELLS | V-CBL | MUTATIONS | UBIQUITIN LIGASES | MYELODYSPLASTIC SYNDROMES | P53 | NIH 3T3 Cells | Neoplasm Transplantation | ras Proteins - genetics | Phosphorylation | Proto-Oncogene Proteins c-cbl - metabolism | Humans | Leukemia, Myeloid - genetics | Molecular Sequence Data | ras Proteins - metabolism | Male | Leukemia, Myeloid - pathology | Allelic Imbalance | Ubiquitination | Base Sequence | Female | Proto-Oncogene Proteins c-cbl - deficiency | Genes, Tumor Suppressor | Proto-Oncogene Proteins c-cbl - genetics | Amino Acid Sequence | Oncogenes - genetics | Mutant Proteins - genetics | Models, Molecular | Mutant Proteins - metabolism | Chromosomes, Human, Pair 11 - genetics | Proto-Oncogene Proteins c-cbl - chemistry | Mice, Knockout | Animals | Uniparental Disomy - genetics | Leukemia, Myeloid - metabolism | Mice, Nude | Mutant Proteins - chemistry | Proto-Oncogene Proteins c-cbl - antagonists & inhibitors | Protein Conformation | Mice | Mutation | Gene mutations | Myelocytic leukemia | Physiological aspects | Tumor suppressor genes | Development and progression | Genetic aspects | Nonlymphoid leukemia | Research | Protein kinases | Proteins | Genes | Amino acids | Kinases | Cells | Clinical outcomes | Crystal structure | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 547 - 559
In mice, deletion and activation of results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these primary and... 
CELLCYCLE | SIGNALING | EPITHELIAL-MESENCHYMAL TRANSITION | ONCOGENIC K-RAS | CANCER-CELLS | SUPPRESSOR | GENE | ONCOLOGY | SRC | KINASE INHIBITOR | EXPRESSION PROFILES | MUTATIONS | TUMORIGENESIS | Lung Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - deficiency | Protein-Tyrosine Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Genomics | Humans | Lung Neoplasms - metabolism | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Cell Movement - genetics | Phosphorylation - genetics | RNA Interference | Gene Expression Regulation, Neoplastic - genetics | MAP Kinase Kinase 1 - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - metabolism | Signal Transduction - genetics | Enzyme Inhibitors - therapeutic use | Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors | Focal Adhesion Protein-Tyrosine Kinases - genetics | Focal Adhesions - genetics | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Mice | TOR Serine-Threonine Kinases | src-Family Kinases - genetics | Protein-Tyrosine Kinases - antagonists & inhibitors | ras Proteins - genetics | Lung Neoplasms - pathology | Cell Transdifferentiation - genetics | Protein-Tyrosine Kinases - genetics | Neoplasm Metastasis - drug therapy | Mice, Mutant Strains | Protein-Serine-Threonine Kinases - antagonists & inhibitors | src-Family Kinases - metabolism | Female | Drug Therapy, Combination | Lung Neoplasms - genetics | Cell Adhesion - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Up-Regulation - genetics | Xenograft Model Antitumor Assays | Neoplasm Metastasis - genetics | Animals | MAP Kinase Kinase 2 - antagonists & inhibitors | Protein Kinase Inhibitors - therapeutic use | Focal Adhesions - metabolism | Proteomics | Protein Kinase Inhibitors - pharmacology | Oncology, Experimental | Analysis | Lung cancer | Development and progression | Metastasis | Research | Cancer | Index Medicus
Journal Article