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mAbs, ISSN 1942-0862, 09/2014, Volume 6, Issue 5, pp. 1265 - 1273
We report a chimeric monoclonal antibody (mAb) directed to a neo-epitope that is exposed in the IgG lower hinge following proteolytic cleavage. The mAb,... 
chimeric antibody | complement-dependent cytotoxicity | IgG fragments | antibody-dependent cell-mediated cytotoxicity | hinge region | Hinge region | Complement-dependent cytotoxicity | Antibody-dependent cell-mediated cytotoxicity | Chimeric antibody | AUTOANTIBODIES | MEDICINE, RESEARCH & EXPERIMENTAL | FC-GAMMA RECEPTORS | SPECIFICITY | SUBCLASSES | TUMOR-CELLS | IDES | IMMUNOGENICITY | ANTI-F(AB) | IMMUNOGLOBULIN-G | BINDING | Blood Platelets - immunology | Epitopes - metabolism | Humans | Antibody-Dependent Cell Cytotoxicity - immunology | Epitopes - immunology | Cysteine Endopeptidases - metabolism | Immunoglobulin Fab Fragments - metabolism | Immunoglobulin G - immunology | Proteolysis | Antibodies, Monoclonal - immunology | Cell Line | Antibodies, Monoclonal, Murine-Derived - immunology | Enzyme-Linked Immunosorbent Assay | Antibodies, Monoclonal - pharmacology | Antibodies, Monoclonal, Murine-Derived - metabolism | Rats | Rituximab | Matrix Metalloproteinase 3 - metabolism | Immunoglobulin Fab Fragments - pharmacology | Animals | Platelet Count | Blood Platelets - metabolism | Dogs | Cell Line, Tumor | Bacterial Proteins - metabolism | Antibodies, Monoclonal - metabolism | Immunoglobulin Fab Fragments - immunology | Antibodies, Monoclonal, Murine-Derived - pharmacology | Antibody-Dependent Cell Cytotoxicity - drug effects | Immunoglobulin G - metabolism
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 6, p. e21246
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Journal of the American Society of Nephrology, ISSN 1046-6673, 06/2011, Volume 22, Issue 6, pp. 1137 - 1143
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