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Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2013, Volume 133, Issue 4, pp. 1099 - 1108.e12
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 02/2019, Volume 143, Issue 2, pp. 726 - 735
Mutations in recombination-activating gene (RAG) 1 and RAG2 are associated with a broad range of clinical and immunologic phenotypes in human subjects. Using a... 
Recombination-activating gene 2 | autoimmunity | VDJ recombination | severe combined immunodeficiency | Omenn syndrome | genotype-phenotype correlation | DEFECTS | V(D)J RECOMBINATION | IMMUNE-DEFICIENCY | OMENN-SYNDROME | IMMUNOLOGY | ALLERGY | DISEASE | SPECTRUM | RAG1/2 | Autoimmunity | Genetic research | Genetic aspects | Genes
Journal Article
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 134, Issue 6, pp. 1375 - 1380
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 2003, Volume 19, Issue 1, pp. 21 - 31
V-H replacement has been proposed as one way to modify unwanted antibody specificities, but analysis of this mechanism has been limited without a dynamic... 
IN-VITRO | 2 STEPS | RECOMBINATION-ACTIVATING GENE | RECEPTOR REVISION | RAG2 PROTEINS | MECHANISM | VARIABLE REGION GENES | HEAVY-CHAIN GENE | V(D)J RECOMBINATION | IMMUNOLOGY | SELF-TOLERANCE
Journal Article
Developmental and Comparative Immunology, ISSN 0145-305X, 04/2018, Volume 81, pp. 105 - 115
The and genes form a recombinase complex that is indispensable for V(D)J recombination, which generates the diversity of immunoglobulins and T-cell receptors.... 
Bidirectional promoter | NWC gene | Evolution of the adaptive immune system | RAG transposon | END-JOINING PATHWAY | V(D)J RECOMBINATION | IMMUNOLOGY | IDENTIFICATION | LOCUS | GENOME | RECOMBINATION ACTIVATING GENE | FISHERIES | ZOOLOGY | INTEGRATION | MICE | PROTEINS | EXPRESSION
Journal Article
Journal of Immunological Methods, ISSN 0022-1759, 12/2017, Volume 451, pp. 71 - 77
Antigen receptor gene assembly is accomplished in developing lymphocytes by the V(D)J recombination reaction, which can be separated into two steps: DNA... 
Nonhomologous end joining (NHEJ) | v-Abl transformed pro-B cells | Recombination-activating gene (RAG) endonuclease | CRISPR/Cas9-mediated gene knock-out | V(D)J recombination | STRAND BREAK REPAIR | XRCC4 | BIOCHEMICAL RESEARCH METHODS | IMMUNOLOGY | GENOME | XLF | PAXX | PATHWAY | LIGASE IV | MICE | END RESECTION | DIFFERENTIATION | Apoptosis - drug effects | Homeodomain Proteins - metabolism | Oncogene Proteins v-abl - antagonists & inhibitors | Precursor Cells, B-Lymphoid - metabolism | Precursor Cells, B-Lymphoid - drug effects | DNA Breaks, Double-Stranded | DNA-Binding Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Precursor Cells, B-Lymphoid - pathology | DNA End-Joining Repair | Clustered Regularly Interspaced Short Palindromic Repeats | Recombinational DNA Repair - drug effects | CRISPR-Associated Proteins - genetics | Imatinib Mesylate - pharmacology | Oncogene Proteins v-abl - genetics | Mice, Inbred C57BL | Genotype | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Oncogene Proteins v-abl - metabolism | Phenotype | Animals | CRISPR-Associated Proteins - metabolism | CRISPR-Cas Systems | Gene Editing - methods | Protein Kinase Inhibitors - pharmacology | G1 Phase Cell Cycle Checkpoints - drug effects | Proto-Oncogene Proteins c-bcl-2 - genetics | Cell Line, Transformed | CRISPR | Cas9-mediated gene knock-out
Journal Article
Journal Article