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PLoS ONE, ISSN 1932-6203, 03/2016, Volume 11, Issue 3, p. e0152591
Background Nicotine is, to a large extent, responsible for smoking-mediated renal dysfunction. This study investigated nicotine's effects on renal tubular... 
KIDNEY-DISEASE | SIGNALING PATHWAYS | CIGARETTE-SMOKING | OXIDATIVE STRESS | RISK-FACTORS | ACETYLCHOLINE-RECEPTOR GENES | MULTIDISCIPLINARY SCIENCES | INJURY | DEATH | PROGRESSION | AMERICAN-INDIANS | Cell Survival - drug effects | Kidney Tubules, Proximal - cytology | M Phase Cell Cycle Checkpoints - drug effects | Receptors, Nicotinic - metabolism | Epithelial Cells - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | NF-kappa B - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Nicotine - pharmacology | G2 Phase Cell Cycle Checkpoints - drug effects | Kidney Tubules, Proximal - metabolism | Epithelial Cells - cytology | Physiological aspects | Genetic aspects | Research | Epithelial cells | Nicotine | Apoptosis | Cdc2 protein | Oxidative stress | Flow cytometry | Cysteine | Transcription factors | Renal function | Bax protein | Bcl-2 protein | Kinases | Medical schools | Proteins | Signal transduction | Receptors | Rodents | Cell cycle | Physiology | Pretreatment | Deoxyribonucleic acid--DNA | NF-κB protein | Immunoglobulins | Internal medicine | Intracellular levels | Extracellular signal-regulated kinase | c-Jun protein | MAP kinase | Gene expression | Cigarettes | Medicine | Studies | Cytometry | Signaling | Inhibitors | Protein kinase | Acetylcholine receptors | Acetylcholine receptors (nicotinic) | N-Acetyl-L-cysteine | Kidney diseases | Diabetes | Hexamethonium | Viability | Histone H3 | Clear cell-type renal cell carcinoma | Smoking | Kidney transplantation | Cancer | Deoxyribonucleic acid | DNA | Acetylcholine
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, p. e0167848
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, p. e30771
Background: Hypoxia-induced renal tubular cell epithelial-mesenchymal transition (EMT) is an important event leading to renal fibrosis. MicroRNAs (miRNAs) are... 
HEPATOCELLULAR-CARCINOMA | REPRESSION | MULTIDISCIPLINARY SCIENCES | GROWTH | TRANSCRIPTION | E-CADHERIN | MESENCHYMAL TRANSITION | EXPRESSION | CANCER | RENAL FIBROGENESIS | FAMILY | Epithelial Cells - metabolism | Receptors, Notch - metabolism | Humans | Molecular Sequence Data | Epithelial-Mesenchymal Transition - genetics | RNA, Messenger - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Kidney Failure, Chronic - pathology | Serrate-Jagged Proteins | Base Sequence | Membrane Proteins - metabolism | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Cell Line | Kidney Tubules, Proximal - cytology | Membrane Proteins - genetics | RNA, Messenger - genetics | Intercellular Signaling Peptides and Proteins - genetics | Epithelial Cells - pathology | Signal Transduction - genetics | Down-Regulation - genetics | Kidney Failure, Chronic - genetics | MicroRNAs - genetics | Cell Hypoxia - genetics | Calcium-Binding Proteins - genetics | RNA, Small Interfering - metabolism | Infection | MicroRNA | Intermediate filament proteins | Analysis | Genes | Stem cells | Vimentin | Nephrology | Mesenchyme | Epithelial cells | Arthritis | mRNA | E-cadherin | Signal transduction | Reporter gene | Transfection | Rodents | Tumorigenesis | Jagged1 protein | Growth factors | Kidneys | MiRNA | Melanoma | siRNA | Gene expression | Polymerase chain reaction | Ribonucleic acids | Fibrosis | Hypoxia | Ligands | Notch protein | Non-coding RNA | Clear cell-type renal cell carcinoma | Cancer
Journal Article
Journal of the American Society of Nephrology, ISSN 1046-6673, 03/2018, Volume 29, Issue 3, pp. 919 - 935
Albuminuria is a key instigator of tubulointerstitial inflammation associated with CKD, but the mechanism through which filtered albumin propagates renal... 
ACTIVATION | EXTRACELLULAR VESICLES | URINARY EXOSOME | MECHANISM | BIOMARKER | RENAL INFLAMMATION | DISEASE | PHENOTYPE | UROLOGY & NEPHROLOGY | NLRP3 INFLAMMASOME | COMMUNICATION | albuminuria | macrophages | CCL2 | mRNA | exosome | extracellular vesicle | Basic Research
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 11/2019, Volume 519, Issue 3, pp. 620 - 625
Renal tubular epithelial cells (RTECs) play pivotal roles in the innate immune response in kidneys. Dendritic cell specific intracellular adhesion molecule–3... 
mTOR | Renal tubular epithelial cells | DC-SIGN | RUNX1
Journal Article
Journal Article
American journal of physiology. Renal physiology, ISSN 0363-6127, 01/2019, Volume 316, Issue 1, pp. F186 - F194
Nudel is a newly discovered factor related to cell migration. The tubular epithelial-mesenchymal transition (EMT) includes four steps: the loss of the adhesive... 
high glucose | Nudel | renal proximal tubular epithelial cells | EMT | WASP | NEURONAL MIGRATION | CYTOPLASMIC DYNEIN | FIBROSIS | DEFECTS | PHYSIOLOGY | high glucose Nudel | PROTEIN | TRANSPORT | PATHWAY | LIS1 | UROLOGY & NEPHROLOGY
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 05/2019, Volume 851, pp. 1 - 12
Cisplatin is a widely used chemotherapeutic drug that often causes acute kidney injury (AKI) in cancer patients. The contribution of miRNAs to the... 
Renal tubular epithelial cells | MicroRNAs | Cisplatin | Apoptosis | ACUTE KIDNEY INJURY | PHARMACOLOGY & PHARMACY | HIPK2 | Antimitotic agents | Medical colleges | Chemotherapy | DNA microarrays | Messenger RNA | MicroRNA | Analysis | Genetic transcription | Tumor proteins | Antineoplastic agents | Cancer
Journal Article
Journal of the American Society of Nephrology, ISSN 1046-6673, 04/2018, Volume 29, Issue 4, pp. 1238 - 1256
Cellular senescence is associated with renal disease progression, and accelerated tubular cell senescence promotes the pathogenesis of renal fibrosis. However,... 
PROTEIN | KIDNEY FIBROSIS | PATHWAY | DNA-DAMAGE | DISEASE | UROLOGY & NEPHROLOGY | IGA NEPHROPATHY | DIABETIC-NEPHROPATHY | EXPRESSION | PROGRESSION | MATRIX METALLOPROTEINASE-7 | Wnt9a | fibroblasts | tubular cells | renal fibrosis | Basic Research | cell senescence
Journal Article
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 05/2019, Volume 316, Issue 5, pp. F1006 - F1015
Experimental studies have shown that pharmacological activation of calcium-sensing receptor (CaSR) attenuates renal fibrosis in some animal models beyond... 
Calcium-sensing receptor | Proximal tubular epithelial cells | Renal fibrosis | Collagen | FIBROSIS | PHYSIOLOGY | TGF-BETA | collagen | INJURY | calcium-sensing receptor | MECHANISMS | renal fibrosis | CALCIMIMETIC R-568 | CHRONIC KIDNEY | DAMAGE | proximal tubular epithelial cells | UROLOGY & NEPHROLOGY | COMMON | PROGRESSION | SNAIL
Journal Article