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1. Full Text Quality control in the initiation of eukaryotic DNA replication
by John F. X. Diffley
Philosophical Transactions: Biological Sciences, ISSN 0962-8436, 12/2011, Volume 366, Issue 1584, pp. 3545 - 3553
Origins of DNA replication must be regulated to ensure that the entire genome is replicated precisely once in each cell cycle. In human cells, this requires... 
Replication origin | Yeasts | DNA replication | Phosphorylation | Interphase | DNA | Cell cycle | Gene expression regulation | Eukaryotic cells | Saccharomycetales | Articles | BIOLOGY | biochemistry | S phase | Bacteria - metabolism | Humans | Cell Cycle Proteins - metabolism | DNA Replication | Origin Recognition Complex - metabolism | Eukaryota - metabolism | Bacteria - genetics | Animals | Eukaryota - genetics | Cell Cycle | Replication Origin | Cell Cycle Proteins - genetics | Origin Recognition Complex - genetics | Review | cell cycle | 1001
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2. Full Text The ADP-ribosyltransferase PARP10/ARTD10 interacts with proliferating cell nuclear antigen (PCNA) and is required for DNA damage tolerance
by Nicolae, Claudia M and Aho, Erin R and Vlahos, Alexander H. S and Choe, Katherine N and De, Subhajyoti and Karras, Georgios I and Moldovan, George-Lucian
Journal of Biological Chemistry, ISSN 0021-9258, 1768, Volume 289, Issue 19, pp. 13627 - 13637
Background: PCNA mono-ubiquitination at stalled replication forks recruits translesion synthesis polymerases for fork restart. Results: The... 
Genomic Instability | POLY(ADP-RIBOSE) | PCNA | Translesion Synthesis | PROTEIN | UBIQUITIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA Replication | GENOME STABILITY | MONOUBIQUITINATED PCNA | REPAIR | DNA Repair | REPLICATION FORK | S-PHASE | DNA Damage | HOMOLOGOUS RECOMBINATION | DVC1 C1ORF124 | ADP-ribosylation | Proto-Oncogene Proteins - metabolism | Humans | Proto-Oncogene Proteins - genetics | DNA-Directed DNA Polymerase - genetics | Poly(ADP-ribose) Polymerases - metabolism | Poly(ADP-ribose) Polymerases - genetics | Proliferating Cell Nuclear Antigen - genetics | DNA Replication - genetics | Sumoylation | Protein Processing, Post-Translational | DNA-Directed DNA Polymerase - metabolism | HeLa Cells | Proliferating Cell Nuclear Antigen - metabolism | DNA and Chromosomes
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3. Full Text A role for DNA polymerase θ in promoting replication through oxidative DNA lesion, thymine glycol, in human cells
by Yoon, Jung-Hoon and Choudhury, Jayati Roy and Park, Jeseong and Prakash, Satya and Prakash, Louise
Journal of Biological Chemistry, ISSN 0021-9258, 1768, Volume 289, Issue 19, pp. 13177 - 13185
Background: Little is known of biological functions of DNA polymerase (pol) in human cells. Results: pol promotes replication through the common oxidation... 
LOW-FIDELITY | BYPASS | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | STABLE REPLICATION | TRANSLESION SYNTHESIS | DNA Replication | DAMAGE | DUPLEX DNA | Lesion Bypass | PLASMID ORIGIN | DNA Polymerase | LATENT ORIGIN | DNA | DNA Repair | DNA Damage | Thymine Glycol | EPSTEIN-BARR-VIRUS | Protein Structure, Tertiary | Cell Line | Fibroblasts - enzymology | DNA Replication - physiology | Oxidation-Reduction | Humans | Thymine - analogs & derivatives | Fibroblasts - cytology | DNA-Directed DNA Polymerase - metabolism | DNA-Directed DNA Polymerase - genetics | Thymine - metabolism | DNA Polymerase θ | DNA and Chromosomes
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4. Full Text Evidence for the kinetic partitioning of polymerase activity on G-quadruplex DNA
by Eddy, Sarah and Maddukuri, Leena and Ketkar, Amit and Zafar, Maroof K and Henninger, Erin E and Pursell, Zachary F and Eoff, Robert L
Biochemistry, ISSN 0006-2960, 05/2015, Volume 54, Issue 20, pp. 3218 - 3230
We have investigated the action of the human DNA polymerase epsilon (hpol epsilon) and eta (hpol eta) catalytic cores on G-quadruplex (G4) DNA substrates... 
HIGH-FIDELITY | ELEMENT | ETA | BYPASS | MECHANISM | STRUCTURAL BASIS | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | REPLICATION FORK | THYMINE DIMER | INSIGHTS | Humans | Protein Binding | Substrate Specificity | DNA Replication | G-Quadruplexes | Base Pair Mismatch | DNA-Directed DNA Polymerase - chemistry | Kinetics | DNA Primers - chemistry | DNA Polymerase II - chemistry
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5. Full Text Viewing Human DNA Polymerase β Faithfully and Unfaithfully Bypass an Oxidative Lesion by Time-Dependent Crystallography
by Vyas, Rajan and Reed, Andrew J and Tokarsky, E. John and Suo, Zucai
Journal of the American Chemical Society, ISSN 0002-7863, 1900, Volume 137, Issue 15, pp. 5225 - 5230
One common oxidative DNA lesion, 8-oxo-7,8-dihydro-2′-deoxyguanine (8-oxoG), is highly mutagenic in vivo due to its anti-conformation forming a Watson–Crick... 
REPAIR | METAL-ION | REPLICATION | FIDELITY | STRUCTURAL BASIS | CRYSTAL-STRUCTURE | TERNARY COMPLEXES | BINARY | CYTOTOXICITY | CHEMISTRY, MULTIDISCIPLINARY | DAMAGE | Catalytic Domain | Diphosphates - metabolism | Biocatalysis | Oxidation-Reduction | Guanine - analogs & derivatives | Humans | DNA Polymerase beta - chemistry | Models, Molecular | Crystallography, X-Ray | Diphosphates - chemistry | Guanine - metabolism | Metals - metabolism | Metals - chemistry | Time Factors | Guanine - chemistry | Protein Conformation | DNA Damage | DNA Polymerase beta - metabolism | X-ray crystallography | Usage | DNA polymerases | Chemical reactions | Chemical properties | Research | Structure | Index Medicus
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6. Full Text Transient hypermutability, chromothripsis and replication-based mechanisms in the generation of concurrent clustered mutations
by Chen, Jian-Min and Férec, Claude and Cooper, David N
Mutation Research-Reviews in Mutation Research, ISSN 1383-5742, 2012, Volume 750, Issue 1, pp. 52 - 59
Clustered mutations may be broadly defined as the presence of two or more mutations within a spatially localized genomic region on a single chromosome. Known... 
Transient hypermutability | Mutational mechanisms | Multiple mutation | Chromothripsis | Complex genomic rearrangement | Non-homologous end joining | INHERITED DISEASE | GENOMIC REARRANGEMENTS | CANCER | REPAIR | EVOLUTION | GENE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SLIPPAGE | GENETICS & HEREDITY | TOXICOLOGY | MULTIPLE MUTATIONS | CHRONOCOORDINATE EVENTS | BREAK-INDUCED REPLICATION | Gene mutations | Genes | Genetic aspects
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7. Full Text Systematic characterization of protein-DNA interactions
by Xie, Zhi and Xie, Zhi and Hu, Shaohui and Hu, Shaohui and Qian, Jiang and Qian, Jiang and Blackshaw, Seth and Blackshaw, Seth and Zhu, Heng and Zhu, Heng
Cellular and Molecular Life Sciences, ISSN 1420-682X, 5/2011, Volume 68, Issue 10, pp. 1657 - 1668
Sequence-specific protein-DNA interactions (PDIs) are critical for regulating many cellular processes, including transcription, DNA replication, repair, and... 
Life Sciences | Biochemistry, general | Transcription factors | DNA-binding specificity | Life Sciences, general | Unconventional DNA-binding proteins | Protein DNA interactions | Protein microarray | Biomedicine general | Cell Biology | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOONLIGHTING PROTEINS | ONE-HYBRID SYSTEM | CELL BIOLOGY | OPEN-ACCESS DATABASE | HUMAN GENOME | REGULATORY NETWORKS | IN-VIVO | FACTOR BINDING-SITES | GENE-EXPRESSION | DNA-Binding Proteins - metabolism | Two-Hybrid System Techniques | DNA - chemistry | Chromatin Immunoprecipitation | SELEX Aptamer Technique | DNA-Binding Proteins - analysis | DNA - metabolism | DNA-Binding Proteins - chemistry | Protein Array Analysis - methods | Medical colleges | Neurosciences | DNA replication | DNA microarrays | DNA | Chemical properties | DNA binding proteins | Ophthalmology | Protein binding | Proteins | Cellular biology | Deoxyribonucleic acid--DNA
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8. Full Text Postreplication repair mechanisms in the presence of DNA adducts in Escherichia coli
by Bichara, Marc and Meier, Matt and Wagner, Jérome and Cordonnier, Agnès and Lambert, Iain B
Mutation Research-Reviews in Mutation Research, ISSN 1383-5742, 2011, Volume 727, Issue 3, pp. 104 - 122
During bacterial replication, DNA polymerases may encounter DNA lesions that block processive DNA synthesis. Uncoupling the replicative helicase from the... 
ssDNA gap repair | Recombination | Postreplication repair | DNA repair | Translesion synthesis | SsDNA gap repair | BETA-SLIDING-CLAMP | RECA PROTEIN FILAMENTS | SINGLE-STRANDED-DNA | SOS-INDUCED MUTAGENESIS | NUCLEOTIDE EXCISION-REPAIR | COORDINATED LEADING-STRAND | OKAZAKI FRAGMENT SIZE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ARRESTED REPLICATION FORKS | GENETICS & HEREDITY | TOXICOLOGY | POLYMERASE-III HOLOENZYME | MIGRATION MOTOR PROTEIN | DNA polymerases | DNA synthesis | DNA | Escherichia coli
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9. Full Text EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseases
by Cousineau, Isabelle and Belmaaza, Abdellah
Molecular Genetics and Genomics, ISSN 1617-4615, 4/2011, Volume 285, Issue 4, pp. 325 - 340
EMSY links the BRCA2 pathway to sporadic breast/ovarian cancer. It encodes a nuclear protein that binds to the BRCA2 N-terminal domain implicated in... 
Life Sciences | Biochemistry, general | Microbial Genetics and Genomics | Estrogens | Aging | Development/abortion | Tumor-suppressor genes | Oncogenes | Animal Genetics and Genomics | Plant Genetics & Genomics | Cell Biology | REPLICATION PROTEIN-A | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOUBLE-STRAND BREAKS | S-PHASE CHECKPOINT | ATR-DEPENDENT PHOSPHORYLATION | TRANSCRIPTION-COUPLED REPAIR | HOMOLOGOUS RECOMBINATION REPAIR | GENOMIC STABILITY | GENETICS & HEREDITY | CANCER SUSCEPTIBILITY | TUMOR-SUPPRESSOR | CELL-CYCLE | Inverted Repeat Sequences - genetics | Rad51 Recombinase - metabolism | Rad51 Recombinase - genetics | Humans | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Signal Transduction - genetics | DNA Repair - genetics | Neoplasm Proteins - metabolism | DNA Breaks, Double-Stranded | Chromosomal Instability - genetics | BRCA2 Protein - metabolism | Models, Biological | Recombination, Genetic | Cell Line, Tumor | DNA Replication - genetics | DNA Damage | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | BRCA2 Protein - genetics | Repressor Proteins - metabolism | Enzymes | Chromatin | Gene mutations | Protein binding | abortion | Original Paper | Development
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10. Full Text Diffractive optics as beam-shaping elements for plastics laser welding
by Grewell, David and Benatar, Avraham
Optical Engineering, ISSN 0091-3286, 11/2007, Volume 46, Issue 11, pp. 118001 - 1180010
This work reviews the use of diffractive optics for beam-shaping of high-power lasers for welding and microwelding of plastics. While the use of lasers to weld... 
diffractive optics | joining | welding | beam shaping | plastics | holograms | microfluidics | Diffractive optics | Welding | Joining | Plastics | Beam shaping | Microfluidics | Holograms | GLASS | DESIGN | FABRICATION | OPTICS | Laser beam welding | Welded joints | Beams (radiation) | Images | Replication | Polymers
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11. Full Text Polymer microreplication using ultrasonic vibration energy
by Yu, Hyun Woo and Lee, Chi Hoon and Jung, Phill Gu and Shin, Bo Sung and Kim, Joon-Ho and Hwang, Kyu-Youn and Ko, Jong Soo
Journal of Micro Nanolithography MEMS and MOEMS, ISSN 1932-5150, 05/2009, Volume 8, Issue 2, pp. 021113 - 021117
Polymethyl methacrylate (PMMA) microstructures were fabricated by a polymeric microreplication technology using ultrasonic vibration energy. A commercial... 
ultrasonic molding | microstructure | Polymethyl methacrylate (PMMA) | polymer replication | nickel mold | Nickel mold | Polymer replication | Microstructure | Ultrasonic molding | STAMPS | MOLDING PROCESS | MATERIALS SCIENCE, MULTIDISCIPLINARY | NANOSCIENCE & NANOTECHNOLOGY | FABRICATION | OPTICS | ENGINEERING, ELECTRICAL & ELECTRONIC | Energy use | Micromolding | Nanocomposites | Microreplication | Ultrasonic vibration | Nanostructure | Polymethyl methacrylates
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12. Full Text Poly(T) Variation in Heteroderid Nematode Mitochondrial Genomes is Predominantly an Artefact of Amplification
by Riepsamen, Angelique H and Riepsamen, Angelique H and Gibson, Tracey and Gibson, Tracey and Rowe, Janet and Rowe, Janet and Chitwood, David J and Chitwood, David J and Subbotin, Sergei A and Subbotin, Sergei A and Dowton, Mark and Dowton, Mark
Journal of Molecular Evolution, ISSN 0022-2844, 2/2011, Volume 72, Issue 2, pp. 182 - 192
We assessed the rate of in vitro polymerase errors at polythymidine [poly(T)] tracts in the mitochondrial DNA (mtDNA) of a heteroderid nematode (Heterodera... 
Polythymidine | Heteroderidae | Microbiology | Mitochondrial DNA | Polymerase slippage | Amplification artefacts | Cell Biology | Plant Genetics & Genomics | Life Sciences | Nematode | Homopolymer | Evolutionary Biology | Plant Sciences | Animal Genetics and Genomics | MOLECULAR CHARACTERIZATION | GENE REARRANGEMENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-POLYMERASE | HETERONOTIA-BINOEI | EVOLUTIONARY BIOLOGY | EVOLUTION | REPLICATION | SIZE VARIATION | SLIPPAGE | SEQUENCE | GENETICS & HEREDITY | PCR AMPLIFICATION | Nucleic Acid Amplification Techniques - methods | Molecular Sequence Data | DNA-Directed DNA Polymerase - chemistry | Electron Transport Complex IV - genetics | Tylenchoidea - genetics | Sequence Analysis, DNA | INDEL Mutation | Genetic Variation | Artifacts | Genome, Helminth | Sequence Alignment | Animals | DNA, Mitochondrial - genetics | Base Sequence | Poly T - genetics | DNA-Directed DNA Polymerase - metabolism | Genome, Mitochondrial | Databases, Nucleic Acid | Phytochemistry | Genomics | Genetic research | Genomes | Agriculture | Polymers | Nematoda | Nematodes | Enzymes | Molecular biology | Mitochondria | molecular evolution
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