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1. Full Text Replication stress and cancer
by Gaillard, Hélène and García-Muse, Tatiana and Aguilera, Andrés
Nature Reviews Cancer, ISSN 1474-175X, 04/2015, Volume 15, Issue 5, pp. 276 - 280
Genome instability is a hallmark of cancer, and DNA replication is the most vulnerable cellular process that can lead to it. Any condition leading to high... 
STRAND BREAK REPAIR | FANCD2 KNOCKOUT MICE | ONCOLOGY | INDUCED SKIN CARCINOGENESIS | COMMON FRAGILE SITE | HUMAN-CELLS | TUMOR-SUPPRESSOR | ONCOGENE-INDUCED SENESCENCE | DNA-DAMAGE-RESPONSE | FANCONI-ANEMIA | S-PHASE CHECKPOINT | DNA Replication - genetics | DNA Damage | Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | Humans | Genomic Instability - genetics | Physiological aspects | Ionizing radiation | Genetic aspects | Mammals | Analysis | DNA damage
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2. Full Text Causes and consequences of replication stress
by Zeman, Michelle K and Cimprich, Karlene A
Nature Cell Biology, ISSN 1465-7392, 01/2014, Volume 16, Issue 1, pp. 2 - 9
Replication stress is a complex phenomenon that has serious implications for genome stability, cell survival and human disease. Generation of aberrant... 
COMMON FRAGILE SITES | DORMANT ORIGINS | DNA-DAMAGE RESPONSE | FORK REVERSAL | ATR ACTIVATION | SYNTHETIC LETHALITY | POSTREPLICATION REPAIR | MAINTAIN GENOME STABILITY | MEIER-GORLIN SYNDROME | RIBONUCLEOTIDE INCORPORATION | CELL BIOLOGY | DNA Replication | Eukaryotic Cells - metabolism | Disease | Models, Biological | Humans | Stress, Physiological
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3. Full Text The ER stress factor XBP1s prevents amyloid-β neurotoxicity
by Casas-Tinto, Sergio and Zhang, Yan and Sanchez-Garcia, Jonatan and Gomez-Velazquez, Melisa and Rincon-Limas, Diego E and Fernandez-Funez, Pedro
Human Molecular Genetics, ISSN 0964-6906, 06/2011, Volume 20, Issue 11, pp. 2144 - 2160
Alzheimer's disease (AD) is an incurable neurodegenerative disorder clinically characterized by progressive cognitive impairment. A prominent pathologic... 
RETINAL DEGENERATION | PRION REPLICATION | UNFOLDED-PROTEIN RESPONSE | RYANODINE RECEPTOR | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CALCIUM-RELEASE | GENETICS & HEREDITY | KNOCK-IN MICE | ENDOPLASMIC-RETICULUM STRESS | AMYOTROPHIC-LATERAL-SCLEROSIS | TRANSCRIPTION FACTOR | Eye - pathology | Neurons - pathology | RNA, Small Interfering - genetics | Calcium - metabolism | Endoplasmic Reticulum - metabolism | Male | Ryanodine Receptor Calcium Release Channel - metabolism | PC12 Cells | RNA Splicing | Transfection | Amyloid beta-Peptides - genetics | Amyloid beta-Peptides - metabolism | Female | Neurons - metabolism | Peptide Fragments - genetics | Drosophila - genetics | Peptide Fragments - metabolism | Rats | DNA-Binding Proteins - genetics | Protein Folding | Animals | Animals, Genetically Modified - genetics | Alzheimer Disease - metabolism | Drosophila Proteins - genetics | RNA, Small Interfering - metabolism | Index Medicus | Brain | Neuroprotection | Transcription factors | Calcium | Neurodegenerative diseases | Neurons | Cognitive ability | Ryanodine receptors | beta -Amyloid | Cytosol | Stress | Neurotoxicity | Activating transcription factor 1 | Pheochromocytoma cells | Mutation | Alzheimer's disease | Endoplasmic reticulum
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4. Full Text Replication stress: Getting back on track
by Berti, Matteo and Vindigni, Alessandro
Nature Structural and Molecular Biology, ISSN 1545-9993, 02/2016, Volume 23, Issue 2, pp. 103 - 109
The replication-stress response enables the DNA replication machinery to overcome DNA lesions or intrinsic replication-fork obstacles, and it is essential to... 
MCM2-7 HELICASE | CELL NUCLEAR ANTIGEN | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENOME STABILITY | DAMAGE TOLERANCE | S-PHASE CHECKPOINT | LEADING-STRAND | CELL BIOLOGY | BIOPHYSICS | FORK REVERSAL | RESTART | CHROMOSOMAL DNA-REPLICATION | BREAK-INDUCED REPLICATION | DNA - genetics | Animals | Signal Transduction | DNA - analysis | DNA Repair | Humans | Stress, Physiological | DNA Replication | DNA - metabolism | DNA Damage | DNA replication | Research | RNA polymerases | Protein binding | Eukaryotes | Deoxyribonucleic acid--DNA | Stress
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5. Full Text Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress
by Tkach, Johnny M and Yimit, Askar and Lee, Anna Y and Riffle, Michael and Costanzo, Michael and Jaschob, Daniel and Hendry, Jason A and Ou, Jiongwen and Moffat, Jason and Boone, Charles and Davis, Trisha N and Nislow, Corey and Brown, Grant W
Nature Cell Biology, ISSN 1465-7392, 09/2012, Volume 14, Issue 9, pp. 966 - 976
Relocalization of proteins is a hallmark of the DNA damage response. We use high-throughput microscopic screening of the yeast GFP fusion collection to develop... 
YEAST | RIBONUCLEOTIDE REDUCTASE | OXIDATIVE STRESS | CHECKPOINT PATHWAYS | METHYL METHANESULFONATE | MESSENGER-RNA | DNTP POOLS | GLOBAL ANALYSIS | SACCHAROMYCES-CEREVISIAE | EXPRESSION | CELL BIOLOGY | Sequence Deletion | Saccharomyces cerevisiae - physiology | Saccharomyces cerevisiae - genetics | Histone Deacetylases - metabolism | Protein Transport - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Protein Transport - genetics | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | DNA Replication - physiology | Gene Deletion | Saccharomyces cerevisiae Proteins - metabolism | DNA Replication - genetics | DNA Damage | Adaptor Proteins, Signal Transducing - metabolism | Protein-Serine-Threonine Kinases - metabolism | GTP-Binding Proteins - metabolism | Physiological aspects | Cellular proteins | DNA replication | Research | DNA damage
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6. Full Text DNA Replication and Oncogene-Induced Replicative Stress
by Hills, Stephanie A and Diffley, John F.X
Current Biology, ISSN 0960-9822, 05/2014, Volume 24, Issue 10, pp. R435 - R444
DNA replication must be tightly regulated to ensure that the genome is accurately duplicated during each cell cycle. When these regulatory mechanisms fail,... 
XENOPUS EGG EXTRACTS | DAMAGE RESPONSE | CYCLIN-E | CANCER DEVELOPMENT | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ORIGIN RECOGNITION COMPLEX | RE-REPLICATION | S-PHASE | FRAGILE SITE | COMPREHENSIVE GENOMIC CHARACTERIZATION | CELL BIOLOGY | Genomic Instability | Oncogenes - genetics | Animals | Cell Transformation, Neoplastic - genetics | Humans | DNA Replication | DNA Damage | Genetic research | DNA replication | Genetic aspects | Genomics | DNA
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7. Full Text Exploiting replicative stress to treat cancer
by Dobbelstein, Matthias and Sørensen, Claus Storgaard
Nature Reviews Drug Discovery, ISSN 1474-1776, 06/2015, Volume 14, Issue 6, pp. 405 - 423
DNA replication in cancer cells is accompanied by stalling and collapse of the replication fork and signalling in response to DNA damage and/or premature... 
SENSITIZES TUMOR-CELLS | CELL-CYCLE CHECKPOINT | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DNA-DAMAGE RESPONSE | HISTONE METHYLTRANSFERASE SET8 | PHARMACOLOGY & PHARMACY | RIBONUCLEOTIDE REDUCTASE GENE | HOMOLOGOUS RECOMBINATION | ONCOGENE-INDUCED SENESCENCE | S-PHASE CHECKPOINT | NEGATIVE BREAST-CANCER | LEUCINE-ZIPPER KINASE | DNA Damage - drug effects | DNA Replication - drug effects | Humans | Treatment Outcome | Antineoplastic Agents - administration & dosage | Neoplasms - drug therapy | Animals | Neoplasms - genetics | Cell Cycle Checkpoints - drug effects | DNA Damage - genetics | DNA Replication - genetics | Cell Cycle Checkpoints - genetics | Drug Delivery Systems - methods | Molecular targeted therapy | DNA replication | Care and treatment | Innovations | Forecasts and trends | Health aspects | Cancer
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