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Cell, ISSN 0092-8674, 03/2007, Volume 128, Issue 6, pp. 1063 - 1076
Methylation of histones has been regarded as a stable modification defining the epigenetic program of the cell, which regulates chromatin structure and... 
DOMAIN-CONTAINING PROTEINS | METHYLATION | CAENORHABDITIS-ELEGANS | METHYLTRANSFERASE | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCAPES X-INACTIVATION | TRITHORAX | RETINOBLASTOMA-BINDING PROTEIN-2 | TRANSCRIPTIONAL REGULATION | CELL BIOLOGY | Caenorhabditis elegans Proteins - chemistry | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Phylogeny | Gene Deletion | Tumor Suppressor Proteins - chemistry | Oxidoreductases, N-Demethylating - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Repressor Proteins - metabolism | Amino Acid Sequence | Tumor Suppressor Proteins - metabolism | Repressor Proteins - genetics | Caenorhabditis elegans - embryology | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Histone Demethylases | Lysine | Drosophila melanogaster - enzymology | Schizosaccharomyces - enzymology | Mice | Histones - metabolism | Caenorhabditis elegans Proteins - genetics | Caenorhabditis elegans - enzymology | Embryonic Stem Cells - metabolism | Oxidoreductases, N-Demethylating - genetics | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | DNA-Binding Proteins - metabolism | Tumor Suppressor Proteins - genetics | Carrier Proteins - chemistry | Nuclear Proteins - genetics | Genes, Homeobox | Protein Structure, Tertiary | Repressor Proteins - chemistry | Embryonic Stem Cells - enzymology | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Oxidoreductases, N-Demethylating - chemistry | Proteins - genetics | Carrier Proteins - genetics | Sequence Alignment | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Retinoblastoma-Binding Protein 2 | Proteins - chemistry | Methylation | Jumonji Domain-Containing Histone Demethylases
Journal Article
Protein Science, ISSN 0961-8368, 08/2016, Volume 25, Issue 8, pp. 1472 - 1482
The nucleosome remodeling and deacetylase (NuRD) complex remodels the genome in the context of both gene transcription and DNA damage repair. It is essential... 
protein structure | transcription regulation | MTA1 | RBBP4 | chromatin | NuRD complex | Chromatin | Protein structure | Transcription regulation | CHROMATIN REMODELER | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRYO-EM | PLURIPOTENCY | MASS-SPECTROMETRY | FACTOR ISWI | SEQUENCE | ARCHITECTURE | PROTEIN COMPLEXES | PROTEOMICS | Nucleosomes - chemistry | Retinoblastoma-Binding Protein 7 - chemistry | Humans | Protein Multimerization | Retinoblastoma-Binding Protein 4 - genetics | Protein Subunits - metabolism | Thermodynamics | Retinoblastoma-Binding Protein 7 - metabolism | Cloning, Molecular | HEK293 Cells | Conserved Sequence | Transcription, Genetic | Protein Interaction Domains and Motifs | Retinoblastoma-Binding Protein 4 - chemistry | Repressor Proteins - metabolism | Retinoblastoma-Binding Protein 4 - metabolism | Protein Subunits - genetics | Recombinant Proteins - metabolism | Amino Acid Sequence | Gene Expression | Repressor Proteins - chemistry | Cross-Linking Reagents - chemistry | Histone Deacetylases - genetics | Protein Structure, Secondary | Histone Deacetylases - chemistry | Models, Molecular | Nucleosomes - metabolism | Recombinant Proteins - chemistry | Repressor Proteins - genetics | Histone Deacetylases - metabolism | Recombinant Proteins - genetics | Retinoblastoma-Binding Protein 7 - genetics | Sequence Alignment | Animals | Protein Subunits - chemistry | Kinetics | Mutation | Crosslinked polymers | Analysis | Genomics | Genetic transcription | Metastasis | Nematoda | Protein binding
Journal Article
Protein Science, ISSN 0961-8368, 12/2016, Volume 25, Issue 12, pp. 2256 - 2267
Many viruses deregulate the cell and force transcription of viral genes by competing with cellular proteins for binding to the transcriptional co‐activators... 
NMR | intrinsically disordered protein | oncogenic viral protein | adenovirus | TRANSCRIPTIONAL ACTIVATION | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | CBP/P300 | CELL-CYCLE CONTROL | P53 TRANSACTIVATION DOMAIN | RETINOBLASTOMA PROTEIN | VIRAL ONCOPROTEIN | KIX DOMAIN | GENE-EXPRESSION | TUMOR-SUPPRESSOR | Adenovirus E1A Proteins - chemistry | E1A-Associated p300 Protein - chemistry | E1A-Associated p300 Protein - genetics | Tumor Suppressor Protein p53 - metabolism | CREB-Binding Protein - chemistry | E1A-Associated p300 Protein - metabolism | Tumor Suppressor Protein p53 - genetics | Amino Acid Motifs | CREB-Binding Protein - genetics | CREB-Binding Protein - metabolism | Adenovirus E1A Proteins - metabolism | Adenovirus E1A Proteins - genetics | Adenoviridae - genetics | Protein Domains | Tumor Suppressor Protein p53 - chemistry | Adenoviridae - metabolism | Adenoviridae - chemistry | Proteins | Genetic transcription | Adenoviruses | Protein binding | Binding sites | Cell cycle | Competition | Deregulation | Transcription factors | Complex formation | Nuclear magnetic resonance--NMR | Transcription | Peptides | p53 Protein | Retinoblastoma protein | Viruses | Homology | Event-related potentials | Early region | Cyclic AMP response element-binding protein | Peptide mapping | CREB-binding protein | Rodents | Serotypes | Retinoblastoma
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 07/2009, Volume 106, Issue 28, pp. 11806 - 11811
Journal Article
Cell, ISSN 0092-8674, 2004, Volume 119, Issue 2, pp. 181 - 193
The retinoblastoma tumor suppressor protein (pRb) regulates gene transcription by binding E2F transcription factors. pRb can recruit several repressor... 
RB | DISTINCT MECHANISMS | CYCLE CONTROL | RETINOBLASTOMA PROTEIN | CHROMATIN | DROSOPHILA FOLLICLE CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | C-ELEGANS | VULVAL DEVELOPMENT | DNA-REPLICATION | NEGATIVE REGULATOR | CELL BIOLOGY | Chromatin - metabolism | Drosophila melanogaster - embryology | Histones - chemistry | Humans | Molecular Sequence Data | E2F Transcription Factors | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Recombinant Fusion Proteins - metabolism | Protein Subunits - metabolism | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | Protein Subunits - isolation & purification | RNA Interference | Gene Expression Regulation, Developmental | Cell Cycle Proteins - genetics | Transcription, Genetic | Protein Subunits - genetics | Oncogene Proteins v-myb - metabolism | Amino Acid Sequence | Caenorhabditis elegans Proteins | Cell Cycle Proteins - isolation & purification | Caenorhabditis elegans - growth & development | Retinoblastoma Protein - isolation & purification | Caenorhabditis elegans - genetics | Retinoblastoma Protein - metabolism | Cell Cycle Proteins - metabolism | DNA Replication | Transcription Factors - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - isolation & purification | Caenorhabditis elegans - anatomy & histology | Drosophila Proteins - isolation & purification | Macromolecular Substances | Transcription Factors - metabolism | Carrier Proteins - genetics | Sequence Alignment | Animals | Carrier Proteins - metabolism | Retinoblastoma Protein - genetics | Recombinant Fusion Proteins - genetics | Oncogene Proteins v-myb - genetics | Transcription Factors - isolation & purification | Cell Nucleus - chemistry | Drosophila Proteins - genetics | Histones - metabolism | Chromatin - genetics | Evolution, Molecular | Tumor suppressor genes | Research | Genetic transcription | Retinoblastoma
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 09/2018, Volume 38, Issue 17
RASSF6 is a member of the tumor suppressor Ras association domain family (RASSF) proteins. RASSF6 is frequently suppressed in human cancers, and its low... 
RB1 | Cell cycle arrest | Tumor suppressor | RASSF6 | Apoptosis | PROMOTER HYPERMETHYLATION | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | tumor suppressor | PROLIFERATION | HIPPO PATHWAY REGULATION | cell cycle arrest | CANCER | FAMILY | P53 | CELL BIOLOGY | E2F | EXPRESSION | Genomic Instability | Humans | Tumor Protein p73 - genetics | Apoptosis - genetics | Tumor Protein p73 - metabolism | Tumor Suppressor Protein p53 - genetics | Gene Knockdown Techniques | Genes, p53 | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | HEK293 Cells | Cell Cycle Checkpoints - genetics | E2F1 Transcription Factor - antagonists & inhibitors | Retinoblastoma Binding Proteins - genetics | Retinoblastoma Binding Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Genes, Retinoblastoma | HCT116 Cells | Retinoblastoma Binding Proteins - deficiency | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Cell Cycle Checkpoints - physiology | E2F1 Transcription Factor - metabolism | Monomeric GTP-Binding Proteins - genetics | Tumor Suppressor Protein p53 - deficiency | Monomeric GTP-Binding Proteins - deficiency | Monomeric GTP-Binding Proteins - metabolism | Models, Biological | DNA Repair | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Ubiquitin-Protein Ligases - deficiency | Apoptosis - physiology | HeLa Cells | Tumor Suppressor Protein p14ARF - genetics | E2F1 Transcription Factor - genetics | Tumor Suppressor Protein p14ARF - metabolism | Ubiquitin-Protein Ligases - genetics
Journal Article
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 02/2011, Volume 20, Issue 4, pp. 731 - 751
Mammalian circadian rhythms are synchronized to the external time by daily resetting of the suprachiasmatic nucleus (SCN) in response to light. As the master... 
RESPONSE ELEMENT | POLY(A) BINDING-PROTEIN | MESSENGER-RNA | RETT-SYNDROME | SUPRACHIASMATIC NUCLEUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SLEEP PHASE SYNDROME | GENETICS & HEREDITY | GENE-EXPRESSION | POLY(A)-BINDING PROTEIN | HISTONE ACETYLTRANSFERASE | ACTIVE GENES | NIH 3T3 Cells | Humans | Methyl-CpG-Binding Protein 2 - metabolism | Chromatin Assembly and Disassembly - genetics | MicroRNAs - metabolism | E1A-Associated p300 Protein - metabolism | Chromatin Assembly and Disassembly - drug effects | Retinoblastoma-Binding Protein 2 - metabolism | Immediate-Early Proteins - metabolism | Period Circadian Proteins - genetics | Light | HEK293 Cells | Suprachiasmatic Nucleus - metabolism | DNA-Binding Proteins | Tumor Suppressor Proteins - metabolism | Signal Transduction | Mice, Inbred C57BL | Circadian Rhythm - genetics | Computational Biology | Gene Expression Regulation | Mice, Transgenic | RNA Stability | Animals | Period Circadian Proteins - metabolism | Mice | MicroRNAs - genetics | Jumonji Domain-Containing Histone Demethylases | Suprachiasmatic nucleus | Calcium | Transcription | CLOCK protein | BTG2 protein | Period 1 protein | Methyl-CpG binding protein | Entrainment | miRNA | Period 2 protein | Circadian rhythms | Obesity | Translation | mRNA turnover | Cyclic AMP | Light effects | Oscillators | Promoters | Chromatin remodeling | Neurological diseases | Period protein | Sleep | MeCP2 protein | Workers | Pacemakers | Cardiovascular diseases | Cancer
Journal Article
Genes and Development, ISSN 0890-9369, 01/2007, Volume 21, Issue 1, pp. 43 - 48
Here we report that RNA interference against ATM inhibited p53 accumulation in cells expressing oncogenic STAT5 and cooperated with Rb inactivation to suppress... 
Senescence | DNA damage | E2F1 | STAT5 | ATM | RasV12 | p53 | ACTIVATION | P19(ARF) | RAS | PHOSPHORYLATION | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | senescence | PREMATURE SENESCENCE | IN-VIVO | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | HUMAN FIBROBLASTS | CHECKPOINT | Protein Kinases - metabolism | Phosphorylation | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Oncogenes - physiology | Cell Cycle Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Genes, ras - physiology | STAT5 Transcription Factor - metabolism | Tumor Suppressor Proteins - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Tumor Suppressor Proteins - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction | RNA, Small Interfering - pharmacology | Retinoblastoma Protein - metabolism | Cell Cycle Proteins - metabolism | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Cellular Senescence - physiology | Ataxia Telangiectasia Mutated Proteins | E2F1 Transcription Factor - metabolism | DNA-Binding Proteins - genetics | Cell Transformation, Neoplastic | Fluorescent Antibody Technique | Retinoblastoma Protein - antagonists & inhibitors | Checkpoint Kinase 2 | Checkpoint Kinase 1 | Fibroblasts - cytology | DNA Damage | Mutation | Aging | Genetic research | Research | Research Communication
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2014, Volume 289, Issue 32, pp. 21844 - 21855
The nucleosome remodeling and deacetylase (NuRD) complex is a widely conserved transcriptional co-regulator that harbors both nucleosome remodeling and histone... 
SOMATIC-CELLS | PROTEIN | DNA METHYLATION | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HISTONE DEACETYLASE COMPLEX | ZINC-FINGER | TRANSCRIPTIONAL REPRESSION | MI-2/NURD COMPLEX | BINDING | DOMAINS | Transcription Factors - chemistry | Retinoblastoma-Binding Protein 7 - chemistry | Humans | Molecular Sequence Data | Retinoblastoma-Binding Protein 4 - genetics | Crystallography, X-Ray | Mi-2 Nucleosome Remodeling and Deacetylase Complex - genetics | Mi-2 Nucleosome Remodeling and Deacetylase Complex - metabolism | Retinoblastoma-Binding Protein 7 - metabolism | Conserved Sequence | Protein Interaction Domains and Motifs | Nuclear Proteins - genetics | Retinoblastoma-Binding Protein 4 - chemistry | Repressor Proteins - metabolism | Retinoblastoma-Binding Protein 4 - metabolism | Amino Acid Sequence | Repressor Proteins - chemistry | Histone Deacetylases - genetics | Histone Deacetylases - chemistry | Chromatin Assembly and Disassembly | Models, Molecular | Nucleosomes - metabolism | Repressor Proteins - genetics | Histone Deacetylases - metabolism | Nuclear Proteins - metabolism | Transcription Factors - genetics | Nuclear Proteins - chemistry | Sequence Homology, Amino Acid | Transcription Factors - metabolism | Retinoblastoma-Binding Protein 7 - genetics | Animals | Mi-2 Nucleosome Remodeling and Deacetylase Complex - chemistry | Histones - metabolism | Gene Regulation | Chromatin | RbAp48 | MTA1 | RBBP4 | Chromatin Structure | NuRD Complex | Protein Structure | Protein Assembly
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2006, Volume 398, Issue 2, pp. 153 - 168
Adipose tissue is a major endocrine organ that exerts a profound influence on whole-body homoeostasis. Two types of adipose tissue exist in mammals: WAT (white... 
Brown adipose tissue (BAT) | White adipose tissue (WAT) | Transcription | Signalling | Peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) | Ion Channels | Signal Transduction | Membrane Proteins - genetics | Humans | Gene Expression Regulation | Adipose Tissue - cytology | Mitochondrial Proteins | Adipose Tissue - metabolism | Carrier Proteins - genetics | Adipose Tissue, Brown - cytology | Animals | Carrier Proteins - metabolism | Adipose Tissue, Brown - metabolism | Cell Differentiation | Membrane Proteins - metabolism | Uncoupling Protein 1 | transcription | NRF, nuclear respiratory factor | brown adipose tissue (BAT) | T3, 3,5,3′-tri-iodothyronine | RXR, retinoid X receptor | Cidea, cell death-inducing DFF45-like effector A | SRC-1, steroid receptor co-activator 1 | ChIP, chromatin immunoprecipitation | PKB, protein kinase B | ES, embryonic stem | FABP, fatty acid-binding protein | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | 4E-BP1, 4E-binding protein 1 | SV40, simian virus 40 | TAg, large T antigen | PRMT1, protein arginine methyltransferase 1 | AR, adrenergic receptor | SREBP-1, sterol regulatory element-binding protein 1 | peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) | PKA, cAMP-dependent protein kinase | RIP140, receptor interacting protein 140 | T4, thyroxine | Dio2, type 2 iodothyronine deiodinase | eNOS, epithelial NO synthase | LRH-1, liver receptor homologue 1 | SNS, sympathetic nervous system | NCoR, nuclear receptor co-repressor | UCP1, uncoupling protein 1 | WAT, white adipose tissue | white adipose tissue (WAT) | ERR, oestrogen-related receptor | LXR, liver X receptor | TR, thyroid hormone receptor | Tfam, mitochondrial transcription factor A | CIP, p300 | pRB, retinoblastoma protein | MAPK, mitogen-activated protein kinase | IRS, insulin receptor substrate | co-integrator-associated protein | PPAR, peroxisome proliferator-activated receptor | SIRT, sirtuin | SV, stromal-vascular | Review | CBP | IGF-1R, IGF-1 receptor | NO, nitric oxide | SHP, small heterodimer partner | Rb, retinoblastoma gene | PGC-1, PPARγ co-activator 1 | S6K, S6 kinase | TZD, thiazolidinedione | CPT-1b, carnitine palmitoyltransferase 1b | signalling | enhancer-binding protein | PRC, PGC-1-related co-activator | BAT, brown adipose tissue | EBP, CCAAT | CREB, cAMP response element-binding protein | Foxc2, forkhead box C2 | SPPARM, selective PPARγ modulator | CBP, CREB-binding protein | TIF2, transcriptional intermediary factor 2 | GABP, GA-binding protein | MEF, mouse embryo fibroblast
Journal Article
Nature, ISSN 0028-0836, 01/2018, Volume 553, Issue 7686, pp. 91 - 95
Treatments that target immune checkpoints, such as the one mediated by programmed cell death protein 1 (PD-1) and its ligand PD-L1, have been approved for... 
CELLS | THERAPY | IMMUNOTHERAPY | STABILIZATION | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | RETINOBLASTOMA-PROTEIN | SPOP | DEPENDENT KINASES | BREAST | REQUIREMENT | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Immunologic Surveillance | Phosphorylation | Humans | Male | Prostatic Neoplasms - immunology | Proteolysis | Cullin Proteins - metabolism | Female | Protein Stability | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Repressor Proteins - metabolism | Tumor Escape - immunology | Cdh1 Proteins - metabolism | Lymphocytes, Tumor-Infiltrating - cytology | Cell Line | Repressor Proteins - chemistry | Programmed Cell Death 1 Receptor - metabolism | Nuclear Proteins - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Nuclear Proteins - chemistry | 14-3-3 Proteins - metabolism | B7-H1 Antigen - metabolism | Animals | Cell Cycle | Neoplasms - immunology | B7-H1 Antigen - biosynthesis | Mice | Proteasome Endopeptidase Complex - metabolism | Cyclin D - metabolism | Lymphocytes, Tumor-Infiltrating - immunology | Animal models | PD-1 protein | Kinases | Cyclin-dependent kinase 4 | Cullin | Degradation | Proteins | Ubiquitination | Cell growth | Lymphocytes | Immunotherapy | Cell cycle | Cyclin D | Ubiquitin-protein ligase | Cyclin-dependent kinases | L1 protein | Immunosurveillance | Anaphase-promoting complex | Patients | Molecular modelling | Immune checkpoint | Cell death | Medical prognosis | PD-L1 protein | Ligands | Mutation | Anaphase | Prostate cancer | Prostate | Tumors | Apoptosis | Cancer
Journal Article