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PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 8, p. e23293
HIV proteins target host hub proteins for transient binding interactions. The presence of viral proteins in the infected cell results in out-competition of... 
REPLICATION | PHOSPHORYLATION | TAT | MULTIDISCIPLINARY SCIENCES | KINASE | IMMUNODEFICIENCY-VIRUS TYPE-1 | SH3 DOMAINS | SHORT LINEAR MOTIFS | BINDING | VIRAL-INFECTION | NEF | rev Gene Products, Human Immunodeficiency Virus - chemistry | Humans | env Gene Products, Human Immunodeficiency Virus - metabolism | rev Gene Products, Human Immunodeficiency Virus - metabolism | nef Gene Products, Human Immunodeficiency Virus - chemistry | tat Gene Products, Human Immunodeficiency Virus - chemistry | CREB-Binding Protein - metabolism | gag Gene Products, Human Immunodeficiency Virus - metabolism | env Gene Products, Human Immunodeficiency Virus - genetics | Human Immunodeficiency Virus Proteins - chemistry | Databases, Protein | nef Gene Products, Human Immunodeficiency Virus - metabolism | gag Gene Products, Human Immunodeficiency Virus - genetics | env Gene Products, Human Immunodeficiency Virus - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Calmodulin - metabolism | Protein Structure, Secondary | tat Gene Products, Human Immunodeficiency Virus - genetics | Models, Molecular | gag Gene Products, Human Immunodeficiency Virus - chemistry | Binding Sites - genetics | Human Immunodeficiency Virus Proteins - metabolism | Proteins - genetics | Protein Interaction Mapping - methods | Proteins - metabolism | nef Gene Products, Human Immunodeficiency Virus - genetics | Hydrophobic and Hydrophilic Interactions | Protein Binding | Human Immunodeficiency Virus Proteins - genetics | rev Gene Products, Human Immunodeficiency Virus - genetics | Amino Acid Motifs - genetics | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Casein Kinase II - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | tat Gene Products, Human Immunodeficiency Virus - metabolism | Physiological aspects | Viral proteins | HIV (Viruses) | Genomics | Protein binding | Phenotypes | Phosphorylation | Hot spots | Crosstalk | Amino acid sequence | Viruses | Genomes | Kinases | Proteins | Conserved sequence | Human immunodeficiency virus--HIV | Computer applications | Mutation | Localization | Bioinformatics | Binding sites | HIV | Human immunodeficiency virus
Journal Article
Journal Article
Molecular Therapy, ISSN 1525-0016, 12/2011, Volume 19, Issue 12, pp. 2228 - 2238
We evaluated the efficacy of structurally flexible, cationic PAMAM dendrimers as a small interfering RNA (siRNA) delivery system in a Rag2 / γc / (RAG-hu)... 
MEDICINE, RESEARCH & EXPERIMENTAL | DOUBLE-STRANDED-RNA | PAMAM DENDRIMERS | PRIMARY-CELLS | SIRNA DELIVERY | CLEAVAGE | POTENT | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PROGRESS | DISEASE | GENETICS & HEREDITY | INTERFERENCE | THERAPIES | HIV Infections - prevention & control | Leukocytes, Mononuclear - metabolism | RNA, Small Interfering - genetics | Humans | rev Gene Products, Human Immunodeficiency Virus - metabolism | Leukocytes, Mononuclear - virology | Viral Load | T-Lymphocytes, Helper-Inducer - virology | CD4-Positive T-Lymphocytes - immunology | Dendrimers | Flow Cytometry | HIV-1 - physiology | RNA, Viral - genetics | T-Lymphocytes, Helper-Inducer - immunology | tat Gene Products, Human Immunodeficiency Virus - antagonists & inhibitors | CD4-Positive T-Lymphocytes - virology | DEAD-box RNA Helicases - metabolism | Interleukin Receptor Common gamma Subunit - physiology | Disease Models, Animal | DNA-Binding Proteins - physiology | Ribonuclease III - metabolism | tat Gene Products, Human Immunodeficiency Virus - genetics | HIV Infections - genetics | HIV Infections - virology | Liver - metabolism | Viremia - genetics | Mice, Knockout | Animals | Viremia - virology | Viremia - prevention & control | Leukocytes, Mononuclear - cytology | Liver - cytology | Mice | Mice, Inbred BALB C | Nanoparticles - administration & dosage | rev Gene Products, Human Immunodeficiency Virus - genetics | rev Gene Products, Human Immunodeficiency Virus - antagonists & inhibitors | RNA, Small Interfering - administration & dosage | tat Gene Products, Human Immunodeficiency Virus - metabolism | Original
Journal Article
Cell, ISSN 0092-8674, 10/2013, Volume 155, Issue 3, pp. 594 - 605
Journal Article
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 11/2018, Volume 46, Issue 21, pp. 11539 - 11552
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2010, Volume 107, Issue 13, pp. 5810 - 5814
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 05/2016, Volume 107, pp. 14 - 28
New antiretroviral agents with alternative mechanisms are needed to complement the combination therapies used to treat HIV-1 infections. Here we report the... 
Human immunodeficiency virus type 1 | Rev | RNA | Transcription | Screen | COMPLEX | ALPHA-HELIX | PROTEIN | SMALL MOLECULES | RRE | PRE-MESSENGER-RNA | RESPONSE ELEMENT | IMMUNODEFICIENCY-VIRUS TYPE-1 | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | BINDING | Anti-HIV Agents - pharmacology | Transcription, Genetic - drug effects | Gene Expression Regulation, Viral - drug effects | rev Gene Products, Human Immunodeficiency Virus - chemistry | Humans | rev Gene Products, Human Immunodeficiency Virus - metabolism | Cyproheptadine - pharmacology | HIV-1 - growth & development | Protein Interaction Domains and Motifs | RNA, Viral - metabolism | Drug Evaluation, Preclinical | Peptide Fragments - genetics | Recombinant Proteins - metabolism | Cell Line | Cell Survival - drug effects | HIV-1 - metabolism | RNA Splicing - drug effects | Peptide Fragments - metabolism | Clomiphene - pharmacology | HIV-1 - drug effects | Anti-HIV Agents - adverse effects | Recombinant Proteins - chemistry | Response Elements - drug effects | Peptide Fragments - chemistry | High-Throughput Screening Assays | Cyproheptadine - adverse effects | Peptide Fragments - antagonists & inhibitors | Small Molecule Libraries | Clomiphene - adverse effects | Genes, Reporter - drug effects | rev Gene Products, Human Immunodeficiency Virus - genetics | rev Gene Products, Human Immunodeficiency Virus - antagonists & inhibitors | HIV (Viruses) | Biosynthesis
Journal Article
PLoS ONE, ISSN 1932-6203, 2015, Volume 10, Issue 12, p. e0143634
Nucleophosmin (NPM1, also known as B23, numatrin or NO38) is a pentameric RNA-binding protein with RNA and protein chaperon functions. NPM1 has increasingly... 
IN-VITRO | TEGUMENT PROTEIN US11 | MULTIDISCIPLINARY SCIENCES | NUCLEOLAR PHOSPHOPROTEIN B23 | NUCLEAR EXPORT | ARGININE-RICH | PROTEOMIC ANALYSIS | TYPE-1 | RNA-BINDING-PROTEIN | CORE PROTEIN | POSTTRANSCRIPTIONAL TRANSACTIVATION | HIV-1 | rev Gene Products, Human Immunodeficiency Virus - chemistry | Biophysical Phenomena | Viral Proteins - chemistry | Humans | Protein Multimerization | RNA-Binding Proteins - chemistry | Cercopithecus aethiops | Models, Molecular | Nuclear Proteins - metabolism | Nuclear Proteins - chemistry | rev Gene Products, Human Immunodeficiency Virus - metabolism | Viral Proteins - metabolism | Peptides, Cyclic - metabolism | Animals | Protein Structure, Quaternary | Protein Binding | HeLa Cells | COS Cells | RNA-Binding Proteins - metabolism | Oligomers | Herpes simplex | Research | Herpes simplex virus | Ribosomes | Protein binding | Laboratories | Viruses | Amino acids | Homology | Biochemistry | Kinases | Proteins | Hepatitis | Hepatology | Human immunodeficiency virus--HIV | Gastroenterology | Localization | Biomedical engineering | Oligomerization | Gene expression | Ribonucleic acid--RNA | Virology | RNA-binding protein | Herpes viruses | Affinity | Molecular biology | Cytoplasm | Binding sites | Viral infections | Apoptosis | RNA | Ribonucleic acid | HIV | Human immunodeficiency virus
Journal Article
Annual Review of Virology, ISSN 2327-056X, 9/2017, Volume 4, Issue 1, pp. 241 - 260
Journal Article