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1. Full Text GTP‐binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo
by Bustelo, Xosé R and Sauzeau, Vincent and Berenjeno, Inmaculada M
BioEssays, ISSN 0265-9247, 04/2007, Volume 29, Issue 4, pp. 356 - 370
Rho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. Although originally implicated in the control of cytoskeletal events, it is... 
TARGETED DISRUPTION | DIRECTED MIGRATION | RAC GTPASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | GENE FAMILY | NEUTROPHIL FUNCTIONS | GROWTH-FACTOR | RHO-GTPASES | CELL-DIFFERENTIATION | KNOCKOUT MICE | VENTRAL BODY-WALL | rho GTP-Binding Proteins - genetics | Gene Expression Regulation | rac GTP-Binding Proteins - metabolism | Phylogeny | Animals | rac GTP-Binding Proteins - classification | rac GTP-Binding Proteins - genetics | rho GTP-Binding Proteins - metabolism | rho GTP-Binding Proteins - classification | Protein Binding | rac GTP-Binding Proteins - chemistry | rho GTP-Binding Proteins - chemistry | Transcription, Genetic - genetics | Aplysia | Analysis | Cell cycle | Physiological aspects | Genetic aspects | Research | G proteins | Genetic transcription
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2. Full Text PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility
by Wang, Xinnan and Winter, Dominic and Ashrafi, Ghazaleh and Schlehe, Julia and Wong, Yao Liang and Selkoe, Dennis and Rice, Sarah and Steen, Judith and LaVoie, Matthew J and Schwarz, Thomas L
Cell, ISSN 0092-8674, 2011, Volume 147, Issue 4, pp. 893 - 906
Cells keep their energy balance and avoid oxidative stress by regulating mitochondrial movement, distribution, and clearance. We report here that two... 
PINK1/PARKIN PATHWAY | KINESIN | INTERACTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | AXONAL-TRANSPORT | MITOPHAGY | DOPAMINERGIC-NEURONS | DEFICIENT MICE | MUTATIONS | DROSOPHILA | CELL BIOLOGY | Protein Kinases - metabolism | Phosphorylation | Humans | Ubiquitin-Protein Ligases - metabolism | Molecular Sequence Data | Rats | Mitochondria - metabolism | Drosophila Proteins - chemistry | Drosophila Proteins - metabolism | Mitochondrial Membranes - metabolism | Animals | Mitochondrial Proteins - metabolism | rho GTP-Binding Proteins - metabolism | Mitochondrial Proteins - chemistry | rho GTP-Binding Proteins - chemistry | Mice | Parkinson Disease - metabolism | Drosophila melanogaster | Ubiquitin | Quarantine | Mitochondrial DNA | Parkinson's disease | Ligases | Cells
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3. Full Text Structural Basis of Dimeric Rasip1 RA Domain Recognition of the Ras Subfamily of GTP-Binding Proteins
by Gingras, Alexandre R and Puzon-McLaughlin, Wilma and Bobkov, Andrey A and Ginsberg, Mark H
Structure, ISSN 0969-2126, 12/2016, Volume 24, Issue 12, pp. 2152 - 2162
Ras-interacting protein 1 (Rasip1) is an endothelial-specific Rap1 and Ras effector, important for vascular development and angiogenesis. Here, we report the... 
Ras-interacting protein 1 (Rasip1) | Rap | rain | Ras | GTP-binding proteins | dimer | crystal structure | Radil | Ras-association (RA) domain | heart of glass (HEG1) | AF-6 | BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RHO | ARHGAP29 | IDENTIFICATION | P21 | CELL BIOLOGY | rap1 GTP-Binding Proteins - metabolism | Protein Structure, Secondary | rap1 GTP-Binding Proteins - chemistry | Humans | Models, Molecular | ras Proteins - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | ras Proteins - chemistry | Protein Binding | Protein Domains | Binding Sites | Dimerization | Structure | Binding proteins | Crystals | Protein binding
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4. Full Text Rho GTPases: Biochemistry and biology
by Jaffe, Aron B and Hall, Alan
Annual Review of Cell and Developmental Biology, ISSN 1081-0706, 2005, Volume 21, Issue 1, pp. 247 - 269
Approximately one percent of the human genome encodes proteins that either regulate or are regulated by direct interaction with members of the Rho family of... 
Morphogenesis | Cytoskeleton | Migration | Cell cycle | BINDING PROTEINS RAC1 | cytoskeleton | cell cycle | CYCLIN D1 EXPRESSION | ACTIN POLYMERIZATION | EPITHELIAL TIGHT JUNCTION | FACTOR-KAPPA-B | DEVELOPMENTAL BIOLOGY | NUCLEOTIDE EXCHANGE FACTORS | CELL BIOLOGY | morphogenesis | migration | NEURONAL POLARITY | CELL-CELL ADHESION | SIGNAL-REGULATED KINASE | AMINO-TERMINAL KINASE | Animals | Models, Biological | Humans | rho GTP-Binding Proteins - metabolism | rho GTP-Binding Proteins - chemistry | Biochemical Phenomena | Biochemistry | Biology
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5. Full Text GEFs and GAPs: Critical Elements in the Control of Small G Proteins
by Bos, Johannes L and Rehmann, Holger and Wittinghofer, Alfred
Cell, ISSN 0092-8674, 06/2007, Volume 129, Issue 5, pp. 865 - 877
Guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) regulate the activity of small guanine nucleotide-binding (G) proteins to... 
CYCLIC-AMP | GUANINE-NUCLEOTIDE-EXCHANGE | STRUCTURAL BASIS | SIGNALING PATHWAY | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GTPASE-ACTIVATING-PROTEIN | TUBEROUS SCLEROSIS | FAMILY PROTEINS | RHO-GTPASES | PLASMA-MEMBRANE | CELL BIOLOGY | Signal Transduction | GTPase-Activating Proteins - antagonists & inhibitors | Humans | Models, Molecular | GTPase-Activating Proteins - chemistry | GTPase-Activating Proteins - metabolism | Neoplasms - drug therapy | Animals | Guanine Nucleotide Exchange Factors - antagonists & inhibitors | Monomeric GTP-Binding Proteins - metabolism | Guanine Nucleotide Exchange Factors - metabolism | Monomeric GTP-Binding Proteins - chemistry | Guanine Nucleotide Exchange Factors - chemistry | Proteins | Physiological aspects | G proteins
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6. Full Text Initiation of Cell Wall Pattern by a Rho- and Microtubule-Driven Symmetry Breaking
by Yoshihisa Oda and Hiroo Fukuda
Science, ISSN 0036-8075, 9/2012, Volume 337, Issue 6100, pp. 1333 - 1336
A specifically patterned cell wall is a determinant of plant cell shape. Yet, the precise mechanisms that underlie initiation of cell wall patterning remain... 
Proteins | Cell culture techniques | Xylem | Cell walls | Microtubules | Epidermal cells | REPORTS | Cell membranes | Plants | Cellular differentiation | Plant cells | ROP | DOMAIN | POLARITY | MULTIDISCIPLINARY SCIENCES | GROWTH | PLANTS | ARABIDOPSIS | PROTEINS | GTPASE | EXPRESSION | FAMILY | Microtubule-Associated Proteins - chemistry | Arabidopsis - enzymology | Xylem - enzymology | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Cell Wall - enzymology | GTPase-Activating Proteins - metabolism | Arabidopsis Proteins - metabolism | Xylem - cytology | Guanine Nucleotide Exchange Factors - metabolism | Cell Shape | rho GTP-Binding Proteins - chemistry | Microtubules - chemistry | Protein Structure, Tertiary | Arabidopsis Proteins - genetics | Guanine Nucleotide Exchange Factors - genetics | Arabidopsis - chemistry | rho GTP-Binding Proteins - genetics | Arabidopsis - cytology | Cell Wall - chemistry | GTPase-Activating Proteins - chemistry | Xylem - chemistry | Arabidopsis Proteins - chemistry | Microtubules - enzymology | rho GTP-Binding Proteins - metabolism | GTPase-Activating Proteins - genetics | Guanine Nucleotide Exchange Factors - chemistry | Genetic aspects | Plant cells and tissues | Research | Plant cell walls | Plant molecular biology | Plant biology | Plasma | Cytoskeleton | Symmetry | Binding | Broken symmetry | Fluid dynamics | Guanosines | Formations | Pits | Walls
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7. Full Text The 'invisible hand': regulation of RHO GTPases by RHOGDIs
by Burridge, Keith and Garcia-Mata, Rafael and Boulter, Etienne
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 08/2011, Volume 12, Issue 8, pp. 493 - 504
The 'invisible hand' is a term originally coined by Adam Smith in The Theory of Moral Sentiments to describe the forces of self-interest, competition and... 
GTP-BINDING PROTEIN | TUMOR PROGRESSION | PERINEURAL INVASION | TYROSINE KINASE | CELL-MIGRATION | CRYSTAL-STRUCTURE | BARRIER FUNCTION | PROTEOMIC ANALYSIS | ACTIVATING MUTANT | GDP-DISSOCIATION-INHIBITOR | CELL BIOLOGY | Neoplasms - metabolism | Phosphorylation | Molecular Chaperones - metabolism | Guanine Nucleotide Dissociation Inhibitors - chemistry | Membrane Microdomains - metabolism | Guanine Nucleotide Dissociation Inhibitors - metabolism | Humans | Multiprotein Complexes | Models, Molecular | Phylogeny | rho-Specific Guanine Nucleotide Dissociation Inhibitors | Animals | Metabolic Networks and Pathways | Models, Biological | rho GTP-Binding Proteins - metabolism | rho GTP-Binding Proteins - chemistry | Guanine Nucleotide Dissociation Inhibitors - genetics | Protein Interaction Domains and Motifs | rho Guanine Nucleotide Dissociation Inhibitor alpha | Evolution, Molecular | Cellular control mechanisms | Physiological aspects | Genetic aspects | Research | Properties | Gene expression | Guanosine triphosphatase | Membrane proteins
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8. Full Text Inside-out, outside-in, and inside–outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction
by Shen, Bo and Delaney, M Keegan and Du, Xiaoping
Current Opinion in Cell Biology, ISSN 0955-0674, 2012, Volume 24, Issue 5, pp. 600 - 606
The integrin family of cell adhesion receptors mediates bi-directional signaling: ‘inside-out’ signaling activates the ligand binding function of integrins and... 
Internal Medicine | MIGRATION | ACTIVATION | RHO ACTIVITY | P115 RHOGEF | RAC | SRC | PLATELET-FUNCTION | KINASE | DISTINCT ROLES | BINDING | CELL BIOLOGY | Animals | Cell Adhesion - physiology | Cell Surface Extensions - metabolism | Humans | Integrins - chemistry | Heterotrimeric GTP-Binding Proteins - chemistry | Cell Size | Heterotrimeric GTP-Binding Proteins - metabolism | Signal Transduction - physiology | Integrins - metabolism | GTP-Binding Protein alpha Subunits, G12-G13 - metabolism | G proteins | Membrane proteins | Integrins
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9. Full Text In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C
by John C. Hunter and Deepak Gurbania and Scott B. Ficarro and Martin A. Carrasco and Sang Min Lim and Hwan Geun Choi and Ting Xie and Jarrod A. Marto and Zhe Chen and Nathanael S. Gray and Kenneth D. Westover
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2014, Volume 111, Issue 24, pp. 8895 - 8900
Directly targeting oncogenic V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (K-Ras) with small-molecule inhibitors has historically been considered... 
Active sites | Medical treatment | Crystals | Amino acids | Biochemistry | Nucleotides | Environmental conservation | Binding sites | Crystal structure | Cancer | ActivX | CPM assay | SMALL MOLECULES | MULTIDISCIPLINARY SCIENCES | SMALL-CELL LUNG | COVALENT DRUGS | PHASE-II | GROWTH-FACTOR RECEPTOR | EVOLUTIONARY CONSERVATION | RHO GTPASES | FUNCTIONAL-ANALYSIS | MEDIATED NUCLEOTIDE EXCHANGE | PROTEIN-KINASE INHIBITORS | Catalytic Domain | GTP-Binding Proteins - chemistry | Signal Transduction | Humans | Phosphatidylinositol 3-Kinases - chemistry | ras Proteins - antagonists & inhibitors | Models, Molecular | Crystallography, X-Ray | Biotin - chemistry | GTP Phosphohydrolases - chemistry | Acetamides - chemistry | Guanosine Diphosphate - analogs & derivatives | ras Proteins - chemistry | Proteomics | Conserved Sequence | Protein Binding | Ligands | Protein Conformation | Guanosine Triphosphate - chemistry | Guanosine Diphosphate - chemistry | Mutation | Genes, ras | Binding Sites | Enzyme inhibitors | Sarcoma | Analysis | Development and progression | Genetic aspects | Research | Structure | Risk factors | Protein binding | Biological Sciences | Physical Sciences
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