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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2005, Volume 386, Issue 2, pp. 201 - 214
The Rho GTPases are a family of molecular switches that are critical regulators of signal transduction pathways in eukaryotic cells. They are known principally... 
Rho | ROK (rho-kinase) | Rac | MLK (mixed-lineage kinase) | PAK (p21-activated kinase) | Cdc42 | BINDING PROTEIN-RHO | SERINE-THREONINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MYOTONIC-DYSTROPHY KINASE | ACTIN STRESS FIBERS | P21-ACTIVATED KINASE | MIXED-LINEAGE KINASE | SMALL GTPASE RHO | ANCHORAGE-INDEPENDENT GROWTH | ROK (Rho-kinase) | CDC42-BINDING KINASE | MYOSIN LIGHT-CHAIN | p21-Activated Kinases | Amino Acid Sequence | Animals | Humans | rho-Associated Kinases | Intracellular Signaling Peptides and Proteins | Molecular Sequence Data | Genetic Variation - physiology | Protein-Serine-Threonine Kinases - metabolism | PBD, p21-binding domain | ROK, Rho-kinase | PDK1, 3-phosphoinositide-dependent kinase 1 | Review | ACC, anti-parallel coiled-coil | MEKK, MAPK | SH3, Src homology 3 | JNK, c-Jun N-terminal kinase | CRIB, Cdc42 and Rac interactive binding | KIM, KI motif | MRCK, myotonin-related Cdc42-binding kinase | MLK, mixed-lineage kinase | PKN, protein kinase novel | PKC, protein kinase C | PAK, p21-activated kinase | Crmp, collapsin response mediator protein | CRIK, citron kinase | R-MLC, regulatory myosin light chain | KI, kinase inhibitory | MKK, MAPK kinase | ERK (extracellular-signal-regulated kinase) kinase kinase | PH, pleckstrin homology | GEF, guanine nucleotide exchange factor | MBS, myosin-binding subunit | PP1, protein phosphatase type 1 | DMPK, myotonic dystrophy kinase | GIT1, G-protein-coupled receptor kinase-interacting target 1 | PIX, PAK-interacting exchange factor | Hsp90, heat shock protein 90 | MAPK, mitogen-activated protein kinase | LIMK, LIM domain kinase
Journal Article
Cancer Science, ISSN 1347-9032, 02/2011, Volume 102, Issue 2, pp. 393 - 399
Malignant gliomas are characterized by high invasive potential and strong angiogenic ability. Constitutive activation of Rho and its downstream target... 
FASUDIL HYDROCHLORIDE | CELLS | GLIOBLASTOMA | INVASION | GTPASES | ONCOLOGY | PHOSPHORYLATION | CEREBRAL VASOSPASM | RADIOTHERAPY | ENDOTHELIAL GROWTH-FACTOR | ADJUVANT TEMOZOLOMIDE | Enzyme-Linked Immunosorbent Assay | Gene Expression - drug effects | Humans | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Brain Neoplasms - blood supply | Extracellular Signal-Regulated MAP Kinases - metabolism | Enzyme Activation - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Brain Neoplasms - metabolism | Glioma - metabolism | Glioma - blood supply | Cell Movement - drug effects | Mitogen-Activated Protein Kinase Kinases - metabolism | Signal Transduction - drug effects | rho-Associated Kinases - metabolism | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Neovascularization, Pathologic - metabolism | Protein Kinase Inhibitors - pharmacology | Gliomas | Analysis | Genetic research | Development and progression | Vascular endothelial growth factor | Protein kinases | Enzyme-linked immunosorbent assay | Endothelium | Protein binding | Cell culture | Animal models | Phosphorylation | Invasiveness | Brain tumors | Extracellular signal-regulated kinase | MAP kinase | Matrix metalloproteinase | Endothelial cells | Gelatinase B | Rho-associated kinase | Western blotting | Polymerase chain reaction | Angiogenesis | Glioma | Glioma cells | Tumors
Journal Article
Nature Communications, ISSN 2041-1723, 05/2016, Volume 7, Issue 1, p. 11363
No effective targeted therapies exist for cancers with somatic KRAS mutations. Here we develop a synthetic lethal chemical screen in isogenic KRAS-mutant and... 
CELL LUNG-CANCER | SURVIVAL | COMBINATION THERAPY | STRATEGY | MULTIDISCIPLINARY SCIENCES | SYNTHETIC LETHAL INTERACTION | RESISTANCE | MUTATIONS | RAS ONCOGENES | EXPRESSION | REVEALS | Lung Neoplasms - drug therapy | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Male | Antineoplastic Agents - administration & dosage | Lung Neoplasms - physiopathology | G2 Phase - drug effects | Tumor Suppressor Protein p53 - genetics | rho-Associated Kinases - antagonists & inhibitors | Cell Cycle Proteins - antagonists & inhibitors | Enzyme Inhibitors - administration & dosage | Cyclin-Dependent Kinase Inhibitor p21 - genetics | rho-Associated Kinases - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Lung Neoplasms - enzymology | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | rho-Associated Kinases - genetics | Proto-Oncogene Proteins - genetics | Cell Division - drug effects | Animals | Proto-Oncogene Proteins p21(ras) - antagonists & inhibitors | Mice | Mice, Inbred BALB C | Mutation | Transcription | Polo-like kinase 1 | Lung cancer | Cyclin-dependent kinases | RhoA protein | Kinases | Rho-associated kinase | Cyclin-dependent kinase | Organic chemistry | Synergistic effects | Cyclin-dependent kinase inhibitor p21 | Transfection | DNA microarrays | Polo-like kinase | Rocks | Inhibition | Tumors | Cancer
Journal Article
Small GTPases, ISSN 2154-1248, 04/2014, Volume 5, Issue 2, p. e29846
Rho-associated coiled-coil containing kinases (ROCK) were originally identified as effectors of the RhoA small GTPase. 1 - 5 They belong to the AGC family of... 
actin | kinase | ROCK | cytoskeleton | signal transduction | Rho | myosin | phosphorylation | Signal transduction | Phosphorylation | Actin | Kinase | Myosin | Cytoskeleton | rho-Associated Kinases - chemistry | Animals | Signal Transduction | rho-Associated Kinases - metabolism | Humans | Actins - metabolism | Cytoskeleton - metabolism | Myosins - metabolism | Apoptosis | Expressed Sequence Tags
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 07/2014, Volume 34, Issue 7, pp. 1429 - 1436
OBJECTIVE—Mitogen-activated protein kinase pathways play an important role in neointima formation secondary to vascular injury, in part by promoting... 
neointima | mitogen-activated protein kinase kinase kinase | MLK3 | PROTEIN-KINASE | DOWN-REGULATION | PROLIFERATION | HYPERPLASIA | APOLIPOPROTEIN-E | IN-VIVO | NUCLEOTIDE EXCHANGE FACTOR | PERIPHERAL VASCULAR DISEASE | GENE-TRANSFER | HEMATOLOGY | SIGNAL-REGULATED KINASE | Cell Proliferation | Hyperplasia | Myocytes, Smooth Muscle - pathology | JNK Mitogen-Activated Protein Kinases - metabolism | Neointima | MAP Kinase Kinase Kinases - deficiency | Time Factors | rho-Associated Kinases - metabolism | Carotid Arteries - enzymology | Carotid Artery Injuries - genetics | Rho Guanine Nucleotide Exchange Factors - metabolism | Myocytes, Smooth Muscle - drug effects | Carotid Artery Injuries - pathology | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Signal Transduction | MAP Kinase Kinase Kinases - genetics | Myocytes, Smooth Muscle - enzymology | Mice, Inbred C57BL | Cells, Cultured | Mice, Knockout | Muscle, Smooth, Vascular - pathology | Animals | Carotid Artery Injuries - enzymology | rho GTP-Binding Proteins - metabolism | Carotid Arteries - pathology | Mice | Protein Kinase Inhibitors - pharmacology | Muscle, Smooth, Vascular - enzymology | cJun NH2-terminal kinase | p63RhoGEF | Rho-kinase | vascular smooth muscle cell | mixed-lineage kinase | RhoA
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2011, Volume 108, Issue 42, pp. 17349 - 17354
Journal Article
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 01/2010, Volume 11, Issue 1, pp. 9 - 22
Journal Article