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Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Nature Communications, ISSN 2041-1723, 05/2016, Volume 7, Issue 1, p. 11363
.... Our results show that dual inhibition of polo-like kinase 1 and RhoA/Rho kinase (ROCK) leads to the synergistic effects in KRAS-mutant cancers... 
CELL LUNG-CANCER | SURVIVAL | COMBINATION THERAPY | STRATEGY | MULTIDISCIPLINARY SCIENCES | SYNTHETIC LETHAL INTERACTION | RESISTANCE | MUTATIONS | RAS ONCOGENES | EXPRESSION | REVEALS | Lung Neoplasms - drug therapy | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Male | Antineoplastic Agents - administration & dosage | Lung Neoplasms - physiopathology | G2 Phase - drug effects | Tumor Suppressor Protein p53 - genetics | rho-Associated Kinases - antagonists & inhibitors | Cell Cycle Proteins - antagonists & inhibitors | Enzyme Inhibitors - administration & dosage | Cyclin-Dependent Kinase Inhibitor p21 - genetics | rho-Associated Kinases - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Lung Neoplasms - enzymology | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | rho-Associated Kinases - genetics | Proto-Oncogene Proteins - genetics | Cell Division - drug effects | Animals | Proto-Oncogene Proteins p21(ras) - antagonists & inhibitors | Mice | Mice, Inbred BALB C | Mutation | Transcription | Polo-like kinase 1 | Lung cancer | Cyclin-dependent kinases | RhoA protein | Kinases | Rho-associated kinase | Cyclin-dependent kinase | Organic chemistry | Synergistic effects | Cyclin-dependent kinase inhibitor p21 | Transfection | DNA microarrays | Polo-like kinase | Rocks | Inhibition | Tumors | Cancer
Journal Article
JOURNAL OF CELL BIOLOGY, ISSN 0021-9525, 09/2013, Volume 202, Issue 6, pp. 901 - 916
...; however, the mechanism underlying Rap1-induced CAB formation remains unknown. Here, we show that myotonic dystrophy kinase-related CDC42-binding kinase (MRCK... 
P21-ACTIVATED KINASE | EXCHANGE FACTOR | SMOOTH-MUSCLE | REGULATORY LIGHT-CHAIN | RHO-KINASE | BARRIER FUNCTION | VE-CADHERIN | ADHERENS JUNCTIONS | CDC42-BINDING KINASE | GROWTH-FACTOR | CELL BIOLOGY | RNA, Small Interfering - genetics | Phosphorylation | Cell Proliferation | rho GTP-Binding Proteins - antagonists & inhibitors | Human Umbilical Vein Endothelial Cells - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Actins - metabolism | cdc42 GTP-Binding Protein - metabolism | Immunoenzyme Techniques | rho-Associated Kinases - antagonists & inhibitors | Telomere-Binding Proteins - genetics | Protein-Tyrosine Kinases - genetics | Myosin Type II - metabolism | rho-Associated Kinases - metabolism | Human Umbilical Vein Endothelial Cells - cytology | cdc42 GTP-Binding Protein - antagonists & inhibitors | Cell Membrane - metabolism | Myosin Type II - genetics | Telomere-Binding Proteins - metabolism | Myotonin-Protein Kinase | rho GTP-Binding Proteins - genetics | Cells, Cultured | Intercellular Junctions - metabolism | rho-Associated Kinases - genetics | Cell Adhesion | Telomere-Binding Proteins - antagonists & inhibitors | Blotting, Western | cdc42 GTP-Binding Protein - genetics | rho GTP-Binding Proteins - metabolism | Cell Movement | Protein-Tyrosine Kinases - antagonists & inhibitors | Junctional complexes (Epithelium) | Cell junctions | Physiological aspects | Actin | Myosin | Endothelium
Journal Article
Journal of bone and mineral research, ISSN 0884-0431, 2011, Volume 26, Issue 4, pp. 730 - 738
.... The aim of this study was to further delineate how matrix stiffness affects intracellular signaling through the mechanotransducers Rho kinase (ROCK... 
mesenchymal stem cell | matrix stiffness | integrin | mechanotransduction | osteogenic differentiation | MATRIX STIFFNESS | OSTEOBLAST DIFFERENTIATION | GROWTH-HORMONE | INTEGRIN | ENDOCRINOLOGY & METABOLISM | OSTEOGENIC DIFFERENTIATION | FOCAL ADHESION KINASE | LINEAGE | MESENCHYMAL STEM CELL | RHOA | MECHANOTRANSDUCTION | RNA, Small Interfering - genetics | Osteogenesis - physiology | Gene Expression - drug effects | Gene Expression - genetics | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Collagen Type I - chemistry | Osteocalcin - genetics | Acrylic Resins - chemical synthesis | Integrin alpha2 - metabolism | Mechanotransduction, Cellular - physiology | rho-Associated Kinases - antagonists & inhibitors | Elasticity - physiology | Mesenchymal Stromal Cells - cytology | Collagen Type I - genetics | rho-Associated Kinases - metabolism | Extracellular Matrix - physiology | Myosin-Light-Chain Phosphatase - metabolism | Osteoblasts - cytology | Phosphorylation - drug effects | Cell Differentiation - physiology | Focal Adhesion Kinase 1 - metabolism | Mesenchymal Stromal Cells - drug effects | Calcification, Physiologic - drug effects | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Osteoblasts - drug effects | Calcification, Physiologic - physiology | Mesenchymal Stromal Cells - metabolism | Acrylic Resins - chemistry | beta Catenin - metabolism | Biomechanical Phenomena | Integrin alpha2 - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Cell Differentiation - drug effects | Protein Kinase Inhibitors - pharmacology | Osteoblasts - metabolism | Focal Adhesion Kinase 1 - antagonists & inhibitors | Core Binding Factor Alpha 1 Subunit - genetics | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 11/2017, Volume 43, Issue 3, pp. 1025 - 1036
...: The cell migration was examined using Boyden chamber, and phosphorylation of each kinase was analyzed by Western blotting. Results... 
Original Paper | SAPK/JNK | Osteoblast | Akt | EGF | Migration | Resveratrol | CELLS | PHYSIOLOGY | KINASE | CANCER | PROSTAGLANDIN-E2 | FAMILY | CELL BIOLOGY | CYCLIC-AMP | IN-VITRO | SAPK/JNK Akt | PATHWAY | BONE | DIFFERENTIATION | Sirtuin 1 - metabolism | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases - metabolism | Stilbenes - pharmacology | Heterocyclic Compounds, 4 or More Rings - pharmacology | rho-Associated Kinases - antagonists & inhibitors | rho-Associated Kinases - metabolism | Flavonoids - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Osteoblasts - cytology | Phosphorylation - drug effects | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Osteoblasts - drug effects | Cells, Cultured | Imidazoles - pharmacology | Sirtuin 1 - antagonists & inhibitors | Anthracenes - pharmacology | Cell Movement - drug effects | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mice | Pyridines - pharmacology | Epidermal Growth Factor - pharmacology | Osteoblasts - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Immunoglobulins | Fractures | Epidermal growth factor | Metabolism | Kinases | Cell adhesion & migration
Journal Article
Cell death and differentiation, ISSN 1476-5403, 2013, Volume 21, Issue 1, pp. 79 - 91
The immunogenic demise of cancer cells can be induced by various chemotherapeutics, such as anthracyclines and oxaliplatin, and provokes an immune response... 
quinacrine | apoptosis | U2OS cells | caspases | endoplasmic reticulum stress | Beclin 1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | RELEASE | AUTOPHAGY | CLEAVAGE | CHEMOTHERAPY | CELL BIOLOGY | CALRETICULIN EXPOSURE | PANNEXIN 1 | ASSAYS | FIND-ME SIGNAL | Connexins - antagonists & inhibitors | RNA-Binding Proteins - genetics | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Cell Death - immunology | rho-Associated Kinases - antagonists & inhibitors | Antineoplastic Agents - toxicity | DNA-Binding Proteins - metabolism | Lysosomes - metabolism | Lysosomal-Associated Membrane Protein 1 - genetics | Myosin Type II - metabolism | RNA Interference | rho-Associated Kinases - metabolism | Adenosine Triphosphate - metabolism | HMGB1 Protein - metabolism | Cell Membrane - metabolism | Cell Death - drug effects | RNA-Binding Proteins - antagonists & inhibitors | Nerve Tissue Proteins - antagonists & inhibitors | DNA-Binding Proteins - antagonists & inhibitors | Connexins - genetics | rho-Associated Kinases - genetics | Lysosomal-Associated Membrane Protein 1 - antagonists & inhibitors | Microtubule-Associated Proteins - antagonists & inhibitors | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Connexins - metabolism | Nerve Tissue Proteins - metabolism | Animals | Autophagy-Related Protein 5 | Cell Line, Tumor | Lysosomal-Associated Membrane Protein 1 - metabolism | Mice | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism | Original Paper
Journal Article
Developmental Biology, ISSN 0012-1606, 10/2014, Volume 394, Issue 1, pp. 142 - 155
...) kinases are prevented from phosphorylating YAP, a key transcriptional co-activator of the TE-specifying gene Cdx2... 
Trophectoderm | Cell lineage | YAP | Cell polarity | CDX2 | Inner cell mass | LINEAGE DIFFERENTIATION | PREIMPLANTATION EMBRYO | STEM-CELLS | KINASE | EPITHELIAL POLARITY | FATE SPECIFICATION | DEVELOPMENTAL BIOLOGY | BINDING PROTEIN RHO | YAP PATHWAY | rho GTP-Binding Proteins - antagonists & inhibitors | Tumor Suppressor Proteins - antagonists & inhibitors | rho-Associated Kinases - antagonists & inhibitors | Ectoderm - metabolism | RNA Interference | rho-Associated Kinases - metabolism | Gene Expression Regulation, Developmental | Tumor Suppressor Proteins - genetics | Mice, Inbred DBA | Cell Differentiation | Protein-Serine-Threonine Kinases - metabolism | Amides - pharmacology | Homeodomain Proteins - biosynthesis | Nanog Homeobox Protein | Phosphoproteins - biosynthesis | Signal Transduction | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - biosynthesis | Protein Kinase C - antagonists & inhibitors | Cell Lineage | Animals | Blastocyst Inner Cell Mass - metabolism | Homeodomain Proteins - antagonists & inhibitors | rho GTP-Binding Proteins - metabolism | Cell Polarity - physiology | Adaptor Proteins, Signal Transducing - biosynthesis | Mice | Pyridines - pharmacology | RNA, Small Interfering | CDX2 Transcription Factor | G proteins | trophectoderm | cell polarity | cell lineage
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 05/2011, Volume 300, Issue 5, pp. 1181 - 1192
Enhanced vascular arginase activity impairs endothelium-dependent vasorelaxation by decreasing l-arginine availability to endothelial nitric oxide (NO)... 
Endothelial nitric oxide synthase dysfunction | PHYSIOLOGY | BLOOD-PRESSURE | P38 MAP KINASE | CELL BIOLOGY | INCREASED ARGINASE ACTIVITY | NITRIC-OXIDE PRODUCTION | INHIBITION | MOUSE MODEL | endothelial nitric oxide synthase dysfunction | CARDIOVASCULAR-DISEASE | SMOOTH-MUSCLE-CELLS | HYPERTENSIVE-RATS | CONTRIBUTES | Phosphorylation | Endothelial Cells | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Endothelium, Vascular - drug effects | Endothelium, Vascular - enzymology | GTP-Binding Protein alpha Subunits, G12-G13 - antagonists & inhibitors | Simvastatin - pharmacology | Angiotensin II Type 1 Receptor Blockers - pharmacology | rho-Associated Kinases - antagonists & inhibitors | Cattle | Arginase - antagonists & inhibitors | Amides - pharmacology | Cell Line | rho-Associated Kinases - physiology | Angiotensin II - pharmacology | p38 Mitogen-Activated Protein Kinases - physiology | RNA, Small Interfering - pharmacology | Endothelium, Vascular - physiopathology | Enzyme Inhibitors - pharmacology | GTP-Binding Protein alpha Subunits, Gq-G11 - antagonists & inhibitors | Imidazoles - pharmacology | Animals | Signal Transduction - drug effects | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Signal Transduction - physiology | Mice | Pyridines - pharmacology | Arginase - physiology | Angiotensin II - physiology | Boronic Acids - pharmacology | Abnormalities | Angiotensin | Physiological aspects | Vascular endothelium | Genetic aspects | Research | Mitogen-activated protein kinases | Index Medicus | Vascular Biology
Journal Article