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rhoa (852) 852
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actin cytoskeleton (256) 256
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rhoa gtp-binding protein (239) 239
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Oncogene, ISSN 0950-9232, 04/2009, Volume 28, Issue 13, pp. 1570 - 1583
The motility of cancer cells in 3D matrices is of two types: mesenchymal motility, in which the cells are elongated and amoeboid motility, in which the cells... 
Amoeboid | Rac | Migration | Invasion | Cancer | Mesenchymal | PERICELLULAR PROTEOLYSIS | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | amoeboid | MECHANISMS | CELL BIOLOGY | ACTIN-RELATED PROTEIN-2 | WAVE2 | MODES | invasion | GTPASES | ONCOLOGY | mesenchymal | GENETICS & HEREDITY | migration | cancer | PLASTICITY | Neoplasms - metabolism | Humans | rac GTP-Binding Proteins - metabolism | rhoA GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - physiology | Cell Shape - genetics | rhoA GTP-Binding Protein - genetics | Cell Culture Techniques - methods | Cell Movement - genetics | Cell Movement - physiology | Neoplasms - genetics | rac GTP-Binding Proteins - genetics | Collagen - pharmacology | Tumor Cells, Cultured | rac GTP-Binding Proteins - physiology | Cell Adhesion - genetics | Neoplasm Invasiveness | rho GTP-Binding Proteins - genetics | Mutant Proteins - metabolism | Signal Transduction - genetics | Mutant Proteins - physiology | rho GTP-Binding Proteins - physiology | rac1 GTP-Binding Protein - physiology | Cell Adhesion - physiology | rho GTP-Binding Proteins - metabolism | Signal Transduction - physiology | Cell Shape - physiology | Neoplasms - pathology | rac1 GTP-Binding Protein - metabolism | Gels - pharmacology | rac1 GTP-Binding Protein - genetics | Physiological aspects | Cellular signal transduction | Motility | Research | Cells | Cancer cells | Signal transduction | Oncology | Genetics | Substrates | Cell adhesion & migration
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2016, Volume 291, Issue 9, pp. 4323 - 4333
...) undergo rapid remodeling into dynamic extracellular matrix-degrading rosettes by distinct G protein-coupled receptor agonists, notably lysophosphatidic acid (LPA... 
Receptors, Lysophosphatidic Acid - metabolism | Lysophospholipids - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Extracellular Matrix - metabolism | Melanoma - enzymology | Podosomes - enzymology | Neoplasm Proteins - antagonists & inhibitors | Receptors, Lysophosphatidic Acid - agonists | Receptors, Lysophosphatidic Acid - genetics | cdc42 GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - genetics | Endothelins - metabolism | Neoplasm Proteins - metabolism | Time-Lapse Imaging | Podosomes - metabolism | RNA Interference | cdc42 GTP-Binding Protein - antagonists & inhibitors | Fluorescence Resonance Energy Transfer | Receptors, Lysophosphatidic Acid - antagonists & inhibitors | Neoplasm Proteins - genetics | Biomarkers - metabolism | Melanoma - metabolism | Recombinant Proteins - metabolism | rac1 GTP-Binding Protein - agonists | rhoA GTP-Binding Protein - antagonists & inhibitors | Recombinant Proteins - genetics | Melanoma - pathology | cdc42 GTP-Binding Protein - agonists | Hydrolysis | Podosomes - pathology | Microscopy, Confocal | Neoplasm Proteins - agonists | cdc42 GTP-Binding Protein - genetics | Receptors, G-Protein-Coupled - antagonists & inhibitors | rac1 GTP-Binding Protein - antagonists & inhibitors | Cell Line, Tumor | Luminescent Proteins - genetics | Receptors, G-Protein-Coupled - genetics | Extracellular Matrix - pathology | Microscopy, Fluorescence | rac1 GTP-Binding Protein - metabolism | Luminescent Proteins - metabolism | rac1 GTP-Binding Protein - genetics | CDC42 | invadopodia | biosensor | fluorescence resonance energy transfer (FRET) | calcium intracellular release | G protein-coupled receptor (GPCR) | Rho (Rho GTPase) | phosphatidylinositide 3-kinase (PI 3-kinase) | imaging | Rac (Rac GTPase) | Cell Biology
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2011, Volume 121, Issue 2, pp. 628 - 639
RHO family proteins are important for the function of inflammatory cells. They are modified with a 20-carbon geranylgeranyl lipid in a process catalyzed by protein geranylgeranyltransferase type I (GGTase... 
INDUCED LUNG-CANCER | RHEUMATOID-ARTHRITIS | PROTEIN PRENYLTRANSFERASES | SIGNAL-TRANSDUCTION | MEDICINE, RESEARCH & EXPERIMENTAL | CELL-DIVISION | K-RAS | DISSOCIATION INHIBITORS | INTERLEUKIN-1-BETA SECRETION | RHO-GTPASES | T-CELLS | Macrophages - physiology | rap1 GTP-Binding Proteins - metabolism | Arthritis - pathology | Mice, Inbred C57BL | cdc42 GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - metabolism | Macrophages - cytology | rhoA GTP-Binding Protein - genetics | Macrophages - enzymology | Mice, Knockout | Animals | Alkyl and Aryl Transferases - genetics | cdc42 GTP-Binding Protein - genetics | Arthritis - immunology | Mice | rap1 GTP-Binding Proteins - genetics | Alkyl and Aryl Transferases - deficiency | Macrophages - immunology | rac1 GTP-Binding Protein - metabolism | Cytokines - immunology | rac1 GTP-Binding Protein - genetics | Physiological aspects | Rheumatoid factor | Macrophages | Rheumatoid arthritis | Transferases | Risk factors | cytology | pathology | Cytokines | Cell and Molecular Biology | physiology | rhoA GTP-Binding Protein | Arthritis | enzymology | Inbred C57BL | Knockout | genetics | deficiency | rap1 GTP-Binding Proteins | Alkyl and Aryl Transferases | cdc42 GTP-Binding Protein | metabolism | rac1 GTP-Binding Protein | Cell- och molekylärbiologi | immunology
Journal Article
PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 1, p. e0147758
A critical and understudied property of endothelial cells is their ability to form lumens and tube networks. Although considerable information has been... 
COLLAGEN MATRIX | 3-DIMENSIONAL EXTRACELLULAR MATRICES | VASCULAR LUMEN FORMATION | IN-VITRO | CELL MORPHOGENESIS | ANGIOGENESIS | ACTIVATING PROTEIN | MULTIDISCIPLINARY SCIENCES | CAPILLARY LUMEN | BLOOD-VESSEL FORMATION | MOLECULAR-MECHANISMS | rap GTP-Binding Proteins - antagonists & inhibitors | ras Proteins - genetics | p120 GTPase Activating Protein - metabolism | Humans | rac GTP-Binding Proteins - metabolism | ras Proteins - metabolism | Male | cdc42 GTP-Binding Protein - metabolism | Phosphoproteins - antagonists & inhibitors | GTPase-Activating Proteins - metabolism | p120 GTPase Activating Protein - genetics | Phosphoproteins - metabolism | rac GTP-Binding Proteins - antagonists & inhibitors | Tubulin - metabolism | RNA Interference | rac GTP-Binding Proteins - genetics | cdc42 GTP-Binding Protein - antagonists & inhibitors | rap GTP-Binding Proteins - genetics | Phorbol Esters - pharmacology | Female | Cell Line | Endothelial Cells - metabolism | GTPase-Activating Proteins - antagonists & inhibitors | ras Proteins - antagonists & inhibitors | Phosphoproteins - genetics | p120 GTPase Activating Protein - antagonists & inhibitors | Animals | Signal Transduction - drug effects | Endothelial Cells - cytology | cdc42 GTP-Binding Protein - genetics | Cytoskeleton - metabolism | Vacuoles - metabolism | Mice | GTPase-Activating Proteins - genetics | rap GTP-Binding Proteins - metabolism | Microscopy, Fluorescence | Endothelial Cells - drug effects | Physiological aspects | Genetic aspects | Cellular signal transduction | Research | Guanosine triphosphatase | Endothelium | Cdc42 protein | Polarization | Membranes | Raf protein | K-Ras protein | Morphogenesis | Proteins | Lumens | Tubulin | Actin | IQGAP1 protein | Tubes | Physiology | Growth factors | Skewed distributions | RhoA protein | Rac1 protein | Pharmacology | siRNA | Rac2 protein | Endothelial cells | Effectors | Cytoskeleton | Membrane trafficking | Regulation | Molecular biology | Vacuoles | Guanosinetriphosphatase | Integrins | Regulators
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 06/2006, Volume 11, Issue 6, pp. 557 - 566
...) as critical regulators of spine structure. In addition, Duo and drebrin are spine-specific proteins that are critical for spine maintenance and spine formation, respectively... 
Dendritic spine | Schizophrenia | Drebrin | Pyramidal neuron | RhoGTPase | Duo | EXCHANGE FACTOR | CORTICAL PYRAMIDAL NEURONS | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | dendritic spine | schizophrenia | NEUROSCIENCES | MEDIODORSAL THALAMIC NUCLEUS | SOMAL SIZE | MESSENGER-RNA | AXON TERMINALS | pyramidal neuron | GENE-EXPRESSION | drebrin | ACTIN CYTOSKELETON | RHO-GTPASES | POSTSYNAPTIC DENSITY | duo | Schizophrenia - metabolism | Humans | Middle Aged | RNA, Messenger - analysis | Male | cdc42 GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - metabolism | Dendritic Spines - metabolism | Gene Expression Profiling | rhoA GTP-Binding Protein - genetics | Guanine Nucleotide Exchange Factors - drug effects | Prefrontal Cortex - drug effects | Dendritic Spines - drug effects | Guanine Nucleotide Exchange Factors - metabolism | Matched-Pair Analysis | Adult | Female | Neuropeptides - genetics | Neuropeptides - drug effects | Protein-Serine-Threonine Kinases - metabolism | Guanine Nucleotide Exchange Factors - genetics | rho GTP-Binding Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Neuropeptides - metabolism | Prefrontal Cortex - cytology | Haplorhini | rho GTP-Binding Proteins - drug effects | Animals | rac1 GTP-Binding Protein - drug effects | cdc42 GTP-Binding Protein - genetics | rho GTP-Binding Proteins - metabolism | Prefrontal Cortex - metabolism | Protein-Serine-Threonine Kinases - drug effects | Antipsychotic Agents - pharmacology | Schizophrenia - drug therapy | cdc42 GTP-Binding Protein - drug effects | rac1 GTP-Binding Protein - metabolism | rac1 GTP-Binding Protein - genetics
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2013, Volume 288, Issue 32, pp. 23543 - 23553
Journal Article
The Journal of cell biology, ISSN 1540-8140, 2003, Volume 162, Issue 2, pp. 223 - 232
Journal Article
Cell Death and Disease, ISSN 2041-4889, 01/2014, Volume 5, Issue 11, pp. e1517 - e1517
... pyrophosphates which were substrates for prenylation processes of small guanine-nucleotide-binding regulatory proteins (small G proteins... 
TRANSLOCASE | CONTAINING BISPHOSPHONATES INHIBIT | ISOPENTENYL PYROPHOSPHATE | GTPASES | PRENYLATION | CLODRONATE | ATP ANALOG | MEVALONATE PATHWAY | CANCER | CELL BIOLOGY | RNA, Small Interfering - genetics | Leucine - pharmacology | Mesothelioma - pathology | Apoptosis - drug effects | Farnesol - pharmacology | Humans | Gene Expression Regulation, Neoplastic | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | cdc42 GTP-Binding Protein - metabolism | rab GTP-Binding Proteins - genetics | rhoA GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - genetics | Protein Prenylation | Transferases - genetics | cdc42 GTP-Binding Protein - antagonists & inhibitors | Transferases - metabolism | Leucine - analogs & derivatives | Diterpenes - pharmacology | rab GTP-Binding Proteins - metabolism | DNA Topoisomerases, Type II - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Signal Transduction | rhoA GTP-Binding Protein - antagonists & inhibitors | Imidazoles - pharmacology | Mesothelioma - genetics | S Phase - genetics | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Diphosphonates - antagonists & inhibitors | Mesothelioma - metabolism | cdc42 GTP-Binding Protein - genetics | rac1 GTP-Binding Protein - antagonists & inhibitors | Cell Line, Tumor | DNA Topoisomerases, Type II - genetics | rab GTP-Binding Proteins - antagonists & inhibitors | Imidazoles - antagonists & inhibitors | S Phase - drug effects | Diphosphonates - pharmacology | rac1 GTP-Binding Protein - metabolism | RNA, Small Interfering - metabolism | rac1 GTP-Binding Protein - genetics | Original
Journal Article
British Journal of Cancer, ISSN 0007-0920, 09/2002, Volume 87, Issue 6, pp. 635 - 644
Journal Article
STEM CELLS, ISSN 1066-5099, 11/2011, Volume 29, Issue 11, pp. 1886 - 1897
.... It is known that biochemical and genetic factors regulate self‐renewal and differentiation, and it has recently been suggested that mechanical and solid... 
Cellular mechanotransduction | Elastic modulus | Neural stem cells | Extracellular matrix | Adipose stem cells | Rho GTP‐binding proteins | Rho GTP-binding proteins | PROGENITOR CELLS | ADULT HIPPOCAMPAL NEUROGENESIS | SELF-RENEWAL | NEURONAL DIFFERENTIATION | ATOMIC-FORCE MICROSCOPE | CELL & TISSUE ENGINEERING | CELL BIOLOGY | MAMMALIAN BRAIN | SHAPE | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | STEM/PROGENITOR CELLS | CENTRAL-NERVOUS-SYSTEM | RAT HIPPOCAMPUS | HEMATOLOGY | Cell Proliferation | Rats, Inbred F344 | Extracellular Matrix - metabolism | Apoptosis - genetics | cdc42 GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - genetics | Mechanotransduction, Cellular - physiology | Neural Stem Cells - cytology | Neurogenesis - genetics | Cell Differentiation - genetics | Microscopy, Atomic Force | Female | Cell Differentiation - physiology | Mechanotransduction, Cellular - genetics | rho GTP-Binding Proteins - genetics | Cells, Cultured | Rats | Animals | Neurogenesis - physiology | cdc42 GTP-Binding Protein - genetics | rho GTP-Binding Proteins - metabolism | Fluorescent Antibody Technique | Apoptosis - physiology | Neural Stem Cells - metabolism | Neural Stem Cells | Elastic Modulus | Extracellular Matrix | Cellular Mechanotransduction | rho GTP-Binding Proteins | Hippocampus
Journal Article