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biochemistry & molecular biology (41) 41
5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole (38) 38
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5,6-dichloro-1-^b-d-ribofuranosylbenzimidazole (5) 5
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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2012, Volume 109, Issue 36, pp. 14532 - 14537
Bromodomain-containing proteins bind acetylated lysine residues on histone tails and are involved in the recruitment of additional factors that mediate histone... 
T lymphocytes | Proteins | Molecules | Betting | Cytokines | Genes | Central nervous system | Histones | Cultured cells | Inflammation | BRD inhibitors | Transcriptional pausing | 5,6-dichloro-1-β-D- ribofuranosylbenzimidazole | Positive transcription elongation factor b | BRD4 | ENCEPHALOMYELITIS | ACTIVATION | 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole | CHROMATIN | MULTIDISCIPLINARY SCIENCES | transcriptional pausing | RECEPTOR | BROMODOMAINS | T(H)17 CELLS | GM-CSF | DISEASE | LEUKEMIA | positive transcription elongation factor b | EXPRESSION | Phosphorylation | Encephalomyelitis, Autoimmune, Experimental - immunology | Gene Expression Profiling | Adoptive Transfer | Positive Transcriptional Elongation Factor B - metabolism | Flow Cytometry | Microarray Analysis | Transcription Factors - immunology | Real-Time Polymerase Chain Reaction | Salivary alpha-Amylases - antagonists & inhibitors | Benzodiazepines - pharmacology | Cytokines - metabolism | Gene Expression Regulation - immunology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | Reverse Transcriptase Polymerase Chain Reaction | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Cell Differentiation - immunology | Animals | Cell Differentiation - drug effects | Transcription, Genetic - immunology | Mice | Thiazoles - pharmacology | Histones - metabolism | CD4-Positive T-Lymphocytes - drug effects | Biological Sciences | 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 07/2000, Volume 20, Issue 14, pp. 5077 - 5086
Journal Article
Journal Article
THROMBOSIS RESEARCH, ISSN 0049-3848, 12/2010, Volume 126, Issue 6, pp. 511 - 516
CK2 is a highly conserved protein kinase involved in several cellular events. CK2 is expressed in platelets but its role in platelet activation remains poorly... 
Protein kinase CK2 | INTEGRIN | SIGNALS | Thrombin | CK2 | 5,6-DICHLORO-1-BETA-D-RIBOFURANOSYLBENZIMIDAZOLE | INHIBITION | PAR1 | PAR4 | PI 3-kinase | PERIPHERAL VASCULAR DISEASE | Casein Kinase 2 | HEMATOLOGY | THROMBIN RECEPTOR | AGGREGATION
Journal Article
FEBS Letters, ISSN 0014-5793, 11/2011, Volume 585, Issue 21, pp. 3360 - 3366
► CKII inhibition induced acetylation of p53 at K382 in HCT116 and HEK293 cells. ► This acetylation was suppressed by SIRT1 activation. ► CKII interacted with... 
Senescence | Tumor suppression | p53 Acetylation | SIRT1 | Protein kinase CKII | phosphate-buffered saline | senescent-associated β-galactosidase | phenylmethylsulfonyl fluoride | SA-β-gal | Sir2 | silent information regulator 2 | NADPH oxidase | CKII | reactive oxygen species | sodium dodecyl sulfate | MBP | protein kinase CKII (also known as casein kinase II) | PBS | SDS | siRNA | small-interfering RNA | histone deacetylase | 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole | DRB | PMSF | NOX | ROS | maltose binding protein | HDAC | CANCER-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CK2 | P16(INK4A) | CELL BIOLOGY | PREMATURE SENESCENCE | BIOPHYSICS | ONCOGENIC RAS | HUMAN FIBROBLASTS | INHIBITORS | TUMORIGENESIS | Sirtuin 1 - metabolism | Cellular Senescence - genetics | RNA, Small Interfering - genetics | HCT116 Cells | Humans | Tumor Suppressor Protein p53 - metabolism | Cellular Senescence - drug effects | Casein Kinase II - genetics | Sirtuin 1 - antagonists & inhibitors | Down-Regulation - genetics | Protein Subunits - metabolism | Acetylation - drug effects | Phosphorylation - genetics | RNA Interference | Protein Stability - drug effects | Casein Kinase II - deficiency | HEK293 Cells | Histone Deacetylase Inhibitors - pharmacology | Lysine - metabolism | Tumor Suppressor Protein p53 - chemistry | Phosphorylation - drug effects | Casein Kinase II - metabolism
Journal Article
Genes and Development, ISSN 0890-9369, 10/1997, Volume 11, Issue 20, pp. 2633 - 2644
Journal Article
FEBS Letters, ISSN 0014-5793, 2010, Volume 584, Issue 14, pp. 3137 - 3142
We have shown that protein kinase CKII (CKII) inhibition induces senescence through the p53-dependent pathway in HCT116 cells. Here we examined the molecular... 
Superoxide anion | Senescence | p53 activation | NADPH oxidase | Protein kinase CKII | DHE | dichlorofluorescein | phosphate-buffered saline | senescent-associated β-galactosidase | N-acetyl-l-cysteine | SA-β-gal | ethidium | FBS | CKII | reactive oxygen species | sodium dodecyl sulfate | protein kinase CKII (also known as casein kinase II) | PBS | SDS | DCF | siRNA | small-interfering RNA | fetal bovine serum | NAC | 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole | dihydroethidium | DRB | NOX | ROS | ETH | P53 activation | SUPEROXIDE-PRODUCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | P16(INK4A) | CELLULAR SENESCENCE | P53 | CELL BIOLOGY | BIOPHYSICS | HUMAN FIBROBLASTS | INHIBITORS | Acetophenones | RNA, Small Interfering - genetics | Colonic Neoplasms - genetics | Reactive Oxygen Species - metabolism | Antioxidants - metabolism | Humans | Aging - drug effects | NADPH Oxidases - metabolism | Acetylcysteine - metabolism | Casein Kinase II - genetics | Colonic Neoplasms - metabolism | Genes, p53 - drug effects | Aging - genetics | Mitochondria - genetics | Superoxides - metabolism | NADPH Oxidases - genetics | Cellular Senescence - genetics | HCT116 Cells | NADPH Oxidases - antagonists & inhibitors | Cellular Senescence - physiology | Mitochondria - metabolism | Antioxidants - pharmacology | Down-Regulation - drug effects | Hydrogen Peroxide - metabolism | Casein Kinase II - metabolism | RNA, Small Interfering - metabolism | Oxidases | Antioxidants | Sulfur compounds | Colon cancer | Hydrogen peroxide | Casein | RNA | Surface active agents | Superoxide | Tumor proteins | Protein kinases
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/1998, Volume 41, Issue 8, pp. 1252 - 1262
We have recently reported that certain ribosylated polyhalogenated benzimidazoles are potent and selective inhibitors of HCMV replication at noncytotoxic... 
CHEMISTRY, MEDICINAL | VIRUS | THERAPY | HELA-CELLS | RNA | CYTOMEGALOVIRUS INFECTIONS | REVERSE-TRANSCRIPTASE | BENZIMIDAZOLE | GANCICLOVIR | TRANSPLANT RECIPIENTS | 5,6-DICHLORO-1-BETA-D-RIBOFURANOSYLBENZIMIDAZOLE | Anti-HIV Agents - pharmacology | Skin - cytology | Humans | Structure-Activity Relationship | Benzimidazoles - chemistry | Anti-HIV Agents - chemical synthesis | Microbial Sensitivity Tests | HIV-1 - growth & development | Ribonucleosides - pharmacology | Antiviral Agents - chemistry | Herpesvirus 1, Human - growth & development | Drug Design | Drug Evaluation, Preclinical | Skin - virology | Fibroblasts - virology | Cell Survival - drug effects | Antiviral Agents - pharmacology | HIV-1 - drug effects | Benzimidazoles - chemical synthesis | KB Cells | Ribonucleosides - chemistry | Viral Plaque Assay | Cell Division - drug effects | Herpesvirus 1, Human - drug effects | Cytomegalovirus - growth & development | HIV-2 - drug effects | Anti-HIV Agents - chemistry | HIV-2 - growth & development | Fibroblasts - drug effects | RNA-Directed DNA Polymerase - biosynthesis | Antiviral Agents - chemical synthesis | Benzimidazoles - pharmacology | HIV-1 - enzymology | Skin - drug effects | Cytomegalovirus - drug effects | 2,5,6-Trichloro-1-(^b-D-ribofuranosyl)benzimidazole | 2,5,6-Trichloro-1-(b-D-ribofuranosyl)benzimidazole
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 05/2000, Volume 20, Issue 9, pp. 2970 - 2983
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
RNA-POLYMERASE-II | CDK-ACTIVATING KINASE | TERMINAL DOMAIN | CHROMATIN STRUCTURE | FACTOR P-TEFB | BIOCHEMISTRY & MOLECULAR BIOLOGY | HIV-1 TAT | CELL-CYCLE | SACCHAROMYCES-CEREVISIAE | HUMAN HOMOLOG | ELONGATION-FACTORS | CELL BIOLOGY | Fungal Proteins - chemistry | Phosphorylation | Cyclin-Dependent Kinases - metabolism | Positive Transcriptional Elongation Factor B | Humans | Molecular Sequence Data | Dichlororibofuranosylbenzimidazole - pharmacology | RNA Polymerase II - metabolism | Recombinant Fusion Proteins - metabolism | Transcriptional Elongation Factors | Gene Products, tat - metabolism | Cell Nucleus - metabolism | Transcription, Genetic | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Chromosomal Proteins, Non-Histone | Enzyme Inhibitors - pharmacology | Gene Expression Regulation | Nuclear Proteins - metabolism | Cyclin-Dependent Kinase 9 | Fungal Proteins - genetics | Nuclear Proteins - chemistry | Blotting, Western | Precipitin Tests | Sequence Homology, Amino Acid | Animals | Mutagenesis | Saccharomyces cerevisiae Proteins | Protein Binding | HeLa Cells | COS Cells | Fungal Proteins - metabolism | P-TEFb protein | cyclin T1 | CDK9 protein | 5,6-dichloro-1-^b-D-ribofuranosylbenzimidazole | SPT5 protein | Transcriptional Regulation
Journal Article
Molecular & Biochemical Parasitology, ISSN 0166-6851, 01/2007, Volume 151, Issue 1, pp. 28 - 40
Journal Article