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ripoptosome (61) 61
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Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 09/2011, Volume 12, Issue 9, pp. 547 - 547
Journal Article
Molecular cell, ISSN 1097-2765, 11/2014, Volume 56, Issue 4, pp. 481 - 495
Receptor interacting protein kinase 3 (RIP3 or RIPK3) has emerged as a central player in necroptosis and a potential target to control inflammatory disease.... 
Ripoptosome | programmed necrosis | cytomegalovirus | TNF | herpesvirus
Journal Article
Pathology - Research and Practice, ISSN 0344-0338, 11/2019, Volume 215, Issue 11, p. 152652
Breast cancer is one of the major causes of cancer related deaths in women worldwide. A major factor responsible for treatment failure in breast cancer is the... 
Ripoptosome | Breast cancer | TNF-α | Necroptosis | RIP kinases
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 05/2018, Volume 200, Issue 10, pp. 3341 - 3346
The mammalian inhibitor of apoptosis proteins (IAPs) are key regulators of cell death and inflammation. A major function of IAPs is to block the formation of a... 
TUMOR-NECROSIS-FACTOR | ACTIVATION | RIPOPTOSOME | TRIGGERS | DEGRADATION | IAPS | MECHANISMS | NLRP3 INFLAMMASOME | CD14 | IMMUNOLOGY | EXPRESSION
Journal Article
Cell Reports, ISSN 2211-1247, 11/2018, Volume 25, Issue 9, pp. 2354 - 2368.e5
IL-1β is a cytokine of pivotal importance to the orchestration of inflammatory responses. Synthesized as an inactive pro-cytokine, IL-1β requires proteolytic... 
ripoptosome | BAX/BAK | caspase-8 | MCL-1 | BCL2 | NLRP3 | intrinsic apoptosis | IL-1β | IAP depletion | GASDERMIN D | B-CELL | VIOPROLIDES | NLRP3 INFLAMMASOME ACTIVATION | CASPASE-8 | RELEASE | INHIBITOR | RECEPTORS | TRANSLATION | CELL-DEATH | CELL BIOLOGY
Journal Article
Journal Article
Cell, ISSN 0092-8674, 10/2013, Volume 155, Issue 3, pp. 552 - 566
Journal Article
Immunity, ISSN 1074-7613, 02/2012, Volume 36, Issue 2, pp. 155 - 157
Inhibitors of apoptosis proteins (IAPs) are important regulators of both cell death and inflammation. In this issue of , report that inhibition of IAPs results... 
RIPOPTOSOME | DEATH | IMMUNOLOGY
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 10/2014, Volume 21, Issue 10, pp. 1511 - 1521
Necroptosis is a form of programmed cell death that depends on the activation of receptor interacting protein kinase-1 (RIPK1) and RIPK3 by receptors such as... 
APOPTOSIS | COMPLEX | RIPOPTOSOME | MLKL | SPECIFICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MIXED LINEAGE KINASE | PROGRAMMED NECROSIS | DOMAIN-LIKE | TNF-ALPHA | CELL-DEATH | CELL BIOLOGY | Protein Kinases - metabolism | Protein Structure, Tertiary | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Tumor Necrosis Factor-alpha - metabolism | Cell Line | Phosphorylation | Protein Kinases - genetics | Cell Survival | Humans | Protein Multimerization | Receptors, Tumor Necrosis Factor, Type I | Caspase 8 - metabolism | Imidazoles - pharmacology | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Necrosis - physiopathology | RNA Interference | Indoles - pharmacology | RNA, Small Interfering | Apoptosis - physiology | Enzyme Activation | Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Receptor-Interacting Protein Serine-Threonine Kinases/genetics | Protein Kinases/genetics | Receptor-Interacting Protein Serine-Threonine Kinases/antagonists & inhibitors | Caspase 8/metabolism | Receptor-Interacting Protein Serine-Threonine Kinases/metabolism | Tumor Necrosis Factor-alpha/antagonists & inhibitors | Indoles/pharmacology | Life Sciences | Tumor Necrosis Factor-alpha/metabolism | Imidazoles/pharmacology | Immunology | Apoptosis/physiology | Protein Kinases/metabolism | Necrosis/physiopathology | Original Paper
Journal Article
Journal Article