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Neuroreport, ISSN 0959-4965, 08/1999, Volume 10, Issue 12, pp. 2563 - 2567
THE early effect of 1-100 mu M roscovitine, a purine analogue and cyclin-dependent kinase inhibitor, was studied on tissue specimens from eight human malignant... 
roscovitine
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 07/2019, Volume 115, p. 108895
Tubulointerstitial fibrosis is the hallmark of diabetic nephropathy, which is the leading cause of end-stage renal disease worldwide. Roscovitine, an inhibitor... 
Roscovitine | Diabetic nephropathy | TGF-β1 | Tubulointerstitial fibrosis | p38 MAPK
Journal Article
International Journal of Oncology, ISSN 1019-6439, 05/2010, Volume 36, Issue 5, pp. 1269 - 1275
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2019, Volume 62, Issue 9, pp. 4606 - 4623
Cyclin-dependent kinases are therapeutic targets frequently deregulated in various cancers. By convenient alkylation of the 5-sulfanyl group, we synthesized... 
APOPTOSIS | POTENT | CHEMISTRY, MEDICINAL | ROSCOVITINE | PURINES | BIOLOGICAL EVALUATION | CELL-CYCLE | SUBGROUPS | ABT-199
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2011, Volume 43, Issue 2, pp. 455 - 464
Abstract Glaucoma, mainly caused by high intraocular pressure (IOP), is characterized by apoptotic death of retinal ganglion cells (RGCs). We investigated the... 
Neurology | Glaucoma | Cdk5/p35 | Roscovitine | Inner retina | NMDA receptor | Apoptosis
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12
The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript." (2013) Correction: Roscovitine... 
Roscovitine | Lymphocytes T | Lymphocytes | Uveitis | CD4 antigen
Journal Article
Indian Journal of Medical Research, ISSN 0971-5916, 12/2018, Volume 148, Issue 7, pp. 140 - 150
The lower recovery of competent oocytes in buffalo species limits the commercialization of in vitro embryo production technology in field condition. In this... 
developmental competence | Blastocysts | cytoplasmic maturation | oocytes | roscovitine | buffalo | Gene expression | Kinases | Embryos | Cyclin-dependent kinases | Cell cycle | Original | Blastocysts - buffalo - cytoplasmic maturation - developmental competence - oocytes - roscovitine
Journal Article
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 62, pp. 105170 - 105183
At present, advanced stage human Papillomavirus (HPV) negative and positive head and neck squamous cell carcinoma (HNSCC) are treated by intense multimodal... 
Roscovitine | Human papillomavirus | Ionizing radiation | HNSCC | Homologous recombination | DNA-DAMAGE RESPONSE | POSITIVE HEAD | PARP | DEPENDENT KINASE INHIBITOR | COMBINATION | RADIATION | roscovitine | CELL BIOLOGY | REPAIR | R-ROSCOVITINE | homologous recombination | human papillomavirus | NECK | ionizing radiation
Journal Article
Organic Letters, ISSN 1523-7060, 10/2017, Volume 19, Issue 19, pp. 5090 - 5093
The first general two-step, one-pot synthetic route to 6-azopurines is presented. Microwave-assisted nucleophilic aromatic substitution of protected... 
REVERSIBLE PHOTOREGULATION | PHOTOCHROMIC PROPERTIES | NUCLEOSIDE | SELICICLIB CYC202 | R-ROSCOVITINE | CHEMISTRY, ORGANIC | ARYL HYDRAZIDES | INHIBITORS | AZOBENZENE PHOTOSWITCHES | DERIVATIVES | CELL-DEATH | Letter
Journal Article
INTERNATIONAL JOURNAL OF ONCOLOGY, ISSN 1019-6439, 05/2010, Volume 36, Issue 5, pp. 1269 - 1275
The phosphorylation suite of Retinoblastoma protein (Rb) plays a role in cell proliferation and apoptosis. Within cells. cyclin dependent kinases (cdks)... 
cdk Roscovitine | PHOSPHORYLATION | PHOSPHATASE | SELICICLIB | P53 | NUCLEAR TARGETING SUBUNIT | CDK INHIBITORS | THERAPY | RETINOBLASTOMA PROTEIN | ONCOLOGY | E2F1 | CYC202 R-ROSCOVITINE | PNUTS | EXPRESSION
Journal Article
Journal Article
11/2008
The effects of alpha1A subunit mutations on presynaptic Ca2+ channel activity and functional development of synaptic properties remain elusive. The calyx of... 
Leaner Mutant Mouse | Calcium Channels | Calyx of Held | Development | Roscovitine | Synaptic Transmission | Presynaptic | 0317
Dissertation
Chinese Journal of Microbiology and Immunology (China), ISSN 0254-5101, 07/2017, Volume 37, Issue 7, pp. 487 - 491
Journal Article
Journal Article
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