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Trends in Cognitive Sciences, ISSN 1364-6613, 2008, Volume 12, Issue 11, pp. 418 - 424
Journal Article
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 04/2016, Volume 106, pp. 1 - 18
[Display omitted] Bromodomains are epigenetic readers of histone acetylation involved in chromatin remodeling and transcriptional regulation. The human... 
BET proteins | Acetylated histones | Drug discovery | Epigenetic drugs | Bromodomains | SELECTIVE-INHIBITION | EPIGENETIC READERS | TRANSCRIPTIONAL ACTIVITY | DISPLACEMENT ASSAYS | SYNERGISTIC ACTIVITY | FRAGMENT-BASED DISCOVERY | SMALL-MOLECULE INHIBITORS | CBP/P300 BROMODOMAIN | CHEMICAL PROBE | PHARMACOLOGY & PHARMACY | Chromatin - metabolism | Transcription, Genetic - drug effects | Transcription Factors - chemistry | Histones - chemistry | Triazoles - chemistry | Cardiovascular Diseases - drug therapy | Humans | Cardiovascular Diseases - pathology | Cardiovascular Diseases - genetics | Autoimmune Diseases - genetics | Azepines - chemistry | Neoplasms - genetics | Antineoplastic Agents - pharmacology | Epigenesis, Genetic - drug effects | Acetylation | Autoimmune Diseases - pathology | Chromatin - drug effects | Histones - antagonists & inhibitors | Autoimmune Diseases - drug therapy | Chromatin - chemistry | Benzodiazepines - pharmacology | Chromatin Assembly and Disassembly | Models, Molecular | Transcription Factors - antagonists & inhibitors | Cardiotonic Agents - chemistry | Cardiotonic Agents - pharmacology | Transcription Factors - genetics | Antineoplastic Agents - chemistry | Drug Discovery | Neoplasms - drug therapy | Azepines - pharmacology | Triazoles - pharmacology | Histones - genetics | Benzodiazepines - chemistry | Neoplasms - pathology | Irritable bowel syndrome | Life Sciences | Biochemistry, Molecular Biology | Biomolecules
Journal Article
Nature, ISSN 0028-0836, 09/2015, Volume 525, Issue 7570, pp. 543 - 547
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 05/2018, Volume 26, Issue 8, pp. 1675 - 1685
[Display omitted] •A series of novel 4-aminoquinazoline derivatives were synthesized and characterized.•Their antiproliferative activities against cancer cell... 
Cell cycle arrest | 4-Aminoquinazoline | PI3K inhibitor | Antiproliferative effects | Apoptosis | CHEMISTRY, MEDICINAL | ANTICANCER AGENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | DUAL INHIBITOR | CANCER DRUG DISCOVERY | BREAST-CANCER | PI3K/AKT PATHWAY | PIK3CA GENE | IN-VIVO | BIOLOGICAL EVALUATION | SELECTIVE INHIBITORS | HIGHLY POTENT
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2014, Volume 124, Issue 6, pp. 2585 - 2598
Activation of the ER stress response is associated with malignant progression of B cell chronic lymphocytic leukemia (CLL). We developed a murine CLL model... 
SELECTIVE-INHIBITION | MULTIPLE-MYELOMA | MEDICINE, RESEARCH & EXPERIMENTAL | IN-VITRO | UNFOLDED PROTEIN RESPONSE | TCL1 | MESSENGER-RNA | TRANSGENIC MOUSE | CHRONIC LYMPHOCYTIC-LEUKEMIA | ENDOPLASMIC-RETICULUM | TARGETING BTK | Endoribonucleases - genetics | Apoptosis - drug effects | Humans | Transcription Factors - deficiency | Endoribonucleases - antagonists & inhibitors | DNA-Binding Proteins - deficiency | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Enzyme Inhibitors - chemistry | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | Pyrazoles - pharmacology | Cell Survival - drug effects | DNA-Binding Proteins - antagonists & inhibitors | Endoplasmic Reticulum Stress - drug effects | Endoribonucleases - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - antagonists & inhibitors | Pyrimidines - pharmacology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Regulatory Factor X Transcription Factors | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Mice, Knockout | Transcription Factors - metabolism | Animals | Signal Transduction - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Cell Line, Tumor | Mice | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Care and treatment | Lymphocytic leukemia | Cancer cells | Development and progression | Genetic aspects | Cellular signal transduction | Gene expression | Leukemia | Rodents | Phenols | Kinases | Stress response | Drug dosages | Immune system | Apoptosis
Journal Article