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Nature genetics, ISSN 1061-4036, 2000, Volume 26, Issue 3, pp. 291 - 299
To identify new immortalizing genes with potential roles in tumorigenesis, we performed a genetic screen aimed to bypass the rapid and tight senescence arrest... 
LYMPHOMAGENESIS | APOPTOSIS | STABILIZES P53 | AMPLIFICATION | INK4A LOCUS | GENETICS & HEREDITY | C-MYC | MDM2 | GENE FAMILY | CELL-CYCLE ARREST | ARF TUMOR-SUPPRESSOR | T-Box Domain Proteins - physiology | Protein Biosynthesis | Humans | E2F Transcription Factors | Cyclin-Dependent Kinase Inhibitor p16 | T-Box Domain Proteins - isolation & purification | Adenocarcinoma - metabolism | Cell Transformation, Neoplastic - genetics | Gene Deletion | Repressor Proteins - isolation & purification | Neoplastic Syndromes, Hereditary - genetics | Genes, BRCA1 | Neoplasm Proteins - genetics | Tumor Suppressor Protein p14ARF | Oncogenes | DNA-Binding Proteins | Fibroblasts - metabolism | Cell Cycle Proteins - isolation & purification | Repressor Proteins - genetics | Transcription Factor DP1 | Breast Neoplasms - genetics | Polycomb Repressive Complex 1 | Neoplasm Proteins - isolation & purification | Proto-Oncogene Proteins p21(ras) - antagonists & inhibitors | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Fibroblasts - cytology | Mice | COS Cells | Cell Cycle Proteins - physiology | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Chromosomes, Human, Pair 17 - genetics | Breast Neoplasms - metabolism | Repressor Proteins - physiology | Transfection | Cell Cycle Proteins - genetics | Female | Adenocarcinoma - genetics | Tumor Cells, Cultured | Nuclear Proteins - genetics | Cellular Senescence - genetics | Promoter Regions, Genetic | E2F1 Transcription Factor | Neoplasm Proteins - biosynthesis | Cells, Cultured | Proto-Oncogene Proteins - genetics | Transcription Factors - antagonists & inhibitors | T-Box Domain Proteins - genetics | Proteins - genetics | Carrier Proteins - genetics | Animals | Gene Amplification | Retinoblastoma-Binding Protein 1 | Fibroblasts | Physiological aspects | Development and progression | Breast cancer | Genetic aspects | Research | Risk factors
Journal Article
Journal Article
Journal Article
Nature Genetics, ISSN 1061-4036, 07/2013, Volume 45, Issue 7, pp. 739 - 746
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 11/2018, Volume 24, Issue 22, pp. 5610 - 5621
Purpose: Because of emergence of resistance to osimertinib, a third-generation EGFR tyrosine kinase inhibitor (TKI), no targeted treatments are available for... 
TYROSINE KINASE INHIBITORS | GEFITINIB | AMPLIFICATION | ONCOLOGY | MUTATION | ACQUIRED-RESISTANCE | MECHANISMS | SENESCENCE | EGFR(T790M) | AZD9291 | EGFR INHIBITOR
Journal Article
SCIENCE, ISSN 0036-8075, 08/1997, Volume 277, Issue 5327, pp. 831 - 834
Most somatic cells die after a finite number of cell divisions, a phenomenon described as senescence. The p21(CIP1/WAF1) gene encodes an inhibitor of... 
IMMORTAL CELLS | MULTIDISCIPLINARY SCIENCES | TELOMERASE ACTIVITY | MECHANISMS | EXPRESSION | CULTURE | CANCER | DIVISION | REPLICATIVE SENESCENCE | P53 | P16(INK4) | Cell death | Genetic aspects | Cell cycle
Journal Article
Obesity Surgery, ISSN 0960-8923, 9/2018, Volume 28, Issue 9, pp. 2804 - 2810
Journal Article
by Liu, XH and Wei, L and Dong, QY and Liu, LY and Zhang, MQ and Xie, Z and Wang, XW
AGING-US, ISSN 1945-4589, 06/2019, Volume 11, Issue 12, pp. 4011 - 4031
Cellular senescence is an important mechanism of autonomous tumor suppression, while its consequence such as the senescence-associated secretory phenotype... 
CRISPR | LIFE-SPAN | CELLS | SECRETORY PHENOTYPE | ALZHEIMERS-DISEASE | EXPRESSION PROFILES | SASP | FAMILY | P53 | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | bypass | cellular senescence | REPRESSION | INFLAMMATION | aging | TUMORIGENESIS
Journal Article
Molecular Therapy, ISSN 1525-0016, 12/2018, Volume 26, Issue 12, pp. 2779 - 2797
Liver sinusoidal endothelial cells (LSECs) have great capacity for liver regeneration, and this capacity can easily switch to profibrotic phenotype, which is... 
Erk1/2 | liver sinusoidal endothelial cell | liver fibrosis | hepatic stellate cell | Akt | liver regeneration | REGRESSION | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | ANGIOGENESIS | VEGF | RESOLUTION | HEPATIC STELLATE CELLS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | SENESCENCE | GROWTH-FACTOR | CAPILLARIZATION | DEACTIVATION | Erk1 | Original
Journal Article