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PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 9, p. e0163887
[This corrects the article DOI: 10.1371/journal.pone.0159826.]. 
Caspase | Shikonin | Caspase-1
Journal Article
Russian Journal of Biopharmaceuticals, ISSN 2073-8099, 2018, Volume 10, Issue 6, pp. 39 - 43
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 3446 - 8
Cytotoxic activities of acetylshikonin and acetoxyisovalerylshikonin alone and in combination with chemotherapeutic agents against parental and drug resistant... 
BREAST-CANCER | PROTEIN | INHIBITION | MESSENGER-RNA | ANALOGS | TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | CANCER DRUG-RESISTANCE | SHIKONIN DERIVATIVES | MULTIDRUG-RESISTANCE | EXPRESSION | Flow cytometry | MDR1 protein | Chemotherapy | Phenotypes | Daunorubicin | Transcription | Shikonin | Multidrug resistance | Cytotoxicity | P-Glycoprotein | Drug resistance
Journal Article
Asian Pacific Journal of Cancer Prevention, ISSN 1513-7368, 2015, Volume 16, Issue 16, pp. 7261 - 7266
Journal Article
Circulation, ISSN 0009-7322, 10/2017, Volume 136, Issue 25, pp. 2468 - 2485
BACKGROUND—An emerging 'metabolic theory' of pulmonary hypertension (PH) suggests that cellular and mitochondrial metabolic dysfunction underlies the pathology... 
splicing factors | hypoxia | Shikonin | mitochondria | pyruvate kinase | TEPP-46 | metabolism
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2016, Volume 39, Issue 6, pp. 969 - 976
Macrophages play pivotal roles in inflammatory responses. Previous studies showed that various natural products exert antiinflammatory effects by regulating... 
Journal Article
Turkish Journal of Pharmaceutical Sciences, ISSN 1304-530X, 04/2018, Volume 15, Issue 1, pp. 38 - 43
Journal Article
Molecular Pharmaceutics, ISSN 1543-8384, 01/2019, Volume 16, Issue 1, pp. 409 - 421
To reduce the pervasive toxicity of natural shikonin, alkannin, and their synthetic analogues and to enhance the selectivity of these chemotherapeutics toward... 
anticancer prodrugs | CYP1B1 | shikonin derivatives | in vivo efficacy | DMAKO-20 | MEDICINE, RESEARCH & EXPERIMENTAL | SHIKONIN | DESIGN | ANTITUMOR-ACTIVITY | 1B1 INHIBITORS | 5-FLUOROURACIL | IN-VITRO | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | ALKANNIN | CYTOTOXICITY | DERIVATIVES | Index Medicus
Journal Article
International Journal of Molecular Medicine, ISSN 1107-3756, 10/2015, Volume 36, Issue 4, pp. 985 - 991
Journal Article
Journal of Clinical Dermatology, ISSN 1000-4963, 05/2016, Volume 45, Issue 5, pp. 323 - 327
Journal Article
The Journal of Physical Chemistry A, ISSN 1089-5639, 02/2018, Volume 122, Issue 5, pp. 1200 - 1208
As the most important component of deep red pigments, alkannin is investigated theoretically in detail based on time-dependent density functional theory... 
PATH | SHIKONIN | PEROXYNITRITE | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | CORRELATION-ENERGY | SENSING MECHANISM | CHEMISTRY | CHEMISTRY, PHYSICAL | TDDFT | INTRAMOLECULAR CHARGE-TRANSFER | FLUORESCENT-PROBE | SOLVENT | Potential energy | Density functionals | Usage | Transition state (Chemistry) | Hydrogen bonding | Analysis
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2010, Volume 33, Issue 5, pp. 816 - 824
Journal Article
by Chai, JD and Zhang, J and Wen, YP and Zou, L and Zhang, XX and Xin, X and Zhou, MH and Xu, JK and Zhang, G
JOURNAL OF THE ELECTROCHEMICAL SOCIETY, ISSN 0013-4651, 03/2019, Volume 166, Issue 6, pp. B388 - B394
An electrochemical sensor based on PEDOT: PSS-beta-CD-SWCNT-COOH/GCE for highly sensitive analysis of shikonin (SHI) in PBS buffer solution was reported.... 
HERBAL DRUG-SHIKONIN | ELECTROCHEMISTRY | DOPAMINE | COMPOSITE FILM | PERFORMANCE | MATERIALS SCIENCE, COATINGS & FILMS
Journal Article
by Su, Z and Yang, Z and Xie, L and Dewitt, J.P and Chen, Y
Cell Death and Differentiation, ISSN 1350-9047, 05/2016, Volume 23, Issue 5, pp. 748 - 756
Necroptosis is a caspase-independent form of regulated cell death executed by the receptor-interacting protein kinase 1 (RIP1), RIP3, and mixed lineage kinase... 
SHIKONIN | TRAIL | RIPK3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROGRAMMED NECROSIS | MYELOID-LEUKEMIA CELLS | DEATH | DRUG-RESISTANCE | AUTOPHAGY | EXPRESSION | APOPTOSIS RESISTANCE | CELL BIOLOGY | Antineoplastic Agents - pharmacology | Neoplasms - pathology | Apoptosis - drug effects | Humans | Necrosis | Neoplasms - drug therapy | Review
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 11/2016, Volume 1863, Issue 11, pp. 2584 - 2593
Shikonin derivatives exert powerful cytotoxic effects including induction of apoptosis. Here, we demonstrate the cytotoxic efficacy of shikonin in vivo in... 
p300 | EGR1 | AKT | FOXO3a | Shikonin-induced apoptosis | SIRT1 | Lung cancer, Non-small cell | Analysis | Cancer cells | Apoptosis
Journal Article
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