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Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 2006, Volume 248, Issue 1, pp. 126 - 135
Endometrial cancer is the most common malignancy of the female genital tract. Its incidence correlates with prolonged estrogen stimulation unopposed by... 
Short-chain dehydrogenase reductase | 17β-Hydroxysteroid dehydrogenase | 20α-Hydroxysteroid dehydrogenase | Aldo-keto reductase | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE-2 | HYDROXYSTEROID DEHYDROGENASES | ER-BETA | short-chain dehydrogenase reductase | RECEPTOR-B | CELL BIOLOGY | INACTIVATION | CARCINOGENESIS | KETO REDUCTASE SUPERFAMILY | ENDOCRINOLOGY & METABOLISM | 20 alpha-hydroxysteroid dehydrogenase | aldo-keto reductase | 17 beta-hydroxysteroid dehydrogenase | EXPRESSION | CARCINOMA | HORMONES | Humans | Endometrial Neoplasms - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Estrogens - analysis | Endometrial Neoplasms - genetics | Isoenzymes - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Progesterone - biosynthesis | Tumor Cells, Cultured | Estradiol - biosynthesis | Endometrium - metabolism | Progesterone - analysis | 20-Hydroxysteroid Dehydrogenases - genetics | Estrogens - biosynthesis | Endometrial Neoplasms - chemistry | Oxidoreductases - metabolism | Isoenzymes - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Endometrium - chemistry | Animals | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases | 3-Hydroxysteroid Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - metabolism | Enzymes | Care and treatment | Endometrial cancer | Phenols | Hormones | Progesterone | Estradiol | Cancer | Index Medicus
Journal Article
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 02/2009, Volume 296, Issue 2, pp. 244 - 255
The objective was to examine pathways of androgen metabolism in abdominal adipose tissue in women. Abdominal subcutaneous (SC) and omental (OM) adipose tissue... 
Omental visceral fat | Adipocyte differentiation | Short-chain dehydrogenases | Aldo-keto reductases | Estrogen | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASES | AROMATASE-ACTIVITY | estrogen | PHYSIOLOGY | short-chain dehydrogenases | adipocyte differentiation | omental visceral fat | HUMAN PREADIPOCYTES | 20-ALPHA-HYDROXYSTEROID DEHYDROGENASE | ESTROGEN-RECEPTOR-BETA | OBESITY | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | aldo-keto reductases | DIFFERENTIATION | STROMAL CELLS | Adipose Tissue - physiology | Humans | Middle Aged | Gene Expression Regulation, Enzymologic - physiology | Hydroxyprostaglandin Dehydrogenases - metabolism | Adipogenesis - physiology | Adipose Tissue - metabolism | Subcutaneous Fat - metabolism | Omentum - enzymology | 3-Hydroxysteroid Dehydrogenases - metabolism | Adult | Female | Hydroxysteroid Dehydrogenases - metabolism | Metabolic Networks and Pathways - physiology | Body Fat Distribution | Adipogenesis - genetics | Cells, Cultured | Hydroxysteroid Dehydrogenases - genetics | Omentum - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Abdominal Fat - metabolism | Metabolic Networks and Pathways - genetics | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases | Models, Biological | 17-Hydroxysteroid Dehydrogenases - genetics | Abdominal Fat - enzymology | Adipose Tissue - enzymology | 3-Hydroxysteroid Dehydrogenases - genetics | Androgens - metabolism | 17-Hydroxysteroid Dehydrogenases - metabolism | Subcutaneous Fat - enzymology | Women | Tissue | Enzymes | Androgens | Body fat | Metabolism | Ribonucleic acid--RNA | Index Medicus
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 03/2016, Volume 472, Issue 1, pp. 231 - 236
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2011, Volume 440, Issue 3, pp. 335 - 344
Human AKR (aldo-keto reductase) 1C proteins (AKR1C1-AKR1C4) exhibit relevant activity with steroids, regulating hormone signalling at the pre-receptor level.... 
Aldo-keto reductase (AKR) | Retinaldehyde | Proliferation | Retinoic acid | Retinol | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASES | proliferation | BIOCHEMISTRY & MOLECULAR BIOLOGY | aldo-keto reductase (AKR) | retinaldehyde | STEROID-HORMONE | DIHYDRODIOL DEHYDROGENASE | retinol | SHORT-CHAIN DEHYDROGENASES/REDUCTASES | BREAST-CANCER CELLS | retinoic acid | METABOLISM | REVEALS ROLES | MCF-7 CELLS | PROSTAGLANDIN-F SYNTHASE | Vitamin A - pharmacology | Vitamin A - chemistry | Cell Proliferation | Hydroxysteroid Dehydrogenases - chemistry | Humans | Transcriptional Activation | 20-Hydroxysteroid Dehydrogenases - chemistry | Retinaldehyde - chemistry | Substrate Specificity | Hydroxyprostaglandin Dehydrogenases - metabolism | Oxidoreductases - chemistry | 3-Hydroxysteroid Dehydrogenases - metabolism | Hydroxysteroid Dehydrogenases - metabolism | Retinaldehyde - physiology | Hydroxyprostaglandin Dehydrogenases - chemistry | Binding Sites | Mutagenesis, Site-Directed | Oxidoreductases - metabolism | Models, Molecular | Receptors, Retinoic Acid - antagonists & inhibitors | Receptors, Retinoic Acid - metabolism | 20-Hydroxysteroid Dehydrogenases - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Aldo-Keto Reductase Family 1 Member C3 | Vitamin A - physiology | Retinaldehyde - pharmacology | Cell Line, Tumor | Protein Binding | 3-Hydroxysteroid Dehydrogenases - chemistry | Kinetics | 3-Hydroxysteroid Dehydrogenases - genetics | Amino Acid Substitution | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2010, Volume 285, Issue 41, pp. 31806 - 31818
Journal Article
FEBS Letters, ISSN 0014-5793, 06/2010, Volume 584, Issue 11, pp. 2279 - 2284
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2007, Volume 402, Issue 3, pp. 419 - 427
To this day, a significant proportion of the human genome remains devoid of functional characterization. In this study, we present evidence that the previously... 
Steroid metabolism | DHRS10 | 17β-hydroxysteroid dehydrogenase | Pre-receptor control | Crystal structure | Short-chain dehydrogenase/reductase | BRAIN-INJURY | 17-BETA-HYDROXYSTEROID DEHYDROGENASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | short-chain dehydrogenase/reductase | WEIGHT-LOSS | SHORT-CHAIN DEHYDROGENASES/REDUCTASES | HUMAN ADIPOSE-TISSUE | steroid metabolism | crystal structure | pre-receptor control | ESTROGEN | REDUCTASE | MOLECULAR-CLONING | TYPE-1 | 17 beta-hydroxysteroid dehydrogenase | EXPRESSION | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Gene Expression | Oxidation-Reduction | Protein Structure, Secondary | Humans | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | Organ Specificity | Cytosol - enzymology | Sequence Alignment | 17-Hydroxysteroid Dehydrogenases - isolation & purification | 17-Hydroxysteroid Dehydrogenases - genetics | Ligands | Structural Homology, Protein | Kinetics | 17-Hydroxysteroid Dehydrogenases - chemistry | 17-Hydroxysteroid Dehydrogenases - metabolism | Binding Sites | NAD - metabolism | Index Medicus | GFP, green fluorescent protein | RMSD, root mean square deviation | HEK-293T cells, HEK-293 cells (human embryonic kidney cells) expressing the large T-antigen of SV40 (simian virus 40) | NCS, non-crystallographic symmetry | TCEP, tris-(2-carboxyethyl)phosphine | reductase | HSD, hydroxysteroid dehydrogenase | SDR, short-chain dehydrogenase | ER, oestrogen receptor | MDR, medium-chain dehydrogenase | DHEA, dehydroepiandrosterone | short-chain dehydrogenase
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 2006, Volume 248, Issue 1, pp. 47 - 55
17β-Hydroxysteroid dehydrogenases (17β-HSDs) belong to the family of short chain dehydrogenases/reductases (SDRs) and aldoketo-reductases (AKRs). Some of the... 
Steroid metabolism | 17β-Hydroxysteroid dehydrogenase | BILE-ACID | 3-KETOSTEROID REDUCTASE | PROLACTIN RECEPTOR |