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1. Full Text One‐year outcomes of sialendoscopic‐assisted salivary duct surgery for sialadenitis without sialolithiasis
by Plonowska, Karolina A and Gurman, Zev R and Humphrey, Amanda and Chang, Jolie L and Ryan, William R
The Laryngoscope, ISSN 0023-852X, 04/2019, Volume 129, Issue 4, pp. 890 - 896
Objectives To prospectively examine durability of long‐term outcomes in sialendoscopy‐assisted salivary duct surgery (SASDS) in chronic obstructive... 
autoimmune sialadenitis | Chronic Obstructive Sialadenitis Symptoms Questionnaire | salivary duct surgery | patient‐reported outcomes | radioiodine‐induced sialadenitis | Sialendoscopy | chronic obstructive sialadenitis | stenosis | patient-reported outcomes | radioiodine-induced sialadenitis | MEDICINE, RESEARCH & EXPERIMENTAL | INTERVENTIONAL SIALENDOSCOPY | STRICTURES | OTORHINOLARYNGOLOGY | SYMPTOMS QUESTIONNAIRE | EXPERIENCE | GLAND | Severity of Illness Index | Salivary Glands - pathology | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Endoscopy - methods | Male | Treatment Outcome | Salivary Glands - surgery | Iodine Radioisotopes - adverse effects | Sialadenitis - surgery | Constriction, Pathologic - surgery | Time Factors | Adult | Female | Salivary Ducts - pathology | Salivary Ducts - surgery | Sialadenitis - etiology | Aged | Medicine, Experimental | Medical research | Analysis
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2. Full Text Sialadenitis without sialolithiasis: Prospective outcomes after sialendoscopy‐assisted salivary duct surgery
by Delagnes, Elise A and Aubin‐Pouliot, Annick and Zheng, Melissa and Chang, Jolie L and Ryan, William R
The Laryngoscope, ISSN 0023-852X, 05/2017, Volume 127, Issue 5, pp. 1073 - 1079
Objectives To prospectively assess symptoms before and after sialendoscopy‐assisted salivary duct surgery (SASDS) in patients with symptomatic sialadenitis... 
radioactive iodine‐induced sialadenitis | salivary duct surgery | outcomes | Sialendoscopy | chronic obstructive sialadenitis | parotid | stenosis | submandibular | radioactive iodine-induced sialadenitis | MEDICINE, RESEARCH & EXPERIMENTAL | DIAGNOSIS | MANAGEMENT | STENOSES | RADIOIODINE-INDUCED SIALADENITIS | GLANDS | OTORHINOLARYNGOLOGY | SYMPTOMS QUESTIONNAIRE | Sialadenitis - surgery | Prospective Studies | Humans | Middle Aged | Endoscopy - methods | Adult | Female | Male | Salivary Ducts - surgery | Surveys and Questionnaires | Treatment Outcome | Aged
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3. Full Text Clinicopathology of Immunoglobulin G4–Related Chronic Sclerosing Sialadenitis
: A Single-Center Study
by Chang, Dun-Hao and Wu, Pao-Shu and Wang, Yu-Chen and Lin, Chin-Hsuan and Li, Wing-Yin and Ma, Hsu and Perng, Chern-Kang
Otolaryngology–Head and Neck Surgery, ISSN 0194-5998, 12/2016, Volume 155, Issue 6, pp. 974 - 981
Objectives To investigate the clinicopathologic characteristics of patients with immunoglobulin G4–related chronic sclerosing sialadenitis (IgG4-RCSS), a... 
salivary gland | IgG4 | pathology | chronic sclerosing sialadenitis | sialadenitis | SURGERY | HEAD | IGG4-RELATED DISEASE | SALIVARY-GLAND | KUTTNER TUMOR | SUBMANDIBULAR-GLAND | OTORHINOLARYNGOLOGY | DACRYOADENITIS | LYMPHOMA | NECK | Predictive Value of Tests | Diagnosis, Differential | Glucocorticoids - therapeutic use | Follow-Up Studies | Immunoglobulin G - blood | Humans | Middle Aged | Immunologic Factors - blood | Male | Treatment Outcome | Sialadenitis - drug therapy | Biomarkers - blood | Biopsy | Sensitivity and Specificity | Sialadenitis - blood | Adult | Female | Aged | Retrospective Studies | Sialadenitis - diagnosis | Sialadenitis - immunology
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4. Full Text One‐Year symptom outcomes after sialolithiasis treatment with sialendoscopy‐assisted salivary duct surgery
by Ryan, William R and Plonowska, Karolina A and Gurman, Zev R and Aubin‐Pouliot, Annick and Chang, Jolie L
The Laryngoscope, ISSN 0023-852X, 02/2019, Volume 129, Issue 2, pp. 396 - 402
Objectives For chronic obstructive sialadenitis, there is a paucity of long‐term prospective evidence of disease‐specific symptom outcomes after... 
sialolith | disease‐specific symptoms | Chronic Obstructive Sialadenitis Symptoms Questionnaire | salivary duct surgery | sialolithiasis | Sialendoscopy | chronic obstructive sialadenitis | disease-specific symptoms | MEDICINE, RESEARCH & EXPERIMENTAL | MANAGEMENT | SIALADENITIS | INTERVENTIONAL SIALENDOSCOPY | SUBMANDIBULAR-GLAND | REMOVAL | DISEASES | ULTRASOUND | OTORHINOLARYNGOLOGY | QUESTIONNAIRE | Prospective Studies | Humans | Middle Aged | Endoscopy - methods | Salivary Gland Calculi - pathology | Male | Treatment Outcome | Salivary Gland Calculi - surgery | Sialadenitis - pathology | Young Adult | Sialadenitis - surgery | Time Factors | Aged, 80 and over | Adult | Female | Salivary Ducts - surgery | Aged
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5. Full Text IgG4‐related sialadenitis and Sjögren's syndrome
by Fragoulis, GE and Zampeli, E and Moutsopoulos, HM
Oral Diseases, ISSN 1354-523X, 03/2017, Volume 23, Issue 2, pp. 152 - 156
IgG4‐related disease (IgG4‐RD) has emerged as a new entity in the last decade. It comprises numerous conditions previously thought to be unrelated.... 
IgG4‐related sialadenitis | Sjögren's syndrome | IgG4‐related disease | IgG4-related sialadenitis | IgG4-related disease | STATEMENT | CELLS | Sjogren's syndrome | PERSPECTIVE | CLINICAL CHARACTERISTICS | SALIVARY-GLAND | MIKULICZS-DISEASE | AUTOIMMUNE PANCREATITIS | RITUXIMAB | DENTISTRY, ORAL SURGERY & MEDICINE | DACRYOADENITIS | Sialadenitis - pathology | Diagnosis, Differential | Salivary Glands - pathology | Sjogren's Syndrome - pathology | Sjogren's Syndrome - diagnosis | Humans | Immunoglobulin G | Sjogren's Syndrome - immunology | Sialadenitis - diagnosis | Sialadenitis - immunology | Autoimmune diseases | Oral diseases | Histopathology
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6. IgG4-related disease: Nomenclature, clinical features, and treatment
by Stone, John H
Seminars in Diagnostic Pathology, ISSN 0740-2570, 11/2012, Volume 29, Issue 4, pp. 177 - 190
Concepts about IgG4-related disease (IgG4-RD) are now emerging swiftly. The condition has been identified in virtually every organ system, and its features are... 
Chronic sclerosing | Sialadenitis | IgG4-related disease | Retroperitoneal | Fibrosis | Pancreatitis | Rituximab | Autoimmune | EOSINOPHILIC ANGIOCENTRIC FIBROSIS | SYSTEMIC-DISEASE | PATHOLOGY | SERUM IGG4 | Retroperitoneal fibrosis | IMMUNOGLOBULIN G4-ASSOCIATED CHOLANGITIS | COMPLICATING AUTOIMMUNE PANCREATITIS | HEPATIC INFLAMMATORY PSEUDOTUMOR | IGG4-POSITIVE PLASMA-CELLS | MEDICAL LABORATORY TECHNOLOGY | Chronic sclerosing sialadenitis | TUBULOINTERSTITIAL NEPHRITIS | Autoimmune pancreatitis | Glucocorticoids - therapeutic use | Immunoglobulin G - blood | Humans | Male | Retroperitoneal Fibrosis - pathology | Sclerosis | Retroperitoneal Fibrosis - metabolism | Female | Sialadenitis - metabolism | B-Lymphocytes - pathology | Drug Therapy, Combination | Autoimmune Diseases - metabolism | B-Lymphocytes - metabolism | Pancreatitis, Chronic - immunology | Autoimmune Diseases - immunology | Terminology as Topic | Autoimmune Diseases - diagnosis | Pancreatitis, Chronic - pathology | Sialadenitis - pathology | B-Lymphocytes - drug effects | Autoimmune Diseases - therapy | Retroperitoneal Fibrosis - immunology | Pancreatitis, Chronic - metabolism | Lymphocyte Depletion - methods | Antibodies, Monoclonal, Murine-Derived - therapeutic use | Practice Guidelines as Topic | Sialadenitis - immunology
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7. Full Text Chronic sclerosing sialadenitis (Küttner tumor) is an IgG4-associated disease
by Geyer, Julia Turbiner and Ferry, Judith A and Harris, Nancy L and Stone, John H and Zukerberg, Lawrence R and Lauwers, Gregory Y and Pilch, Ben Z and Deshpande, Vikram
American Journal of Surgical Pathology, ISSN 0147-5185, 02/2010, Volume 34, Issue 2, pp. 202 - 210
Background: Chronic sclerosing sialadenitis is a fibroinflammatory disease of the salivary glands, characteristically of the submandibular gland. One prior... 
Kü | Ttner tumor | Gren syndrome | Plasma cells | IgG4 | Chronic sclerosing sialadenitis | Lymphoepithelial sialadenitis | Sjö | SURGERY | SJOGRENS-SYNDROME | PATHOLOGY | plasma cells | SALIVARY-GLAND | Kuttner tumor | AUTOIMMUNE PANCREATITIS | LYMPHADENOPATHY | CHOLANGITIS | lymphoepithelial sialadenitis | chronic sclerosing sialadenitis | Sjogren syndrome | Parotid Diseases - immunology | Sjogren's Syndrome - pathology | Submandibular Gland Diseases - pathology | Tissue Array Analysis | Humans | Middle Aged | Autoimmune Diseases - immunology | Sjogren's Syndrome - immunology | Male | Submandibular Gland Diseases - immunology | Sclerosis | Plasma Cells - pathology | Sialadenitis - pathology | Biopsy | Immunoglobulin G - immunology | Aged, 80 and over | Adult | Female | Parotid Diseases - pathology | Aged | Autoimmune Diseases - pathology | Chronic Disease | Plasma Cells - immunology | Sialadenitis - immunology
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8. Full Text Acute sialadenitis associated with 2017–2018 influenza A infection: A case series
by Stafford, John A and Moore, Charles A and Mark, Jonathan R
The Laryngoscope, ISSN 0023-852X, 11/2018, Volume 128, Issue 11, pp. 2500 - 2502
The influenza A virus has accounted for the majority of influenza infections in the 2017 to 2018 flu season, with the typical clinical presentation including... 
Sialadenitis | influenza | salivary glands | parotid | submandibular | MEDICINE, RESEARCH & EXPERIMENTAL | VIRUS | OTORHINOLARYNGOLOGY | Acute Disease | Sialadenitis - therapy | Influenza A virus | United States | Humans | Middle Aged | Adult | Female | Influenza, Human - virology | Sialadenitis - diagnosis | Sialadenitis - virology | Health aspects | Influenza
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9. Full Text Lymphoid organisation in labial salivary gland biopsies is a possible predictor for the development of malignant lymphoma in primary Sjögren's syndrome
by Theander, Elke and Vasaitis, Lilian and Baecklund, Eva and Nordmark, Gunnel and Warfvinge, Gunnar and Liedholm, Rolf and Brokstad, Karl and Jonsson, Roland and Jonsson, Malin V and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för medicinska vetenskaper and Reumatologi
Annals of the Rheumatic Diseases, ISSN 0003-4967, 08/2011, Volume 70, Issue 8, pp. 1363 - 1368
Objective The development of non-Hodgkin's lymphoma (NHL) confers a high risk of mortality in primary Sjögren's syndrome (pSS) patients, but the sensitivity... 
MORTALITY | TARGET ORGAN | AUTOIMMUNE | MEMORY | DISEASE | RISK | CLASSIFICATION | MECHANISMS | COHORT | RHEUMATOLOGY | AUTOANTIBODY PRODUCTION | Prognosis | Sjogren's Syndrome - pathology | Sialadenitis - epidemiology | Humans | Middle Aged | Sialadenitis - complications | Male | Germinal Center - pathology | Lymphoma, Non-Hodgkin - epidemiology | Sweden - epidemiology | Sialadenitis - pathology | Salivary Glands, Minor - pathology | Biopsy | Epidemiologic Methods | Sjogren's Syndrome - epidemiology | Adult | Female | Aged | Sjogren's Syndrome - complications | Lip - pathology | Lymphoma, Non-Hodgkin - etiology | Disease | Microscopy | Laboratories | Mortality | Lymphomas | Patients | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
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10. IgG4-related disease in the head and neck
by Ferry, Judith A and Deshpande, Vikram
Seminars in Diagnostic Pathology, ISSN 0740-2570, 11/2012, Volume 29, Issue 4, pp. 235 - 244
Lymphoid infiltrates are relatively common in the ocular adnexa and the salivary glands. They are of a variety of types and include both reactive processes and... 
Sialadenitis | Orbital pseudotumor | pseudolymphoma | IgG4-related disease | Dacryoadenitis | Orbital | SYSTEMIC-DISEASE | CHRONIC SCLEROSING SIALADENITIS | LYMPHOMA | Orbital pseudolymphoma | MEDICAL LABORATORY TECHNOLOGY | PATHOLOGY | GLAND | KUTTNER TUMOR | Biomarkers - metabolism | Orbital Diseases - metabolism | Diagnosis, Differential | Immunoglobulin G - blood | Humans | Autoimmune Diseases - immunology | Male | Autoimmune Diseases - diagnosis | Orbital Diseases - diagnosis | Lymphoma, B-Cell, Marginal Zone - diagnosis | Orbital Diseases - immunology | Sjogren's Syndrome - diagnosis | Female | Head and Neck Neoplasms - diagnosis | Sialadenitis - metabolism | Sialadenitis - diagnosis | Autoimmune Diseases - metabolism | Sialadenitis - immunology
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11. Full Text Clinical and pathological characteristics of IgG4‐related sclerosing sialadenitis
by Ohta, Nobuo and Kurakami, Kazuya and Ishida, Akihiro and Furukawa, Takatoshi and Saito, Fumiaki and Kakehata, Seiji and Izuhara, Kenji
The Laryngoscope, ISSN 0023-852X, 03/2012, Volume 122, Issue 3, pp. 572 - 577
Objectives/Hypothesis: A new concept of IgG4‐related sclerosing sialadenitis characterized by high serum IgG4 levels and tissue infiltration of IgG4‐expressing... 
autoimmune pancreatitis | Level of Evidence: 4 | IgG4‐related sclerosing sialadenitis | cholangitis | IgG4-related sclerosing sialadenitis | FIBROSIS | MEDICINE, RESEARCH & EXPERIMENTAL | OTORHINOLARYNGOLOGY | TUMOR | IGG4 | CANCER | RETROPERITONEAL | MIKULICZS-DISEASE | Immunohistochemistry | Glucocorticoids - therapeutic use | Prognosis | Follow-Up Studies | Humans | Middle Aged | Antibodies, Anti-Idiotypic - immunology | Male | Sclerosis - immunology | Sialadenitis - drug therapy | Plasma Cells - pathology | Sclerosis - drug therapy | Sialadenitis - pathology | Sclerosis - pathology | Immunoglobulin G - immunology | Female | Aged | Immunoglobulin G - metabolism | Plasma Cells - immunology | Sialadenitis - immunology
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12. Full Text Differential diagnosis of IgG4-related sialadenitis, primary Sjögren syndrome, and chronic obstructive submandibular sialadenitis
by Hong, X and Li, W and Xie, X.-Y and Zhang, Z.-Y and Chen, Y and Gao, Y and Peng, X and Su, J.-Z and Zhang, Y.-Y and Wang, Z and Cai, Z.-G and Zhang, L and Liu, Y.-Y and He, J and Ren, L.-M and Li, Z.-G and Yu, G.-Y
British Journal of Oral and Maxillofacial Surgery, ISSN 0266-4356, 2016, Volume 55, Issue 2, pp. 179 - 184
Abstract Our aim was to differentiate IgG4-related sialadenitis, primary Sjögren syndrome, and chronic obstructive submandibular sialadenitis by analysing... 
Surgery | Differential diagnosis | Salivary glands | Chronic obstructive submandibular sialadenitis | IgG4-related sialadenitis | Primary Sjögren syndrome | CRITERIA | SURGERY | DENTISTRY, ORAL SURGERY & MEDICINE | CHRONIC SCLEROSING SIALADENITIS | Primary Sjogren syndrome | MIKULICZS-DISEASE | KUTTNER TUMOR | Diagnosis, Differential | Sjogren's Syndrome - diagnosis | Humans | Immunoglobulin G | Middle Aged | Submandibular Gland Diseases - diagnosis | Female | Male | Retrospective Studies | Sialadenitis - diagnosis | Chronic Disease | Sialadenitis - immunology
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13. Full Text Comorbid diseases of IgG4‐related sialadenitis in the head and neck region
by Hong, Xia and Sun, Zhi‐Peng and Li, Wei and Chen, Yan and Gao, Yan and Su, Jia‐Zeng and Wang, Zhen and Cai, Zhi‐Gang and Li, Tong‐Tong and Zhang, Lei and Liu, Xiao‐Jing and Liu, Yan‐Ying and He, Jing and Li, Zhan‐Guo and Yu, Guang‐Yan
The Laryngoscope, ISSN 0023-852X, 09/2015, Volume 125, Issue 9, pp. 2113 - 2118
Objectives/Hypothesis To further recognize the comorbid diseases of immunoglobulin G4‐related sialadenitis (IgG4‐RS) in the head and neck region and to observe... 
salivary gland | IgG4‐related sialadenitis | comorbid diseases | head and neck | rhinosinusitis | lymphadenopathy | ocular adnexa | IgG4-related sialadenitis | MEDICINE, RESEARCH & EXPERIMENTAL | LYMPH-NODES | ENLARGEMENT | IMMUNOGLOBULIN G4-RELATED DISEASE | PREVALENCE | LESIONS | AUTOIMMUNE PANCREATITIS | OTORHINOLARYNGOLOGY | DACRYOADENITIS | MANIFESTATIONS | Immunohistochemistry | Follow-Up Studies | Humans | Middle Aged | Male | Tomography, X-Ray Computed | Lymphadenitis - epidemiology | Sinusitis - epidemiology | Young Adult | Lymphadenitis - diagnosis | Comorbidity - trends | Immunoglobulin G - immunology | Aged, 80 and over | Adult | Female | Retrospective Studies | Neck | Sialadenitis - diagnosis | Child | Autoimmune Diseases - epidemiology | Diagnosis, Differential | Sialadenitis - epidemiology | Sinusitis - diagnosis | Autoimmune Diseases - immunology | Antibodies, Anti-Idiotypic - immunology | Autoimmune Diseases - diagnosis | China - epidemiology | Adolescent | Aged | Sialadenitis - immunology | Comorbidity | Health aspects | Immunoglobulin G | Analysis
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14. Full Text Salivary duct stenosis: Short‐term symptom outcomes after sialendoscopy‐assisted salivary duct surgery
by Delagnes, Elise A and Zheng, Melissa and Aubin‐Pouliot, Annick and Chang, Jolie L and Ryan, William R
The Laryngoscope, ISSN 0023-852X, 12/2017, Volume 127, Issue 12, pp. 2770 - 2776
Objectives To prospectively assess short‐term symptom change after sialendoscopy‐assisted salivary duct surgery (SASDS) for salivary duct stenosis. Study... 
Sialendoscopy | salivary duct surgery | sialadenitis | stenosis | chronic obstructive sialadenitis symptoms | MEDICINE, RESEARCH & EXPERIMENTAL | DIAGNOSIS | SIALOENDOSCOPY | RADIOIODINE-INDUCED SIALADENITIS | STRICTURES | OTORHINOLARYNGOLOGY | OBSTRUCTION | QUESTIONNAIRE | Prospective Studies | Salivary Gland Diseases - surgery | Humans | Middle Aged | Symptom Assessment | Male | Treatment Outcome | Sialadenitis - surgery | Constriction, Pathologic - surgery | Time Factors | Adult | Diagnostic Self Evaluation | Female | Salivary Ducts - surgery | Aged | Endoscopy | Stenosis
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15. Full Text Ultrasonographic Features of Immunoglobulin G4-Related Sialadenitis
by Li, Wei and Xie, Xiao-Yan and Su, Jia-Zeng and Hong, Xia and Chen, Yan and Gao, Yan and Zhang, Zu-Yan and Yu, Guang-Yan
Ultrasound in Medicine & Biology, ISSN 0301-5629, 2016, Volume 42, Issue 1, pp. 167 - 175
Abstract The aim of this study was to determine the role of ultrasonography in the diagnosis and follow-up evaluation of immunoglobulin G4-related... 
Radiology | Immunoglobulin G4-related sialadenitis | Submandibular gland | Salivary gland | Diagnosis | Ultrasonography | IGG4-RELATED SYSTEMIC-DISEASE | SJOGRENS-SYNDROME | SCLEROSING SIALADENITIS | MIKULICZS-DISEASE | ACOUSTICS | RIEDELS THYROIDITIS | GLANDS | AUTOIMMUNE PANCREATITIS | IMAGING FEATURES | SPECTRUM | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | BRAIN | Sialadenitis - diagnostic imaging | Parotid Gland - immunology | Diagnosis, Differential | Parotid Gland - diagnostic imaging | Immunomodulation | Humans | Immunoglobulin G | Middle Aged | Male | Sialadenitis - drug therapy | Young Adult | Submandibular Gland - diagnostic imaging | Aged, 80 and over | Adult | Female | Aged | Submandibular Gland - immunology | Sialadenitis - immunology | Ultrasound imaging | Immunoglobulins
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16. Full Text Salivary Gland Function 5 Years After Radioactive Iodine Ablation in Patients with Differentiated Thyroid Cancer: Direct Comparison of Pre- and Postablation Scintigraphies and Their Relation to Xerostomia Symptoms
by Jeong, Shin Young and Kim, Hae Won and Lee, Sang-Woo and Ahn, Byeong-Cheol and Lee, Jaetae
Thyroid, ISSN 1050-7256, 05/2013, Volume 23, Issue 5, pp. 69 - 616
Background: Chronic sialadenitis is one of the most frequent chronic complications after radioactive iodine (RAI) therapy for thyroid cancer. To evaluate the... 
Thyroid Radiology and Nuclear Medicine | QUANTITATIVE-EVALUATION | RADIOIODINE THERAPY | ENDOCRINOLOGY & METABOLISM | SJOGRENS-SYNDROME | FLOW-RATES | DYSFUNCTION | CARCINOMA | Sialadenitis - diagnostic imaging | Prevalence | Follow-Up Studies | Xerostomia - physiopathology | Submandibular Gland Diseases - epidemiology | Humans | Middle Aged | Submandibular Gland Diseases - diagnostic imaging | Submandibular Gland - secretion | Male | Iodine Radioisotopes - adverse effects | Salivary Glands - diagnostic imaging | Young Adult | Iodine Radioisotopes - therapeutic use | Submandibular Gland - diagnostic imaging | Salivary Glands - radiation effects | Adult | Female | Sialadenitis - etiology | Republic of Korea - epidemiology | Xerostomia - epidemiology | Sialadenitis - physiopathology | Severity of Illness Index | Thyroid Neoplasms - surgery | Sialadenitis - epidemiology | Salivary Glands - secretion | Thyroid Neoplasms - radiotherapy | Combined Modality Therapy - adverse effects | Thyroidectomy | Radiopharmaceuticals - administration & dosage | Submandibular Gland - radiation effects | Thyroid Neoplasms - physiopathology | Iodine Radioisotopes - administration & dosage | Radionuclide Imaging | Salivary Glands - physiopathology | Submandibular Gland - physiopathology | Submandibular Gland Diseases - physiopathology | Aged | Radiopharmaceuticals - adverse effects | Submandibular Gland Diseases - etiology | Xerostomia - etiology | Dose-Response Relationship, Radiation | Xerostomia - diagnostic imaging | Radiopharmaceuticals - therapeutic use
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