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sigma-1 receptor (432) 432
index medicus (363) 363
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alzheimer's disease (37) 37
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health aspects (34) 34
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receptors, sigma - physiology (33) 33
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sigma‐1 receptor (33) 33
depression (32) 32
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signal transduction (26) 26
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methyl-d-aspartate (23) 23
inhibition (22) 22
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ethylenediamines - pharmacology (21) 21
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Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 03/2013, Volume 168, Issue 6, pp. 1445 - 1455
Background and Purpose The Sigma‐1 receptor (Sig1R) impacts on calcium ion signalling and has a plethora of ligands. This study investigated Sig1R and its... 
cationic channels | endothelial cells | histamine | calcium channels | vascular endothelial growth factor | hydrogen peroxide | Sigma‐1 receptor | TRP channels | Sigma-1 receptor | ACTIVATION | ANGIOGENESIS | DEPENDENCE | INTRACELLULAR CA2 | CALCIUM | PHARMACOLOGY & PHARMACY | Endothelium, Vascular - cytology | Humans | Endothelium, Vascular - drug effects | Protein Transport - drug effects | Receptors, sigma - antagonists & inhibitors | Vascular Endothelial Growth Factor A - metabolism | Histamine - metabolism | RNA Interference | Membrane Transport Modulators - pharmacology | HEK293 Cells | Receptors, sigma - metabolism | TRPC Cation Channels - genetics | Membrane Potentials - drug effects | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Cells, Cultured | Receptors, sigma - agonists | Receptors, sigma - genetics | TRPC Cation Channels - antagonists & inhibitors | Patch-Clamp Techniques | TRPM Cation Channels - antagonists & inhibitors | Calcium Signaling - drug effects | Endothelium, Vascular - metabolism | TRPC Cation Channels - metabolism | TRPM Cation Channels - genetics | Ligands | RNA, Small Interfering | TRPM Cation Channels - metabolism | Kinetics | Fluorescence | Histamine | Calcium channels | Hydrogen peroxide | Vascular endothelial growth factor | Endothelium | Research Papers
Journal Article
Neuropharmacology, ISSN 0028-3908, 01/2019, Volume 144, pp. 244 - 255
The histamine H receptor is a G protein-coupled receptor (GPCR) drug target that is highly expressed in the CNS, where it acts as both an auto- and... 
Kinetics | S 38093-2 | Sigma-1 receptor | Receptor occupancy | Histamine H3 receptor
Journal Article
Journal Article
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 03/2014, Volume 34, Issue 10, pp. 3545 - 3558
The general effects of cocaine are not well understood at the molecular level. What is known is that the dopamine D-1 receptor plays an important role. Here we... 
HETEROMERS | ACTIVATION | STRIATAL SLICES | RAT | BETA-ARRESTINS | DISEASE | SIGMA-1 RECEPTORS | MECHANISMS | PROXIMITY LIGATION ASSAY | AGONISTS | NEUROSCIENCES
Journal Article
Neuropharmacology, ISSN 0028-3908, 02/2015, Volume 89, pp. 215 - 224
In early Alzheimer's disease (AD) brain, reduction of sigma-1 receptors (σ R) is detected. In this study, we employed male heterozygous σ R knockout (σ R )... 
Sigma-1 receptor (σ1R) | Alzheimer's disease (AD) | N-methyl-D-aspartate receptor (NMDAr) | β-Amyloid (Aβ) | Apoptosis | Spatial memory | R | Sigma-1 receptor (σ | Spatial memory β-Amyloid (Aβ)
Journal Article