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Cell Metabolism, ISSN 1550-4131, 2006, Volume 3, Issue 5, pp. 343 - 353
Although the class I phosphoinositide 3-kinase (PI3K) pathway is central to the metabolic actions of insulin, its mechanism of action is not well understood.... 
SIGNALING
Journal Article
Science Signaling, ISSN 1945-0877, 01/2018, Volume 11, Issue 513, p. eaas9779
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e47936
Glucagon-like peptide-1 (GLP-1) released from intestinal L cells in response to nutrients has many physiological effects but particularly enhances... 
PATHWAYS | CELLS | ACTIVATION | HEALTHY-SUBJECTS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DEGRADATION | SMALL-MOLECULE AGONISTS | SECRETION | GASTRIC-INHIBITORY POLYPEPTIDE | TYPE-2 DIABETES-MELLITUS | Receptors, Glucagon - antagonists & inhibitors | Calcium - metabolism | Allosteric Regulation | Humans | Peptide Fragments - pharmacology | Extracellular Signal-Regulated MAP Kinases - metabolism | Sulfones - pharmacology | Extracellular Signal-Regulated MAP Kinases - genetics | Quinoxalines - pharmacology | Peptides - metabolism | Transfection | Biotransformation | Adenosine Monophosphate - biosynthesis | Receptors, Glucagon - agonists | Cell Line | Gene Expression | Peptide Fragments - metabolism | Glucagon-Like Peptide 1 - metabolism | Glucagon-Like Peptide 1 - analogs & derivatives | Glucagon-Like Peptide 1 - pharmacology | Rats | Receptors, Glucagon - metabolism | Peptides - pharmacology | Insulin - metabolism | Animals | Glucagon-Like Peptide-1 Receptor | Calcium Signaling - drug effects | Type 2 diabetes | Care and treatment | Glucagon | Metabolites | Physiological aspects | Research | Risk factors | Physiological effects | Peptides | Insulinoma | Systematic review | Hormones | Glucose | Peptide hormones | Calcium signalling | Proteins | Allosteric properties | Intestine | Penicillin | Nutrients | Physiology | Glucagon-like peptide 1 | Recombinant | Peptidase | AMP | Diabetes mellitus | Extracellular signal-regulated kinase | Pharmacology | L cells | Insulin | Affinity | Ligands | Diabetes | Calcium (extracellular)
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, p. e36800
The dysregulation of receptor protein tyrosine kinase (RPTK) function can result in changes in cell proliferation, cell growth and metastasis leading to... 
TYROSINE KINASE TYRO3 | APOPTOTIC CELLS | PI3 KINASE | BIOLOGY | SURVIVAL ACTIVITIES | FAMILY RECEPTORS | SMOOTH-MUSCLE-CELLS | TAM RECEPTORS | GROWTH-FACTOR | PROTEIN-S | ARREST-SPECIFIC GENE | Proto-Oncogene Proteins - metabolism | Cell Line | Up-Regulation | Phosphorylation | Cell Proliferation | Signal Transduction | Intercellular Signaling Peptides and Proteins - genetics | Rats | Proto-Oncogene Proteins - genetics | Phosphatidylinositol 3-Kinases - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | MAP Kinase Signaling System | Intercellular Signaling Peptides and Proteins - metabolism | Animals | Transfection | Receptor Protein-Tyrosine Kinases - genetics | c-Mer Tyrosine Kinase | Tyrosine | Protein kinases | Mitogens | Analysis | Cell proliferation | Transformation | Immunoprecipitation | Kinases | Metastases | Axl protein | Skin cancer | Proteins | Signal transduction | Receptors | Cell activation | Cell growth | Rodents | Fibroblasts | Protein-tyrosine kinase receptors | Growth factors | Protein-tyrosine kinase | Immunoglobulins | Immune response | Melanoma | Extracellular signal-regulated kinase | MAP kinase | 1-Phosphatidylinositol 3-kinase | Polymerase chain reaction | Studies | Signaling | Molecular modelling | Inhibitors | Mutagenesis | Transformations (mathematics) | Receptor mechanisms | Tumors
Journal Article
PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 4, p. e0154638
[This corrects the article DOI: 10.1371/journal.pone.0147830.]. 
Signaling
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 6, p. e21549
Background: Acidification of the cytoplasm and the extracellular environment is associated with many physiological and pathological conditions, such as intense... 
TUMOR PH | ACTIVATED PROTEIN-KINASE | CARDIAC-ARREST | CYTOPLASMIC PH | MULTIDISCIPLINARY SCIENCES | INTRACELLULAR PH | PHOSPHATIDIC-ACID | TUBEROUS SCLEROSIS | CELL-GROWTH | EXTRACELLULAR PH | HUMAN CANCER | Phosphorylation - physiology | Cell Line | Tumor Suppressor Proteins - metabolism | Humans | Multiprotein Complexes | Signal Transduction - genetics | Mechanistic Target of Rapamycin Complex 1 | Proteins - genetics | Phosphorylation - genetics | Animals | Proteins - metabolism | Tumor Suppressor Proteins - genetics | Cell Line, Tumor | Signal Transduction - physiology | TOR Serine-Threonine Kinases | Hydrogen-Ion Concentration | Tuberous sclerosis | Protein biosynthesis | Hydrogen-ion concentration | Protein kinases | Tuberous sclerosis 2 protein | Drugs | Cell culture | Phosphorylation | Brain cancer | Acidification | Raf protein | AKT protein | Cytotoxicity | Hamartin | Biosynthesis | Biochemistry | Kinases | pH effects | TSC1 protein | Autophagy | Proteins | Breast carcinoma | Signal transduction | Pathways | Hydrogen ions | Immunotherapy | Fibroblasts | Physiology | Vascular endothelial growth factor | Starvation | Extracellular signal-regulated kinase | Energy expenditure | Substrate inhibition | Embryo fibroblasts | Metabolism | TSC2 protein | Signaling | Acids | Perfusion | Protein synthesis | Protein kinase | Signal processing | Hypoxia | Molecular biology | Biosensors | Cytoplasm | Tumors
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 3, p. e16781
Icaritin, a compound from Epimedium Genus, has selective estrogen receptor (ER) modulating activities, and posses antitumor activity. Here, we examined... 
CYCLIN-DEPENDENT KINASES | SIGNALING PATHWAYS | INHIBITION | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | MAP KINASES | DEATH | STRESS | TRANSIENT | ESTROGEN-RECEPTOR | Endometrial Neoplasms - enzymology | Apoptosis - drug effects | Humans | Enzyme Activation - drug effects | Flavonoids - therapeutic use | Proto-Oncogene Proteins c-bcl-2 - metabolism | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Caspases - biosynthesis | Cell Line, Tumor | Enzyme Induction - drug effects | Endometrial Neoplasms - drug therapy | Endometrial Neoplasms - pathology | Female | Cell Proliferation - drug effects | Flavonoids - pharmacology | Cell Cycle - drug effects | Flavonoids - chemistry | Mitogen-Activated Protein Kinase 1 - metabolism | Cytochrome c | Endometrial cancer | Health aspects | Estrogen | Cancer | Apoptosis | Cell proliferation | Cytochrome | Phosphorylation | Bax protein | Bcl-2 protein | Estrogens | Estrogen receptors | Activation | Kinases | ADP | MAP kinase kinase | Anticancer properties | Cell activation | Cell growth | Antitumor agents | Ribose | Inhibition | Pretreatment | Endometrium | Cyclin-dependent kinases | Extracellular signal-regulated kinase | Caspase | Poly(ADP-ribose) polymerase | MAP kinase | Polymerase | Inhibitors | Cyclin-dependent kinase inhibitor p27
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e35826
Receptor tyrosine kinase signaling cooperates with WNT/beta-catenin signaling in regulating many biological processes, but the mechanisms of their interaction... 
INSULIN | MECHANISM | BIOLOGY | DYSPLASIA | MUTATIONS | WNT | FGFR3 | CANCER | LRP6 | Phosphorylation | Humans | Gene Expression Regulation | Phosphatidylinositol 3-Kinases - metabolism | Glycogen Synthase Kinase 3 - metabolism | Wnt Proteins - metabolism | Receptor Protein-Tyrosine Kinases | beta Catenin - metabolism | Proto-Oncogene Proteins c-akt - genetics | beta Catenin - genetics | Phosphatidylinositol 3-Kinases - genetics | Low Density Lipoprotein Receptor-Related Protein-6 - genetics | Low Density Lipoprotein Receptor-Related Protein-6 - metabolism | MAP Kinase Signaling System - genetics | Wnt Proteins - genetics | Glycogen Synthase Kinase 3 - genetics | Wnt Signaling Pathway - genetics | HEK293 Cells | Mitogen-Activated Protein Kinases - genetics | Proto-Oncogene Proteins c-akt - metabolism | Mitogen-Activated Protein Kinases - metabolism | Wnt protein | AKT protein | Biology | Kinases | Throat cancer | Proteins | Signal transduction | β-catenin | Immunology | TrkA protein | Protein-tyrosine kinase receptors | Physiology | Standard deviation | Protein-tyrosine kinase | Fibroblast growth factor receptor 2 | Tyrosine | Epidermal growth factor receptors | Extracellular signal-regulated kinase | MAP kinase | Biophysics | Cadherin | Biological activity | 1-Phosphatidylinositol 3-kinase | Golgi apparatus | Medicine | Signaling | Low density lipoprotein receptors | Mutation | Prostate cancer | Fibroblast growth factor receptors | Tumors
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e62705
Background: A-kinase anchoring proteins (AKAPs) are scaffolding molecules that coordinate and integrate G-protein signaling events to regulate development,... 
PROTEIN-KINASE-A | BREAST-CANCER | CELL INVASIVENESS | MULTIDISCIPLINARY SCIENCES | HEART-FAILURE | MOUSE | EXCHANGE FACTOR AKAP13 | RECEPTOR | INDUCED CARDIOMYOCYTE HYPERTROPHY | ANCHORING PROTEIN | SIGNALING COMPLEX | Embryo, Mammalian | Minor Histocompatibility Antigens | Heart - embryology | Myocardial Contraction - drug effects | Male | A Kinase Anchor Proteins - genetics | Gene Expression Regulation, Developmental | Guanine Nucleotide Exchange Factors - metabolism | Electrocardiography | Female | A Kinase Anchor Proteins - metabolism | Heart - physiopathology | Protein Structure, Tertiary | Guanine Nucleotide Exchange Factors - genetics | Signal Transduction | Breeding | Cardiomegaly - physiopathology | Organ Size | Stroke Volume - drug effects | Mice, Transgenic | Animals | Cardiomegaly - chemically induced | Heart - drug effects | Mice | Isoproterenol - adverse effects | Cardiomegaly - metabolism | Heart | Protein kinase A | Cell culture | Cardiovascular disease | Isoproterenol | Kinases | Guanine | Defects | Eutrophication | Proteins | Embryogenesis | Fertility | Rodents | Physiology | Guanine nucleotide exchange factor | Heart diseases | Anchoring | Pharmaceutical sciences | Heart failure | Contractility | Cardiomyocytes | Pharmacology | Breast cancer | Embryos | Muscle contraction | Signaling | Scaffolding | Isoforms | Mutation | Alzheimers disease | Viability | Binding sites | Hypertrophy | Ejection
Journal Article