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Cellular Signalling, ISSN 0898-6568, 06/2017, Volume 34, pp. 38 - 46
The COP9 signalosome (CSN) is a multi-protein complex that is highly conserved in eukaryotes. Due to its regulatory impact on processes such as cell cycle, DNA... 
WNT signalling pathway | CSN5/JAB1 | MLN-4924 | DKK1 | COP9 signalosome/CSN | Colorectal cancer | TARGET | ACTIVATION | JAB1/CSN5 | DKKI | BETA-CATENIN | NEGATIVE REGULATOR | CELL BIOLOGY | COLON-CANCER | GENE | COP9 SIGNALOSOME | NEDD8-ACTIVATING ENZYME | EXPRESSION | Peptide Hydrolases - genetics | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Recombinant Proteins - biosynthesis | RNA, Messenger - metabolism | Wnt Proteins - metabolism | COP9 Signalosome Complex - antagonists & inhibitors | Intercellular Signaling Peptides and Proteins - metabolism | Wnt Proteins - genetics | RNA Interference | Intracellular Signaling Peptides and Proteins - genetics | Colorectal Neoplasms - metabolism | Peptide Hydrolases - metabolism | HCT116 Cells | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Intercellular Signaling Peptides and Proteins - genetics | Recombinant Proteins - genetics | Cyclopentanes - pharmacology | Pyrimidines - pharmacology | Recombinant Proteins - pharmacology | Down-Regulation - drug effects | beta Catenin - metabolism | Wnt Signaling Pathway - drug effects | Cell Line, Tumor | COP9 Signalosome Complex - genetics | Colorectal Neoplasms - pathology | COP9 Signalosome Complex - metabolism | RNA, Small Interfering - metabolism | Gene expression | Ligases | Cancer cells | RNA
Journal Article
Leukemia, ISSN 0887-6924, 01/2019, Volume 33, Issue 1, pp. 171 - 180
Immunomodulatory drugs (IMiDs) including lenalidomide and pomalidomide bind cereblon (CRBN) and activate the CRL4(C)(RBN) ubiquitin ligase to trigger... 
MULTIPLE-MYELOMA | DEXAMETHASONE | ONCOLOGY | HIGH-DOSE THERAPY | COP9 SIGNALOSOME | BONE-MARROW | LENALIDOMIDE | DEGRADATION | THALIDOMIDE | HEMATOLOGY | E3 UBIQUITIN LIGASE | TRANSPLANTATION | Prognosis | Peptide Hydrolases - genetics | Humans | Gene Expression Regulation, Neoplastic | Bortezomib - pharmacology | Ikaros Transcription Factor - genetics | COP9 Signalosome Complex - antagonists & inhibitors | Multiple Myeloma - drug therapy | Ubiquitination | Proteolysis | Biomarkers, Tumor - metabolism | Antineoplastic Agents - pharmacology | Ikaros Transcription Factor - metabolism | Tumor Cells, Cultured | Peptide Hydrolases - metabolism | Enzyme Inhibitors - pharmacology | Cyclopentanes - pharmacology | Pyrimidines - pharmacology | Multiple Myeloma - pathology | CRISPR-Cas Systems | Biomarkers, Tumor - genetics | COP9 Signalosome Complex - genetics | COP9 Signalosome Complex - metabolism | Immunologic Factors - pharmacology | Multiple Myeloma - genetics | Research | Drug resistance | Gene expression | Immunity | Cancer cells | Ubiquitin | CRISPR | Regulators | Transcription factors | Deactivation | Immunomodulation | Toxicity | Multiple myeloma | Cytotoxicity | Genomes | Medical screening | Proteasome inhibitors | Cullin | Degradation | Screening | Sensitivity | Inhibitors | Proteasomes | Sensitivity enhancement | Pretreatment | Ubiquitin-protein ligase
Journal Article
Journal Article
Cellular Signalling, ISSN 0898-6568, 09/2018, Volume 49, pp. 79 - 86
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2014, Volume 111, Issue 45, pp. 16005 - 16010
Journal Article
Journal Article