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Pharmaceutical Research, ISSN 0724-8741, 6/2015, Volume 32, Issue 6, pp. 1864 - 1883
To develop a population physiologically-based pharmacokinetic (PBPK) model for simvastatin (SV) and its active metabolite, simvastatin acid (SVA), that allows... 
Biochemistry, general | Biomedical Engineering | drug-drug interactions | Biomedicine | Pharmacy | PBPK | simvastatin | Medical Law | population model | Pharmacology/Toxicology | OATP1B1 | HYDROXY ACID | VARIANTS | DRUG-INTERACTIONS | "simvastatin" | QUANTIFICATION | IN-VITRO DATA | "population model" | "OATP1B1" | STATINS | CHEMISTRY, MULTIDISCIPLINARY | DISPOSITION | PRIOR DISTRIBUTIONS | "PBPK" | PHARMACOLOGY & PHARMACY | "drug-drug interactions" | PRAVASTATIN | INHIBITORS | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Activation, Metabolic | Cytochrome P-450 Enzyme Inhibitors - therapeutic use | Simvastatin - adverse effects | Humans | Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood | Biological Availability | Muscle, Skeletal - metabolism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - chemistry | Healthy Volunteers | Simvastatin - blood | Organic Anion Transporters - metabolism | Tissue Distribution | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Organic Anion Transporters - genetics | Drug Interactions | Liver - drug effects | Muscle, Skeletal - drug effects | Muscular Diseases - chemically induced | Pharmacogenetics | Reproducibility of Results | Simvastatin - chemistry | Muscular Diseases - metabolism | Simvastatin - administration & dosage | Liver - metabolism | Simvastatin - pharmacokinetics | Simvastatin - analogs & derivatives | Polymorphism, Genetic | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Models, Biological | Solute Carrier Organic Anion Transporter Family Member 1b1 | Metabolites | Simvastatin | Drug interactions | Liver | Cytochrome P-450 | Antilipemic agents | Side effects | Pharmacology | Kinetics | Statins | Index Medicus
Journal Article
Pharmacogenetics and Genomics, ISSN 1744-6872, 12/2006, Volume 16, Issue 12, pp. 873 - 879
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 10/2014, Volume 96, Issue 4, pp. 423 - 428
Journal Article
Journal Article
Experimental Eye Research, ISSN 0014-4835, 03/2007, Volume 84, Issue 3, p. 464
Proliferative vitreoretinopathy (PVR) is a major cause of the failure of rhegmatogenous retinal detachment surgery. The pathogenesis of PVR includes a fibrotic... 
Simvastatin
Journal Article
European Journal of Heart Failure, ISSN 1388-9842, 01/2007, Volume 9, Issue 1, p. 30
Simvastatin can prevent cardiac remodelling after myocardial infarction, though the exact mechanisms are uncertain. Myocardial no-reflow is associated with... 
Simvastatin
Journal Article
Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 02/2019, Volume 164, pp. 258 - 267
[Display omitted] •LC–MS/MS assay for simvastatin, atorvastatin, rosuvastatin, and active metabolites.•Assay was validated following FDA bioanalytical... 
Obese subjects from GBS | Hyperlipidemic plasma | Simvastatin and metabolite | Rosuvastatin | Atorvastatin and metabolites | LC–MS/MS | MS-MS METHOD | LC-MS/MS | CHEMISTRY, ANALYTICAL | ACID | SIMULTANEOUS QUANTITATION | PHARMACOLOGY & PHARMACY | SIMULTANEOUS QUANTIFICATION | Simvastatin - therapeutic use | Gastric Bypass | Chromatography, High Pressure Liquid - methods | Hyperlipidemias - blood | Rosuvastatin Calcium - therapeutic use | Humans | Middle Aged | Male | Simvastatin - pharmacology | Obesity - blood | Simvastatin - blood | Atherosclerosis - etiology | Adult | Female | Atorvastatin - blood | Hydroxymethylglutaryl-CoA Reductase Inhibitors | Rosuvastatin Calcium - blood | Tandem Mass Spectrometry - methods | Hyperlipidemias - complications | Obesity - surgery | Tandem Mass Spectrometry - instrumentation | Reproducibility of Results | Obesity - complications | Hyperlipidemias - drug therapy | Rosuvastatin Calcium - pharmacology | Atorvastatin - therapeutic use | Postoperative Period | Chromatography, High Pressure Liquid - instrumentation | Atorvastatin - pharmacology | Calibration | Simvastatin - analogs & derivatives | Atorvastatin - analogs & derivatives | Atherosclerosis - prevention & control | Preoperative Period | Obesity | Medical research | Simvastatin | Gastric bypass | Organic acids | Cardiovascular agents | Antilipemic agents | Metabolites | Analysis | Formic acid | Medicine, Experimental | Nitriles | LC-MS | Hyperlipidemic Plasma | Obese Subjects from GBS
Journal Article
European Journal of Clinical Pharmacology, ISSN 0031-6970, 3/2015, Volume 71, Issue 3, pp. 341 - 355
Systemic exposure to rosuvastatin is approximately double that of Caucasians in Asian subjects. We investigated whether this pattern of increased exposure... 
SLCO1B1 | Pharmacogenetics | Biomedicine | Caucasian | Pharmacology/Toxicology | Pharmacokinetics | Asian | ABCG2 | WHITE | ADULT MALE-VOLUNTEERS | RISK | OATP1B1 | DISPOSITION | MARKEDLY AFFECTS | TRANSPORT | SYSTEMIC EXPOSURE | DISEASE | PHARMACOLOGY & PHARMACY | HEALTHY-VOLUNTEERS | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Simvastatin - adverse effects | Atorvastatin Calcium - blood | Humans | Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood | Middle Aged | Rosuvastatin Calcium - adverse effects | Asian Continental Ancestry Group - genetics | Male | Simvastatin - blood | Young Adult | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Organic Anion Transporters - genetics | ATP-Binding Cassette Transporters - genetics | Adult | Female | Neoplasm Proteins - genetics | Rosuvastatin Calcium - blood | Atorvastatin Calcium - adverse effects | Atorvastatin Calcium - pharmacokinetics | European Continental Ancestry Group - genetics | Rosuvastatin Calcium - pharmacokinetics | Genotype | Simvastatin - pharmacokinetics | Simvastatin - analogs & derivatives | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Adolescent | Polymorphism, Single Nucleotide - genetics | Aged | Solute Carrier Organic Anion Transporter Family Member 1b1 | Genetic aspects | Rosuvastatin | Simvastatin | Antilipemic agents | Genotype & phenotype | Whites | Pharmacology | Statins | Asians | Polymorphism
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 06/2015, Volume 372, Issue 25, pp. 2387 - 2397
In this trial, patients with an acute coronary syndrome within the previous 10 days were randomly assigned to simvastatin plus either ezetimibe or placebo. At... 
CHOLESTEROL ABSORPTION | CARDIAC OUTCOMES | MEDICINE, GENERAL & INTERNAL | MYOCARDIAL-INFARCTION | EFFICACY | CARDIOVASCULAR OUTCOMES | CLINICAL-TRIALS | SIMVASTATIN | PRIMARY PREVENTION | IMPROVE-IT | ATORVASTATIN | Simvastatin - therapeutic use | Double-Blind Method | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Azetidines - adverse effects | Ezetimibe | Kaplan-Meier Estimate | Male | Anticholesteremic Agents - adverse effects | Acute Coronary Syndrome - drug therapy | Anticholesteremic Agents - therapeutic use | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Azetidines - therapeutic use | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Triglycerides - blood | Cardiovascular Diseases - epidemiology | Cardiovascular Diseases - mortality | Cholesterol, LDL - blood | Female | Aged | Drug Therapy, Combination | Usage | Simvastatin | Analysis | Practice guidelines (Medicine) | Dosage and administration | Drug therapy, Combination | Acute coronary syndrome | Drug therapy | Myocardial infarction | Cerebral infarction | Lipoproteins (low density) | Stroke | Angina | Cholesterol | Intestine | Gallbladder | Acute coronary syndromes | Cardiovascular diseases | Statins | Pharmaceuticals | Cancer | Life Sciences | Human health and pathology | Cardiology and cardiovascular system
Journal Article