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1. Full Text Harnessing T cells to fight cancer with BiTE® antibody constructs – past developments and future directions
by Klinger, Matthias and Benjamin, Jonathan and Kischel, Roman and Stienen, Sabine and Zugmaier, Gerhard
Immunological Reviews, ISSN 0105-2896, 03/2016, Volume 270, Issue 1, pp. 193 - 208
Summary Bispecific T‐cell engager (BiTE®) antibody constructs represent a novel immunotherapy that bridges cytotoxic T cells to tumor cells, thereby inducing... 
blinatumomab | non‐Hodgkin's lymphoma | bispecific T‐cell engager (BiTE®) | acute myeloid leukemia | acute lymphoblastic leukemia | immunotherapy | Bispecific T-cell engager (BiTE | Acute lymphoblastic leukemia | Non-Hodgkin's lymphoma | Acute myeloid leukemia | Blinatumomab | Immunotherapy | ADULT PATIENTS | GEMTUZUMAB OZOGAMICIN | SINGLE-CHAIN ANTIBODY | ENGAGING ANTIBODY | IMMUNOLOGY | bispecific T-cell engager (BiTE (R)) | non-Hodgkin's lymphoma | EP-CAM | ACUTE LYMPHOBLASTIC-LEUKEMIA | CHRONIC LYMPHOCYTIC-LEUKEMIA | TERM-FOLLOW-UP | MINIMAL RESIDUAL DISEASE | COLONY-FORMING CELLS | T-Lymphocyte Subsets - immunology | Antibodies, Bispecific - pharmacology | Antigens, Neoplasm - immunology | Humans | Neoplasms - mortality | Treatment Outcome | Antineoplastic Agents - therapeutic use | Neoplasms - diagnosis | Antibodies, Bispecific - immunology | Antibodies, Bispecific - therapeutic use | Lymphocyte Activation - immunology | Neoplasms - therapy | Animals | Neoplasms - immunology | T-Lymphocyte Subsets - metabolism | Protein Engineering | Antineoplastic Agents - pharmacology | Viral antibodies | Antibodies | Lymphomas | T cells | Leukemia
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2. Full Text Structures of a pan‐specific antagonist antibody complexed to different isoforms of TGFβ reveal structural plasticity of antibody–antigen interactions
by Moulin, Aaron and Mathieu, Magali and Lawrence, Catherine and Bigelow, Russell and Levine, Mark and Hamel, Christine and Marquette, Jean‐Piere and Parc, Josiane and Loux, Christophe and Ferrari, Paul and Capdevila, Cecile and Dumas, Jacques and Dumas, Bruno and Rak, Alexey and Bird, Julie and Qiu, Huawei and Pan, Clark Q and Edmunds, Tim and Wei, Ronnie R
Protein Science, ISSN 0961-8368, 12/2014, Volume 23, Issue 12, pp. 1698 - 1707
Various important biological pathways are modulated by TGFβ isoforms; as such they are potential targets for therapeutic intervention. Fresolimumab, also known... 
antibody | receptor | transforming growth factor beta | X‐ray crystallography | fibrosis | pan‐specific inhibitor | protein complex | ligand | X-ray crystallography | pan-specific inhibitor | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | MODEL | KNOCKOUT MICE | INHIBITION | EXPRESSION | Transforming Growth Factor beta - immunology | Humans | Models, Molecular | Crystallography, X-Ray | Transforming Growth Factor beta - chemistry | Antibodies, Neutralizing - immunology | Antibody Specificity - immunology | Protein Isoforms - chemistry | Antibodies, Neutralizing - chemistry | Immunoglobulin Fab Fragments - chemistry | Protein Conformation | Immunoglobulin Fab Fragments - immunology | Protein Isoforms - immunology | Antigen-Antibody Reactions - immunology | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Single-Chain Antibodies - chemistry | Single-Chain Antibodies - immunology | Fv | Antibodies | Antigens | Fab | Isoforms | Crystal structure
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3. Full Text Antibody fragments
: Hope and hype
by Nelson, Aaron L
mAbs, ISSN 1942-0862, 01/2010, Volume 2, Issue 1, pp. 77 - 83
The antibody molecule is modular, and separate domains can be extracted through biochemical or genetic means. It is clear from review of the literature that a... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Antibodydrug conjugate | Technology development | scFv | Antibody fragments | Fab | THERAPEUTICS | CELLS | SINGLE-CHAIN ANTIBODY | CANCER-THERAPY | DEVELOPMENT TRENDS | antibody fragments | BISPECIFIC ANTIBODY | INSTRUMENTS & INSTRUMENTATION | antibody-drug conjugate | DOMAIN ANTIBODIES | PROTEINS | technology development
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4. Full Text Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity
by Steinhardt, James J and Guenaga, Javier and Turner, Hannah L and McKee, Krisha and Louder, Mark K and O'Dell, Sijy and Chiang, Chi-I and Lei, Lin and Galkin, Andrey and Andrianov, Alexander K and Doria-Rose, Nicole A and Bailer, Robert T and Ward, Andrew B and Mascola, John R and Li, Yuxing
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 877 - 12
HIV-1 broadly neutralizing antibodies (bNAbs) are being explored as passively administered therapeutic and preventative agents. However, the extensively... 
BISPECIFIC ANTIBODIES | SHIV INFECTION | POTENT NEUTRALIZATION | BROADLY NEUTRALIZING ANTIBODIES | MULTIDISCIPLINARY SCIENCES | IMPROVES PROTECTION | CD4 BINDING | HUMAN MONOCLONAL-ANTIBODIES | HUMAN-IMMUNODEFICIENCY-VIRUS | FITNESS COST | BREADTH | Protein Subunits - immunology | env Gene Products, Human Immunodeficiency Virus - immunology | Antiviral Agents - immunology | Humans | Epitopes - immunology | Antibodies, Neutralizing - immunology | env Gene Products, Human Immunodeficiency Virus - genetics | HIV Antibodies - immunology | Antiviral Agents - chemistry | Antibodies, Neutralizing - therapeutic use | env Gene Products, Human Immunodeficiency Virus - antagonists & inhibitors | Drug Design | Single-Chain Antibodies - therapeutic use | HIV Antibodies - therapeutic use | HIV Antibodies - pharmacology | Antiviral Agents - pharmacology | Single-Chain Antibodies - pharmacology | Antiviral Agents - therapeutic use | HIV-1 - drug effects | Antibodies, Neutralizing - pharmacology | Epitopes - genetics | HIV-1 - genetics | Microscopy, Electron | HIV Antibodies - chemistry | HIV-1 - immunology | Antibodies, Neutralizing - chemistry | HIV Infections - drug therapy | Mutation | Drug Combinations | Single-Chain Antibodies - chemistry | Single-Chain Antibodies - immunology | Antiviral agents | Antibodies | Crosslinking | Glycoproteins | Pharmacology | Epitopes | Chemical compounds | Glycan | CD4 antigen | Human immunodeficiency virus--HIV | Avidity | Binding sites | Neutralization
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5. Full Text Potent antibody therapeutics by design
by Carter, Paul J
Nature Reviews Immunology, ISSN 1474-1733, 05/2006, Volume 6, Issue 5, pp. 343 - 357
Antibodies constitute the most rapidly growing class of human therapeutics and the second largest class of drugs after vaccines. The generation of potent... 
DEPENDENT CELLULAR CYTOTOXICITY | PHAGE DISPLAY LIBRARIES | COMPLEMENTARITY-DETERMINING REGIONS | PHASE-I TRIAL | FC-GAMMA-RIIIA | HUMAN-IGG ANTIBODIES | HUMAN MONOCLONAL-ANTIBODY | SINGLE-CHAIN FV | RESPIRATORY-SYNCYTIAL-VIRUS | IMMUNOLOGY | RESHAPING HUMAN-ANTIBODIES | Antibodies, Monoclonal - therapeutic use | Animals | Humans | Antibodies, Monoclonal - chemistry | Drug Design
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6. Full Text The coming of age of engineered multivalent antibodies
by Nuñez-Prado, Natalia and Compte, Marta and Harwood, Seandean and Álvarez-Méndez, Ana and Lykkemark, Simon and Sanz, Laura and Álvarez-Vallina, Luis
Drug Discovery Today, ISSN 1359-6446, 05/2015, Volume 20, Issue 5, pp. 588 - 594
The development of monoclonal antibody (mAb) technology has had a profound impact on medicine. The therapeutic use of first-generation mAb achieved... 
BISPECIFIC ANTIBODIES | TANDEM DIABODY | EFFICIENT HETERODIMERIZATION | SINGLE-CHAIN FV | DOMAIN ANTIBODIES | HIGH-AVIDITY | THERAPEUTIC ANTIBODIES | ANTIGEN-BINDING | PHARMACOLOGY & PHARMACY | T-CELLS | TARGETED DELIVERY | Antibody Specificity | Protein Engineering - methods | Humans | Antibodies, Monoclonal - adverse effects | Antibodies, Monoclonal - therapeutic use | Drug Discovery - methods | Structure-Activity Relationship | Epitopes | Antibodies, Bispecific - immunology | Antibodies, Bispecific - therapeutic use | Animals | Antibodies, Bispecific - adverse effects | Protein Conformation | Antibodies, Monoclonal - immunology | Viral antibodies | Antibodies
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7. Full Text Antibody arrays for high-throughput screening of antibody-antigen interactions
by Mundy, Chris R and Gorick, Barbara D and Tomlinson, Ian M and de Wildt, Ruud M. T
Nature Biotechnology, ISSN 1087-0156, 09/2000, Volume 18, Issue 9, pp. 989 - 994
We have developed a novel technique for high-throughput screening of recombinant antibodies, based on the creation of antibody arrays. Our method uses robotic... 
High throughput | Array screening | Phage display | Antibody | Single-chain variable fragment (scFv) | PHAGE DISPLAY LIBRARIES | REPERTOIRE | antibody | PROTEIN | array screening | single-chain variable fragment (scFv) | SINGLE-CHAIN ANTIBODIES | AFFINITY HUMAN-ANTIBODIES | high throughput | FRAGMENTS | phage display | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MICROARRAYS | SELECTION | BINDING | EXPRESSION | Amino Acid Sequence | Molecular Probe Techniques | Bacteria - chemistry | Enzyme-Linked Immunosorbent Assay | Oligonucleotide Array Sequence Analysis | Antibodies - chemistry | Humans | Molecular Sequence Data | Recombinant Proteins - chemistry | Peptide Library | Bacteria - genetics | Antigen-Antibody Reactions | Blotting, Western | Robotics | Proteins - metabolism | Biochemistry - methods | Biosensing Techniques - methods | Protein Conformation | Serum Albumin, Bovine - chemistry | HeLa Cells | Proteins - chemistry | Serum Albumin - chemistry | antibody arrays | high-throughput screening
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8. Full Text Antibody tumor penetration: Transport opposed by systemic and antigen-mediated clearance
by Thurber, Greg M and Schmidt, Michael M and Wittrup, K. Dane
Advanced Drug Delivery Reviews, ISSN 0169-409X, 2008, Volume 60, Issue 12, pp. 1421 - 1434
Antibodies have proven to be effective agents in cancer imaging and therapy. One of the major challenges still facing the field is the heterogeneous... 
Binding site barrier | Drug distribution | Tumor targeting | Immunotherapy | Antibodies | Affinity | Cellular trafficking | Mathematical modeling | Pharmacokinetics | cellular trafficking | INTERSTITIAL FLUID PRESSURE | tumor targeting | HUMAN-MELANOMA XENOGRAFTS | SOLID TUMORS | PRODRUG THERAPY ADEPT | BINDING-SITE BARRIER | METASTATIC COLORECTAL-CANCER | B-CELL LYMPHOMA | immunotherapy | drug distribution | pharmacokinetics | mathematical modeling | SINGLE-CHAIN FV | PHARMACOLOGY & PHARMACY | antibodies | VASCULAR-PERMEABILITY FACTOR | binding site barrier | affinity | ENDOTHELIAL GROWTH-FACTOR | Models, Theoretical | Neoplasms - metabolism | Antibodies - therapeutic use | Capillary Permeability | Antibodies - metabolism | Humans | Antibody Affinity | Metabolic Clearance Rate | Permeability | Endocytosis | Neoplasm Metastasis | Neoplasms - therapy | Animals | Antigens - physiology | Biological Transport | Diffusion | Drugs | Viral antibodies | Drug delivery systems | Vehicles | Tumors
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9. Full Text Antibody or Antibody Fragments : Implications for Molecular Imaging and Targeted Therapy of Solid Tumors
by Xenaki, Katerina T and Oliveira, Sabrina and van Bergen En Henegouwen, Paul M P
Frontiers in Immunology, ISSN 1664-3224, 2017, Volume 8, p. 1287
The use of antibody-based therapeutics has proven very promising for clinical applications in cancer patients, with multiple examples of antibodies and... 
cancer therapy | antibody fragments | single-domain antibodies | antibody | nanobody | molecular imaging | Molecular imaging | Nanobody | Antibody | Antibody fragments | Cancer therapy | Single-domain antibodies | HALF-LIFE | PENETRATION | MODELING ANALYSIS | IMMUNOLOGY | ALBUMIN-BINDING DOMAIN | CANCER | TRANSPORT | NEONATAL FC-RECEPTOR | AFFINITY | SINGLE-CHAIN FV | DIFFUSION
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