06/2018, OECD Guidelines for the Testing of Chemicals, Section 4, 21
The present Key Event based Test Guideline (TG) addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. More...
h-CLAT | Environment | skin sensitisation | in vitro method
h-CLAT | Environment | skin sensitisation | in vitro method
eBook
Contact Dermatitis, ISSN 0105-1873, 09/2017, Volume 77, Issue 3, pp. 151 - 158
Summary Background Patients with lower leg dermatitis, chronic venous insufficiency or chronic leg ulcers have a high prevalence of contact sensitization....
contact sensitization | chronic leg ulcer | chronic venous insufficiency | patch testing | SERIES | ALLERGY | DERMATOLOGY | Allergens - adverse effects | Lanolin - adverse effects | Dermatology | Humans | Middle Aged | Resins, Plant - adverse effects | Male | Patch Tests - methods | Myroxylon - adverse effects | Leg Ulcer - epidemiology | Balsams - adverse effects | Dermatitis, Allergic Contact - diagnosis | Eczema - epidemiology | Perfume - adverse effects | Adult | Female | Aged | Leg Dermatoses - epidemiology | Allergy | Allergens | Care and treatment | Ulcers | Aminoglycosides | Skin | Inflammation | Sulfates | Dermatitis | Allergic reaction | Testing | Gentamicin | Turpentine | Alcohol | Allergies | Leg | Hydroquinone | Contact dermatitis | Neomycin | Varicose veins | Leg ulcers | Sulfate
contact sensitization | chronic leg ulcer | chronic venous insufficiency | patch testing | SERIES | ALLERGY | DERMATOLOGY | Allergens - adverse effects | Lanolin - adverse effects | Dermatology | Humans | Middle Aged | Resins, Plant - adverse effects | Male | Patch Tests - methods | Myroxylon - adverse effects | Leg Ulcer - epidemiology | Balsams - adverse effects | Dermatitis, Allergic Contact - diagnosis | Eczema - epidemiology | Perfume - adverse effects | Adult | Female | Aged | Leg Dermatoses - epidemiology | Allergy | Allergens | Care and treatment | Ulcers | Aminoglycosides | Skin | Inflammation | Sulfates | Dermatitis | Allergic reaction | Testing | Gentamicin | Turpentine | Alcohol | Allergies | Leg | Hydroquinone | Contact dermatitis | Neomycin | Varicose veins | Leg ulcers | Sulfate
Journal Article
Allergy, ISSN 0105-4538, 01/2019, Volume 74, Issue 1, pp. 165 - 175
Background The generation of IgE‐mediated food allergy in humans is silent and only diagnosed upon manifestation of clinical symptoms. While experimental...
epicutaneous sensitization | anaphylaxis | IgG1+ memory B cells | IgE‐mediated food allergy | Th2 immunity | IgG1 | IgE-mediated food allergy | memory B cells | DENDRITIC CELLS | MAST-CELLS | IMMUNOLOGY | GERMINAL-CENTER | MEMORY B | IgG1(+) memory B cells | ALLERGY | IN-VIVO | PEANUT ANTIGEN | PLATELET-ACTIVATING-FACTOR | PROMOTES | EXPOSURE | Genetically modified animals | Medical research | Food allergy | Allergens | Biological products | Dendritic cells | Immunoglobulin G | Immunoglobulin E | Albumin | Development and progression | B cells | Analysis | Medicine, Experimental | Flow cytometry | Immunity | Lymph nodes | Anaphylaxis | Germinal centers | CD73 antigen | Immunity (humoral) | Food hypersensitivity | Food | Food allergies | Ovalbumin | Signs and symptoms | Phenotypes | Immunological memory | Memory cells | Peanuts | Albumen | Therapeutic applications | CD80 antigen | Drainage | Depletion | Lymphocytes B | Skin | Classical pathway
epicutaneous sensitization | anaphylaxis | IgG1+ memory B cells | IgE‐mediated food allergy | Th2 immunity | IgG1 | IgE-mediated food allergy | memory B cells | DENDRITIC CELLS | MAST-CELLS | IMMUNOLOGY | GERMINAL-CENTER | MEMORY B | IgG1(+) memory B cells | ALLERGY | IN-VIVO | PEANUT ANTIGEN | PLATELET-ACTIVATING-FACTOR | PROMOTES | EXPOSURE | Genetically modified animals | Medical research | Food allergy | Allergens | Biological products | Dendritic cells | Immunoglobulin G | Immunoglobulin E | Albumin | Development and progression | B cells | Analysis | Medicine, Experimental | Flow cytometry | Immunity | Lymph nodes | Anaphylaxis | Germinal centers | CD73 antigen | Immunity (humoral) | Food hypersensitivity | Food | Food allergies | Ovalbumin | Signs and symptoms | Phenotypes | Immunological memory | Memory cells | Peanuts | Albumen | Therapeutic applications | CD80 antigen | Drainage | Depletion | Lymphocytes B | Skin | Classical pathway
Journal Article
1999, Technical report, ISBN 0773807278, Volume no. 78., 27
Book
Journal of Investigative Dermatology, ISSN 0022-202X, 03/2012, Volume 132, Issue 3, pp. 949 - 963
For at least half a century, noninvasive techniques have been available to quantify skin barrier function, and these have shown that a number of human skin...
ATOPIC-DERMATITIS | ICHTHYOSIS VULGARIS | STRATUM-CORNEUM | EPIDERMOLYSIS-BULLOSA PRURIGINOSA | TRANSEPIDERMAL WATER-LOSS | EPIDERMAL BARRIER | FILAGGRIN MUTATIONS | OF-FUNCTION MUTATIONS | THYMIC STROMAL LYMPHOPOIETIN | LANGERHANS CELLS | DERMATOLOGY | Allergens - immunology | Skin - metabolism | Humans | Dermatitis, Atopic - immunology | Permeability | Dermatitis, Atopic - metabolism | Allergens - metabolism | Skin - immunology | epicutaneous sensitization | allergen | barrier | Atopic dermatitis
ATOPIC-DERMATITIS | ICHTHYOSIS VULGARIS | STRATUM-CORNEUM | EPIDERMOLYSIS-BULLOSA PRURIGINOSA | TRANSEPIDERMAL WATER-LOSS | EPIDERMAL BARRIER | FILAGGRIN MUTATIONS | OF-FUNCTION MUTATIONS | THYMIC STROMAL LYMPHOPOIETIN | LANGERHANS CELLS | DERMATOLOGY | Allergens - immunology | Skin - metabolism | Humans | Dermatitis, Atopic - immunology | Permeability | Dermatitis, Atopic - metabolism | Allergens - metabolism | Skin - immunology | epicutaneous sensitization | allergen | barrier | Atopic dermatitis
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2012, Volume 129, Issue 5, pp. 1334 - 1342.e1
Background We have observed patients clinically allergic to red meat and meat-derived gelatin. Objective We describe a prospective evaluation of the clinical...
Allergy and Immunology | Food allergy | colloid | anaphylaxis | gelatin | α-galactose | red meat | RISK-FACTORS | REACTIVITY | IMMUNOLOGY | CHILDREN | RUBELLA VACCINE | CETUXIMAB | IGE ANTIBODIES | ALLERGY | RELEVANCE | ANAPHYLACTOID REACTIONS | alpha-galactose | IMMUNOGLOBULIN-E | Allergens - adverse effects | Predictive Value of Tests | Galactose - metabolism | Immunization | Prospective Studies | Skin Tests | Gelatin - adverse effects | Humans | Middle Aged | Male | Immunoglobulin E - blood | Young Adult | Galactose - analogs & derivatives | Galactose - immunology | Animals | Food Hypersensitivity - immunology | Cattle | Meat - adverse effects | Adolescent | Gelatin - immunology | Adult | Female | Aged | Food Hypersensitivity - diagnosis | Drugs | Anaphylaxis | Intravenous administration | Gelatin | Colloids | Hypersensitivity | Venom | Bites | Immunoglobulin E | Food hypersensitivity | Skin tests | Meat | food allergy
Allergy and Immunology | Food allergy | colloid | anaphylaxis | gelatin | α-galactose | red meat | RISK-FACTORS | REACTIVITY | IMMUNOLOGY | CHILDREN | RUBELLA VACCINE | CETUXIMAB | IGE ANTIBODIES | ALLERGY | RELEVANCE | ANAPHYLACTOID REACTIONS | alpha-galactose | IMMUNOGLOBULIN-E | Allergens - adverse effects | Predictive Value of Tests | Galactose - metabolism | Immunization | Prospective Studies | Skin Tests | Gelatin - adverse effects | Humans | Middle Aged | Male | Immunoglobulin E - blood | Young Adult | Galactose - analogs & derivatives | Galactose - immunology | Animals | Food Hypersensitivity - immunology | Cattle | Meat - adverse effects | Adolescent | Gelatin - immunology | Adult | Female | Aged | Food Hypersensitivity - diagnosis | Drugs | Anaphylaxis | Intravenous administration | Gelatin | Colloids | Hypersensitivity | Venom | Bites | Immunoglobulin E | Food hypersensitivity | Skin tests | Meat | food allergy
Journal Article
Toxicology in Vitro, ISSN 0887-2333, 08/2015, Volume 29, Issue 5, pp. 901 - 916
The U-SENS™ assay, formerly known as MUSST (Myeloid U937 Skin Sensitization Test), is an method to assess skin sensitization. Dendritic cell activation...
MUSST | CD86 induction | U-SENS | Dendritic cells | Skin sensitization | Predictivity | SCREENING CONTACT ALLERGENS | TEST H-CLAT | LYMPH-NODE ASSAY | U-SENS (TM) | PREDICTION | PEPTIDE REACTIVITY | IN-VITRO | POTENCY | CHEMICALS | END-POINTS | TOXICOLOGY | RISK-ASSESSMENT | Dermatitis, Contact - immunology | Reproducibility of Results | Animals | Skin Tests | U937 Cells | Animal Testing Alternatives | Dendritic Cells - immunology | Humans | Toxicity Tests - methods | Mice | Local Lymph Node Assay | Allergens - toxicity | Medical tests | Skin | Index Medicus
MUSST | CD86 induction | U-SENS | Dendritic cells | Skin sensitization | Predictivity | SCREENING CONTACT ALLERGENS | TEST H-CLAT | LYMPH-NODE ASSAY | U-SENS (TM) | PREDICTION | PEPTIDE REACTIVITY | IN-VITRO | POTENCY | CHEMICALS | END-POINTS | TOXICOLOGY | RISK-ASSESSMENT | Dermatitis, Contact - immunology | Reproducibility of Results | Animals | Skin Tests | U937 Cells | Animal Testing Alternatives | Dendritic Cells - immunology | Humans | Toxicity Tests - methods | Mice | Local Lymph Node Assay | Allergens - toxicity | Medical tests | Skin | Index Medicus
Journal Article
Human and Experimental Toxicology, ISSN 0960-3271, 12/2015, Volume 34, Issue 12, p. 1222
Skin sensitization associated with allergic contact dermatitis is a common health problem and is an important consideration for toxicologists in safety...
Toxicology | Skin | Dermatitis | Risk assessment | Allergies
Toxicology | Skin | Dermatitis | Risk assessment | Allergies
Journal Article
Journal of Applied Toxicology, ISSN 0260-437X, 09/2016, Volume 36, Issue 9, pp. 1150 - 1162
One of the top priorities of the Interagency Coordinating Committee for the Validation of Alternative Methods (ICCVAM) is the identification and evaluation of...
LLNA | KeratinoSens | support vector machine | allergic contact dermatitis | skin sensitization | DPRA | integrated decision strategy | machine learning | h‐CLAT | h-CLAT | RISK-ASSESSMENT MODEL | LINE ACTIVATION TEST | TEST H-CLAT | LYMPH-NODE ASSAY | PREDICTIVE PERFORMANCE | PIG MAXIMIZATION TEST | IN-VITRO METHODS | CONTACT ALLERGENS | TOXICOLOGY | TESTING STRATEGY | PEPTIDE REACTIVITY ASSAY | Decision Making | Cell Line | Animal Testing Alternatives - methods | Reproducibility of Results | Risk Assessment | Humans | Computational Biology | Xenobiotics - toxicity | Dermatitis, Allergic Contact - pathology | Local Lymph Node Assay | Animals | Mice | Allergens - toxicity | Skin - drug effects | Analysis | Skin | Machine learning | Cruelty to animals | Lymphatic system | Toxicology | Skin care products | Cosmetics industry | Index Medicus | Skin sensitization
LLNA | KeratinoSens | support vector machine | allergic contact dermatitis | skin sensitization | DPRA | integrated decision strategy | machine learning | h‐CLAT | h-CLAT | RISK-ASSESSMENT MODEL | LINE ACTIVATION TEST | TEST H-CLAT | LYMPH-NODE ASSAY | PREDICTIVE PERFORMANCE | PIG MAXIMIZATION TEST | IN-VITRO METHODS | CONTACT ALLERGENS | TOXICOLOGY | TESTING STRATEGY | PEPTIDE REACTIVITY ASSAY | Decision Making | Cell Line | Animal Testing Alternatives - methods | Reproducibility of Results | Risk Assessment | Humans | Computational Biology | Xenobiotics - toxicity | Dermatitis, Allergic Contact - pathology | Local Lymph Node Assay | Animals | Mice | Allergens - toxicity | Skin - drug effects | Analysis | Skin | Machine learning | Cruelty to animals | Lymphatic system | Toxicology | Skin care products | Cosmetics industry | Index Medicus | Skin sensitization
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 02/2019, Volume 20, Issue 3
There is an increasing demand for alternative in vitro methods to replace animal testing, and, to succeed, new methods are required to be at least as accurate...
next generation in vitro tests | MODELS | BIOCHEMISTRY & MOLECULAR BIOLOGY | genomics | skin sensitization | adverse outcome pathways | GARD ASSAY | machine learning | CHEMISTRY, MULTIDISCIPLINARY | PREDICTION
next generation in vitro tests | MODELS | BIOCHEMISTRY & MOLECULAR BIOLOGY | genomics | skin sensitization | adverse outcome pathways | GARD ASSAY | machine learning | CHEMISTRY, MULTIDISCIPLINARY | PREDICTION
Journal Article
2008, Harmonization Project document, ISBN 9789241563604, Volume no. 5., iv, 85
This publication presents the conclusions of an IPCS Workshop on Skin Sensitization in Chemical Risk Assessment. The workshop focused on the question of...
toxicity | Toxicology | physiopathology | Risk Assessment | methods | Hazardous substances | Dermatitis, Contact | Health risk assessment | Physiological effect | Chemicals | Skin tests
toxicity | Toxicology | physiopathology | Risk Assessment | methods | Hazardous substances | Dermatitis, Contact | Health risk assessment | Physiological effect | Chemicals | Skin tests
Book
Regulatory Toxicology and Pharmacology, ISSN 0273-2300, 08/2014, Volume 69, Issue 3, pp. 529 - 545
Since the OECD published the Adverse Outcome Pathway (AOP) for skin sensitization, many efforts have focused on how to integrate and interpret nonstandard...
Read-across | Adverse Outcome Pathway (AOP) | Expert systems | TIMES-SS | Integrated Approaches to Testing and Assessment (IATA) | (Q)SAR | Adverse outcome pathway (AOP) | Integrated approaches to testing and assessment (IATA) | ADVERSE OUTCOME PATHWAYS | Assessment (IATA) | TOXICOLOGICAL END-POINTS | MEDICINE, LEGAL | SCREENING CONTACT ALLERGENS | LYMPH-NODE ASSAY | GENE-EXPRESSION CHANGES | Integrated Approaches to Testing and | INCORPORATING MOLECULAR FLEXIBILITY | PHARMACOLOGY & PHARMACY | NONANIMAL-BASED PREDICTION | TOXICOLOGY | RISK-ASSESSMENT | MECHANISTIC APPLICABILITY DOMAINS | CELL-LINE | Dermatitis, Allergic Contact - immunology | Risk Assessment | Humans | Protein Binding - immunology | Dermatitis, Allergic Contact - etiology | Allergens - immunology | Th1 Cells | Organisation for Economic Co-Operation and Development | U937 Cells | Allergens - chemistry | Cell Line, Tumor | Quantitative Structure-Activity Relationship | Skin - immunology | Skin | Index Medicus
Read-across | Adverse Outcome Pathway (AOP) | Expert systems | TIMES-SS | Integrated Approaches to Testing and Assessment (IATA) | (Q)SAR | Adverse outcome pathway (AOP) | Integrated approaches to testing and assessment (IATA) | ADVERSE OUTCOME PATHWAYS | Assessment (IATA) | TOXICOLOGICAL END-POINTS | MEDICINE, LEGAL | SCREENING CONTACT ALLERGENS | LYMPH-NODE ASSAY | GENE-EXPRESSION CHANGES | Integrated Approaches to Testing and | INCORPORATING MOLECULAR FLEXIBILITY | PHARMACOLOGY & PHARMACY | NONANIMAL-BASED PREDICTION | TOXICOLOGY | RISK-ASSESSMENT | MECHANISTIC APPLICABILITY DOMAINS | CELL-LINE | Dermatitis, Allergic Contact - immunology | Risk Assessment | Humans | Protein Binding - immunology | Dermatitis, Allergic Contact - etiology | Allergens - immunology | Th1 Cells | Organisation for Economic Co-Operation and Development | U937 Cells | Allergens - chemistry | Cell Line, Tumor | Quantitative Structure-Activity Relationship | Skin - immunology | Skin | Index Medicus
Journal Article
Pain, ISSN 0304-3959, 12/2013, Volume 154, Issue 12, pp. 2707 - 2714
Experimental combination of nerve growth factor (NGF) evoked sensitization and ultraviolet-B (UV-B)–induced inflammation causes spontaneous pain and...
UV-B | NaV | Pain | Axonal excitability | NGF | HUMAN SKIN | ROOT GANGLION NEURONS | NEUROSCIENCES | CLINICAL NEUROLOGY | NERVE GROWTH-FACTOR | SODIUM CURRENTS | MESSENGER-RNA | MECHANICAL HYPERALGESIA | ANESTHESIOLOGY | PRIMARY SENSORY NEURONS | UP-REGULATION | Hot Temperature - adverse effects | Humans | Middle Aged | Nociceptors - physiology | Male | Pain - chemically induced | Ultraviolet Rays - adverse effects | Young Adult | Pain Measurement - methods | Pain - physiopathology | Adult | Nerve Growth Factor - toxicity | Inflammation - diagnosis | Physical Stimulation - adverse effects | Inflammation - physiopathology | Pain - diagnosis | Nerve growth factor | Inflammation
UV-B | NaV | Pain | Axonal excitability | NGF | HUMAN SKIN | ROOT GANGLION NEURONS | NEUROSCIENCES | CLINICAL NEUROLOGY | NERVE GROWTH-FACTOR | SODIUM CURRENTS | MESSENGER-RNA | MECHANICAL HYPERALGESIA | ANESTHESIOLOGY | PRIMARY SENSORY NEURONS | UP-REGULATION | Hot Temperature - adverse effects | Humans | Middle Aged | Nociceptors - physiology | Male | Pain - chemically induced | Ultraviolet Rays - adverse effects | Young Adult | Pain Measurement - methods | Pain - physiopathology | Adult | Nerve Growth Factor - toxicity | Inflammation - diagnosis | Physical Stimulation - adverse effects | Inflammation - physiopathology | Pain - diagnosis | Nerve growth factor | Inflammation
Journal Article